메뉴 건너뛰기




Volumn 93, Issue 4, 2011, Pages 201-210

Intracellular leptin-signaling pathways in hypothalamic neurons: The emerging role of phosphatidylinositol-3 kinase-phosphodiesterase-3B-cAMP pathway

Author keywords

cAMP; Diet induced obesity; Hypothalamus; Leptin; Leptin resistance; Phosphodiesterase 3B; PI3K; STAT3

Indexed keywords

CILOSTAMIDE; CYCLIC AMP; INSULIN RECEPTOR SUBSTRATE 1; JANUS KINASE 2; LEPTIN; MELANIN CONCENTRATING HORMONE; NEUROPEPTIDE Y; NEUROTENSIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHODIESTERASE III; PHOSPHODIESTERASE IIIB; PROOPIOMELANOCORTIN; STAT3 PROTEIN; UNCLASSIFIED DRUG;

EID: 79959375716     PISSN: 00283835     EISSN: 14230194     Source Type: Journal    
DOI: 10.1159/000326785     Document Type: Article
Times cited : (60)

References (78)
  • 1
    • 70449255388 scopus 로고
    • The effects of lesions in the hy-pothalamus in parabiotic rats
    • Hervey GR: The effects of lesions in the hy-pothalamus in parabiotic rats. J Physiol 1959; 145:336-352.
    • (1959) J Physiol , vol.145 , pp. 336-352
    • Hervey, G.R.1
  • 2
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • DOI 10.1038/372425a0
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human ho-mologue. Nature 1994; 372: 425-432. (Pubitemid 24365442)
    • (1994) Nature , vol.372 , Issue.6505 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 3
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • DOI 10.1038/27376
    • Friedman JM, Halaas JL: Leptin and the reg-ulation of body weight in mammals. Nature 1998; 395: 763-770. (Pubitemid 28485436)
    • (1998) Nature , vol.395 , Issue.6704 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 4
    • 0347320633 scopus 로고    scopus 로고
    • Leptin signaling in the hypothalamus: Emphasis on energy homeostasis and leptin resistance
    • DOI 10.1016/j.yfrne.2003.10.001
    • Sahu A: Leptin signaling in the hypothala-mus: emphasis on energy homeostasis and leptin resistance. Front Neuroendocrinol 2003; 24: 225-253. (Pubitemid 38064317)
    • (2003) Frontiers in Neuroendocrinology , vol.24 , Issue.4 , pp. 225-253
    • Sahu, A.1
  • 6
    • 77954275244 scopus 로고    scopus 로고
    • Environmental and genetic activation of a brain-adipocyte BDNF/ leptin axis causes cancer remission and inhi-bition
    • Cao L, Liu X, Lin EJ, Wang C, Choi EY, Riban V, Lin B, During MJ: Environmental and genetic activation of a brain-adipocyte BDNF/ leptin axis causes cancer remission and inhi-bition. Cell 2010; 142:52-64.
    • (2010) Cell , vol.142 , pp. 52-64
    • Cao, L.1    Liu, X.2    Lin, E.J.3    Wang, C.4    Choi, E.Y.5    Riban, V.6    Lin, B.7    During, M.J.8
  • 7
  • 8
    • 77649272503 scopus 로고    scopus 로고
    • Distribution of leptin-sensitive cells in the post-natal and adult mouse brain
    • Caron E, Sachot C, Prevot V, Bouret SG: Distribution of leptin-sensitive cells in the post-natal and adult mouse brain. J Comp Neurol 2010; 518: 459-476.
    • (2010) J Comp Neurol , vol.518 , pp. 459-476
    • Caron, E.1    Sachot, C.2    Prevot, V.3    Bouret, S.G.4
  • 10
    • 33845572889 scopus 로고    scopus 로고
    • Studies on the physiological functions of the melanocortin system
    • DOI 10.1210/er.2006-0034
    • Cone RD: Studies on the physiological func-tions of the melanocortin system. Endocr Rev 2006; 27:736-749. (Pubitemid 44936057)
    • (2006) Endocrine Reviews , vol.27 , Issue.7 , pp. 736-749
    • Cone, R.D.1
  • 11
    • 2542487416 scopus 로고    scopus 로고
    • Minireview: A hypothalamic role in energy balance with special emphasis on leptin
    • DOI 10.1210/en.2004-0032
    • Sahu A: A hypothalamic role in energy bal-ance with special emphasis on leptin. Endocrinology 2004; 145: 2613-2620. (Pubitemid 38686205)
    • (2004) Endocrinology , vol.145 , Issue.6 , pp. 2613-2620
    • Sahu, A.1
  • 12
    • 0031789878 scopus 로고    scopus 로고
    • Leptin decreases food intake induced by melanin-concentrating hormone (MCH), galanin (GAL) and neuropeptide Y (NPY) in the rat
    • DOI 10.1210/en.139.11.4739
    • Sahu A: Leptin decreases food intake in-duced by melanin-concentrating hormone, galanin and neuropeptide Y in the rat. Endocrinology 1998; 139: 4739-4742. (Pubitemid 28487794)
    • (1998) Endocrinology , vol.139 , Issue.11 , pp. 4739-4742
    • Sahu, A.1
  • 13
    • 0036150908 scopus 로고    scopus 로고
    • PRL-releasing peptide interacts with leptin to reduce food intake and body weight
    • DOI 10.1210/en.143.2.368
    • Ellacott KL, Lawrence CB, Rothwell NJ, Luckman SM: PRL-releasing peptide inter-acts with leptin to reduce food intake and body weight. Endocrinology 2002; 143:368-374. (Pubitemid 34107188)
    • (2002) Endocrinology , vol.143 , Issue.2 , pp. 368-374
    • Ellacott, K.L.J.1    Lawrence, C.B.2    Rothwell, N.J.3    Luckman, S.M.4
  • 14
    • 58749086043 scopus 로고    scopus 로고
    • The geometry of leptin action in the brain: More complicated than a simple ARC
    • Myers MG Jr, Munzberg H, Leinninger GM, Leshan RL: The geometry of leptin action in the brain: more complicated than a simple ARC. Cell Metab 2009; 9: 117-123.
    • (2009) Cell Metab , vol.9 , pp. 117-123
    • Myers, Jr.M.G.1    Munzberg, H.2    Leinninger, G.M.3    Leshan, R.L.4
  • 15
    • 33748931457 scopus 로고    scopus 로고
    • Central nervous system control of food intake and body weight
    • DOI 10.1038/nature05026, PII NATURE05026
    • Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW: Central nervous system control of food intake and body weight. Nature 2006; 443: 289-295. (Pubitemid 44435142)
    • (2006) Nature , vol.443 , Issue.7109 , pp. 289-295
    • Morton, G.J.1    Cummings, D.E.2    Baskin, D.G.3    Barsh, G.S.4    Schwartz, M.W.5
  • 17
    • 72649103549 scopus 로고    scopus 로고
    • Endogenous leptin signaling in the caudal nu-cleus tractus solitarius and area postrema is required for energy balance regulation
    • Hayes MR, Skibicka KP, Leichner TM, Guar-nieri DJ, DiLeone RJ, Bence KK, Grill HJ: Endogenous leptin signaling in the caudal nu-cleus tractus solitarius and area postrema is required for energy balance regulation. Cell Metab 2010; 11:77-83.
    • (2010) Cell Metab , vol.11 , pp. 77-83
    • Hayes, M.R.1    Skibicka, K.P.2    Leichner, T.M.3    Guar-Nieri, D.J.4    Dileone, R.J.5    Bence, K.K.6    Grill, H.J.7
  • 20
    • 77955296183 scopus 로고    scopus 로고
    • Disruption of hypotha-lamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels
    • Ring LE, Zeltser LM: Disruption of hypotha-lamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels. J Clin Invest 2010; 120: 2931-2941.
    • (2010) J Clin Invest , vol.120 , pp. 2931-2941
    • Ring, L.E.1    Zeltser, L.M.2
  • 21
    • 0036321620 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase-phosphodiesterase 3b-cyclic AMP pathway in hypothalamic action of leptin on feeding
    • DOI 10.1038/nn885
    • Zhao AZ, Huan JN, Gupta S, Pal R, Sahu A: A phosphatidylinositol 3-kinase phosphodi-esterase-3B cyclic AMP pathway in hypotha-lamic action of leptin on feeding. Nat Neuro-sci 2002; 5:727-728. (Pubitemid 34827588)
    • (2002) Nature Neuroscience , vol.5 , Issue.8 , pp. 727-728
    • Zhao, A.Z.1    Huan, J.-N.2    Gupta, S.3    Pal, R.4    Sahu, A.5
  • 22
    • 43549114292 scopus 로고    scopus 로고
    • Mechanisms of leptin action and leptin resis-tance
    • Myers MG, Cowley MA, Munzberg H: Mechanisms of leptin action and leptin resis-tance. Annu Rev Physiol 2008; 70:537-556.
    • (2008) Annu Rev Physiol , vol.70 , pp. 537-556
    • Myers, M.G.1    Cowley, M.A.2    Munzberg, H.3
  • 23
    • 62749109421 scopus 로고    scopus 로고
    • Hypothalamic ERK mediates the anorectic and thermogenic sympathetic ef-fects of leptin
    • Rahmouni K, Sigmund CD, Haynes WG, Mark AL: Hypothalamic ERK mediates the anorectic and thermogenic sympathetic ef-fects of leptin. Diabetes 2009; 58: 536-542.
    • (2009) Diabetes , vol.58 , pp. 536-542
    • Rahmouni, K.1    Sigmund, C.D.2    Haynes, W.G.3    Mark, A.L.4
  • 24
    • 0035313069 scopus 로고    scopus 로고
    • Leptin-induced nuclear translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation
    • Hubschle T, Thom E, Watson A, Roth J, Klaus S, Meyerhof W: Leptin-induced nucle-ar translocation of STAT3 immunoreactivity in hypothalamic nuclei involved in body weight regulation. J Neurosci 2001; 21: 2413-2424. (Pubitemid 32240538)
    • (2001) Journal of Neuroscience , vol.21 , Issue.7 , pp. 2413-2424
    • Hubschle, T.1    Thom, E.2    Watson, A.3    Roth, J.4    Klaus, S.5    Meyerhof, W.6
  • 26
    • 40849124301 scopus 로고    scopus 로고
    • Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons
    • DOI 10.1210/me.2007-0389
    • Piper ML, Unger EK, Myers MG Jr, Xu AW: Specific physiological roles for signal trans-ducer and activator of transcription-3 in leptin receptor-expressing neurons. Mol Endocrinol 2008; 22:751-759. (Pubitemid 351397800)
    • (2008) Molecular Endocrinology , vol.22 , Issue.3 , pp. 751-759
    • Piper, M.L.1    Unger, E.K.2    Myers Jr., M.G.3    Xu, A.W.4
  • 27
    • 46349110307 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis
    • DOI 10.1210/en.2007-0945
    • Gong L, Yao F, Hockman K, Heng HH, Mor-ton GJ, Takeda K, Akira S, Low MJ, Rubin-stein M, MacKenzie RG: Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neu-ropeptide Y neurons for normal energy ho-meostasis. Endocrinology 2008; 149:3346-3354. (Pubitemid 351919579)
    • (2008) Endocrinology , vol.149 , Issue.7 , pp. 3346-3354
    • Gong, L.1    Yao, F.2    Hockman, K.3    Heng, H.H.4    Morton, G.J.5    Takeda, K.6    Akira, S.7    Low, M.J.8    Rubinstein, M.9    MacKenzie, R.G.10
  • 28
    • 33845867730 scopus 로고    scopus 로고
    • Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased Pomc expression, mild obesity, and defects in compensatory refeeding
    • DOI 10.1210/en.2006-1119
    • Xu AW, Ste-Marie L, Kaelin CB, Barsh GS: Inactivation of signal transducer and activator of transcription-3 in proopiomelanocor-tin (POMC) neurons causes decreased POMC expression, mild obesity, and defects in compensatory refeeding. Endocrinology 2007; 148:72-80. (Pubitemid 46021439)
    • (2007) Endocrinology , vol.148 , Issue.1 , pp. 72-80
    • Xu, A.W.1    Ste-Marie, L.2    Kaelin, C.B.3    Barsh, G.S.4
  • 29
    • 34247102713 scopus 로고    scopus 로고
    • Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration
    • DOI 10.1016/j.neulet.2007.02.074, PII S0304394007002431
    • Mutze J, Roth J, Gerstberger R, Hubschle T: Nuclear translocation of the transcription factor STAT5 in the rat brain after systemic leptin administration. Neurosci Lett 2007; 417:286-291. (Pubitemid 46589788)
    • (2007) Neuroscience Letters , vol.417 , Issue.3 , pp. 286-291
    • Mutze, J.1    Roth, J.2    Gerstberger, R.3    Hubschle, T.4
  • 31
    • 0034009080 scopus 로고    scopus 로고
    • Regulation of cAMP and cGMP signaling: New phosphodiesterases and new functions
    • DOI 10.1016/S0955-0674(99)00073-3
    • Soderling SH, Beavo JA: Regulation of cAMP and cGMP signaling: new phosphodiester-ases and new functions. Curr Opin Cell Biol 2000; 12:174-179. (Pubitemid 30142563)
    • (2000) Current Opinion in Cell Biology , vol.12 , Issue.2 , pp. 174-179
    • Soderling, S.H.1    Beavo, J.A.2
  • 32
    • 33748686575 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use
    • DOI 10.1124/pr.58.3.5
    • Bender AT, Beavo JA: Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev 2006; 58: 488-520. (Pubitemid 44394910)
    • (2006) Pharmacological Reviews , vol.58 , Issue.3 , pp. 488-520
    • Bender, A.T.1    Beavo, J.A.2
  • 33
  • 34
    • 0027978406 scopus 로고
    • Intracerebroventricular injection of dibutyryl cyclic adenosine 3',5'-monophosphate increases hypothalamic levels of neuropeptide Y
    • DOI 10.1016/0006-8993(94)91306-4
    • Akabayashi A, Zaia CT, Gabriel SM, Silva I, Cheung WK, Leibowitz SF: Intracerebroven-tricular injection of dibutyryl cyclic adeno-sine 3',5'-monophosphate increases hypo-thalamic levels of neuropeptide Y Brain Res 1994; 660:323-328. (Pubitemid 24303635)
    • (1994) Brain Research , vol.660 , Issue.2 , pp. 323-328
    • Akabayashi, A.1    Zaia, C.T.B.V.2    Gabriel, S.M.3    Silva, I.4    Cheung, W.K.5    Leibowitz, S.F.6
  • 35
    • 0035866077 scopus 로고    scopus 로고
    • Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus
    • Shimizu-Albergine M, Ippolito DL, Beavo JA: Downregulation of fasting-induced cAMP response element-mediated gene in-duction by leptin in neuropeptide Y neurons of the arcuate nucleus. J Neurosci 2001; 21: 1238-1246. (Pubitemid 32128768)
    • (2001) Journal of Neuroscience , vol.21 , Issue.4 , pp. 1238-1246
    • Shimizu-Albergine, M.1    Ippolito, D.L.2    Beavo, J.A.3
  • 36
    • 0028949423 scopus 로고
    • Distinc-tive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phos-phodiesterases
    • Reinhardt RR, Chin E, Zhou J, Taira M, Mu-rata T, Manganiello VC, Bondy CA: Distinc-tive anatomical patterns of gene expression for cGMP-inhibited cyclic nucleotide phos-phodiesterases. J Clin Invest 1995; 95:1528-1538.
    • (1995) J Clin Invest , vol.95 , pp. 1528-1538
    • Reinhardt, R.R.1    Chin, E.2    Zhou, J.3    Taira, M.4    Mu-Rata, T.5    Manganiello, V.C.6    Bondy, C.A.7
  • 37
    • 0025215525 scopus 로고
    • Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors
    • Beavo JA, Reifsnyder, DH: Primary sequence of cyclic nucleotide phosphodiesterase iso-zymes and the design of selective inhibitors. Trends Pharmacol Sci 1990; 11:150-155. (Pubitemid 20118008)
    • (1990) Trends in Pharmacological Sciences , vol.11 , Issue.4 , pp. 150-155
    • Beavo, J.A.1    Reifsnyder, D.H.2
  • 41
    • 79959377503 scopus 로고    scopus 로고
    • Leptin signaling in the hypothalamus does not involve activation of protein kinase B/AKT in the rat hypothala-mus
    • Program No. 20.1. San Diego Society for Neuroscience
    • Koshinaka K, Sahu A: Leptin signaling in the hypothalamus does not involve activation of protein kinase B/AKT in the rat hypothala-mus. Program No. 20.1. 2007 Neuroscience Meeting Planner. San Diego, Society for Neuroscience, 2007.
    • (2007) Neuroscience Meeting Planner , vol.2007
    • Koshinaka, K.1    Sahu, A.2
  • 42
    • 79959373599 scopus 로고    scopus 로고
    • Evidence showing phosphodiesterase-3B co-localization in proopiomelanocortin and neuropeptide y expressing neurons in the hypothalamus: Further insight into leptin signaling
    • Toronto June 2-5 abstr P4-4
    • Litvin D, Sahu M, Koshinaka K, Sahu A: Evidence showing phosphodiesterase-3B co-localization in proopiomelanocortin and neuropeptide Y expressing neurons in the hypothalamus: further insight into leptin signaling. 89th Annual Meeting of the Endo-crine Society, Toronto, June 2-5, 2007, abstr P4-4.
    • (2007) 89th Annual Meeting of the Endo-crine Society
    • Litvin, D.1    Sahu, M.2    Koshinaka, K.3    Sahu, A.4
  • 43
    • 79959378496 scopus 로고    scopus 로고
    • Leptin receptor expressing neurons co-express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activa-tion in PDE3B neurons in the hypothalamus: Potential mechanism of leptin signaling
    • Program No. 783.25 Washington, Society for Neuroscience
    • Sahu A, Sahu M: Leptin receptor expressing neurons co-express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activa-tion in PDE3B neurons in the hypothalamus: potential mechanism of leptin signaling. Program No. 783.25. 2008 Neuroscience Meeting Planner. Washington, Society for Neuroscience, 2008.
    • (2008) 2008 Neuroscience Meeting Planner
    • Sahu, A.1    Sahu, M.2
  • 44
    • 77953693953 scopus 로고    scopus 로고
    • A role of phosphodiesterase-3B pathway in mediating leptin action on pro-opiomelanocortin and neurotensin neurons in the hypothalamus
    • Sahu A: A role of phosphodiesterase-3B pathway in mediating leptin action on pro-opiomelanocortin and neurotensin neurons in the hypothalamus. Neurosci Lett 2010; 479:18-21.
    • (2010) Neurosci Lett , vol.479 , pp. 18-21
    • Sahu, A.1
  • 45
    • 0031919849 scopus 로고    scopus 로고
    • Jaks and STATs: Bio-logical implications
    • Leonard WJ, O'Shea JJ: Jaks and STATs: bio-logical implications. Annu Rev Immunol 1998; 16: 293-322.
    • (1998) Annu Rev Immunol , vol.16 , pp. 293-322
    • Leonard, W.J.1    O'Shea, J.J.2
  • 46
    • 77649272503 scopus 로고    scopus 로고
    • Distribution of leptin-sensitive cells in the post-natal and adult mouse brain
    • Caron E, Sachot C, Prevot V, Bouret SG: Distribution of leptin-sensitive cells in the post-natal and adult mouse brain. J Comp Neurol 2010; 518: 459-476.
    • (2010) J Comp Neurol , vol.518 , pp. 459-476
    • Caron, E.1    Sachot, C.2    Prevot, V.3    Bouret, S.G.4
  • 47
    • 0038747134 scopus 로고    scopus 로고
    • Role of signal transducer and activator of transcription 3 in regulation of hypothalamic Proopiomelanocortin gene expression by leptin
    • DOI 10.1210/en.2002-221037
    • Munzburg H, Huo L, Nillni EA, Hollenberg AN, Bjorbaek C: Role of signal transducer and activator of transcription-3 in regula-tion of hypothalamic proopiomelanocortin gene expression by leptin. Endocrinology 2003; 144:2121-2131. (Pubitemid 36543352)
    • (2003) Endocrinology , vol.144 , Issue.5 , pp. 2121-2131
    • Munzberg, H.1    Huo, L.2    Nillni, E.A.3    Hollenberg, A.N.4    Bjorbaek, C.5
  • 48
    • 40849083773 scopus 로고    scopus 로고
    • Hypothalamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice
    • DOI 10.1210/en.2007-1307
    • Metlakunta AS, Sahu M, Sahu A: Hypotha-lamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the de-velopment of diet-induced obesity in FVB/N mice. Endocrinology 2008; 149:1121-1128. (Pubitemid 351397951)
    • (2008) Endocrinology , vol.149 , Issue.3 , pp. 1121-1128
    • Metlakunta, A.S.1    Sahu, M.2    Sahu, A.3
  • 49
    • 27644513401 scopus 로고    scopus 로고
    • Hypothalamic phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion
    • DOI 10.1111/j.1365-2826.2005.01362.x
    • Sahu A, Metlakunta AS: Hypothalamic phosphatidylinositol 3-kinase-phosphodies-terase-3B cyclic AMP pathway of leptin sig-nalling is impaired following chronic central leptin infusion. J Neuroendocrinol 2005; 17: 720-726. (Pubitemid 41568098)
    • (2005) Journal of Neuroendocrinology , vol.17 , Issue.11 , pp. 720-726
    • Sahu, A.1    Metlakunta, A.S.2
  • 50
    • 34249829624 scopus 로고    scopus 로고
    • Leptin suppresses ghrelin-induced activation of neuropeptide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase- and phosphodiesterase 3-mediated pathway
    • DOI 10.1210/en.2006-1240
    • Kohno D, Nakata M, Maekawa F, Fujiwara K, Maejima Y, Kuramochi M, Shimazaki T, Okano H, Onaka T, Yada T: Leptin suppress-es ghrelin-induced activation of neuropep-tide Y neurons in the arcuate nucleus via phosphatidylinositol 3-kinase-and phos-phodiesterase 3-mediated pathway. Endocrinology 2007; 148: 2251-2263. (Pubitemid 46997030)
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2251-2263
    • Kohno, D.1    Nakata, M.2    Maekawa, F.3    Fujiwara, K.4    Maejima, Y.5    Kuramochi, M.6    Shimazaki, T.7    Okano, H.8    Onaka, T.9    Yada, T.10
  • 51
    • 33745768460 scopus 로고    scopus 로고
    • Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release
    • DOI 10.1523/JNEUROSCI.5126-05.2006
    • Malcher-Lopes R, Di S, Marcheselli VS, Weng FJ, Stuart CT, Bazan NG, Tasker JG: Opposing crosstalk between leptin and glu-cocorticoids rapidly modulates synaptic ex-citation via endocannabinoid release. J Neu-rosci 2006; 26: 6643-6650. (Pubitemid 44318346)
    • (2006) Journal of Neuroscience , vol.26 , Issue.24 , pp. 6643-6650
    • Malcher-Lopes, R.1    Di, S.2    Marcheselli, V.S.3    Weng, F.-J.4    Stuart, C.T.5    Bazan, N.G.6    Tasker, J.G.7
  • 52
    • 2542490348 scopus 로고    scopus 로고
    • Minireview: Glucocorticoids - Food intake, abdominal obesity, and wealthy nations in 2004
    • DOI 10.1210/en.2004-0037
    • Dallman MF, La Fleur SE, Pecoraro NC, Go-mez F, Houshyar H, Akana SF: Glucocorti-coids-food intake, abdominal obesity, and wealthy nations in 2004. Endocrinology 2004; 145:2633-2638. (Pubitemid 38686208)
    • (2004) Endocrinology , vol.145 , Issue.6 , pp. 2633-2638
    • Dallman, M.F.1    La Fleur, S.E.2    Pecoraro, N.C.3    Gomez, F.4    Houshyar, H.5    Akana, S.F.6
  • 53
    • 29144464338 scopus 로고    scopus 로고
    • Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit
    • DOI 10.1016/j.neuron.2005.10.021, PII S089662730500886X
    • Jo YH, Chen YJ, Chua SC Jr, Talmage DA, Role LW: Integration of endocannabinoid and leptin signaling in an appetite-related neural circuit. Neuron 2005; 48:1055-1066. (Pubitemid 41814707)
    • (2005) Neuron , vol.48 , Issue.6 , pp. 1055-1066
    • Jo, Y.-H.1    Chen, Y.-J.J.2    Chua Jr., S.C.3    Talmage, D.A.4    Role, L.W.5
  • 61
    • 0034107525 scopus 로고    scopus 로고
    • Development of high fat diet-induced obesity and leptin resistance in C57B1/6J mice
    • Lin S, Thomas TC, Storlien LH, Huang XF: Development of high fat diet-induced obesi-ty and leptin resistance in C57Bl/6J mice. Int J Obes Relat Metab Disord 2000; 24:639-646. (Pubitemid 30323498)
    • (2000) International Journal of Obesity , vol.24 , Issue.5 , pp. 639-646
    • Lin, S.1    Thomas, T.C.2    Storlien, L.H.3    Huang, X.F.4
  • 67
    • 49049114337 scopus 로고    scopus 로고
    • The role of hypothalamic mammalian target of rapamycin complex 1 signaling in dietinduced obesity
    • Cota D, Matter EK, Woods SC, Seeley RJ: The role of hypothalamic mammalian target of rapamycin complex 1 signaling in dietinduced obesity. J Neurosci 2008; 28:7202-7208.
    • (2008) J Neurosci , vol.28 , pp. 7202-7208
    • Cota, D.1    Matter, E.K.2    Woods, S.C.3    Seeley, R.J.4
  • 68
    • 9244219587 scopus 로고    scopus 로고
    • Region-specific leptin resistance within the hypothalamus of diet-induced obese mice
    • DOI 10.1210/en.2004-0726
    • Munzberg H, Flier JS, Bjorbaek C: Region-specific leptin resistance within the hypo-thalamus of dietinduced obese mice. Endocrinology 2004; 145:4880-4889. (Pubitemid 39551104)
    • (2004) Endocrinology , vol.145 , Issue.11 , pp. 4880-4889
    • Munzberg, H.1    Flier, J.S.2    Bjorbaek, C.3
  • 69
    • 79959373925 scopus 로고    scopus 로고
    • Evidence suggesting impaired hypothalamic phosphati-dylinositol 3-kinase pathway of leptin signaling during the development of dietinduced obesity in mice
    • Metlakunta AR, Sahu A: Evidence suggesting impaired hypothalamic phosphati-dylinositol 3-kinase pathway of leptin signaling during the development of dietinduced obesity in mice. Front Neuro Endocrinol 2006; 27:10.
    • (2006) Front Neuro Endocrinol , vol.27 , pp. 10
    • Metlakunta, A.R.1    Sahu, A.2
  • 70
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • Bjorbaek C, Elmquist JK, Frantz JD, Shoel-son SE, Flier JS: Identification of SOCS-3 as a potential mediator of central leptin resis-tance. Mol Cell 1998; 1:619-625. (Pubitemid 128374698)
    • (1998) Molecular Cell , vol.1 , Issue.4 , pp. 619-625
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 72
    • 3142782772 scopus 로고    scopus 로고
    • Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3
    • DOI 10.1038/nm1072
    • Howard JK, Cave BJ, Oksanen LJ, Tzameli I, Bjorbaek C, Flier JS: Enhanced leptin sensi-tivity and attenuation of dietinduced obesity in mice with haploinsufficiency of Socs3. Nat Med 2004; 10:734-738. (Pubitemid 38937639)
    • (2004) Nature Medicine , vol.10 , Issue.7 , pp. 734-738
    • Howard, J.K.1    Cave, B.J.2    Oksanen, L.J.3    Tzameli, I.4    Bjoorbaek, C.5    Flier, J.S.6
  • 73
    • 0033695523 scopus 로고    scopus 로고
    • Differential expression of hypo-thalamic neuropeptides in the early phase of dietinduced obesity in mice
    • Ziotopoulou M, Mantzoros CS, Hileman SM, Flier JS: Differential expression of hypo-thalamic neuropeptides in the early phase of dietinduced obesity in mice. Am J Physiol Endocrinol Metab 2000; 279:E838-E845.
    • (2000) Am J Physiol Endocrinol Metab , vol.279
    • Ziotopoulou, M.1    Mantzoros, C.S.2    Hileman, S.M.3    Flier, J.S.4
  • 74
    • 79959372860 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 interacts with the phosphatidylinositol 3-kinase pathway of leptin signaling in the hypothalamus
    • Pro-gram No. 60.10 Atlanta, Society for Neuroscience
    • Sahu A, Metlakunta AR, Sahu M: Suppressor of cytokine signaling-3 interacts with the phosphatidylinositol 3-kinase pathway of leptin signaling in the hypothalamus. Pro-gram No. 60.10. 2006 Neuroscience Meeting Planner. Atlanta, Society for Neuroscience, 2006.
    • (2006) 2006 Neuroscience Meeting Planner
    • Sahu, A.1    Metlakunta, A.R.2    Sahu, M.3
  • 75
  • 76
    • 0036798083 scopus 로고    scopus 로고
    • Resistance to the satiety action of leptin following chronic central leptin infusion is associated with the development of leptin resistance in neuropeptide Y neurones
    • DOI 10.1046/j.1365-2826.2002.00840.x
    • Sahu A: Resistance to the satiety action of leptin following chronic central leptin infu-sion is associated with the development of leptin resistance in neuropeptide Y neu-rones. J Neuroendocrinol 2002; 14: 796-804. (Pubitemid 35203477)
    • (2002) Journal of Neuroendocrinology , vol.14 , Issue.10 , pp. 796-804
    • Sahu, A.1
  • 77
    • 45449097234 scopus 로고    scopus 로고
    • Effects of chronic central leptin in-fusion on proopiomelanocortin and neuro-tensin gene expression in the rat hypothala-mus
    • Sahu A: Effects of chronic central leptin in-fusion on proopiomelanocortin and neuro-tensin gene expression in the rat hypothala-mus. Neurosci Lett 2008; 440: 125-129.
    • (2008) Neurosci Lett , vol.440 , pp. 125-129
    • Sahu, A.1
  • 78
    • 0042922605 scopus 로고    scopus 로고
    • Leptin signaling in the hypothalamus during chronic central leptin infusion
    • DOI 10.1210/en.2002-0148
    • Pal R, Sahu A: Leptin signaling in the hypo-thalamus during chronic central leptin infu-sion. Endocrinology 2003; 144: 3789-3798. (Pubitemid 37088731)
    • (2003) Endocrinology , vol.144 , Issue.9 , pp. 3789-3798
    • Pal, R.1    Sahu, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.