-
1
-
-
0030022346
-
EGF or PDGF receptors activate atypical PKCλ through phosphatidylinositol 3-kinase
-
Akimoto, K. et al. (1996) EGF or PDGF receptors activate atypical PKCλ through phosphatidylinositol 3-kinase. EMBO J., 15, 788-798.
-
(1996)
EMBO J.
, vol.15
, pp. 788-798
-
-
Akimoto, K.1
-
2
-
-
12644301164
-
3-Phosphoinositide-dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase
-
Alessi, D.R. et al. (1997) 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol., 7, 776-789.
-
(1997)
Curr. Biol.
, vol.7
, pp. 776-789
-
-
Alessi, D.R.1
-
3
-
-
0027178812
-
Protein kinase C ζ isoform is critical for mitogenic signal transduction
-
Berra, E., Díaz-Meco, M.T., Dominguez, I., Municio, M.M., Sanz, L., Lozano, J., Chapkin, R.S. and Moscat, J. (1993) Protein kinase C ζ isoform is critical for mitogenic signal transduction. Cell, 74, 555-563.
-
(1993)
Cell
, vol.74
, pp. 555-563
-
-
Berra, E.1
Díaz-Meco, M.T.2
Dominguez, I.3
Municio, M.M.4
Sanz, L.5
Lozano, J.6
Chapkin, R.S.7
Moscat, J.8
-
4
-
-
0029617910
-
Evidence for a role of MEK and MAPK during signal transduction by protein kinase C ζ
-
Berra, E., Díaz-Meco, M.T., Lozno, J., Frutos, S., Municio, M.M., Sanchez, P., Sanz, L. and Moscat, J. (1995) Evidence for a role of MEK and MAPK during signal transduction by protein kinase C ζ. EMBO J., 14, 6157-6163.
-
(1995)
EMBO J.
, vol.14
, pp. 6157-6163
-
-
Berra, E.1
Díaz-Meco, M.T.2
Lozno, J.3
Frutos, S.4
Municio, M.M.5
Sanchez, P.6
Sanz, L.7
Moscat, J.8
-
5
-
-
0029994358
-
Integrin-mediated activation of mitogen-activated protein (MAP) or extracellular signal-related kinase kinase (MEK) is independent of Ras
-
Chen, Q., Lin, T.H., Der, C.J. and Juliano, R.L. (1996) Integrin-mediated activation of mitogen-activated protein (MAP) or extracellular signal-related kinase kinase (MEK) is independent of Ras. J. Biol. Chem., 271, 18122-18127.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 18122-18127
-
-
Chen, Q.1
Lin, T.H.2
Der, C.J.3
Juliano, R.L.4
-
6
-
-
0028240869
-
Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits
-
Crespo, P., Xu, N., Simonds, W.F. and Gutkind, J.S. (1994) Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits. Nature, 369, 418-420.
-
(1994)
Nature
, vol.369
, pp. 418-420
-
-
Crespo, P.1
Xu, N.2
Simonds, W.F.3
Gutkind, J.S.4
-
7
-
-
0030044360
-
Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors
-
Daub, H., Weiss, F.U., Wallasch, C. and Ullrich, A. (1996) Role of transactivation of the EGF receptor in signaling by G-protein-coupled receptors. Nature, 379, 557-560.
-
(1996)
Nature
, vol.379
, pp. 557-560
-
-
Daub, H.1
Weiss, F.U.2
Wallasch, C.3
Ullrich, A.4
-
8
-
-
0028176502
-
ζ PKC induces phosphorylation and inactivation of IκB-α in vitro
-
Díaz-Meco, M.T. et al. (1994) ζ PKC induces phosphorylation and inactivation of IκB-α in vitro. EMBO J., 13, 2842-2848.
-
(1994)
EMBO J.
, vol.13
, pp. 2842-2848
-
-
Díaz-Meco, M.T.1
-
9
-
-
0029907265
-
A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation
-
Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S.A. and Schlessinger, J.A (1996) A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation. Nature, 383, 547-550.
-
(1996)
Nature
, vol.383
, pp. 547-550
-
-
Dikic, I.1
Tokiwa, G.2
Lev, S.3
Courtneidge, S.A.4
Schlessinger, J.A.5
-
10
-
-
0029166667
-
A synthetic inhibitor of the mitogen-activated protein kinase cascade
-
Dudley, D.T., Pang, L., Decker, S.J., Bridges, A.J. and Saltiel, A.R. (1995) A synthetic inhibitor of the mitogen-activated protein kinase cascade. Proc. Natl Acad. Sci. USA, 92, 7686-7689.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 7686-7689
-
-
Dudley, D.T.1
Pang, L.2
Decker, S.J.3
Bridges, A.J.4
Saltiel, A.R.5
-
11
-
-
0027981333
-
Phosphoinositide 3-kinase activity is required for insulin-stimulated glucose transport but not for Ras activation in CHO cells
-
Hara, K. et al. (1994) Phosphoinositide 3-kinase activity is required for insulin-stimulated glucose transport but not for Ras activation in CHO cells. Proc. Natl Acad. Sci. USA, 91, 7415-7419.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 7415-7419
-
-
Hara, K.1
-
12
-
-
0029943493
-
Phosphatidylinositol 3-kinase is an early intermediate in the Gβγ-mediated mitogen-activated protein kinase signaling pathway
-
Hawes, B.E., Luttrell, L.M., van Biesen, T. and Lefkowitz, R.J. (1996) Phosphatidylinositol 3-kinase is an early intermediate in the Gβγ-mediated mitogen-activated protein kinase signaling pathway. J. Biol. Chem., 271, 12133-12136.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 12133-12136
-
-
Hawes, B.E.1
Luttrell, L.M.2
Van Biesen, T.3
Lefkowitz, R.J.4
-
13
-
-
0031053360
-
Akt signaling: Linking membrane events to life and death decisions
-
Hemmings, B.A. (1997) Akt signaling: linking membrane events to life and death decisions. Science, 275, 628-630.
-
(1997)
Science
, vol.275
, pp. 628-630
-
-
Hemmings, B.A.1
-
14
-
-
0028091046
-
Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts
-
Hordijk, P.L., Verlaan, I., van Corven, E.J. and Moolenaar, W.H. (1994) Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. J. Biol. Chem., 269, 645-651.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 645-651
-
-
Hordijk, P.L.1
Verlaan, I.2
Van Corven, E.J.3
Moolenaar, W.H.4
-
16
-
-
0029943605
-
Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
-
Klippel, A., Reinhard, C., Kavanaugh, W.M., Apell, G., Escobedo, M.A. and Williams, L.T. (1996) Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol. Cell. Biol., 16, 4117-4127.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 4117-4127
-
-
Klippel, A.1
Reinhard, C.2
Kavanaugh, W.M.3
Apell, G.4
Escobedo, M.A.5
Williams, L.T.6
-
17
-
-
0028670476
-
i-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G βγ activation of p21ras
-
i-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G βγ activation of p21ras. Proc. Natl Acad. Sci. USA, 91, 12706-12710.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 12706-12710
-
-
Koch, W.J.1
Hawes, B.E.2
Allen, L.F.3
Leftowitz, R.J.4
-
18
-
-
0030924612
-
i-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc
-
i-mediated activation of the Ras/MAP kinase pathway involves a 100 kDa tyrosine-phosphorylated Grb2 SH3 binding protein, but not Src nor Shc. EMBO J., 16, 3097-3105.
-
(1997)
EMBO J.
, vol.16
, pp. 3097-3105
-
-
Kranenburg, O.1
Verlaan, I.2
Hordijk, P.3
Moolenaar, W.H.4
-
19
-
-
0030892639
-
Protein kinase C-ζ mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells
-
Liao, D.F., Monia, B., Dean, N. and Berk, B.C. (1997) Protein kinase C-ζ mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells. J. Biol. Chem., 272, 6146-6150.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 6146-6150
-
-
Liao, D.F.1
Monia, B.2
Dean, N.3
Berk, B.C.4
-
20
-
-
0031037296
-
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ
-
Lopez-Ilasaca, M., Crespo, P., Pellici, G., Gutkind, J.S. and Wetzker, R. (1997) Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ. Science, 275, 394-397.
-
(1997)
Science
, vol.275
, pp. 394-397
-
-
Lopez-Ilasaca, M.1
Crespo, P.2
Pellici, G.3
Gutkind, J.S.4
Wetzker, R.5
-
21
-
-
0029778177
-
Role of c-Src tyrosine kinase in G protein-coupled receptor-and Gβγ subunit-mediated activation of mitogen-activated protein kinases
-
Luttrell, L.M., Hawes, B.E., van Biesen, T., Luttrell, D.K., Lansing, T.J. and Lefkowitz, R.J. (1996) Role of c-Src tyrosine kinase in G protein-coupled receptor-and Gβγ subunit-mediated activation of mitogen-activated protein kinases. J. Biol. Chem., 271, 19443-19450.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 19443-19450
-
-
Luttrell, L.M.1
Hawes, B.E.2
Van Biesen, T.3
Luttrell, D.K.4
Lansing, T.J.5
Lefkowitz, R.J.6
-
22
-
-
0030884103
-
PKB/Akt: Connecting phosphoinositide 3-kinase to cell survival and beyond
-
Marte, B.M. and Downward, J. (1997) PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. Trends Biochem. Sci., 22, 355-358.
-
(1997)
Trends Biochem. Sci.
, vol.22
, pp. 355-358
-
-
Marte, B.M.1
Downward, J.2
-
23
-
-
0027157640
-
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976
-
Martiny-Baron, G., Kazanietz, M.G., Mischak, H.M., Blumbeg, P.M., Kochs, G., Hug, H., Marmé, D. and Schächtele, C. (1993) Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976. J. Biol. Chem., 268, 9194-9197.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 9194-9197
-
-
Martiny-Baron, G.1
Kazanietz, M.G.2
Mischak, H.M.3
Blumbeg, P.M.4
Kochs, G.5
Hug, H.6
Marmé, D.7
Schächtele, C.8
-
24
-
-
0028903101
-
Lysophosphatidic acid signalling
-
Moolenaar, W.H. (1995) Lysophosphatidic acid signalling. Curr. Opin. Cell Biol., 7, 203-210.
-
(1995)
Curr. Opin. Cell Biol.
, vol.7
, pp. 203-210
-
-
Moolenaar, W.H.1
-
25
-
-
0027535742
-
Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
-
Nakanishi, H., Brewer, K.A. and Exton, J.H. (1993) Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem., 268, 13-16.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 13-16
-
-
Nakanishi, H.1
Brewer, K.A.2
Exton, J.H.3
-
26
-
-
0028124504
-
Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology-2 domains, in insulin-stimulated Ras activation
-
Noguchi, T., Matozaki, T., Horita, K., Fujioka, Y. and Kasuga, M. (1994) Role of SH-PTP2, a protein-tyrosine phosphatase with Src homology-2 domains, in insulin-stimulated Ras activation. Mol. Cell. Biol., 14, 6674-6682.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 6674-6682
-
-
Noguchi, T.1
Matozaki, T.2
Horita, K.3
Fujioka, Y.4
Kasuga, M.5
-
27
-
-
0026355723
-
CSK: A protein-tyrosine kinase involved in regulation of src family kinases
-
Okada, M., Nada, S., Yamanashi, Y., Yamamoto, T. and Nakagawa, H. (1991) CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J. Biol. Chem., 266, 24249-24252.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 24249-24252
-
-
Okada, M.1
Nada, S.2
Yamanashi, Y.3
Yamamoto, T.4
Nakagawa, H.5
-
28
-
-
0001613219
-
Protein kinase C ζ subspecies from rat brain: Its structure, expression, and properties
-
Ono, Y., Fujii, T., Ogita, K., Kikkawa, U., Igarashi, K. and Nishizuka, Y. (1989) Protein kinase C ζ subspecies from rat brain: its structure, expression, and properties. Proc. Natl Acad. Sci. USA, 86, 3099-3101.
-
(1989)
Proc. Natl Acad. Sci. USA
, vol.86
, pp. 3099-3101
-
-
Ono, Y.1
Fujii, T.2
Ogita, K.3
Kikkawa, U.4
Igarashi, K.5
Nishizuka, Y.6
-
29
-
-
0028584245
-
The phosphatidylinositol 3-kinase α is required for DNA synthesis induced by some, but not all, growth factors
-
Roche, S., Koegl, M. and Courtneidge, S.A. (1994) The phosphatidylinositol 3-kinase α is required for DNA synthesis induced by some, but not all, growth factors. Proc. Natl Acad. Sci. USA, 91, 9185-9189.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 9185-9189
-
-
Roche, S.1
Koegl, M.2
Courtneidge, S.A.3
-
30
-
-
0028924009
-
A dominant-negative mutant mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways
-
Sakaue, M., Bowtell, D. and Kasuga, M. (1995) A dominant-negative mutant mSOS1 inhibits insulin-induced Ras activation and reveals Ras-dependent and -independent insulin signaling pathways. Mol. Cell. Biol., 15, 379-388.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 379-388
-
-
Sakaue, M.1
Bowtell, D.2
Kasuga, M.3
-
31
-
-
0039791449
-
Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes
-
Schönwasser, D.C., Marais, R.M., Marshall, C.J. and Parker, P.J. (1998) Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol., 18, 790-798.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 790-798
-
-
Schönwasser, D.C.1
Marais, R.M.2
Marshall, C.J.3
Parker, P.J.4
-
32
-
-
0030810216
-
Protein kinase C-ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes
-
Standaert, M.L., Galloway, L., Karnam, P., Bandyopadhyay, G., Moscat, J. and Farese, R.V. (1997) Protein kinase C-ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. J. Biol. Chem., 272, 30075-30082.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 30075-30082
-
-
Standaert, M.L.1
Galloway, L.2
Karnam, P.3
Bandyopadhyay, G.4
Moscat, J.5
Farese, R.V.6
-
33
-
-
0028334738
-
A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits
-
Stephens, L., Smrcka, A., Cooke, F.T., Jackson, T.R., Sternweis, P.C. and Hawkins, P.T. (1994) A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits. Cell, 77, 83-93.
-
(1994)
Cell
, vol.77
, pp. 83-93
-
-
Stephens, L.1
Smrcka, A.2
Cooke, F.T.3
Jackson, T.R.4
Sternweis, P.C.5
Hawkins, P.T.6
-
34
-
-
0030887632
-
The Gβγ sensitivity of a P13K is dependent upon a tightly associated adaptor, p101
-
Stephens, L.R. et al. (1997) The Gβγ sensitivity of a P13K is dependent upon a tightly associated adaptor, p101. Cell, 89, 105-114.
-
(1997)
Cell
, vol.89
, pp. 105-114
-
-
Stephens, L.R.1
-
35
-
-
0032578999
-
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
-
Stephens, L. et al. (1998) Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science, 279, 710-714.
-
(1998)
Science
, vol.279
, pp. 710-714
-
-
Stephens, L.1
-
36
-
-
0029090212
-
Cloning and characterization of a G-protein activated human phosphoinositide 3-kinase
-
Stoyanov, B. et al. (1995) Cloning and characterization of a G-protein activated human phosphoinositide 3-kinase. Science, 269, 690-693.
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
-
37
-
-
0030982219
-
Angiotensin II stimulates mitogen-activated protein kinases and protein synthesis by a Ras-independent pathway in vascular smooth muscle cells
-
Takahashi, T., Kawahara, Y., Okuda, M., Ueno, H., Takeshita, A. and Yokoyama, M. (1997) Angiotensin II stimulates mitogen-activated protein kinases and protein synthesis by a Ras-independent pathway in vascular smooth muscle cells. J. Biol. Chem., 272, 16018-16022.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16018-16022
-
-
Takahashi, T.1
Kawahara, Y.2
Okuda, M.3
Ueno, H.4
Takeshita, A.5
Yokoyama, M.6
-
38
-
-
7144228599
-
Lysophosphatidic acid-induced association of SHP-2 with SHPS-1: Roles of RHO, FAK, and a SRC family kinase
-
Takeda, H. et al. (1998) Lysophosphatidic acid-induced association of SHP-2 with SHPS-1: roles of RHO, FAK, and a SRC family kinase. Oncogene, 16, 3019-3028.
-
(1998)
Oncogene
, vol.16
, pp. 3019-3028
-
-
Takeda, H.1
-
39
-
-
0029028786
-
G protein βγ subunits stimulate phosphorylation of Shc adapter protein
-
Touhara, K., Hawes, B.E., van Biesen, T. and Lefkowitz, R.J. (1995) G protein βγ subunits stimulate phosphorylation of Shc adapter protein. Proc. Natl Acad. Sci. USA, 92, 9284-9287.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 9284-9287
-
-
Touhara, K.1
Hawes, B.E.2
Van Biesen, T.3
Lefkowitz, R.J.4
-
40
-
-
15144355033
-
Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2: Roles of FAK and SRC family kinases
-
Tsuda, M. et al. (1998) Integrin-mediated tyrosine phosphorylation of SHPS-1 and its association with SHP-2: roles of FAK and SRC family kinases. J. Biol. Chem., 273, 13223-13229.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13223-13229
-
-
Tsuda, M.1
-
41
-
-
0028977847
-
Receptor-tyrosine-kinase-and Gβγ-mediated MAP kinase activation by a common signalling pathway
-
van Biesen, T., Hawes, B.E., Luttrell, D.K., Krueger, K.M., Touhara, K., Porfiri, E., Sakaue, M., Luttrell, L.M. and Lefkowitz, R.J. (1995) Receptor-tyrosine-kinase-and Gβγ-mediated MAP kinase activation by a common signalling pathway. Nature, 376, 781-784.
-
(1995)
Nature
, vol.376
, pp. 781-784
-
-
Van Biesen, T.1
Hawes, B.E.2
Luttrell, D.K.3
Krueger, K.M.4
Touhara, K.5
Porfiri, E.6
Sakaue, M.7
Luttrell, L.M.8
Lefkowitz, R.J.9
-
42
-
-
0029670821
-
o-protein α-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism
-
o-protein α-subunits activate mitogen-activated protein kinase via a novel protein kinase C-dependent mechanism. J. Biol. Chem., 271, 1266-1269.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 1266-1269
-
-
Van Biesen, T.1
Hawes, B.E.2
Raymond, J.R.3
Luttrell, L.M.4
Koch, W.J.5
Lefkowitz, R.J.6
-
43
-
-
0028170210
-
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)
-
Vlahos, C.J., Matter, W.F., Hui, K.Y. and Brown, R.F. (1994) A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002). J. Biol. Chem., 269, 5241-5248.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5241-5248
-
-
Vlahos, C.J.1
Matter, W.F.2
Hui, K.Y.3
Brown, R.F.4
-
44
-
-
0027374488
-
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
-
Yano, H., Nakanishi, S., Kimura, K., Hanai, N., Saitoh, Y., Fukui, Y., Nonomura, Y. and Matsuda, Y. (1993) Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem., 268, 25846-25856.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 25846-25856
-
-
Yano, H.1
Nakanishi, S.2
Kimura, K.3
Hanai, N.4
Saitoh, Y.5
Fukui, Y.6
Nonomura, Y.7
Matsuda, Y.8
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