The impact of age-related dysregulation of the angiotensin system on mitochondrial redox balance

Frontiers in Physiology

Volumn 5, Issue Nov, 2014, Pages

  Vajapey, Ramya ^a   Rini, David ^b   Walston, Jeremy ^b   Abadir, Peter ^b  

^a NORTHEAST OHIO MEDICAL UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Angiotensin II; Angiotensin II type 1 receptor blockers; Frailty; Mitochondria; Mitochondrial angiotensin system; Redox regulation

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; ADENYLATE KINASE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN RECEPTOR ANTAGONIST; CANDESARTAN HEXETIL; CELL NUCLEUS DNA; COPPER ZINC SUPEROXIDE DISMUTASE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPROSARTAN; EXTRACELLULAR SUPEROXIDE DISMUTASE; IRBESARTAN; LOSARTAN; MANGANESE SUPEROXIDE DISMUTASE; MITOCHONDRIAL DNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 4; TELMISARTAN; VALSARTAN; XANTHINE OXIDASE;

AGING; ALZHEIMER DISEASE; ANTIHYPERTENSIVE ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ATHEROSCLEROSIS; BINDING AFFINITY; DISEASE COURSE; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME SYNTHESIS; FRAIL ELDERLY; HEART FAILURE; HEART INFARCTION; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERTENSION; KIDNEY FIBROSIS; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL REDOX BALANCE; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATION REDUCTION STATE; POSITIVE FEEDBACK; PROTEIN EXPRESSION; PROTEIN FUNCTION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; RESPIRATORY CHAIN; REVIEW; SARCOPENIA; SIGNAL TRANSDUCTION; VASCULAR DISEASE;

EID: 84911941225     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2014.00439     Document Type: Review

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