메뉴 건너뛰기




Volumn 18, Issue 2, 1999, Pages 386-395

PI 3-kinase γ and protein kinase C-ζ mediate RAS-independent activation of MAP kinase by a G(i) protein-coupled receptor

Author keywords

Atypical PKC; G(i) protein; LPA; MAP kinase; PI3K

Indexed keywords

ANTIPORTER; GUANINE NUCLEOTIDE BINDING PROTEIN; INHIBITOR PROTEIN; INSULIN; LYSOPHOSPHATIDIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE C; RAF PROTEIN; RAS PROTEIN; RECEPTOR; WORTMANNIN;

EID: 0033555721     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.2.386     Document Type: Article
Times cited : (137)

References (44)
  • 1
    • 0030022346 scopus 로고    scopus 로고
    • EGF or PDGF receptors activate atypical PKCλ through phosphatidylinositol 3-kinase
    • Akimoto, K. et al. (1996) EGF or PDGF receptors activate atypical PKCλ through phosphatidylinositol 3-kinase. EMBO J., 15, 788-798.
    • (1996) EMBO J. , vol.15 , pp. 788-798
    • Akimoto, K.1
  • 2
    • 12644301164 scopus 로고    scopus 로고
    • 3-Phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase
    • Alessi, D.R. et al. (1997) 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol., 7, 776-789.
    • (1997) Curr. Biol. , vol.7 , pp. 776-789
    • Alessi, D.R.1
  • 5
    • 0029994358 scopus 로고    scopus 로고
    • Integrin-mediated activation of mitogen-activated protein (MAP) or extracellular signal-related kinase kinase (MEK) is independent of Ras
    • Chen, Q., Lin, T.H., Der, C.J. and Juliano, R.L. (1996) Integrin-mediated activation of mitogen-activated protein (MAP) or extracellular signal-related kinase kinase (MEK) is independent of Ras. J. Biol. Chem., 271, 18122-18127.
    • (1996) J. Biol. Chem. , vol.271 , pp. 18122-18127
    • Chen, Q.1    Lin, T.H.2    Der, C.J.3    Juliano, R.L.4
  • 6
    • 0028240869 scopus 로고
    • Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits
    • Crespo, P., Xu, N., Simonds, W.F. and Gutkind, J.S. (1994) Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature, 369, 418-420.
    • (1994) Nature , vol.369 , pp. 418-420
    • Crespo, P.1    Xu, N.2    Simonds, W.F.3    Gutkind, J.S.4
  • 7
    • 0030044360 scopus 로고    scopus 로고
    • Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors
    • Daub, H., Weiss, F.U., Wallasch, C. and Ullrich, A. (1996) Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors. Nature, 379, 557-560.
    • (1996) Nature , vol.379 , pp. 557-560
    • Daub, H.1    Weiss, F.U.2    Wallasch, C.3    Ullrich, A.4
  • 8
    • 0028176502 scopus 로고
    • ζ PKC induces phosphorylation and inactivation of IκB-α in vitro
    • Díaz-Meco, M.T. et al. (1994) ζ PKC induces phosphorylation and inactivation of IκB-α in vitro. EMBO J., 13, 2842-2848.
    • (1994) EMBO J. , vol.13 , pp. 2842-2848
    • Díaz-Meco, M.T.1
  • 9
    • 0029907265 scopus 로고    scopus 로고
    • A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
    • Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S.A. and Schlessinger, J.A (1996) A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature, 383, 547-550.
    • (1996) Nature , vol.383 , pp. 547-550
    • Dikic, I.1    Tokiwa, G.2    Lev, S.3    Courtneidge, S.A.4    Schlessinger, J.A.5
  • 11
    • 0027981333 scopus 로고
    • Phosphoinositide 3-kinase activity is required for insulin-stimulated glucose transport but not for Ras activation in CHO cells
    • Hara, K. et al. (1994) Phosphoinositide 3-kinase activity is required for insulin-stimulated glucose transport but not for Ras activation in CHO cells. Proc. Natl Acad. Sci. USA, 91, 7415-7419.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 7415-7419
    • Hara, K.1
  • 12
    • 0029943493 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is an early intermediate in the Gβγ-mediated mitogen-activated protein kinase signaling pathway
    • Hawes, B.E., Luttrell, L.M., van Biesen, T. and Lefkowitz, R.J. (1996) Phosphatidylinositol 3-kinase is an early intermediate in the Gβγ-mediated mitogen-activated protein kinase signaling pathway. J. Biol. Chem., 271, 12133-12136.
    • (1996) J. Biol. Chem. , vol.271 , pp. 12133-12136
    • Hawes, B.E.1    Luttrell, L.M.2    Van Biesen, T.3    Lefkowitz, R.J.4
  • 13
    • 0031053360 scopus 로고    scopus 로고
    • Akt signaling: Linking membrane events to life and death decisions
    • Hemmings, B.A. (1997) Akt signaling: linking membrane events to life and death decisions. Science, 275, 628-630.
    • (1997) Science , vol.275 , pp. 628-630
    • Hemmings, B.A.1
  • 14
    • 0028091046 scopus 로고
    • Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts
    • Hordijk, P.L., Verlaan, I., van Corven, E.J. and Moolenaar, W.H. (1994) Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. J. Biol. Chem., 269, 645-651.
    • (1994) J. Biol. Chem. , vol.269 , pp. 645-651
    • Hordijk, P.L.1    Verlaan, I.2    Van Corven, E.J.3    Moolenaar, W.H.4
  • 16
    • 0029943605 scopus 로고    scopus 로고
    • Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
    • Klippel, A., Reinhard, C., Kavanaugh, W.M., Apell, G., Escobedo, M.A. and Williams, L.T. (1996) Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell. Biol., 16, 4117-4127.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4117-4127
    • Klippel, A.1    Reinhard, C.2    Kavanaugh, W.M.3    Apell, G.4    Escobedo, M.A.5    Williams, L.T.6
  • 17
    • 0028670476 scopus 로고
    • i-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G βγ activation of p21ras
    • i-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G βγ activation of p21ras. Proc. Natl Acad. Sci. USA, 91, 12706-12710.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 12706-12710
    • Koch, W.J.1    Hawes, B.E.2    Allen, L.F.3    Leftowitz, R.J.4
  • 18
    • 0030924612 scopus 로고    scopus 로고
    • i-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc
    • i-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc. EMBO J., 16, 3097-3105.
    • (1997) EMBO J. , vol.16 , pp. 3097-3105
    • Kranenburg, O.1    Verlaan, I.2    Hordijk, P.3    Moolenaar, W.H.4
  • 19
    • 0030892639 scopus 로고    scopus 로고
    • Protein kinase C-ζ mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells
    • Liao, D.F., Monia, B., Dean, N. and Berk, B.C. (1997) Protein kinase C-ζ mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells. J. Biol. Chem., 272, 6146-6150.
    • (1997) J. Biol. Chem. , vol.272 , pp. 6146-6150
    • Liao, D.F.1    Monia, B.2    Dean, N.3    Berk, B.C.4
  • 20
    • 0031037296 scopus 로고    scopus 로고
    • Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ
    • Lopez-Ilasaca, M., Crespo, P., Pellici, G., Gutkind, J.S. and Wetzker, R. (1997) Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ. Science, 275, 394-397.
    • (1997) Science , vol.275 , pp. 394-397
    • Lopez-Ilasaca, M.1    Crespo, P.2    Pellici, G.3    Gutkind, J.S.4    Wetzker, R.5
  • 21
    • 0029778177 scopus 로고    scopus 로고
    • Role of c-Src tyrosine kinase in G protein-coupled receptor-and Gβγ subunit-mediated activation of mitogen-activated protein kinases
    • Luttrell, L.M., Hawes, B.E., van Biesen, T., Luttrell, D.K., Lansing, T.J. and Lefkowitz, R.J. (1996) Role of c-Src tyrosine kinase in G protein-coupled receptor-and Gβγ subunit-mediated activation of mitogen-activated protein kinases. J. Biol. Chem., 271, 19443-19450.
    • (1996) J. Biol. Chem. , vol.271 , pp. 19443-19450
    • Luttrell, L.M.1    Hawes, B.E.2    Van Biesen, T.3    Luttrell, D.K.4    Lansing, T.J.5    Lefkowitz, R.J.6
  • 22
    • 0030884103 scopus 로고    scopus 로고
    • PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
    • Marte, B.M. and Downward, J. (1997) PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci., 22, 355-358.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 355-358
    • Marte, B.M.1    Downward, J.2
  • 24
    • 0028903101 scopus 로고
    • Lysophosphatidic acid signalling
    • Moolenaar, W.H. (1995) Lysophosphatidic acid signalling. Curr. Opin. Cell Biol., 7, 203-210.
    • (1995) Curr. Opin. Cell Biol. , vol.7 , pp. 203-210
    • Moolenaar, W.H.1
  • 25
    • 0027535742 scopus 로고
    • Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
    • Nakanishi, H., Brewer, K.A. and Exton, J.H. (1993) Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem., 268, 13-16.
    • (1993) J. Biol. Chem. , vol.268 , pp. 13-16
    • Nakanishi, H.1    Brewer, K.A.2    Exton, J.H.3
  • 26
    • 0028124504 scopus 로고
    • Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology-2 domains, in insulin-stimulated Ras activation
    • Noguchi, T., Matozaki, T., Horita, K., Fujioka, Y. and Kasuga, M. (1994) Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology-2 domains, in insulin-stimulated Ras activation. Mol. Cell. Biol., 14, 6674-6682.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6674-6682
    • Noguchi, T.1    Matozaki, T.2    Horita, K.3    Fujioka, Y.4    Kasuga, M.5
  • 27
    • 0026355723 scopus 로고
    • CSK: A protein-tyrosine kinase involved in regulation of src family kinases
    • Okada, M., Nada, S., Yamanashi, Y., Yamamoto, T. and Nakagawa, H. (1991) CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J. Biol. Chem., 266, 24249-24252.
    • (1991) J. Biol. Chem. , vol.266 , pp. 24249-24252
    • Okada, M.1    Nada, S.2    Yamanashi, Y.3    Yamamoto, T.4    Nakagawa, H.5
  • 28
    • 0001613219 scopus 로고
    • Protein kinase C ζ subspecies from rat brain: Its structure, expression, and properties
    • Ono, Y., Fujii, T., Ogita, K., Kikkawa, U., Igarashi, K. and Nishizuka, Y. (1989) Protein kinase C ζ subspecies from rat brain: its structure, expression, and properties. Proc. Natl Acad. Sci. USA, 86, 3099-3101.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 3099-3101
    • Ono, Y.1    Fujii, T.2    Ogita, K.3    Kikkawa, U.4    Igarashi, K.5    Nishizuka, Y.6
  • 29
    • 0028584245 scopus 로고
    • The phosphatidylinositol 3-kinase α is required for DNA synthesis induced by some, but not all, growth factors
    • Roche, S., Koegl, M. and Courtneidge, S.A. (1994) The phosphatidylinositol 3-kinase α is required for DNA synthesis induced by some, but not all, growth factors. Proc. Natl Acad. Sci. USA, 91, 9185-9189.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 9185-9189
    • Roche, S.1    Koegl, M.2    Courtneidge, S.A.3
  • 30
    • 0028924009 scopus 로고
    • A dominant-negative mutant mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways
    • Sakaue, M., Bowtell, D. and Kasuga, M. (1995) A dominant-negative mutant mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways. Mol. Cell. Biol., 15, 379-388.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 379-388
    • Sakaue, M.1    Bowtell, D.2    Kasuga, M.3
  • 31
    • 0039791449 scopus 로고    scopus 로고
    • Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
    • Schönwasser, D.C., Marais, R.M., Marshall, C.J. and Parker, P.J. (1998) Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol., 18, 790-798.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 790-798
    • Schönwasser, D.C.1    Marais, R.M.2    Marshall, C.J.3    Parker, P.J.4
  • 32
    • 0030810216 scopus 로고    scopus 로고
    • Protein kinase C-ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes
    • Standaert, M.L., Galloway, L., Karnam, P., Bandyopadhyay, G., Moscat, J. and Farese, R.V. (1997) Protein kinase C-ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. J. Biol. Chem., 272, 30075-30082.
    • (1997) J. Biol. Chem. , vol.272 , pp. 30075-30082
    • Standaert, M.L.1    Galloway, L.2    Karnam, P.3    Bandyopadhyay, G.4    Moscat, J.5    Farese, R.V.6
  • 33
    • 0028334738 scopus 로고
    • A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits
    • Stephens, L., Smrcka, A., Cooke, F.T., Jackson, T.R., Sternweis, P.C. and Hawkins, P.T. (1994) A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits. Cell, 77, 83-93.
    • (1994) Cell , vol.77 , pp. 83-93
    • Stephens, L.1    Smrcka, A.2    Cooke, F.T.3    Jackson, T.R.4    Sternweis, P.C.5    Hawkins, P.T.6
  • 34
    • 0030887632 scopus 로고    scopus 로고
    • The Gβγ sensitivity of a P13K is dependent upon a tightly associated adaptor, p101
    • Stephens, L.R. et al. (1997) The Gβγ sensitivity of a P13K is dependent upon a tightly associated adaptor, p101. Cell, 89, 105-114.
    • (1997) Cell , vol.89 , pp. 105-114
    • Stephens, L.R.1
  • 35
    • 0032578999 scopus 로고    scopus 로고
    • Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
    • Stephens, L. et al. (1998) Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science, 279, 710-714.
    • (1998) Science , vol.279 , pp. 710-714
    • Stephens, L.1
  • 36
    • 0029090212 scopus 로고
    • Cloning and characterization of a G-protein activated human phosphoinositide 3-kinase
    • Stoyanov, B. et al. (1995) Cloning and characterization of a G-protein activated human phosphoinositide 3-kinase. Science, 269, 690-693.
    • (1995) Science , vol.269 , pp. 690-693
    • Stoyanov, B.1
  • 37
    • 0030982219 scopus 로고    scopus 로고
    • Angiotensin II stimulates mitogen-activated protein kinases and protein synthesis by a Ras-independent pathway in vascular smooth muscle cells
    • Takahashi, T., Kawahara, Y., Okuda, M., Ueno, H., Takeshita, A. and Yokoyama, M. (1997) Angiotensin II stimulates mitogen-activated protein kinases and protein synthesis by a Ras-independent pathway in vascular smooth muscle cells. J. Biol. Chem., 272, 16018-16022.
    • (1997) J. Biol. Chem. , vol.272 , pp. 16018-16022
    • Takahashi, T.1    Kawahara, Y.2    Okuda, M.3    Ueno, H.4    Takeshita, A.5    Yokoyama, M.6
  • 38
    • 7144228599 scopus 로고    scopus 로고
    • Lysophosphatidic acid-induced association of SHP-2 with SHPS-1: Roles of RHO, FAK, and a SRC family kinase
    • Takeda, H. et al. (1998) Lysophosphatidic acid-induced association of SHP-2 with SHPS-1: roles of RHO, FAK, and a SRC family kinase. Oncogene, 16, 3019-3028.
    • (1998) Oncogene , vol.16 , pp. 3019-3028
    • Takeda, H.1
  • 40
    • 15144355033 scopus 로고    scopus 로고
    • Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2: Roles of FAK and SRC family kinases
    • Tsuda, M. et al. (1998) Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2: roles of FAK and SRC family kinases. J. Biol. Chem., 273, 13223-13229.
    • (1998) J. Biol. Chem. , vol.273 , pp. 13223-13229
    • Tsuda, M.1
  • 43
    • 0028170210 scopus 로고
    • A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
    • Vlahos, C.J., Matter, W.F., Hui, K.Y. and Brown, R.F. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem., 269, 5241-5248.
    • (1994) J. Biol. Chem. , vol.269 , pp. 5241-5248
    • Vlahos, C.J.1    Matter, W.F.2    Hui, K.Y.3    Brown, R.F.4
  • 44
    • 0027374488 scopus 로고
    • Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
    • Yano, H., Nakanishi, S., Kimura, K., Hanai, N., Saitoh, Y., Fukui, Y., Nonomura, Y. and Matsuda, Y. (1993) Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem., 268, 25846-25856.
    • (1993) J. Biol. Chem. , vol.268 , pp. 25846-25856
    • Yano, H.1    Nakanishi, S.2    Kimura, K.3    Hanai, N.4    Saitoh, Y.5    Fukui, Y.6    Nonomura, Y.7    Matsuda, Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.