Expression of NOXI, a superoxide-generating NADPH oxidase, in colon cancer and inflammatory bowel disease

Journal of Pathology

Volumn 207, Issue 2, 2005, Pages 164-176

  Szanto, Ildiko ^a   Rubbia Brandt, L ^a   Kiss, P ^a   Steger, K ^b   Banfi, B ^a   Kovari, E ^a   Herrmann, F ^a   Hadengue, A ^a   Krause, K H ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Colon cancer; Inflammatory bowel disease; Intra lesional lymphocytes; NADPH oxidase; NOXI; Reactive oxygen species

Indexed keywords

MESSENGER RNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 1; UNCLASSIFIED DRUG; NOX1 PROTEIN, HUMAN; RNA; TUMOR PROTEIN;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER LOCALIZATION; CLINICAL ARTICLE; COLON ADENOCARCINOMA; COLON CANCER; COLON CARCINOGENESIS; COLON MUCOSA; CONTROLLED STUDY; CORRELATION ANALYSIS; CROHN DISEASE; CRYPT CELL; DOT HYBRIDIZATION; ENTERITIS; EPITHELIUM CELL; FEMALE; HISTOPATHOLOGY; HOST RESISTANCE; HUMAN; HUMAN TISSUE; ILEUM; IN SITU HYBRIDIZATION; LYMPHOCYTE FUNCTION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR DIFFERENTIATION; ULCERATIVE COLITIS; ADENOCARCINOMA; ANIMAL; BAGG ALBINO MOUSE; COLON; COLON TUMOR; LYMPHOCYTE; METABOLISM; METHODOLOGY; MIDDLE AGED; RECTUM; RECTUM TUMOR;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; COLITIS, ULCERATIVE; COLON; COLONIC NEOPLASMS; CROHN DISEASE; FEMALE; HUMANS; ILEUM; IN SITU HYBRIDIZATION; INFLAMMATORY BOWEL DISEASES; LYMPHOCYTES; MALE; MICE; MICE, INBRED BALB C; MIDDLE AGED; NADPH OXIDASE; NEOPLASM PROTEINS; REACTIVE OXYGEN SPECIES; RECTAL NEOPLASMS; RECTUM; RNA, MESSENGER; RNA, NEOPLASM;

EID: 26044457052     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1824     Document Type: Article

References (30)

1. Lambeth JD. NOX enzymes and the biology of reactive oxygen. Nat Rev Immunol 2004;4(3):181-189.
2. Mates JM, Sanchez-Jimenez FM. Role of reactive oxygen species in apoptosis: implications for cancer therapy. Int J Biochem Cell Biol 2000;32(2):157-170.
3. Hoidal JR. Reactive oxygen species and cell signalling. Am J Resp Cell Mol Biol 2001;25(6):661-663.
4. Klein JA, Ackerman SL. Oxidative stress, cell cycle, and neurodegeneration. J Clin Invest 2003;111(6):785-793.
5. Harrison D, Griendling KK, Landmesser U, Hornig B, Drexler H. Role of oxidative stress in atherosclerosis. Am J Cardiol 2003; 91(3A):7A-11A.
6. Hildeman DA, Mitchell T, Kappler J, Marrack P. T cell apoptosis and reactive oxygen species. J Clin Invest 2003; 111(5):575-581.
7. + channel generated through alternative splicing of the NADPH oxidase homolog NOH-1. Science 2000;287(5450):138-142.
8. Cheng G, Cao Z, Xu X, van Meir EG, Lambeth JD. Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5. Gene 2001;269(1-2):131-140.
9. Dupuy C, Ohayon R, Valent A, Noel-Hudson MS, Deme D, Virion A. Purification of a novel flavoprotein involved in the thyroid NADPH oxidase. Cloning of the porcine and human cDNAs. J Biol Chem 1999;274(52):37 265-37 269.
10. Lambeth JD, Cheng G, Arnold RS, Edens WA. Novel homologs of gp91phox. Trends Biochem Sci 2000;25(10):459-461.
11. 2+-activated NADPH oxidase in testis, spleen, and lymph nodes. J Biol Chem 2001;276(40):37 594-37 601.
12. Banfi B, Clark RA, Steger K, Krause KH. Two novel proteins activate superoxide generation by the NADPH oxidase NOX1. J Biol Chem 2003;278(6):3510-3513.
13. Geiszt M, Lekstrom K, Witta J, Leto TL. Proteins homologous to p47phox and p67phox support superoxide production by NAD(P)H oxidase 1 in colon epithelial cells. J Biol Chem 2003;278(22):20 006-20 012.
14. Takeya R, Ueno N, Kami K, Taura M, Kohjima M, Izaki T, et al. Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases. J Biol Chem 2003;278(27):25 234-25 246.
15. Kawahara T, Kuwano Y, Teshima-Kondo S, Takeya R, Sumimoto H, Kishi K, et al. Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to Toll-like receptor 5 signalling in large intestinal epithelial cells. J Immunol 2004; 172(5):3051-3058.
16. Kawahara T, Kohjima M, Kuwano Y, Mino H, Teshima-Kondo S, Takeya R, et al. Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells. Am J Physiol Cell Physiol 2005; 288:C450-C457.
17. Chamulitrat W, Schmidt R, Tomakidi P, Stremmel W, Chunglok W, Kawahara T, et al. Association of gp91phox homolog Nox1 with anchorage-independent growth and MAP kinase-activation of transformed human keratinocytes. Oncogene 2003;22(38):6045-6053.
18. Suh YA, Arnold RS, Lassegue B, Shi J, Xu X, Sorescu D, et al. Cell transformation by the superoxide-generating oxidase Mox1. Nature 1999;401(6748):79-82.
19. Geiszt M, Lekstrom K, Brenner S, Hewitt SM, Dana R, Malech HL, et al. NAD(P)H oxidase 1, a product of differentiated colon epithelial cells, can partially replace glycoprotein 91phox in the regulated production of superoxide by phagocytes. J Immunol 2003; 171(1):299-306.
20. Glebov OK, Rodriguez LM, Nakahara K, Jenkins J, Cliatt J, Humbyrd CJ, et al. Distinguishing right from left colon by the pattern of gene expression. Cancer Epidemiol Biomarkers Prev 2003;12(8):755-762.
21. Lim SD, Sun C, Lambeth JD, Marshall F, Arnin M, Chung L, et al. Increased Nox1 and hydrogen peroxide in prostate cancer. Prostate 2005;62:200-207.
22. Arnold RS, Shi J, Murad E, Whalen AM, Sun CQ, Polavarapu R, et al. Hydrogen peroxide mediates the cell growth and transformation caused by the mitogenic oxidase Nox1. Proc Natl Acad Sci USA 2001;98(10):5550-5555.
23. Iacopetta B. Are there two sides to colorectal cancer? Int J Cancer 2002;101(5):403-408.
24. Geiszt M, Lekstrom K, Leto TL. Analysis of mRNA transcripts from the NAD(P)H oxidase 1 (Nox1) gene. Evidence against production of the NADPH oxidase homolog-1 short (NOH-1S) transcript variant. J Biol Chem 2004;279(49):51 661-51 668.
25. Bates MD, Erwin CR, Sanford LP, Wiginton D, Bezerra JA, Schatzman LC, et al. Novel genes and functional relationships in the adult mouse gastrointestinal tract identified by microarray analysis. Gastroenterology 2002;122(5):1467-1482.
26. Ortega-Cava CF, Ishihara S, Rumi MA, Kawashima K, Ishimura N, Kazumori H, et al. Strategic compartmentalization of Toll-like receptor 4 in the mouse gut. J Immunol 2003; 170(8):3977-3985.
27. Blau S, Rubinstein A, Bass P, Singaram C, Kohen R. Differences in the reducing power along the rat GI tract: lower antioxidant capacity of the colon. Mol Cell Biochem 1999; 194(1-2):185-191.
28. Guarner F, Malagelada JR. Gut flora in health and disease. Lancet 2003;361(9356):512-519.
29. Edwards CA, Parrett AM. Intestinal flora during the first months of life: new perspectives. Br J Nutr 2002;88(suppl 1):S11-18.
30. Ouwehand AC, Tuomola EM, Lee YK, Salminen S. Microbial interactions to intestinal mucosal models. Methods Enzymol 2001; 337:200-212.