Identification and characterization of a functional mitochondrial angiotensin system

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 36, 2011, Pages 14849-14854

  Abadir, Peter M ^a   Foster, D Brian ^a   Crow, Michael ^a   Cooke, Carol A ^a   Rucker, Jasma J ^a   Jain, Alka ^a   Smith, Barbara J ^a   Burks, Tyesha N ^a   Cohn, Ronald D ^a   Fedarko, Neal S ^a   Carey, Robert M ^b   O'Rourke, Brian ^a   Walston, Jeremy D ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

ATP; Bioenergetics; Frailty

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; LOSARTAN; NITRIC OXIDE;

ANIMAL CELL; ARTICLE; BREATHING; HUMAN; HUMAN CELL; LONG TERM CARE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RECEPTOR DENSITY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM;

AGING; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; AUTOCRINE COMMUNICATION; CELL LINE; CHRONIC DISEASE; HUMANS; KIDNEY; LOSARTAN; MICE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; NITRIC OXIDE; OXYGEN CONSUMPTION; RECEPTOR, ANGIOTENSIN, TYPE 1; RECEPTOR, ANGIOTENSIN, TYPE 2; RENIN-ANGIOTENSIN SYSTEM;

EID: 80052585322     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1101507108     Document Type: Article

References (50)

1. Leri A, et al. (1998) Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell. J Clin Invest 101:1326-1342. (Pubitemid 28166830)
2. 2 receptors in postinfarcted hypertrophied myocytes and stretch-mediated apoptotic cell death. Am J Pathol 156:1663-1672.
3. Sadoshima J, Xu Y, Slayter HS, Izumo S (1993) Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 75:977-984. (Pubitemid 24014554)
4. Cook JL, Zhang Z, Re RN (2001) In vitro evidence for an intracellular site of angiotensin action. Circ Res 89:1138-1146. (Pubitemid 34627871)
5. Robertson AL, Jr., Khairallah PA (1971) Angiotensin II: Rapid localization in nuclei of smooth and cardiac muscle. Science 172:1138-1139.
6. 2 receptors in endothelial cells and isolated ischemic rat hearts. J Hypertens Suppl 11:S234-S235.
7. Ratliff BB, Sekulic M, Rodebaugh J, Solhaug MJ (2010) Angiotensin II regulates NOS expression in afferent arterioles of the developing porcine kidney. Pediatr Res 68:29-34.
8. Siragy HM, Inagami T, Ichiki T, Carey RM (1999) Sustained hypersensitivity to angiotensin II and its mechanism in mice lacking the subtype-2 (AT2) angiotensin receptor. Proc Natl Acad Sci USA 96:6506-6510. (Pubitemid 29256696)
9. Siragy HM, De Gasparo M, Carey RM (2000) Angiotensin type 2 receptor mediates valsartan-induced hypotension in conscious rats. Hypertension 35:1074-1077. (Pubitemid 30327260)
10. 2-receptor-null mice. Hypertension 42:600-604.
11. 2) receptors are functionally linked to nitric oxide production. Am J Physiol Renal Physiol 296:F1484-F1493.
12. Michel T, Feron O (1997) Nitric oxide synthases: Which, where, how, and why? J Clin Invest 100:2146-2152.
13. Bates TE, Loesch A, Burnstock G, Clark JB (1995) Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver. Biochem Biophys Res Commun 213:896-900.
14. Valdez LB, Boveris A (2007) Mitochondrial nitric oxide synthase, a voltage-dependent enzyme, is responsible for nitric oxide diffusion to cytosol. Front Biosci 12:1210-1219. (Pubitemid 46846826)
15. Burwell LS, Brookes PS (2008) Mitochondria as a target for the cardioprotective effects of nitric oxide in ischemia-reperfusion injury. Antioxid Redox Signal 10:579-599.
16. Ghafourifar P, Richter C (1997) Nitric oxide synthase activity in mitochondria. FEBS Lett 418:291-296. (Pubitemid 27515942)
17. 2 uptake. Am J Physiol Heart Circ Physiol 281:H2282-H2288.
18. Valdez LB, et al. (2004) Heart mitochondrial nitric oxide synthase. Effects of hypoxia and aging. Mol Aspects Med 25:49-59. (Pubitemid 38401931)
19. Maisterrena B, Comte J, Gautheron DC (1974) Purification of pig heart mitochondrial membranes. Enzymatic and morphological characterization as compared to microsomes. Biochim Biophys Acta 367:115-126.
20. Wardman P (2007) Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: Progress, pitfalls, and prospects. Free Radic Biol Med 43:995-1022.
21. Nicholls DG, Ferguson SJ (2002) Bioenergetics 3 (Academic, London)3rd Ed.
22. Anderson S (1997) Ageing and the renin-angiotensin system. Nephrol Dial Transplant 12:1093-1094.
23. Reckelhoff JF, Baylis C (1992) Proximal tubular metalloprotease activity is decreased in the senescent rat kidney. Life Sci 50:959-963.
24. Thompson MM, Oyama TT, Kelly FJ, Kennefick TM, Anderson S (2000) Activity and responsiveness of the renin-angiotensin system in the aging rat. Am J Physiol Regul Integr Comp Physiol 279:R1787-R1794.
25. Haller H, Lindschau C, Erdmann B, Quass P, Luft FC (1996) Effects of intracellular angiotensin II in vascular smooth muscle cells. Circ Res 79:765-772. (Pubitemid 26317824)
26. Kent KM, Goodfriend TL, McCallum ZT, Dempsey PJ, Cooper T (1972) Inotropic agents in hypoxic cat myocardium: Depression and potentiation. Circ Res 30:196-204.
27. Allmann D, Page IH (1974) Angiotensin (Springer, Berlin).
28. Goodfriend TL, et al. (1972) Clinical and conceptual uses of angiotensin receptors. Hypertension 1972, eds Genest J, Koiw E (Springer, New York), pp 549-563.
29. Goodfriend T, Fyhrquist F, Allmann D (1974) Biochemical effects of angiotensins. Handbook of Experimental Pharmacology, eds Page I, Bumpus FM (Springer, New York), pp 511-517.
30. Glossmann H, Baukal A, Catt KJ (1974) Angiotensin II receptors in bovine adrenal cortex. Modification of angiotensin II binding by guanyl nucleotides. J Biol Chem 249:664-666.
31. Mazzocchi G, Robba C, Rebuffat P, Nussdorfer GG (1980) Investigations on the turnover of adrenocortical mitochondria. XV. A stereological study of the effect of chronic treatment with angiotensin II on the size and number of the mitochondria in the zona glomerulosa of the rat. Cell Tissue Res 210:333-337. (Pubitemid 10028047)
32. Pfanner N, Hoeben P, Tropschug M, Neupert W (1987) The carboxyl-terminal two-thirds of the ADP/ATP carrier polypeptide contains sufficient information to direct translocation into mitochondria. J Biol Chem 262:14851-14854.
33. Jensen RE, Dunn CD (2002) Protein import into and across the mitochondrial inner membrane: Role of the TIM23 and TIM22 translocons. Biochim Biophys Acta 1592:25-34. (Pubitemid 35015162)
34. Dedkova EN, Blatter LA (2009) Characteristics and function of cardiac mitochondrial nitric oxide synthase. J Physiol 587:851-872.
35. Lacza Z, et al. (2006) Mitochondrial NO and reactive nitrogen species production: Does mtNOS exist? Nitric Oxide 14:162-168. (Pubitemid 43165882)
36. Brown GC, Cooper CE (1994) Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase. FEBS Lett 356:295-298. (Pubitemid 24376992)
37. 1 receptor antagonist. J Biol Chem 276:39721-39726.
38. Guan H, et al. (1996) Nitric oxide and the depressor response to angiotensin blockade in hypertension. Hypertension 27:19-24. (Pubitemid 26020665)
39. De Cavanagh EM, et al. (2006) Renal mitochondrial dysfunction in spontaneously hypertensive rats is attenuated by losartan but not by amlodipine. Am J Physiol Regul Integr Comp Physiol 290:R1616-R1625. (Pubitemid 43830828)
40. Monteiro P, Duarte AI, Gonçalves LM, Providência LA (2005) Valsartan improves mitochondrial function in hearts submitted to acute ischemia. Eur J Pharmacol 518:158-164. (Pubitemid 41133640)
41. Benigni A, et al. (2009) Disruption of the Ang II type 1 receptor promotes longevity in mice. J Clin Invest 119:524-530.
42. 2 receptor-mediated natriuresis in rats. Hypertension 51:460-465.
43. Chua HL, Jois S, Sim MK, Go ML (2004) Transport of angiotensin peptides across the Caco-2 monolayer. Peptides 25:1327-1338. (Pubitemid 39180065)
44. Reaux A, Fournie-Zaluski MC, Llorens-Cortes C (2001) Angiotensin III: A central regulator of vasopressin release and blood pressure. Trends Endocrinol Metab 12:157-162. (Pubitemid 33713556)
45. 2 receptor in inflammation and oxidative stress: Opposing effects in lean and obese Zucker rats. Am J Physiol Renal Physiol 300:F700-F706.
46. Jones SP, Bolli R (2006) The ubiquitous role of nitric oxide in cardioprotection. J Mol Cell Cardiol 40:16-23. (Pubitemid 43012113)
47. Cavadini P, Gakh O, Isaya G (2002) Protein import and processing reconstituted with isolated rat liver mitochondria and recombinant mitochondrial processing peptidase. Methods 26:298-306. (Pubitemid 34971569)
48. Chen JQ, Delannoy M, Cooke C, Yager JD (2004) Mitochondrial localization of ERα and ERβ in human MCF7 cells. Am J Physiol Endocrinol Metab 286:E1011-E1022. (Pubitemid 38668826)
49. Choi SW, Gerencser AA, Nicholls DG (2009) Bioenergetic analysis of isolated cerebrocortical nerve terminals on a microgram scale: Spare respiratory capacity and stochastic mitochondrial failure. J Neurochem 109:1179-1191.
50. Scaduto RC, Jr., Grotyohann LW (1999) Measurement of mitochondrial membrane potential using fluorescent rhodamine derivatives. Biophys J 76:469-477.