ACE-dependent and chymase-dependent angiotensin II generation in normal and glucose-stimulated human mesangial cells

Experimental Biology and Medicine

Volumn 233, Issue 8, 2008, Pages 1035-1043

  Cristovam, Priscila C ^a   Arnoni, Carine P ^a   De Andrade, Maria Claudina C ^a   Casarini, Dulce E ^a   Pereira, Luciana G ^a   Schor, Nestor ^a   Boim, Mirian A ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Captopril; Chymostatin; Diabetic nephropathy

Indexed keywords

ANGIOTENSIN II; CHYMASE; CHYMASE INHIBITOR; CHYMOSTATIN; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUCOSE; LOSARTAN; MESSENGER RNA; CAPTOPRIL; OLIGOPEPTIDE;

ARTICLE; CELL LINE; CELL LYSATE; CELL STIMULATION; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; MESANGIUM CELL; UPREGULATION; BIOSYNTHESIS; CELL CULTURE; DIABETIC NEPHROPATHY; DRUG EFFECT; GENETICS; METABOLISM;

ANGIOTENSIN II; CAPTOPRIL; CELLS, CULTURED; CHYMASES; DIABETIC NEPHROPATHIES; GLUCOSE; HUMANS; LOSARTAN; MESANGIAL CELLS; OLIGOPEPTIDES; PEPTIDYL-DIPEPTIDASE A; RNA, MESSENGER;

EID: 50649091175     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.3181/0708-RM-229     Document Type: Article

References (30)

1. van Kats JP, Schalekamp MA, Verdouw PD, Duncker DJ, Danser AH. Intrarenal angiotensin II: interstitial and cellular levels and site of production. Kidney Int 60:2311-2317, 2001.
2. Vidotti DB, Casarini DE, Cristovam PC, Leite CA, Schor N, Boim MA. High glucose concentration stimulates intracellular renin activity and angiotensin II generation in rat mesangial cells. Am J Physiol Renal Physiol 286:F1039-F1045, 2004.
3. Price DA, Porter LE, Gordon M, Fisher ND, De'Oliveira JM, Laffel LM, Passan DR, Williams GH, Hollenberg NK. The paradox of the low-renin state in diabetic nephropathy. J Am Soc Nephrol 10:2382-2391, 1999.
4. Urata H, Healy B, Stewart RW, Bumpus FM, Husain A. Angiotensin II-forming pathways in normal and failing human hearts. Circ Res 66: 883-890, 1990.
5. Urata H, Kinoshita A, Misono KS, Bumpus FM, Husain A. Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J Biol Chem 265:22348-22357, 1990.
6. Dell'Italia LJ, Husain A. Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases. Curr Opin Cardiol 17: 374-379, 2002.
7. Richard V, Hurel-Merle S, Scalbert E, Ferry G, Lallemand F, Bessou JP, Thuillez C. Functional evidence for a role of vascular chymase in the production of angiotensin II in isolated human arteries. Circulation 104:750-752, 2001.
8. Takai S, Jin D, Nishimoto M, Yuda A, Sakaguchi M, Kamoshita K, Ishida K, Sukenaga Y, Sasaki S, Miyazaki M. Oral administration of a specific chymase inhibitor, NK3201, inhibits vascular proliferation in grafted vein. Life Sci 69:1725-1732, 2001.
9. Takai S, Yuda A, Jin D, Nishimoto M, Sakagichi M, Sasaki S, Miyazaki M. Inhibition of chymase reduces vascular proliferation in dog grafted veins. FEBS Lett 467:141-144, 2000.
10. Huang XR, Chen WY, Truong LD, Lan HY. Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease. J Am Soc Nephrol 14:1738-1747, 2003.
11. Urata H, Strobel F, Ganten D. Widespread tissue distribution of human chymase. J Hypertens 12(Suppl):S17-S22, 1994.
12. Wei CC, Tian B, Perry G, Meng QC, Chen YF, Oparil S, Dell'Italia LJ. Differential ANG II generation in plasma and tissue of mice with decreased expression of the ACE gene. Am J Physiol Heart Circ Physiol 282:H2254-H2258, 2002.
13. Singh R, Singh AK, Alavi N, Leehey DJ. Mechanism of increased angiotensin II levels in glomerular mesangial cells cultured in high glucose. J Am Soc Nephrol 14:873-880, 2003.
14. King SJ, Oparil S. Converting-enzyme inhibitors increase converting-enzyme mRNA and activity in endothelial cells. Am J Physiol 263: C743-C749, 1992.
15. Voors AA, Pinto YM, Buikema H, Urata H, Oosterga M, Rooks G, Grandjean JG, Ganten D, van Gilst WH. Dual pathway for angiotensin II formation in human internal mammary arteries. Br J Pharmacol 125: 1028-1032, 1998.
16. Zhou Y, Poczatek MH, Berecek KH, Murphy-Ullrich JE. Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions. Biochem Biophys Res Commun 339:633-641, 2006.
17. Friedland J, Silverstein E. A sensitive fluorimetric assay for serum angiotensin-converting enzyme. Am J Clin Pathol 66:416-424, 1976.
18. Leehey DJ, Singh AK, Alavi N, Singh R. Role of angiotensin II in diabetic nephropathy. Kidney Int Suppl 77:S93-S98, 2000.
19. Ruilope LM. Renin-angiotensin-aldosterone system blockade and renal protection: angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers? Acta Diabetol 42(Suppl 1):S33-S41, 2005.
20. Andrade AQ, Casarini DE, Schor N, Boim MA. Characterization of renin mRNA expression and enzyme activity in rat and mouse mesangial cells. Braz J Med Biol Res 35:17-24, 2002.
21. Andrade MC, Quinto BM, Carmona AK, Ribas OS, Boim MA, Schor N, Casarini DE. Purification and characterization of angiotensin I-converting enzymes from mesangial cells in culture. J Hypertens 16: 2063-2074, 1998.
22. Hall JE. Historical perspective of the renin-angiotensin system. Mol Biotechnol 24:27-39, 2003.
23. Balcells E, Meng QC, Johnson WH, Jr, Oparil S, Dell'Italia LJ. Angiotensin II formation from ACE and chymase in human and animal hearts: methods and species considerations. Am J Physiol 273:H1769-H1774, 1997.
24. Singh R, Leehey DJ. Effect of ACE inhibitors on angiotensin II in rat mesangial cells cultured in high glucose. Biochem Biophys Res Commun 357:1040-1045, 2007.
25. Fleming I, Kohlstedt K, Busse R. New fACEs to the renin-angiotensin system. Physiology (Bethesda) 20:91-95, 2005.
26. Caughey GH, Lazarus SC, Viro NF, Gold WM, Nadel JA. Tryptase and chymase: comparison of extraction and release in two dog mastocytoma lines. Immunology 63:339-344, 1988.
27. Urata H, Boehm KD, Philip A, Kinoshita A, Gabrovsek J, Bumpus FM, Husain A. Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart. J Clin Invest 91:1269-1281, 1993.
28. Leite CA, Cristovam PC, Leitao AA, Miranda A, Andrade MC, Di Marco G, Casarini DE, Boim MA. Renin similar to the submaxillary gland form is expressed in mouse mesangial cells: subcellular localization and all generation under control and glucose-stimulated conditions. Cell Physiol Biochem 13:357-366, 2003.
29. Re R. Intracellular renin-angiotensin system: the tip of the intracrine physiology iceberg. Am J Physiol Heart Circ Physiol 293:H905-H906, 2007.
30. Cook JL, Zhang Z, Re RN. In vitro evidence for an intracellular site of angiotensin action. Circ Res 89:1138-1146, 2001.