Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure

Experimental Physiology

Volumn 98, Issue 2, 2013, Pages 435-443

  Li, Peng ^a   Cui, Bai Ping ^a   Zhang, Ling Li ^a   Sun, Hai Jian ^a   Liu, Tong Yan ^a   Zhu, Guo Qing ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

9 (TETRAHYDRO 2 FURYL)ADENINE; ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; N ACETYL ALPHA INTERMEDIN[4-10]CYCLO[4 NORLEUCINE 5 ASPARTIC ACID 7 [3 (2 NAPHTHYL)ALANINE] 10 LYSINAMIDE];

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; BLOOD PRESSURE; CONTROLLED STUDY; KIDNEY NERVE; MEAN ARTERIAL PRESSURE; NERVE CONDUCTION; NONHUMAN; PARAVENTRICULAR THALAMIC NUCLEUS; PROTEIN FUNCTION; RAT; SYMPATHETIC TONE;

EID: 84872674785     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2012.067256     Document Type: Article

References (45)

1. Averill DB (2000). Neurochemical and peptidergic pathways of the baroreflex arc in the medulla oblongata: an introduction. Brain Res Bull 51, 103-105.
2. Caruso C, Carniglia L, Durand D, Gonzalez PV, Scimonelli TN & Lasaga M (2012). Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP-protein kinase A pathway. Mol Cell Endocrinol 348, 47-54.
3. Chapleau MW & Sabharwal R (2011). Methods of assessing vagus nerve activity and reflexes. Heart Fail Rev 16, 109-127.
4. 1 receptors in paraventricular nucleus contribute to sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive rats. Exp Physiol 96, 94-103.
5. Crestani CC, Alves FH, Busnardo C, Resstel LB & Correa FM (2010). N-Methyl-D-aspartate glutamate receptors in the hypothalamic paraventricular nucleus modulate cardiac component of the baroreflex in unanesthetized rats. Neurosci Res 67, 317-326.
6. Dar MS (2011). Sustained antagonism of acute ethanol-induced ataxia following microinfusion of cyclic AMP and cpt-cAMP in the mouse cerebellum. Pharmacol Biochem Behav 98, 341-348.
7. da Silva AA, do Carmo JM, Kanyicska B, Dubinion J, Brandon E & Hall JE (2008). Endogenous melanocortin system activity contributes to the elevated arterial pressure in spontaneously hypertensive rats. Hypertension 51, 884-890.
8. Datta S & Prutzman SL (2005). Novel role of brain stem pedunculopontine tegmental adenylyl cyclase in the regulation of spontaneous REM sleep in the freely moving rat. J Neurophysiol 94, 1928-1937.
9. Dubinion JH, da Silva AA & Hall JE (2010). Enhanced blood pressure and appetite responses to chronic central melanocortin-3/4 receptor blockade in dietary-induced obesity. J Hypertens 28, 1466-1470.
10. Ferguson AV, Latchford KJ & Samson WK (2008). The paraventricular nucleus of the hypothalamus - a potential target for integrative treatment of autonomic dysfunction. Expert Opin Ther Targets 12, 717-727.
11. Fisher JP & Fadel PJ (2010). Therapeutic strategies for targeting excessive central sympathetic activation in human hypertension. Exp Physiol 95, 572-580.
12. Gan XB, Duan YC, Xiong XQ, Li P, Cui BP, Gao XY & Zhu GQ (2011). Inhibition of cardiac sympathetic afferent reflex and sympathetic activity by baroreceptor and vagal afferent inputs in chronic heart failure. PLoS One 6, e25784.
13. Giraudo SQ, Billington CJ & Levine AS (1998). Feeding effects of hypothalamic injection of melanocortin 4 receptor ligands. Brain Res 809, 302-306.
14. 7]α-melanocyte-stimulating hormone for long-lasting protection against ischemic stroke, in Mongolian gerbils. Eur J Pharmacol 538, 48-56.
15. Giuliani D, Mioni C, Bazzani C, Zaffe D, Botticelli AR, Capolongo S, Sabba A, Galantucci M, Iannone A, Grieco P, Novellino E, Colombo G, Tomasi A, Catania A & Guarini S (2007). Selective melanocortin MC4 receptor agonists reverse haemorrhagic shock and prevent multiple organ damage. Br J Pharmacol 150, 595-603.
16. Grassi G, Seravalle G & Quarti-Trevano F (2010). The 'neuroadrenergic hypothesis' in hypertension: current evidence. Exp Physiol 95, 581-586.
17. Haynes WG, Morgan DA, Djalali A, Sivitz WI & Mark AL (1999). Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 33, 542-547.
18. Kask A, Mutulis F, Muceniece R, Pahkla R, Mutule I, Wikberg JE, Rago L & Schioth HB (1998). Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology 139, 5006-5014.
19. Kc P & Dick TE (2010). Modulation of cardiorespiratory function mediated by the paraventricular nucleus. Respir Physiol Neurobiol 174, 55-64.
20. Kuo JJ, Silva AA & Hall JE (2003). Hypothalamic melanocortin receptors and chronic regulation of arterial pressure and renal function. Hypertension 41, 768-774.
21. Légrádi G & Lechan RM (1999). Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 140, 3643-3652.
22. Li YF, Jackson KL, Stern JE, Rabeler B & Patel KP (2006a). Interaction between glutamate and GABA systems in the integration of sympathetic outflow by the paraventricular nucleus of the hypothalamus. Am J Physiol Heart Circ Physiol 291, H2847-H2856.
23. Li YF, Wang W, Mayhan WG & Patel KP (2006b). Angiotensin-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide. Am J Physiol Regul Integr Comp Physiol 290, R1035-R1043.
24. Ludvig N & Moshe SL (1989). Different behavioral and electrographic effects of acoustic stimulation and dibutyryl cyclic AMP injection into the inferior colliculus in normal and in genetically epilepsy-prone rats. Epilepsy Res 3, 185-190.
25. Mountjoy KG (2010). Distribution and function of melanocortin receptors within the brain. Adv Exp Med Biol 681, 29-48.
26. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB & Cone RD (1994). Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8, 1298-1308.
27. Olivan MV, Bonagamba LG & Machado BH (2001). Involvement of the paraventricular nucleus of the hypothalamus in the pressor response to chemoreflex activation in awake rats. Brain Res 895, 167-172.
28. Oosterom J, Garner KM, den Dekker WK, Nijenhuis WA, Gispen WH, Burbach JP, Barsh GS & Adan RA (2001). Common requirements for melanocortin-4 receptor selectivity of structurally unrelated melanocortin agonist and endogenous antagonist, Agouti protein. J Biol Chem 276, 931-936.
29. Paxinos G & Watson C (2005). The Rat Brain in Stereotaxic Coordinates, 5th edn. Elsevier Academic Press, San Diego .
30. Roselli-Rehfuss L, Mountjoy KG, Robbins LS, Mortrud MT, Low MJ, Tatro JB, Entwistle ML, Simerly RB & Cone RD (1993). Identification of a receptor for γ melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc Natl Acad Sci USA 90, 8856-8860.
31. Rossi NF, Maliszewska-Scislo M, Chen H, Black SM, Sharma S, Ravikov R & Augustyniak RA (2010). Neuronal nitric oxide synthase within paraventricular nucleus: blood pressure and baroreflex in two-kidney, one-clip hypertensive rats. Exp Physiol 95, 845-857.
32. Sayk F, Heutling D, Dodt C, Iwen KA, Wellhoner JP, Scherag S, Hinney A, Hebebrand J & Lehnert H (2010). Sympathetic function in human carriers of melanocortin-4 receptor gene mutations. J Clin Endocrinol Metab 95, 1998-2002.
33. Shi Z, Chen WW, Xiong XQ, Han Y, Zhou YB, Zhang F, Gao XY & Zhu GQ (2012). Sympathetic activation by chemical stimulation of white adipose tissues in rats. J Appl Physiol 112, 1008-1014.
34. Siljee-Wong JE (2011). Melanocortin MC4 receptor expression sites and local function. Eur J Pharmacol 660, 234-240.
35. Singru PS, Sanchez E, Fekete C & Lechan RM (2007). Importance of melanocortin signaling in refeeding-induced neuronal activation and satiety. Endocrinology 148, 638-646.
36. Sutton GM, Duos B, Patterson LM & Berthoud HR (2005). Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through extracellular signal-regulated kinase signaling in rat solitary nucleus. Endocrinology 146, 3739-3747.
37. Valenti D, Manente GA, Moro L, Marra E & Vacca RA (2011). Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway. Biochem J 435, 679-688.
38. Voisey J, Carroll L & van Daal A (2003). Melanocortins and their receptors and antagonists. Curr Drug Targets 4, 586-597.
39. Ward KR, Bardgett JF, Wolfgang L & Stocker SD (2011). Sympathetic response to insulin is mediated by melanocortin 3/4 receptors in the hypothalamic paraventricular nucleus. Hypertension 57, 435-441.
40. Xu B, Chen WW, Fan ZD, Han Y, Xiong XQ, Gao XY & Zhu GQ (2011a). Responses of neurons in paraventricular nucleus to activation of cardiac afferents and acute myocardial ischemia in rats. Exp Physiol 96, 295-304.
41. Xu Y, Gao Q, Gan XB, Chen L, Zhang L, Zhu GQ & Gao XY (2011b). Endogenous hydrogen peroxide in paraventricular nucleus mediates sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive rats. Exp Physiol 96, 1282-1292.
42. Yang Y (2011). Structure, function and regulation of the melanocortin receptors. Eur J Pharmacol 660, 125-130.
43. Yang Y, Chen M, Lai Y, Gantz I, Yagmurlu A, Georgeson KE & Harmon CM (2003). Molecular determination of agouti-related protein binding to human melanocortin-4 receptor. Mol Pharmacol 64, 94-103.
44. Yang YK, Dickinson CJ, Zeng Q, Li JY, Thompson DA & Gantz I (1999). Contribution of melanocortin receptor exoloops to Agouti-related protein binding. J Biol Chem 274, 14100-14106.
45. Ye ZY & Li DP (2011). Activation of the melanocortin-4 receptor causes enhanced excitation in presympathetic paraventricular neurons in obese Zucker rats. Regul Pept 166, 112-120.