Inhibition of adipose differentiation by phosphatidylinositol 3-kinase inhibitors

Journal of Cellular Physiology

Volumn 178, Issue 1, 1999, Pages 9-16

  Xia, Xianmin ^a   Serrero, Ginette ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENZYME INHIBITION; ENZYME MECHANISM; INHIBITION KINETICS; LIPOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA;

EID: 3743152831     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1097-4652(199901)178:1<9::aid-jcp2>3.0.co;2-%23     Document Type: Article

References (50)

1. Ahmed N, Grmes HL, Bllacosa A, Chen TO, Tsichlis PN. 1997. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc Natl Acad Sci USA 94:3627-3632.
2. Ailhaud G, Grimaldi P, Negrel R. 1992. Cellular and molecular aspects of adipose tissue development. Annu Rev Nutr 12:207-233.
3. Backer J, Myers M, Shoelson S, Chin D, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik E, Schlessinger J, White, M. 1992. The phosphatidylinositol 3-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J 11:3469-3479.
4. S6 kinase pathway induces B16 melanoma cell differentiation. J Biol Chem 271:31824-31830.
5. Carpenter C, Auger K, Duckworth B, Hou W, Schaffhausen B, Cantley L. 1993. A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity. Mol Cell Biol 13:1657-1665.
6. Chawla A, Schwarz EJ. 1994. Peroxisome proliferator-activated receptor PPAR γ: Adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135:798-800.
7. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR. 1994. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis and glucose transporter translocation. Mol Cell Biol 14:4902-4911.
8. Coolican SA, Samuel DS, Ewton DZ, McWade FJ, Florini JR. 1997. The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathways. J Biol Chem 272:6653-6672.
9. Cornelius P, MacDougald OA, Lane MD. 1994. Regulation of adipocyte development. Annu Rev Nutr 14:99-129.
10. Dhand R, Hiles I, Panayotou G, Roche S, Fry J, Gout I, Totty N, Truong O, Vicendo P, Yonezawa K, Kasuga M, Courtneidge S, Waterfield M. 1994. PI 3-kinase: structural and functional analysis of intersubunit interactions. EMBO J 13:522-533.
11. Ettinger SL, Lauener RW, Duronio V. 1996. Protein kinase cδ specifically associated with phosphatidylinositol 3-kinase following cytokine stimulation. J Biol Chem 271:14514-14518.
12. 2 is a ligand for the adipocyte determination factor PPARγ. Cell 83:803-812.
13. Franke TF, Yang S-I, Chan TO, Katta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phophatidylinositol 3-kinase. Cell 81:727-736.
14. Green H, Kehinde O. 1975. An established preadipose cell line and its culture. II. Factors affecting the adipose conversion. Cell 5:19-27.
15. Hawkins PT, Eguinoa A, Qui RG, Stokoe D, Cooke FT, Walters R, Wennstrom S, Claesson WL, Evans T, Symons M, Stephens L. 1995. PDGF stimulates an increase in GTP-rac via activation of phosphoinositide 3-kinase. Curr Biol 5:393-403.
16. Hu E, Tontonoz P, Spiegelman BM. 1995. Transdifferentiation of myoblasts by the adipogenic transcription factors PPARγ and C/EBPα. Proc Natl Acad Sci USA 92:9856-9860.
17. Jiang HP, Serrero G. 1992. Isolation and characterization of a full-length cDNA coding for an adipose differentiation-related protein. Proc Natl Acad Sci USA 89:7856-7860.
18. Jiang HP, Harris SE, Serrero G. 1992. Molecular cloning of a differentiation related mRNA in the adipogenic cell line 1246. Cell Growth Differ 3:21-30.
19. Kahn CR, White M, Shoelson S, Backer J, Araki E, Cheatham B, Csermely P, Folli F, Goldstein B, Huertas P, Rothernberg P, Saad M, Siddle K, Sun X-J, Wilden P, Yamada K, Kahn S. 1993. The insulin receptor and its substrate: Molecular determinants of early events in insulin action. Recent Prog Horm Res 48:291-339.
20. Kaliman P, Vinals F, Testar X, Palacin M, Zorzano A. 1995. Disruption of Glut1 glucose carrier trafficing in L6E9 and Sol8 myoblasts by the phosphatidylinositol 3-kinase inhibitor wortmannin. Biochem J 312:471-477.
21. Kaliman P, Vinals F, Textar X, Palacin M, Zorzano A. 1996. Phosphatidylinositol 3-kinase inhibitors block differentiation of skeletal muscle cells. J Biol Chem 271:19146-19151.
22. Kapeller R, Cantley L. 1994. Phosphatidylinositol 3-kinase. Bioessays 16:565-576.
23. Kaplan DR, Whitman M, Schaffhausen B, Pallas DC, White MF, Cantley L, Roberts TM. 1987. Common elements in growth factor stimulation and oncogenic transformation: 85 kDa phosphoprotein and phosphatidylinositol kinase acitvity. Cell 50:1021-1029.
24. Keller SR, Lamphere L, Lavan BE, Kuhne MR, Lienhard GE. 1993. Insulin and IGF-1 signaling through the insulin receptor substrate 1. Mol Reprod Dev 35:346-351.
25. Kimura K, Hattori S, Kabuyama Y, Shizawa Y, Takayanagi J, Nakamura S, Toki S, Matsuda Y, Onodera K, Fukui Y. 1994. Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase. J Biol Chem 269:18961-18967.
26. Kliewer SA, Forman BM, Blumberg B, Ong ES, Borgmeyer U, Mangelsdorf DJ, Umesono K, Evans, RM. 1994. Differential expression and activation of a family of murine peroxisome proliferator-activated receptors. Proc Natl Acad Sci USA 91:7355-7359.
27. Kohn AD, Summers SA, Birnbaum MJ, Roth RA. 1996. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271:31372-31378.
28. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
29. Lam K, Carpenter C, Ruderman N, Friel J, Kelly K. 1994. The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. J Biol Chem 269:20648-20652.
30. Lehman JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA. 1997. Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272:3406-3410.
31. MacDougald OA, Lane MD. 1995. Transcriptional regulation of gene expression during adipocyte defferentiation. Annu Rev Biochem 64:345-373.
32. Magun R, Burgering BMTh, Coffer PJ, Pardasani D, Lin Y, Chabot J, Sorisky A. 1996. Expression of a constitutively activated form of protein kinase B (c-AKT) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology 137:3590-3593.
33. Mandrup S, Lane MD. 1997. Regulating adipogenesis. J Biol Chem 272:5367-5370.
34. Myers M, Sun X-J, White M. 1994. The IRS-1 signaling system. Trends Biochem Sci 19:289-292.
35. Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M. 1994. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. J Biol Chem 269: 3568-3573.
36. Panayotou G, Bax B, Gout I, Federswisch M, Wrobolowski B, Dhand R, Fry MJ, Blundell TL, Wollmer A, Waterfield MD. 1992. Interaction of the p85 subunit of PI 3-kinase and its N-terminal SH2 domain with a PDGF receptor phosphorylation site: structural features and analysis of conformational changes. EMBO J 11: 4261-4272.
37. Schu PV, Takegawa K, Fry MJ, Stack JH, Waterfield MD, Emr SD. 1993. Phosphatidylinositol 3-kinase encoded by yeast VPS34 gene essential for protein sorting. Science 260:690-693.
38. Serrero, G. 1984. Study of a teratoma-derived adipogenic cell line 1246 and isolation of an insulin independent variant in serum-free medium. In: Fisher G, Wieser RJ, editors. Hormonally Defined Media, a Tool in Cell Biology. New York: Springer-Verlag. p 310-313.
39. Serrero G, Khoo JC. 1982. An in vivo model to study adipose differentiation in serum free medium. Anal Biochem 120:351-359.
40. Serrero G, Mills D. 1987. EGF inhibits the differentiation of adipocyte precursors in primary culture. Biochem Biophys Res Commun 146: 194-202.
41. Serrero G, Mills D. 1991. Physiological role of epidermal growth factor on adipose tissue development in vivo. Proc Natl Acad Sci USA 88: 3912-3916.
42. 2 inhibits early and late markers of differentiation in the adipogenic cell line 1246. Endocrinology 131:2545-2551.
43. Tomiyama K, Nakata H, Sasa H, Arimura S, Nishio E, Watanabe Y. 1995. Wortmannin, a specific phosphatidylinositol 3 kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells. Biochem Biophys Res Commun 212:263-269.
44. Tontonoz P, Hu E, Spiegelman BM. 1995. Regulation of adipocyte gene expression and differentiation by peroxisome proliferator activated receptor γ. Curr Opin Genet Dev 5:571-576.
45. Ui M, Okada T, Hazeki K, Hazeki O. 1995. Wortmannin as a unique probe for an intracellular signaling protein, phosphoinositide 3-kinase. Trends Biochem Sci 20:303-307.
46. Valius M, Kazlauskas A. 1993. Phospholipase c-γ1 and phosphatidyl. inositol 3-kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell 73:321-334.
47. Vlahos CJ, Matter WF, Hui KY, Brown RF. 1994. A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one LY294002. J Biol Chem 269:241-5248.
48. Weng QP, Andrabi K, Kuppel A, Kozlowski MT, Williams LT, Auruch J. 1995. Phosphatidylinositol 3-kinase signals activation of p7056 kinase in situ through site specific p70 phosphorylation. Proc Natl Acad Sci USA 92:5744-5748.
49. Whitman M, Downes CP, Keeler M, Keller T, Cantley L. 1988. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate. Nature 332:644-646.
50. Yonezawa K, Ueda H, Hara K, Nishida K, Ando A, Chavanieu A, Matsuba H, Shii K, Yokono K, Fukui Y, Calas B, Grigorescu F, Dhand R, Gout I, Otsu M, Waterfield M, Kasaga M. 1992. Insulin-dependent formation of a complex containing an 85-kDa subunit of phosphatidylinositol 3-kinase and tyrosine-phosphorylated insulin receptor substrate 1. J Biol Chem 267:25958-25965.