Chemical biology and the limits of reductionism

Nature Chemical Biology

Volumn 4, Issue 11, 2008, Pages 635-638

  Peterson, Randall T ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ACTIVITY; BIOLOGY; HIGH THROUGHPUT SCREENING; MOLECULAR INTERACTION; NOTE; PRIORITY JOURNAL; PROTEIN TARGETING; REDUCTION;

EID: 54249085844     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio1108-635     Document Type: Note

References (20)

1. Bender, A. et al. Comb. Chem. High Throughput Screen. 10, 719-731 (2007).
2. Seiler, K.P. et al. Nucleic Acids Res. 36, D351-D359 (2008).
3. Rosania, G.R., Crippen, G., Woolf, P., States, D. & Shedden, K. Pharm. Res. 24, 1791-1802 (2007).
4. Guha, R. & Schurer, S.C. J. Comput. Aided Mol. Des. 22, 367-384 (2008).
5. Zhou, Y. et al. J. Chem. Inf. Model. 47, 1386-1394 (2007).
6. Hoon, S. et al. Nat. Chem. Biol. 4, 498-506 (2008).
7. Hillenmeyer, M.E. et al. Science 320, 362-365 (2008).
8. Eggert, U.S. et al. PLoS Biol. 2, e379 (2004).
9. Lamb, J. et al. Science 313, 1929-1935 (2006).
10. Esengil, H. & Chen, J.K. Mol. Biosyst. 4, 300-308 (2008).
11. Kwok, T.C. et al. Nature 441, 91-95 (2006).
12. Peterson, R.T. et al. Nat. Biotechnol. 22, 595-599 (2004).
13. Stern, H.M. et al. Nat. Chem. Biol. 1, 366-370 (2005).
14. North, T.E. et al. Nature 447, 1007-1011 (2007).
15. Yu, P.B. et al. Nat. Chem. Biol. 4, 33-41 (2008).
16. Owens, K.N. et al. PLoS Genet. 4, e1000020 (2008).
17. Feng, B.Y., Shelat, A., Doman, T.N., Guy, R.K. & Shoichet, B.K. Nat. Chem. Biol. 1, 146-148 (2005).
18. Fojo, T. Oncologist 13, 277-283 (2008).
19. Zhang, X., Crespo, A. & Fernandez, A. Trends Biotechnol. 26, 295-301 (2008).
20. Inglese, J., Shamu, C.E. & Guy, R.K. Nat. Chem. Biol. 3, 438-441 (2007).