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Volumn 38, Issue , 2014, Pages 131-142

Systems biology, complexity, and the impact on antiepileptic drug discovery

Author keywords

Antiepileptic drug; Drug discovery; Drug resistance in epilepsy; Modeling; Multitarget drug; Phenotypic screening; Polypharmacology; Systems biology; Systems network pharmacology

Indexed keywords

ANTICONVULSIVE AGENT;

EID: 84910646137     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2013.08.029     Document Type: Review
Times cited : (32)

References (167)
  • 1
    • 61849168873 scopus 로고    scopus 로고
    • Milestones in epilepsy
    • Reynolds E.H. Milestones in epilepsy. Epilepsia 2009, 50:338-342.
    • (2009) Epilepsia , vol.50 , pp. 338-342
    • Reynolds, E.H.1
  • 2
    • 62149130133 scopus 로고    scopus 로고
    • The clinical concept of epilepsy
    • Reynolds E.H., Rodin E. The clinical concept of epilepsy. Epilepsia 2009, 50(Suppl. 3):2-7.
    • (2009) Epilepsia , vol.50 , pp. 2-7
    • Reynolds, E.H.1    Rodin, E.2
  • 3
    • 84872163082 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI)
    • Bialer M., Johannessen S.I., Levy R.H., Perucca E., Tomson T., White H.S. Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI). Epilepsy Res 2013, 103:2-30.
    • (2013) Epilepsy Res , vol.103 , pp. 2-30
    • Bialer, M.1    Johannessen, S.I.2    Levy, R.H.3    Perucca, E.4    Tomson, T.5    White, H.S.6
  • 4
    • 20544475805 scopus 로고    scopus 로고
    • Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms
    • Schmidt D., Löscher W. Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia 2005, 46:858-877.
    • (2005) Epilepsia , vol.46 , pp. 858-877
    • Schmidt, D.1    Löscher, W.2
  • 5
    • 77954476039 scopus 로고    scopus 로고
    • In search of models of pharmacoresistant epilepsy
    • Wahab A., Albus K., Gabriel S., Heinemann U. In search of models of pharmacoresistant epilepsy. Epilepsia 2010, 51(Suppl. 3):154-159.
    • (2010) Epilepsia , vol.51 , pp. 154-159
    • Wahab, A.1    Albus, K.2    Gabriel, S.3    Heinemann, U.4
  • 7
    • 78650118698 scopus 로고    scopus 로고
    • Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research
    • Löscher W., Brandt C. Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research. Pharmacol Rev 2010, 62:668-700.
    • (2010) Pharmacol Rev , vol.62 , pp. 668-700
    • Löscher, W.1    Brandt, C.2
  • 8
    • 0034945680 scopus 로고    scopus 로고
    • Antiepileptogenic agents. How close are we?
    • Temkin N.R., Jarell A.D., Anderson G.D. Antiepileptogenic agents. How close are we?. Drugs 2001, 61:1045-1055.
    • (2001) Drugs , vol.61 , pp. 1045-1055
    • Temkin, N.R.1    Jarell, A.D.2    Anderson, G.D.3
  • 9
    • 79953724893 scopus 로고    scopus 로고
    • Efficacy of new antiepileptic drugs
    • Schmidt D. Efficacy of new antiepileptic drugs. Epilepsy Curr 2011, 11:9-11.
    • (2011) Epilepsy Curr , vol.11 , pp. 9-11
    • Schmidt, D.1
  • 11
    • 79953705357 scopus 로고    scopus 로고
    • Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma
    • Löscher W., Schmidt D. Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 2011, 52:657-678.
    • (2011) Epilepsia , vol.52 , pp. 657-678
    • Löscher, W.1    Schmidt, D.2
  • 13
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology: a brief overview
    • Kitano H. Systems biology: a brief overview. Science 2002, 295:1662-1664.
    • (2002) Science , vol.295 , pp. 1662-1664
    • Kitano, H.1
  • 14
    • 0742305866 scopus 로고    scopus 로고
    • Network biology: understanding the cell's functional organization
    • Barabási A.L., Oltvai Z.N. Network biology: understanding the cell's functional organization. Nat Rev Genet 2004, 5:101-113.
    • (2004) Nat Rev Genet , vol.5 , pp. 101-113
    • Barabási, A.L.1    Oltvai, Z.N.2
  • 15
    • 34247587012 scopus 로고    scopus 로고
    • Getting closer to the whole picture
    • Sauer U., Heinemann M., Zamboni N. Getting closer to the whole picture. Science 2007, 316:550-551.
    • (2007) Science , vol.316 , pp. 550-551
    • Sauer, U.1    Heinemann, M.2    Zamboni, N.3
  • 16
    • 55749084529 scopus 로고    scopus 로고
    • Puzzling challenges in contemporary neuroscience: insights from complexity and emergence in epileptogenic circuits
    • Garcia-Cairasco N. Puzzling challenges in contemporary neuroscience: insights from complexity and emergence in epileptogenic circuits. Epilepsy Behav 2009, 14(Suppl. 1):54-63.
    • (2009) Epilepsy Behav , vol.14 , pp. 54-63
    • Garcia-Cairasco, N.1
  • 18
    • 84856454917 scopus 로고    scopus 로고
    • Systems biology impact on antiepileptic drug discovery
    • Margineanu D.G. Systems biology impact on antiepileptic drug discovery. Epilepsy Res 2012, 98:104-115.
    • (2012) Epilepsy Res , vol.98 , pp. 104-115
    • Margineanu, D.G.1
  • 21
    • 35148824614 scopus 로고    scopus 로고
    • Network pharmacology. Network biology illuminates our understanding of drug action
    • Hopkins A.L. Network pharmacology. Network biology illuminates our understanding of drug action. Nat Biotechnol 2007, 24:1110-1111.
    • (2007) Nat Biotechnol , vol.24 , pp. 1110-1111
    • Hopkins, A.L.1
  • 22
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: the next paradigm in drug discovery
    • Hopkins A.L. Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 2008, 4:682-690.
    • (2008) Nat Chem Biol , vol.4 , pp. 682-690
    • Hopkins, A.L.1
  • 23
  • 24
    • 79956140184 scopus 로고    scopus 로고
    • Getting pharmaceutical R&D back on target
    • Bunnage M.E. Getting pharmaceutical R&D back on target. Nat Chem Biol 2011, 7:335-339.
    • (2011) Nat Chem Biol , vol.7 , pp. 335-339
    • Bunnage, M.E.1
  • 27
    • 5044229321 scopus 로고    scopus 로고
    • The impact of systems approaches on biological problems in drug discovery
    • Hood L., Perlmutter R.M. The impact of systems approaches on biological problems in drug discovery. Nat Biotechnol 2004, 22:1215-1217.
    • (2004) Nat Biotechnol , vol.22 , pp. 1215-1217
    • Hood, L.1    Perlmutter, R.M.2
  • 28
    • 13844276627 scopus 로고    scopus 로고
    • Target-based drug discovery: is something wrong?
    • Sams-Dodd F. Target-based drug discovery: is something wrong?. Drug Discov Today 2005, 10:139-147.
    • (2005) Drug Discov Today , vol.10 , pp. 139-147
    • Sams-Dodd, F.1
  • 29
    • 77649182705 scopus 로고    scopus 로고
    • Unveiling the role of network and systems biology in drug discovery
    • Pujol A., Mosca R., Farrés J., Aloy P. Unveiling the role of network and systems biology in drug discovery. Trends Pharmacol Sci 2010, 31:115-122.
    • (2010) Trends Pharmacol Sci , vol.31 , pp. 115-122
    • Pujol, A.1    Mosca, R.2    Farrés, J.3    Aloy, P.4
  • 30
    • 70349847876 scopus 로고    scopus 로고
    • Network analyses in systems pharmacology
    • Berger S.I., Iyengar R. Network analyses in systems pharmacology. Bioinformatics 2009, 25:2466-2472.
    • (2009) Bioinformatics , vol.25 , pp. 2466-2472
    • Berger, S.I.1    Iyengar, R.2
  • 32
    • 20844432908 scopus 로고    scopus 로고
    • Can cell systems biology rescue drug discovery?
    • Butcher E.C. Can cell systems biology rescue drug discovery?. Nat Rev Drug Discov 2005, 4:461-467.
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 461-467
    • Butcher, E.C.1
  • 34
    • 0034625005 scopus 로고    scopus 로고
    • Cell signaling pathways as control modules: complexity for simplicity?
    • Lauffenburger D.A. Cell signaling pathways as control modules: complexity for simplicity?. Proc Natl Acad Sci U S A 2000, 97:5031-5033.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5031-5033
    • Lauffenburger, D.A.1
  • 35
    • 5044227742 scopus 로고    scopus 로고
    • The evolution of molecular biology into systems biology
    • Westerhoff H.V., Palsson B.O. The evolution of molecular biology into systems biology. Nat Biotechnol 2004, 22:1249-1252.
    • (2004) Nat Biotechnol , vol.22 , pp. 1249-1252
    • Westerhoff, H.V.1    Palsson, B.O.2
  • 36
    • 33845484059 scopus 로고    scopus 로고
    • Advanced computing for systems biology
    • Burrage K., Hood L., Ragan M.A. Advanced computing for systems biology. Brief Bioinform 2006, 7:390-398.
    • (2006) Brief Bioinform , vol.7 , pp. 390-398
    • Burrage, K.1    Hood, L.2    Ragan, M.A.3
  • 37
    • 27844446240 scopus 로고    scopus 로고
    • Embracing complexity, inching closer to reality
    • Schadt E.E., Sachs A., Friend S. Embracing complexity, inching closer to reality. Sci STKE 2005, 295:pe40.
    • (2005) Sci STKE , vol.295 , pp. pe40
    • Schadt, E.E.1    Sachs, A.2    Friend, S.3
  • 39
    • 7444253428 scopus 로고    scopus 로고
    • Systems biology and new technologies enable predictive and preventative medicine
    • Hood L., Heath J.R., Phelps M.E., Lin B. Systems biology and new technologies enable predictive and preventative medicine. Science 2004, 306:640-643.
    • (2004) Science , vol.306 , pp. 640-643
    • Hood, L.1    Heath, J.R.2    Phelps, M.E.3    Lin, B.4
  • 40
    • 62549088294 scopus 로고    scopus 로고
    • Systems biology and its application to the understanding of neurological diseases
    • Villoslada P., Steinman L., Baranzini S.E. Systems biology and its application to the understanding of neurological diseases. Ann Neurol 2009, 65:124-139.
    • (2009) Ann Neurol , vol.65 , pp. 124-139
    • Villoslada, P.1    Steinman, L.2    Baranzini, S.E.3
  • 41
    • 58949094360 scopus 로고    scopus 로고
    • Deciphering complex mechanisms in neuro-degenerative diseases: the advent of systems biology
    • Noorbakhsh F., Overall C.M., Power C. Deciphering complex mechanisms in neuro-degenerative diseases: the advent of systems biology. Trends Neurosci 2009, 32:88-100.
    • (2009) Trends Neurosci , vol.32 , pp. 88-100
    • Noorbakhsh, F.1    Overall, C.M.2    Power, C.3
  • 42
    • 0028245445 scopus 로고
    • A measure for brain complexity: relating functional segregation and integration in the nervous system
    • Tononi G., Sporns O., Edelman G.M. A measure for brain complexity: relating functional segregation and integration in the nervous system. Proc Natl Acad Sci U S A 1994, 91:5033-5037.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 5033-5037
    • Tononi, G.1    Sporns, O.2    Edelman, G.M.3
  • 43
    • 0033515743 scopus 로고    scopus 로고
    • Complexity and the nervous system
    • Koch C., Laurent G. Complexity and the nervous system. Science 1999, 284:96-98.
    • (1999) Science , vol.284 , pp. 96-98
    • Koch, C.1    Laurent, G.2
  • 44
    • 62749130783 scopus 로고    scopus 로고
    • Learning about brain physiology and complexity from the study of the epilepsies
    • Garcia-Cairasco N. Learning about brain physiology and complexity from the study of the epilepsies. Braz J Med Biol Res 2009, 42:76-86.
    • (2009) Braz J Med Biol Res , vol.42 , pp. 76-86
    • Garcia-Cairasco, N.1
  • 45
    • 77957552437 scopus 로고    scopus 로고
    • Epileptic hypersynchrony revisited
    • Margineanu D.G. Epileptic hypersynchrony revisited. Neuroreport 2010, 21:963-967.
    • (2010) Neuroreport , vol.21 , pp. 963-967
    • Margineanu, D.G.1
  • 46
    • 0035044178 scopus 로고    scopus 로고
    • On the cellular and network bases of epileptic seizures
    • McCormick D.A., Contreras D. On the cellular and network bases of epileptic seizures. Annu Rev Physiol 2001, 63:815-846.
    • (2001) Annu Rev Physiol , vol.63 , pp. 815-846
    • McCormick, D.A.1    Contreras, D.2
  • 48
    • 47749115285 scopus 로고    scopus 로고
    • Computer modelling of epilepsy
    • Lytton W.W. Computer modelling of epilepsy. Nat Rev Neurosci 2008, 9:626-637.
    • (2008) Nat Rev Neurosci , vol.9 , pp. 626-637
    • Lytton, W.W.1
  • 50
    • 70350464493 scopus 로고    scopus 로고
    • Prediction by modeling that epilepsy may be caused by very small functional changes in ion channels
    • Thomas E.A., Reid C.A., Berkovic S.F., Petrou S. Prediction by modeling that epilepsy may be caused by very small functional changes in ion channels. Arch Neurol 2009, 66:1225-1232.
    • (2009) Arch Neurol , vol.66 , pp. 1225-1232
    • Thomas, E.A.1    Reid, C.A.2    Berkovic, S.F.3    Petrou, S.4
  • 51
  • 52
    • 84869088193 scopus 로고    scopus 로고
    • Sodium channels and the neurobiology of epilepsy
    • Oliva M., Berkovic S.F., Petrou S. Sodium channels and the neurobiology of epilepsy. Epilepsia 2012, 53:1849-1859.
    • (2012) Epilepsia , vol.53 , pp. 1849-1859
    • Oliva, M.1    Berkovic, S.F.2    Petrou, S.3
  • 53
    • 77954625557 scopus 로고    scopus 로고
    • Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies
    • Kwan P., Arzimanoglou A., Berg A.T., Brodie M.J., Hauser W.A., Mathern G., et al. Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies. Epilepsia 2010, 51:1069-1077.
    • (2010) Epilepsia , vol.51 , pp. 1069-1077
    • Kwan, P.1    Arzimanoglou, A.2    Berg, A.T.3    Brodie, M.J.4    Hauser, W.A.5    Mathern, G.6
  • 54
    • 67649128771 scopus 로고    scopus 로고
    • Mechanisms of drug resistance in epilepsy: relevance for antiepileptic drug discovery
    • Margineanu D.G., Klitgaard H. Mechanisms of drug resistance in epilepsy: relevance for antiepileptic drug discovery. Expert Opin Drug Discov 2009, 4:23-32.
    • (2009) Expert Opin Drug Discov , vol.4 , pp. 23-32
    • Margineanu, D.G.1    Klitgaard, H.2
  • 55
    • 70350060190 scopus 로고    scopus 로고
    • Identification of pharmacoresistant epilepsy
    • Berg A.T. Identification of pharmacoresistant epilepsy. Neurol Clin 2009, 27:1003-1013.
    • (2009) Neurol Clin , vol.27 , pp. 1003-1013
    • Berg, A.T.1
  • 56
    • 77954668304 scopus 로고    scopus 로고
    • Pharmacoresistant epilepsy: from pathogenesis to current and emerging therapies
    • Pati S., Alexopoulos A.V. Pharmacoresistant epilepsy: from pathogenesis to current and emerging therapies. Cleve Clin J Med 2010, 77:457-467.
    • (2010) Cleve Clin J Med , vol.77 , pp. 457-467
    • Pati, S.1    Alexopoulos, A.V.2
  • 58
    • 0034598762 scopus 로고    scopus 로고
    • Early identification of refractory epilepsy
    • Kwan P., Brodie M.J. Early identification of refractory epilepsy. N Engl J Med 2000, 342:315-319.
    • (2000) N Engl J Med , vol.342 , pp. 315-319
    • Kwan, P.1    Brodie, M.J.2
  • 59
    • 1342309941 scopus 로고    scopus 로고
    • The new antiepileptic drugs - scientific review
    • Laroche S.M., Helmers S.L. The new antiepileptic drugs - scientific review. J Am Med Assoc 2004, 291:605-614.
    • (2004) J Am Med Assoc , vol.291 , pp. 605-614
    • Laroche, S.M.1    Helmers, S.L.2
  • 61
    • 23044500398 scopus 로고    scopus 로고
    • Drug resistance in brain diseases and the role of drug efflux transporters
    • Löscher W., Potschka H. Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci 2005, 6:591-602.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 591-602
    • Löscher, W.1    Potschka, H.2
  • 62
    • 34848910711 scopus 로고    scopus 로고
    • ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsy
    • Lazarowski A., Czornyj L., Lubienieki F., Girardi E., Vazquez S., D'Giano C. ABC transporters during epilepsy and mechanisms underlying multidrug resistance in refractory epilepsy. Epilepsia 2007, 48(Suppl. 5):140-149.
    • (2007) Epilepsia , vol.48 , pp. 140-149
    • Lazarowski, A.1    Czornyj, L.2    Lubienieki, F.3    Girardi, E.4    Vazquez, S.5    D'Giano, C.6
  • 63
    • 30344467212 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of pharmacoresistance in epilepsy
    • Remy S., Beck H. Molecular and cellular mechanisms of pharmacoresistance in epilepsy. Brain 2006, 129:18-35.
    • (2006) Brain , vol.129 , pp. 18-35
    • Remy, S.1    Beck, H.2
  • 64
    • 33847125762 scopus 로고    scopus 로고
    • Plasticity of antiepileptic drug targets
    • Beck H. Plasticity of antiepileptic drug targets. Epilepsia 2007, 48(Suppl. 1):14-18.
    • (2007) Epilepsia , vol.48 , pp. 14-18
    • Beck, H.1
  • 65
    • 33645500633 scopus 로고    scopus 로고
    • Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy
    • Rambeck B., Jürgens U.H., May T.W., Pannek H.W., Behne F., Ebner A., et al. Comparison of brain extracellular fluid, brain tissue, cerebrospinal fluid, and serum concentrations of antiepileptic drugs measured intraoperatively in patients with intractable epilepsy. Epilepsia 2006, 47:681-694.
    • (2006) Epilepsia , vol.47 , pp. 681-694
    • Rambeck, B.1    Jürgens, U.H.2    May, T.W.3    Pannek, H.W.4    Behne, F.5    Ebner, A.6
  • 66
    • 84866686711 scopus 로고    scopus 로고
    • Neuropathology of the blood-brain barrier and pharmaco-resistance in human epilepsy
    • Liu J.Y., Thom M., Catarino C.B., Martinian L., Figarella-Branger D., Bartolomei F., et al. Neuropathology of the blood-brain barrier and pharmaco-resistance in human epilepsy. Brain 2012, 135:3115-3133.
    • (2012) Brain , vol.135 , pp. 3115-3133
    • Liu, J.Y.1    Thom, M.2    Catarino, C.B.3    Martinian, L.4    Figarella-Branger, D.5    Bartolomei, F.6
  • 67
    • 33845866924 scopus 로고    scopus 로고
    • Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays
    • Baltes S., Fedrowitz M., Luna Tortos C., Potschka H., Löscher W. Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays. J Pharmacol Exp Ther 2007, 320:331-343.
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 331-343
    • Baltes, S.1    Fedrowitz, M.2    Luna Tortos, C.3    Potschka, H.4    Löscher, W.5
  • 68
    • 33846271368 scopus 로고    scopus 로고
    • Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein
    • Baltes S., Gastens A.M., Fedrowitz M., Potschka H., Kaever V., Löscher W. Differences in the transport of the antiepileptic drugs phenytoin, levetiracetam and carbamazepine by human and mouse P-glycoprotein. Neuropharmacology 2007, 52:333-346.
    • (2007) Neuropharmacology , vol.52 , pp. 333-346
    • Baltes, S.1    Gastens, A.M.2    Fedrowitz, M.3    Potschka, H.4    Kaever, V.5    Löscher, W.6
  • 69
    • 36949040830 scopus 로고    scopus 로고
    • Drug resistance in epilepsy: why is a simple explanation not enough?
    • Löscher W., Sills G.J. Drug resistance in epilepsy: why is a simple explanation not enough?. Epilepsia 2007, 48:2370-2372.
    • (2007) Epilepsia , vol.48 , pp. 2370-2372
    • Löscher, W.1    Sills, G.J.2
  • 70
    • 80053506403 scopus 로고    scopus 로고
    • Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected
    • Löscher W., Luna-Tortós C., Römermann K., Fedrowitz M. Do ATP-binding cassette transporters cause pharmacoresistance in epilepsy? Problems and approaches in determining which antiepileptic drugs are affected. Curr Pharm Des 2011, 17:2808-2828.
    • (2011) Curr Pharm Des , vol.17 , pp. 2808-2828
    • Löscher, W.1    Luna-Tortós, C.2    Römermann, K.3    Fedrowitz, M.4
  • 71
    • 33746824653 scopus 로고    scopus 로고
    • Limited P-glycoprotein mediated efflux for anti-epileptic drugs
    • Crowe A., Teoh Y.-K. Limited P-glycoprotein mediated efflux for anti-epileptic drugs. J Drug Target 2006, 14:291-300.
    • (2006) J Drug Target , vol.14 , pp. 291-300
    • Crowe, A.1    Teoh, Y.-K.2
  • 72
    • 80053566885 scopus 로고    scopus 로고
    • In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein
    • Zhang C., Zuo Z., Kwan P., Baum L. In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein. Epilepsia 2011, 52:1894-1904.
    • (2011) Epilepsia , vol.52 , pp. 1894-1904
    • Zhang, C.1    Zuo, Z.2    Kwan, P.3    Baum, L.4
  • 74
    • 0036583181 scopus 로고    scopus 로고
    • 2+ channel causes a long-lasting modification of neuronal firing mode after status epilepticus
    • 2+ channel causes a long-lasting modification of neuronal firing mode after status epilepticus. J Neurosci 2002, 22:3645-3655.
    • (2002) J Neurosci , vol.22 , pp. 3645-3655
    • Su, H.1    Sochivko, D.2    Becker, A.3    Chen, J.4    Jiang, Y.5    Yaari, Y.6
  • 75
    • 7044222366 scopus 로고    scopus 로고
    • Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons
    • Shah M.M., Anderson A.E., Leung V., Lin X., Johnston D. Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons. Neuron 2004, 44:495-508.
    • (2004) Neuron , vol.44 , pp. 495-508
    • Shah, M.M.1    Anderson, A.E.2    Leung, V.3    Lin, X.4    Johnston, D.5
  • 76
    • 0036321057 scopus 로고    scopus 로고
    • Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites
    • Poolos N.P., Migliore M., Johnston D. Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites. Nat Neurosci 2002, 5:767-774.
    • (2002) Nat Neurosci , vol.5 , pp. 767-774
    • Poolos, N.P.1    Migliore, M.2    Johnston, D.3
  • 78
    • 0037669865 scopus 로고    scopus 로고
    • + channels in hippocampal neurons of control and chronically epileptic rats
    • + channels in hippocampal neurons of control and chronically epileptic rats. Eur J Neurosci 2003, 17:2648-2658.
    • (2003) Eur J Neurosci , vol.17 , pp. 2648-2658
    • Remy, S.1    Urban, B.W.2    Elger, C.E.3    Beck, H.4
  • 80
    • 34247129585 scopus 로고    scopus 로고
    • Altered distribution of KCC2 in cortical dysplasia in patients with intractable epilepsy
    • Munakata M., Watanabe M., Otsuki T., Nakama H., Arima K., Itoh M., et al. Altered distribution of KCC2 in cortical dysplasia in patients with intractable epilepsy. Epilepsia 2007, 48:837-844.
    • (2007) Epilepsia , vol.48 , pp. 837-844
    • Munakata, M.1    Watanabe, M.2    Otsuki, T.3    Nakama, H.4    Arima, K.5    Itoh, M.6
  • 82
    • 0019205460 scopus 로고
    • Immunological aspects of epilepsy
    • Aarli J.A., Fontana A. Immunological aspects of epilepsy. Epilepsia 1980, 21:451-457.
    • (1980) Epilepsia , vol.21 , pp. 451-457
    • Aarli, J.A.1    Fontana, A.2
  • 83
    • 0027151791 scopus 로고
    • Immunological aspects of epilepsy
    • Aarli J.A. Immunological aspects of epilepsy. Brain Dev 1993, 15:41-49.
    • (1993) Brain Dev , vol.15 , pp. 41-49
    • Aarli, J.A.1
  • 84
    • 0033667848 scopus 로고    scopus 로고
    • Epilepsy and the immune system
    • Aarli J.A. Epilepsy and the immune system. Arch Neurol 2000, 57:1689-1692.
    • (2000) Arch Neurol , vol.57 , pp. 1689-1692
    • Aarli, J.A.1
  • 85
    • 33644625777 scopus 로고    scopus 로고
    • Brain inflammation in epilepsy: experimental and clinical evidence
    • Vezzani A., Granata T. Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 2005, 46:1724-1743.
    • (2005) Epilepsia , vol.46 , pp. 1724-1743
    • Vezzani, A.1    Granata, T.2
  • 86
  • 88
    • 84873482748 scopus 로고    scopus 로고
    • Glia-neuronal interactions in ictogenesis and epileptogenesis: role of inflammatory mediators
    • National Center for Biotechnology Information (US), Bethesda (MD), J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta (Eds.)
    • Vezzani A., Auvin S., Ravizza T., Aronica E. Glia-neuronal interactions in ictogenesis and epileptogenesis: role of inflammatory mediators. Jasper's basic mechanisms of the epilepsies [Internet] 2012, National Center for Biotechnology Information (US), Bethesda (MD), [http://www.ncbi.nlm.nih.gov/books/NBK98146/pdf/vezzani.pdf]. 4th ed. J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta (Eds.).
    • (2012) Jasper's basic mechanisms of the epilepsies [Internet]
    • Vezzani, A.1    Auvin, S.2    Ravizza, T.3    Aronica, E.4
  • 89
    • 33751099302 scopus 로고    scopus 로고
    • Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy
    • Gorter J.A., van Vliet E.A., Aronica E., Breit T., Rauwerda H., Lopes da Silva F.H., et al. Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy. J Neurosci 2006, 26:11083-11110.
    • (2006) J Neurosci , vol.26 , pp. 11083-11110
    • Gorter, J.A.1    van Vliet, E.A.2    Aronica, E.3    Breit, T.4    Rauwerda, H.5    Lopes da Silva, F.H.6
  • 90
    • 79953135552 scopus 로고    scopus 로고
    • Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics
    • Marchi N., Granata T., Freri E., Ciusani E., Ragona F., Puvenna V., et al. Efficacy of anti-inflammatory therapy in a model of acute seizures and in a population of pediatric drug resistant epileptics. PLoS One 2011, 6(3):e18200. 10.1371/journal.pone.0018200.
    • (2011) PLoS One , vol.6 , Issue.3 , pp. e18200
    • Marchi, N.1    Granata, T.2    Freri, E.3    Ciusani, E.4    Ragona, F.5    Puvenna, V.6
  • 91
    • 23044435896 scopus 로고    scopus 로고
    • Astrocytes, from brain glue to communication elements: the revolution continues
    • Volterra A., Meldolesi J. Astrocytes, from brain glue to communication elements: the revolution continues. Nat Rev Neurosci 2005, 6:626-640.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 626-640
    • Volterra, A.1    Meldolesi, J.2
  • 92
    • 84885349589 scopus 로고    scopus 로고
    • Astrocyte dysfunction in epilepsy
    • National Center for Biotechnology Information (US), Bethesda (MD), J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta (Eds.)
    • Steinhäuser C., Seifert G. Astrocyte dysfunction in epilepsy. Jasper's basic mechanisms of the epilepsies [Internet] 2012, National Center for Biotechnology Information (US), Bethesda (MD), [http://www.ncbi.nlm.nih.gov/books/NBK98180/pdf/steinhauser.pdf]. 4th ed. J.L. Noebels, M. Avoli, M.A. Rogawski, R.W. Olsen, A.V. Delgado-Escueta (Eds.).
    • (2012) Jasper's basic mechanisms of the epilepsies [Internet]
    • Steinhäuser, C.1    Seifert, G.2
  • 94
    • 38449093605 scopus 로고    scopus 로고
    • Glutamate and astrocytes - key players in human mesial temporal lobe epilepsy?
    • Eid T., Williamson A., Lee T.S., Petroff O.A., de Lanerolle N.C. Glutamate and astrocytes - key players in human mesial temporal lobe epilepsy?. Epilepsia 2008, 49(Suppl. 2):42-52.
    • (2008) Epilepsia , vol.49 , pp. 42-52
    • Eid, T.1    Williamson, A.2    Lee, T.S.3    Petroff, O.A.4    de Lanerolle, N.C.5
  • 95
  • 96
    • 23844531501 scopus 로고    scopus 로고
    • New facets of the neuropathology and molecular profile of human temporal lobe epilepsy
    • de Lanerolle N.C., Lee T.S. New facets of the neuropathology and molecular profile of human temporal lobe epilepsy. Epilepsy Behav 2005, 7:190-203.
    • (2005) Epilepsy Behav , vol.7 , pp. 190-203
    • de Lanerolle, N.C.1    Lee, T.S.2
  • 98
    • 33748857971 scopus 로고    scopus 로고
    • Functional changes in astroglial cells in epilepsy
    • Binder D.K., Steinhäuser C. Functional changes in astroglial cells in epilepsy. Glia 2006, 54:358-368.
    • (2006) Glia , vol.54 , pp. 358-368
    • Binder, D.K.1    Steinhäuser, C.2
  • 99
    • 33644519960 scopus 로고    scopus 로고
    • Astrocyte dysfunction in neurological disorders: a molecular perspective
    • Seifert G., Schilling K., Steinhäuser C. Astrocyte dysfunction in neurological disorders: a molecular perspective. Nat Rev Neurosci 2006, 7:194-206.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 194-206
    • Seifert, G.1    Schilling, K.2    Steinhäuser, C.3
  • 100
    • 38449112392 scopus 로고    scopus 로고
    • Astrocytic function and its alteration in the epileptic brain
    • Jabs R., Seifert G., Steinhäuser C. Astrocytic function and its alteration in the epileptic brain. Epilepsia 2008, 49(Suppl. 2):3-12.
    • (2008) Epilepsia , vol.49 , pp. 3-12
    • Jabs, R.1    Seifert, G.2    Steinhäuser, C.3
  • 101
    • 0034881396 scopus 로고    scopus 로고
    • Can gap-junction blockade preferentially inhibit neuronal hypersynchrony vs. excitability?
    • Margineanu D.G., Klitgaard H. Can gap-junction blockade preferentially inhibit neuronal hypersynchrony vs. excitability?. Neuropharmacology 2001, 41:377-383.
    • (2001) Neuropharmacology , vol.41 , pp. 377-383
    • Margineanu, D.G.1    Klitgaard, H.2
  • 102
    • 0013652589 scopus 로고    scopus 로고
    • Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances
    • Hinterkeuser S., Schröder W., Hager G., Seifert G., Blümcke I., Elger C.E., et al. Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances. Eur J Neurosci 2000, 12:2087-2096.
    • (2000) Eur J Neurosci , vol.12 , pp. 2087-2096
    • Hinterkeuser, S.1    Schröder, W.2    Hager, G.3    Seifert, G.4    Blümcke, I.5    Elger, C.E.6
  • 103
    • 33745003688 scopus 로고    scopus 로고
    • The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus
    • Wallraff A., Kohling R., Heinemann U., Theis M., Willecke K., Steinhäuser C. The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus. J Neurosci 2006, 26:5438-5447.
    • (2006) J Neurosci , vol.26 , pp. 5438-5447
    • Wallraff, A.1    Kohling, R.2    Heinemann, U.3    Theis, M.4    Willecke, K.5    Steinhäuser, C.6
  • 104
    • 0344430036 scopus 로고    scopus 로고
    • The molecular basis of water transport in the brain
    • Amiry-Moghaddam M., Ottersen O.P. The molecular basis of water transport in the brain. Nat Rev Neurosci 2003, 4:991-1001.
    • (2003) Nat Rev Neurosci , vol.4 , pp. 991-1001
    • Amiry-Moghaddam, M.1    Ottersen, O.P.2
  • 105
    • 9344269387 scopus 로고    scopus 로고
    • Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with Kir4.1
    • Nagelhus E.A., Mathiisen T.M., Ottersen O.P. Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with Kir4.1. Neuroscience 2004, 129:905-913.
    • (2004) Neuroscience , vol.129 , pp. 905-913
    • Nagelhus, E.A.1    Mathiisen, T.M.2    Ottersen, O.P.3
  • 107
    • 0036872333 scopus 로고    scopus 로고
    • Gap junctions and connexin expression in the normal and pathological central nervous system
    • Rouach N., Avignone E., Même W., Koulakoff A., Venance L., Blomstrand F., et al. Gap junctions and connexin expression in the normal and pathological central nervous system. Biol Cell 2002, 94:457-475.
    • (2002) Biol Cell , vol.94 , pp. 457-475
    • Rouach, N.1    Avignone, E.2    Même, W.3    Koulakoff, A.4    Venance, L.5    Blomstrand, F.6
  • 108
    • 0036498359 scopus 로고    scopus 로고
    • Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy
    • Fonseca C.G., Green C.R., Nicholson L.F. Upregulation in astrocytic connexin 43 gap junction levels may exacerbate generalized seizures in mesial temporal lobe epilepsy. Brain Res 2002, 929:105-116.
    • (2002) Brain Res , vol.929 , pp. 105-116
    • Fonseca, C.G.1    Green, C.R.2    Nicholson, L.F.3
  • 109
    • 33746173312 scopus 로고    scopus 로고
    • Antiepileptic effect of gap-junction blockers in a rat model of refractory focal cortical epilepsy
    • Nilsen K.E., Kelso A.R.C., Cock H.R. Antiepileptic effect of gap-junction blockers in a rat model of refractory focal cortical epilepsy. Epilepsia 2006, 47:1169-1175.
    • (2006) Epilepsia , vol.47 , pp. 1169-1175
    • Nilsen, K.E.1    Kelso, A.R.C.2    Cock, H.R.3
  • 110
    • 68149174964 scopus 로고    scopus 로고
    • Excitatory effects of gap junction blockers on cerebral cortex seizure-like activity in rats and mice
    • Voss L.J., Jacobson G., Sleigh J.W., Steyn-Ross A., Steyn-Ross M. Excitatory effects of gap junction blockers on cerebral cortex seizure-like activity in rats and mice. Epilepsia 2009, 50:1971-1978.
    • (2009) Epilepsia , vol.50 , pp. 1971-1978
    • Voss, L.J.1    Jacobson, G.2    Sleigh, J.W.3    Steyn-Ross, A.4    Steyn-Ross, M.5
  • 111
    • 84863810900 scopus 로고    scopus 로고
    • Connexin36 gap junction blockade is ineffective at reducing seizure-like event activity in neocortical mouse slices
    • Voss L.J., Mutsaerts N., Sleigh J.W. Connexin36 gap junction blockade is ineffective at reducing seizure-like event activity in neocortical mouse slices. Epilepsy Res Treat 2010, [Article ID 310753]. 10.1155/2010/310753.
    • (2010) Epilepsy Res Treat
    • Voss, L.J.1    Mutsaerts, N.2    Sleigh, J.W.3
  • 112
    • 79953138392 scopus 로고    scopus 로고
    • Is connexin36 critical for GABAergic hypersynchronization in the hippocampus?
    • Beaumont M., Maccaferri G. Is connexin36 critical for GABAergic hypersynchronization in the hippocampus?. J Physiol 2011, 589:1663-1680.
    • (2011) J Physiol , vol.589 , pp. 1663-1680
    • Beaumont, M.1    Maccaferri, G.2
  • 113
    • 60149107686 scopus 로고    scopus 로고
    • Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: animal and human studies
    • Juszczak G.R., Swiergiel A.H. Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: animal and human studies. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33:181-198.
    • (2009) Prog Neuropsychopharmacol Biol Psychiatry , vol.33 , pp. 181-198
    • Juszczak, G.R.1    Swiergiel, A.H.2
  • 114
    • 84871391370 scopus 로고    scopus 로고
    • Tales of a dirty drug: carbenoxolone, gap junctions, and seizures
    • Connors B.W. Tales of a dirty drug: carbenoxolone, gap junctions, and seizures. Epilepsy Curr 2012, 12:66-68.
    • (2012) Epilepsy Curr , vol.12 , pp. 66-68
    • Connors, B.W.1
  • 115
    • 79957852030 scopus 로고    scopus 로고
    • Gap junctions and epileptic seizures - two sides of the same coin?
    • Volman V., Perc M., Bazhenov M. Gap junctions and epileptic seizures - two sides of the same coin?. PLoS One 2011, 6(5):e20572. 10.1371/journal.pone.0020572.
    • (2011) PLoS One , vol.6 , Issue.5 , pp. e20572
    • Volman, V.1    Perc, M.2    Bazhenov, M.3
  • 116
    • 0035371032 scopus 로고    scopus 로고
    • Developing networks play a similar melody
    • Ben Ari Y. Developing networks play a similar melody. Trends Neurosci 2001, 24:353-360.
    • (2001) Trends Neurosci , vol.24 , pp. 353-360
    • Ben, A.Y.1
  • 117
    • 0037384485 scopus 로고    scopus 로고
    • Cation-chloride co-transporters in neuronal communication, development and trauma
    • Payne J.A., Rivera C., Voipio J., Kaila K. Cation-chloride co-transporters in neuronal communication, development and trauma. Trends Neurosci 2003, 26:199-206.
    • (2003) Trends Neurosci , vol.26 , pp. 199-206
    • Payne, J.A.1    Rivera, C.2    Voipio, J.3    Kaila, K.4
  • 119
    • 27944503013 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of epilepsy in the human brain
    • Avoli M., Louvel J., Pumain R., Köhling R. Cellular and molecular mechanisms of epilepsy in the human brain. Prog Neurobiol 2005, 77:166-200.
    • (2005) Prog Neurobiol , vol.77 , pp. 166-200
    • Avoli, M.1    Louvel, J.2    Pumain, R.3    Köhling, R.4
  • 120
    • 34249802037 scopus 로고    scopus 로고
    • Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue
    • Majores M., Schoch S., Lie A., Becker A.J. Molecular neuropathology of temporal lobe epilepsy: complementary approaches in animal models and human disease tissue. Epilepsia 2007, 48(Suppl. 2):4-12.
    • (2007) Epilepsia , vol.48 , pp. 4-12
    • Majores, M.1    Schoch, S.2    Lie, A.3    Becker, A.J.4
  • 121
    • 55349109688 scopus 로고    scopus 로고
    • Pathways to cancer therapy
    • Jones D. Pathways to cancer therapy. Nat Rev Drug Discov 2008, 7:875-876.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 875-876
    • Jones, D.1
  • 122
    • 77949415427 scopus 로고    scopus 로고
    • Mechanisms of action of antiepileptic drugs: the search for synergy
    • Stafstrom C.E. Mechanisms of action of antiepileptic drugs: the search for synergy. Curr Opin Neurol 2010, 23:157-163.
    • (2010) Curr Opin Neurol , vol.23 , pp. 157-163
    • Stafstrom, C.E.1
  • 123
    • 79955685813 scopus 로고    scopus 로고
    • Combining AEDs - rational polytherapy?
    • Brodie M.J., Sills G.J. Combining AEDs - rational polytherapy?. Seizure 2011, 20:369-375.
    • (2011) Seizure , vol.20 , pp. 369-375
    • Brodie, M.J.1    Sills, G.J.2
  • 124
    • 84856458040 scopus 로고    scopus 로고
    • Antiepileptic drug combinations - have newer agents altered clinical outcomes?
    • Stephen L.J., Forsyth M., Kelly K., Brodie M.J. Antiepileptic drug combinations - have newer agents altered clinical outcomes?. Epilepsy Res 2012, 98:194-198.
    • (2012) Epilepsy Res , vol.98 , pp. 194-198
    • Stephen, L.J.1    Forsyth, M.2    Kelly, K.3    Brodie, M.J.4
  • 125
    • 0036342414 scopus 로고    scopus 로고
    • New horizons in the development of antiepileptic drugs
    • Löscher W., Schmidt D. New horizons in the development of antiepileptic drugs. Epilepsy Res 2002, 50:3-16.
    • (2002) Epilepsy Res , vol.50 , pp. 3-16
    • Löscher, W.1    Schmidt, D.2
  • 126
    • 59249102753 scopus 로고    scopus 로고
    • From ion channels to complex networks: magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy
    • Bianchi M.T., Pathmanathan J., Cash S.S. From ion channels to complex networks: magic bullet versus magic shotgun approaches to anticonvulsant pharmacotherapy. Med Hypotheses 2009, 72:297-305.
    • (2009) Med Hypotheses , vol.72 , pp. 297-305
    • Bianchi, M.T.1    Pathmanathan, J.2    Cash, S.S.3
  • 127
    • 79961212342 scopus 로고    scopus 로고
    • Antiepileptic drug discovery: does mechanism of action matter?
    • Schmidt D. Antiepileptic drug discovery: does mechanism of action matter?. Epilepsy Behav 2011, 21:342-343.
    • (2011) Epilepsy Behav , vol.21 , pp. 342-343
    • Schmidt, D.1
  • 128
    • 79955677603 scopus 로고    scopus 로고
    • Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs
    • Löscher W. Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs. Seizure 2011, 20:359-368.
    • (2011) Seizure , vol.20 , pp. 359-368
    • Löscher, W.1
  • 129
    • 84869088933 scopus 로고    scopus 로고
    • Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design
    • Simonato M., Löscher W., Cole A.J., Dudek F.E., Engel J., Kaminski R.M., et al. Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design. Epilepsia 2012, 53:1860-1867.
    • (2012) Epilepsia , vol.53 , pp. 1860-1867
    • Simonato, M.1    Löscher, W.2    Cole, A.J.3    Dudek, F.E.4    Engel, J.5    Kaminski, R.M.6
  • 130
    • 0028220347 scopus 로고
    • Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?
    • Löscher W., Schmidt D. Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?. Epilepsy Res 1994, 17:95-134.
    • (1994) Epilepsy Res , vol.17 , pp. 95-134
    • Löscher, W.1    Schmidt, D.2
  • 131
    • 0025307686 scopus 로고
    • New targets for drug action: is high selectivity always beneficial?
    • Fredholm B., Abbott A. New targets for drug action: is high selectivity always beneficial?. Trends Pharmacol Sci 1990, 11:175-178.
    • (1990) Trends Pharmacol Sci , vol.11 , pp. 175-178
    • Fredholm, B.1    Abbott, A.2
  • 133
    • 1242313225 scopus 로고    scopus 로고
    • Emergent properties of CNS neuronal networks as targets for pharmacology: application to anticonvulsant drug action
    • Faingold C.L. Emergent properties of CNS neuronal networks as targets for pharmacology: application to anticonvulsant drug action. Prog Neurobiol 2004, 72:55-85.
    • (2004) Prog Neurobiol , vol.72 , pp. 55-85
    • Faingold, C.L.1
  • 134
    • 77954488198 scopus 로고    scopus 로고
    • A human systems biology approach to discover new drug targets in epilepsy
    • Loeb J.A. A human systems biology approach to discover new drug targets in epilepsy. Epilepsia 2010, 51(Suppl. 3):171-177.
    • (2010) Epilepsia , vol.51 , pp. 171-177
    • Loeb, J.A.1
  • 135
    • 79957838889 scopus 로고    scopus 로고
    • Identifying targets for preventing epilepsy using systems biology
    • Loeb J.A. Identifying targets for preventing epilepsy using systems biology. Neurosci Lett 2011, 497:205-212.
    • (2011) Neurosci Lett , vol.497 , pp. 205-212
    • Loeb, J.A.1
  • 136
    • 34848819985 scopus 로고    scopus 로고
    • Activity-dependent gene expression correlates with interictal spiking in human neocortical epilepsy
    • Rakhade S.N., Shah A.K., Agarwal R., Yao B., Asano E., Loeb J.A. Activity-dependent gene expression correlates with interictal spiking in human neocortical epilepsy. Epilepsia 2007, 48(Suppl. 5):86-95.
    • (2007) Epilepsia , vol.48 , pp. 86-95
    • Rakhade, S.N.1    Shah, A.K.2    Agarwal, R.3    Yao, B.4    Asano, E.5    Loeb, J.A.6
  • 137
    • 70349576489 scopus 로고    scopus 로고
    • An animal model to study the clinical significance of interictal spiking
    • Barkmeier D.T., Loeb J.A. An animal model to study the clinical significance of interictal spiking. Clin EEG Neurosci 2009, 40:234-238.
    • (2009) Clin EEG Neurosci , vol.40 , pp. 234-238
    • Barkmeier, D.T.1    Loeb, J.A.2
  • 138
    • 54249085844 scopus 로고    scopus 로고
    • Chemical biology and the limits of reductionism
    • Peterson R.T. Chemical biology and the limits of reductionism. Nat Chem Biol 2008, 4:635-638.
    • (2008) Nat Chem Biol , vol.4 , pp. 635-638
    • Peterson, R.T.1
  • 139
    • 0036747357 scopus 로고    scopus 로고
    • Seizure freedom with more than one antiepileptic drug
    • Stephen L.J., Brodie M.J. Seizure freedom with more than one antiepileptic drug. Seizure 2002, 11:349-351.
    • (2002) Seizure , vol.11 , pp. 349-351
    • Stephen, L.J.1    Brodie, M.J.2
  • 140
    • 68949213747 scopus 로고    scopus 로고
    • Rational polytherapy
    • French J.A., Faught E. Rational polytherapy. Epilepsia 2009, 50(Suppl. 8):63-68.
    • (2009) Epilepsia , vol.50 , pp. 63-68
    • French, J.A.1    Faught, E.2
  • 141
    • 84859858803 scopus 로고    scopus 로고
    • Drug discovery in the age of systems biology: the rise of computational approaches for data integration
    • Iskar M., Zeller G., Zhao X.-M., van Noort V., Bork P. Drug discovery in the age of systems biology: the rise of computational approaches for data integration. Curr Opin Biotechnol 2011, 23:1-8.
    • (2011) Curr Opin Biotechnol , vol.23 , pp. 1-8
    • Iskar, M.1    Zeller, G.2    Zhao, X.-M.3    van Noort, V.4    Bork, P.5
  • 142
    • 84856385436 scopus 로고    scopus 로고
    • Established and emerging trends in computational drug discovery in the structural genomics era
    • Taboureau O., Baell J.B., Fernández-Recio J., Villoutreix B.O. Established and emerging trends in computational drug discovery in the structural genomics era. Chem Biol 2012, 19:29-41.
    • (2012) Chem Biol , vol.19 , pp. 29-41
    • Taboureau, O.1    Baell, J.B.2    Fernández-Recio, J.3    Villoutreix, B.O.4
  • 143
    • 84860296344 scopus 로고    scopus 로고
    • The impact of network biology in pharmacology and toxicology
    • Panagiotou G., Taboureau O. The impact of network biology in pharmacology and toxicology. SAR QSAR Environ Res 2012, 10.1080/1062936X.2012.657237.
    • (2012) SAR QSAR Environ Res
    • Panagiotou, G.1    Taboureau, O.2
  • 144
    • 84877580262 scopus 로고    scopus 로고
    • Structure and dynamics of molecular networks: a novel paradigm of drug discovery
    • Csermely P., Korcsmáros T., Kiss H.J.M., London G., Nussinov R. Structure and dynamics of molecular networks: a novel paradigm of drug discovery. Pharmacol Ther 2013, 138:333-408.
    • (2013) Pharmacol Ther , vol.138 , pp. 333-408
    • Csermely, P.1    Korcsmáros, T.2    Kiss, H.J.M.3    London, G.4    Nussinov, R.5
  • 145
    • 77956836440 scopus 로고    scopus 로고
    • A systems biology approach to identify effective cocktail drugs
    • Wu Z., Zhao X.-M., Chen L. A systems biology approach to identify effective cocktail drugs. BMC Syst Biol 2010, 4(Suppl. 2):S7.
    • (2010) BMC Syst Biol , vol.4 , pp. S7
    • Wu, Z.1    Zhao, X.-M.2    Chen, L.3
  • 146
    • 84872740925 scopus 로고    scopus 로고
    • Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders
    • Geldenhuys W.J., Van der Schyf C.J. Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders. Expert Opin Drug Discov 2013, 8:115-129.
    • (2013) Expert Opin Drug Discov , vol.8 , pp. 115-129
    • Geldenhuys, W.J.1    Van der Schyf, C.J.2
  • 147
    • 3042798891 scopus 로고    scopus 로고
    • The neurobiology of antiepileptic drugs
    • Rogawski M.A., Löscher W. The neurobiology of antiepileptic drugs. Nat Rev Neurosci 2004, 5:553-564.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 553-564
    • Rogawski, M.A.1    Löscher, W.2
  • 148
    • 77950479087 scopus 로고    scopus 로고
    • The anticonvulsants market
    • Mackey C. The anticonvulsants market. Nat Rev Drug Discov 2010, 9:265-266.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 265-266
    • Mackey, C.1
  • 149
    • 0002100772 scopus 로고    scopus 로고
    • Levetiracetam mechanisms of action
    • Lippincott Williams & Wilkins, Philadelphia, R.H. Levy, R.H. Mattson, R.H. Mattson, B.S. Meldrum, E. Perucca (Eds.)
    • Margineanu D.G., Klitgaard H. Levetiracetam mechanisms of action. Antiepileptic drugs 2002, 419-427. Lippincott Williams & Wilkins, Philadelphia. 5th ed. R.H. Levy, R.H. Mattson, R.H. Mattson, B.S. Meldrum, E. Perucca (Eds.).
    • (2002) Antiepileptic drugs , pp. 419-427
    • Margineanu, D.G.1    Klitgaard, H.2
  • 151
  • 152
    • 77955114844 scopus 로고    scopus 로고
    • Is Pharma running out of brainy ideas?
    • Miller G. Is Pharma running out of brainy ideas?. Science 2010, 329:502-504.
    • (2010) Science , vol.329 , pp. 502-504
    • Miller, G.1
  • 153
    • 84872188829 scopus 로고    scopus 로고
    • Why are antiepileptic drugs used for nonepileptic conditions?
    • Bialer M. Why are antiepileptic drugs used for nonepileptic conditions?. Epilepsia 2012, 53(Suppl. 7):26-33.
    • (2012) Epilepsia , vol.53 , pp. 26-33
    • Bialer, M.1
  • 155
    • 79952267810 scopus 로고    scopus 로고
    • Traditional drug-discovery model ripe for reform
    • Cressey D. Traditional drug-discovery model ripe for reform. Nature 2011, 471:17-18.
    • (2011) Nature , vol.471 , pp. 17-18
    • Cressey, D.1
  • 156
    • 79956099883 scopus 로고    scopus 로고
    • Social engineering for virtual 'big science' in systems biology
    • Kitano H., Ghosh S., Matsuoka Y. Social engineering for virtual 'big science' in systems biology. Nat Chem Biol 2011, 7:323-326.
    • (2011) Nat Chem Biol , vol.7 , pp. 323-326
    • Kitano, H.1    Ghosh, S.2    Matsuoka, Y.3
  • 157
    • 79959929769 scopus 로고    scopus 로고
    • How were new medicines discovered?
    • Swinney D.C., Anthony J. How were new medicines discovered?. Nat Rev Drug Discov 2011, 10:507-519.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 507-519
    • Swinney, D.C.1    Anthony, J.2
  • 158
    • 84861490509 scopus 로고    scopus 로고
    • Modern phenotypic drug discovery is a viable, neoclassic pharma strategy
    • Lee J.A., Uhlik M.T., Moxham C.M., Tomandl D., Sall D.J. Modern phenotypic drug discovery is a viable, neoclassic pharma strategy. J Med Chem 2012, 55:4527-4538.
    • (2012) J Med Chem , vol.55 , pp. 4527-4538
    • Lee, J.A.1    Uhlik, M.T.2    Moxham, C.M.3    Tomandl, D.4    Sall, D.J.5
  • 159
    • 84876069345 scopus 로고    scopus 로고
    • Phenotypic screening, take two
    • Kotz J. Phenotypic screening, take two. SciBX 2012, 5(15). 10.1038/scibx.2012.380.
    • (2012) SciBX , vol.5 , Issue.15
    • Kotz, J.1
  • 160
    • 84863085673 scopus 로고    scopus 로고
    • Multi-target drugs: the trend of drug research and development
    • Lu J.-J., Pan W., Hu Y.-J., Wang Y.-T. Multi-target drugs: the trend of drug research and development. PLoS One 2012, 7(6):e40262. 10.1371/journal.pone.0040262.
    • (2012) PLoS One , vol.7 , Issue.6 , pp. e40262
    • Lu, J.-J.1    Pan, W.2    Hu, Y.-J.3    Wang, Y.-T.4
  • 161
    • 36949037520 scopus 로고    scopus 로고
    • Antiepileptic drugs in non-epilepsy disorders
    • Johannessen Landmark C. Antiepileptic drugs in non-epilepsy disorders. CNS Drugs 2008, 22:27-47.
    • (2008) CNS Drugs , vol.22 , pp. 27-47
    • Johannessen, L.C.1
  • 162
    • 3142774111 scopus 로고    scopus 로고
    • The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions
    • Rogawski M., Loscher W. The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. Nat Med 2004, 10:685-692.
    • (2004) Nat Med , vol.10 , pp. 685-692
    • Rogawski, M.1    Loscher, W.2
  • 163
    • 33750576990 scopus 로고    scopus 로고
    • The role of serendipity in drug discovery
    • Ban T.A. The role of serendipity in drug discovery. Dialogues Clin Neurosci 2006, 8:335-344.
    • (2006) Dialogues Clin Neurosci , vol.8 , pp. 335-344
    • Ban, T.A.1
  • 164
    • 77954637806 scopus 로고    scopus 로고
    • Toward standardized usage of the word serendipity in the historiography of psychopharmacology
    • Baumeister A.A., Hawkins M.F., López-Muñoz F. Toward standardized usage of the word serendipity in the historiography of psychopharmacology. J Hist Neurosci 2010, 19:253-270.
    • (2010) J Hist Neurosci , vol.19 , pp. 253-270
    • Baumeister, A.A.1    Hawkins, M.F.2    López-Muñoz, F.3
  • 165
    • 33745251005 scopus 로고    scopus 로고
    • New antiepileptic drugs that are second generation to existing antiepileptic drugs
    • Bialer M. New antiepileptic drugs that are second generation to existing antiepileptic drugs. Expert Opin Investig Drugs 2006, 15:637-647.
    • (2006) Expert Opin Investig Drugs , vol.15 , pp. 637-647
    • Bialer, M.1
  • 166
    • 67650215631 scopus 로고    scopus 로고
    • Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions
    • Łuszczki J.J. Third-generation antiepileptic drugs: mechanisms of action, pharmacokinetics and interactions. Pharmacol Rep 2009, 61:197-216.
    • (2009) Pharmacol Rep , vol.61 , pp. 197-216
    • Łuszczki, J.J.1
  • 167
    • 74049163222 scopus 로고    scopus 로고
    • Key factors in the discovery and development of new antiepileptic drugs
    • Bialer M., White H.S. Key factors in the discovery and development of new antiepileptic drugs. Nat Rev Drug Discov 2010, 9:68-82.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 68-82
    • Bialer, M.1    White, H.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.