Melanocortin-4 receptor mRNA is expressed in sympathetic nervous system outflow neurons to white adipose tissue

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 289, Issue 5 58-5, 2005, Pages

  Song, C Kay ^a   Jackson, Raven M ^a   Harris, Ruth B S ^a,b   Richard, Denis ^c   Bartness, Timothy J ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

Lipolysis; Obesity; Pseudorabies virus; Siberian hamster

Indexed keywords

MELANOCORTIN; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 4 RECEPTOR AGONIST; MELANOTAN II; MESSENGER RNA; NEUROPEPTIDE; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BODY FAT; BRAIN CELL; CELL LABELING; CONTROLLED STUDY; ENERGY BALANCE; ENERGY EXPENDITURE; FOOD INTAKE; HAMSTER; HYPOTHALAMUS; HYPOTHALAMUS NUCLEUS; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; LIPID METABOLISM; LIPOLYSIS; MALE; NEUROANATOMY; NONHUMAN; NUCLEOTIDE SEQUENCE; PEPTIDE ANALYSIS; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PSEUDORABIES HERPETOVIRUS; SOLITARY TRACT NUCLEUS; SUPRACHIASMATIC NUCLEUS; THALAMUS MIDLINE NUCLEUS; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE; ANIMALS; CRICETINAE; HERPESVIRUS 1, SUID; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MALE; NEURONS; PHODOPUS; RECEPTOR, MELANOCORTIN, TYPE 4; RNA, MESSENGER; SYMPATHETIC NERVOUS SYSTEM;

EID: 27144523482     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00348.2005     Document Type: Article

References (54)

1. Ballantyne B. Histochemical and biochemical aspects of cholinesterase activity of adipose tissue. Arch Int Pharmacodyn Ther 173: 343-350, 1968.
2. Bamshad M, Aoki VT, Adkison MG, Warren WS, and Bartness TJ. Central nervous system origins of the sympathetic nervous system outflow to white adipose tissue. Am J Physiol Regul Integr Comp Physiol 275: R291-R299, 1998.
3. Barkai A and Allweis C. Effect of electrical stimulation of the hypothalamus on plasma free fatty acid concentration in cats. J Lipid Res 13: 725-732, 1972.
4. Barkai A and Allweis C. Effect of electrical stimulation of the hypothalamus on plasma levels of free fatty acids and glucose in rats. Metabolism 21: 921-927, 1972.
5. Bartness TJ and Bamshad M. Innervation of mammalian white adipose tissue: Implications for the regulation of total body fat. Am J Physiol Regul Integr Comp Physiol 275: R1399-R1411, 1998.
6. Bartness TJ, Demas GE, and Song CK. Central nervous system innervation of white adipose tissue. In: Adipose Tissue, edited by Klaus S. Georgetown, TX: Landes Bioscience, 2001, p. 116-130.
7. Bartness TJ, Song CK, Shi H, Bowers RR, and Foster MT. Brain-adipose tissue cross talk. Proc Nutr Soc 64: 53-64, 2005.
8. Berthoud HR. Multiple neural systems controlling food intake and body weight. Neurosci Biobehav Rev 26: 393-428, 2002.
9. Boston BA and Cone KD. Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line. Endocrinology 137: 2043-2050, 1996.
10. Bowers RR, Festuccia WTL, Song CK, Shi H, Migliorini RH, and Bartness TJ. Sympathetic innervation of white adipose tissue and its regulation of fat cell number. Am J Physiol Regul Integr Comp Physiol 286: R1167-R1175, 2004.
11. Bronstein DM, Shafer MKH, Watson SJ, and Akil H. Evidence that β-endorphin is synthesized in cells in the nucleus tractus solitarius: detection of POMC mRNA. Brain Res 587: 269-275, 1992.
12. Caulliez R, Viarouge C, and Nicolaidis S. Electrical stimulation of the suprachiasmatic nucleus region modifies energy metabolism in the rat. In: New Functional Aspects of the Suprachiasmatic Nucleus of the Hypothalamus, edited by Nakagawa H, Oomura Y, and Nagai K. London: John Libbey, 1991, p. 75-84.
13. Cettour-Rose P, and Rohner-Jeanrenaud F. The leptin-like effects of 3-D peripheral administration of a melanocortin agonist are more marked in genetically obese Zucker (fa/fa) than in lean rats. Endocrinology 143: 2277-2283, 2002.
14. Cummings DE and Schwartz MW. Melanocortins and body weight: a tale of two receptors. Nat Genet 26: 8-9, 2000.
15. Day DE and Bartuess TJ. Agouti-related protein increases food hoarding, but not food intake by Siberian hamsters. Am J Physiol Regul Integr Comp Physiol 286: R38-R45, 2004.
16. Garofalo MAR, Kettelhut IC, Roselino JES, and Migliorini RH. Effect of acute cold exposure on norepinephrine turnover rates in rat white adipose tissue. J Auton Nerv Syst 60: 206-208, 1996.
17. Grill HJ, Ginsberg AB, Seeley RJ, and Kaplan JM. Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight. J Neurosci 18: 10128-10135, 1998.
18. Gross J and Migliorini RH. Further evidence for a central regulation of free fatty acid mobilization in the rat. Am J Physiol Endocrinol Metab Gastrointest Physiol 232: E165-E171, 1977.
19. Gwyn DG, Ritchie TC, and Coulter JD. The central distribution of vagal catecholaminergic neurons which project into the abdomen in the rat. Brain Res 328: 139-144, 1985.
20. Haskell-Luevano C, Miwa H, Dickinson C, Hruby VJ, Yamada T, and Gantz I. Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R. Biochem Biophys Res Commun 204: 1137-1142, 1994.
21. Haynes WG, Morgan DA, Djalali A, Sivitz WI, and Mark AL. Interactions between the melanocortin system and leptin in control of sympathetic nerve traffic. Hypertension 33: 542-547, 1999.
22. Hoggard N, Hunter L, Duncan JS, and Rayner DV. Regulation of adipose tissue leptin secretion by alpha-melanocyte-stimulating hormone and agouti-related protein: further evidence of an interaction between leptin and the melanocortin signalling system. J Mol Endocrinol 32: 145-153, 2004.
23. Hwa JJ, Ghibaudi L, Gao J, and Parker EM. Central melanocortin system modulates energy intake and expenditure of obese and lean Zucker rats. Am J Physiol Regul Integr Comp Physiol 281: R444-R451, 2001.
24. Jansen ASP, Hoffman JL, and Loewy AD. CNS sites involved in sympathetic and parasympathetic control of the pancreas: a viral tracing study. Brain Res 766: 29-38, 1997.
25. Kalia M, Fuxe K, Goldstein M, Harfstrand A, Agnati LF, and Coyle JT. Evidence for the existence of putative dopamine-, adrenaline- and noradrenaline-containing vagal motor neurons in the brainstem of the rat. Neurosci Lett 50: 57-62, 1984.
26. Kishi T, Aschkenasi CJ, Lee CE, Mountjoy KG, Saper CB, and Elmquist JK. Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J Comp Neurol 457: 213-235, 2003.
27. Kreier F, Fliers E, Voshol PJ, Van Eden CG, Havekes LM, Kalsbeek A, Van Heijningen CL, Sluiter AA, Mettenleiter TC, Romijn JA, Sauerwein HP, and Buijs RM. Selective parasympathetic innervation of subcutaneous and intra-abdominal fat-functional implications. J Clin Invest 110: 1243-1250, 2002.
28. Kumon A, Takahashi A, Hara T, and Shimazu T. Mechanism of lipolysis induced by electrical stimulation of the hypothalamus in the rabbit. J Lipid Res 17: 551-558, 1976.
29. Liu H, Kishi T, Roseberry AG, Cai X, Lee CE, Montez JM, Friedman JM, and Elmquist JK. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci 23: 7143-7154, 2003.
30. Loewy AD, Franklin MF, and Haxhiu MA. CNS monoamine cell groups projecting to pancreatic vagal motor neurons: a transneuronal labeling study using a pseudorabies virus. Brain Res 638: 248-260, 1994.
31. Luiten PGM, ter Horst GJ, Karst H, and Steffens AB. The course of paraventricular hypothalamic efferents to autonomic structures in medulla and spinal cord. Brain Res 329: 374-378, 1985.
32. Mountjoy KG, Mortrud MT, Low MJ, Simerly RB, and Cone RD. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol Endocrinol 8: 1298-1308, 1994.
33. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, and Barsh GS. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278: 135-138, 1997.
34. Oro L, Wallenberg LR, and Bolme P. Influence of electrical supramedullary stimulation on the plasma level of free fatty acids, blood pressure and heart rate in the dog. Acta Med Scand 178: 697, 1965.
35. Palkovits M. Interconnections between the neuroendocrine hypothalamus and the central autonomie system. Front Neuroendocrinol 20: 270-295, 1999.
36. Palkovits M, Mezey E, and Eskay R. Pro-opiomelanocortin-derived peptides (ACTH/β-endorphin/α-MSH) in the brainstem baroceptor areas of the rat. Brain Res 436: 323-328, 1987.
37. Paxinos G and Franklin KBJ. The Mouse Brain in Stereotaxic Coordinates. San Diego: Academic, 2001.
38. Rahmouni K, Haynes WG, Morgan DA, and Mark AL. Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. J Neurosci 23: 5998-6004, 2003.
39. Raposinho PD, White RB, and Aubert ML. The melanocortin agonist melanotan-II reduces the orexigenic and adipogenic effects of neuropeptide Y (NPY) but does not affect the NPY-driven suppressive effects on the gonadotropic and somatotropic axes in the male rat. J Neuroendocrinol 15: 173-181, 2003.
40. Schuhler S, Horan TL, Hastings MH, Mercer JG, Morgan PJ, and Ebling FJ. Feeding and behavioural effects of central administration of the melanocortin 3/4-R antagonist SHU9119 in obese and lean Siberian hamsters. Behav Brain Res 152: 177-185, 2004.
41. Schuhler S, Horan TL, Hastings MH, Mercer JG, Morgan PJ, and Ebling FJ. Decrease of food intake by MC4-R agonist MTII in Siberian hamsters in long and short photoperiods. Am J Physiol Regul Integr Comp Physiol 284: R227-R232, 2003.
42. Shi H and Bartness TJ. Neurochemical phenotype of sympathetic nervous system outflow from brain to white fat. Brain Res Bull 54: 375-385, 2001.
43. Smith JE, Jansen ASP, Gilbey MP, and Loewy AD. CNS cell groups projecting to sympathetic outflow of tail artery: neural circuits involved in heat loss in the rat. Brain Res 786: 153-164, 1998.
44. Song CK and Bartness TJ. CNS sympathetic outflow neurons to white fat that express melatonin receptors may mediate seasonal adiposity. Am J Physiol Regul Integr Comp Physiol 281: R666-R672, 2001.
45. Song CK, Enquist LW, and Bartness TJ. New developments in viral tracings of neural circuits. Virus Res 2005.
46. Standish A, Enquist LW, Escardo JA, and Schwaber JS. Central neuronal circuit innervating the rat heart defined by transneuronal transport of pseudorabies virus. J Neurosci 15: 1998-2012, 1995.
47. Strack AM, Sawyer WB, Platt KB, and Loewy AD. CNS cell groups regulating the sympathetic outflow to adrenal gland as revealed by transneuronal cell body labeling with pseudorabies virus. Brain Res 491: 274-296, 1989.
48. Takahashi A and Shimazu T. Hypothalamic regulation of lipid metabolism in the rat: effect of hypothalamic stimulation on lipolysis. J Auton Nerv Syst 4: 195-205, 1981.
49. Van Der Ploeg LH, Martin WJ, Howard AD, Nargund RP, Austin CP, Guan X, Drisko J, Cashen D, Sebhat I, Patchett AA, Figueroa DJ, DiLella AG, Connolly BM, Weinberg DH, Tan CP, Palyha OC, Pong SS, MacNeil T, Rosenblum C, Vongs A, Tang R, Yu H, Sailer AW, Fong TM, Huang C, Tota MR, Chang RS, Stearns R, Tamvakopoulos C, Christ G, Drazen DL, Spar BD, Nelson RJ, and MacIntyre DE. A role for the melanocortin 4 receptor in sexual function. Proc Natl Acad Sci USA 99: 11381-11386, 2002.
50. Vergoni AV and Bertolini A. Role of melanocortins in the central control of feeding. Eur J Pharmacol 405: 25-32, 2000.
51. Williams DL, Bowers RR, Bartness TJ, Kaplan JM, and Grill HJ. Brainstem melanocortin 3/4 receptor stimulation increases uncoupling protein gene expression in brown fat. Endocrinology 144: 4692-4697, 2003.
52. Yasuda T, Masaki T, Kakuma T, and Yoshimatsu H. Hypothalamic melanocortin system regulates sympathetic nerve activity in brown adi-pose tissue. Exp Biol Med (Maywood) 229: 235-239, 2004.
53. Youngstrom TG and Bartness TJ. Catecholaminergic innervation of white adipose tissue in the Siberian hamster. Am J Physiol Regul Integr Comp Physiol 268: R744-R751, 1995.
54. Zheng H, Patterson LM, Phifer CB, and Berthoud HR. Brainstem melanocortinergic modulation of meal size and identification of hypothalamic POMC projections. Am J Physiol Regul Integr Comp Physiol 289: R247-R258, 2005.