Epileptic hypersynchrony revisited

NeuroReport

Volumn 21, Issue 15, 2010, Pages 963-967

  Margineanu, Doru Georg ^a  

^a UNIVERSITY OF MONS   (Belgium)

Author keywords

brain wiring; Ca2+ induced Ca2+ release; cation chloride co transport; epileptic hypersynchrony; extracellular space; gap junctions; glutamate gliotransmission; neuronal hyperexcitability; neuronal synchronization

Indexed keywords

ANTICONVULSIVE AGENT;

BRAIN FUNCTION; EPILEPTIC DISCHARGE; HUMAN; NERVE CELL EXCITABILITY; NERVE CELL NETWORK; NEUROTRANSMISSION; PRIORITY JOURNAL; REVIEW; SYNAPSE;

ANIMALS; ANTICONVULSANTS; BRAIN; CORTICAL SYNCHRONIZATION; EPILEPSY; HUMANS; NEURAL PATHWAYS;

EID: 77957552437     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e32833ed111     Document Type: Review

References (31)

1. Fisher RS, van Emde Boas W, Blume W, Elger C, Genton P, Lee P, Engel J Jr. Epileptic seizures and epilepsy: definitions proposed by the ILAE and the IBE. Epilepsia 2005;46:470-472.
2. Schmidt D, Löscher W. Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia 2005;46:858-877. (Pubitemid 40847354)
3. White HS, Smith MD, Wilcox KS. Mechanisms of action of antiepileptic drugs. Int Rev Neurobiol 2007;81:85-110.
4. Jermakowicz WJ, Casagrande VA. Neural networks a century after Cajal. Brain Res Rev 2007;55:264-284.
5. Varela F, Lachaux J-P, Rodriguez E, Martinerie J. The brainweb: phase synchronization and large-scale integration. Nature Rev Neurosci 2001;2:229-239.
6. Axmacher N, Mormann F, Fernández G, Elger CE, Fell J. Memory formation by neuronal synchronization. Brain Res Rev 2006;52:170-182.
7. Uhlhaas PJ, Singer W. Abnormal neural oscillations and synchrony in schizophrenia. Nature Rev Neurosci 2010;11:100-113.
8. Welsh JP, Ahn ES, Placantonakis DG. Is autism due to brain desynchronization? Int J Dev Neurosci 2005;23:253-263.
9. Kramer MA, Chang FL, Cohen ME, Hudson D, Szeri AJ. Synchronization measures of the scalp electroencephalogram can discriminate healthy from Alzheimer's subjects. Int J Neural Syst 2007;17:61-69.
10. Gale JT, Amirnovin R, Williams ZM, Flaherty AW, Eskandar EN. From symphony to cacophony: pathophysiology of the human basal ganglia in Parkinson disease. Neurosci Biobehav Rev 2008;32:378-387.
11. Van Drongelen W, Koch H, Marcuccilli C, Pena F, Ramirez J-M. Synchrony levels during evoked seizure-like bursts in mouse neocortical slices. J Neurophysiol 2003;90:1571-1580.
12. Li Y, Nicolaescu-Fleming I, Colpan ME, Mogul DJ. Neuronal desynchronization as a trigger for seizure generation. IEEE Trans Neural Syst Rehabil Eng 2008;16:62-73.
13. Jiruska P, Csicsvari J, Powell AD, Fox JE, Chang W-C, Vreugdenhil M, et al. High-frequency network activity, global increase in neuronal activity, and synchrony expansion precede epileptic seizures in vitro. J Neurosci 2010;30:5690-5701.
14. Margineanu DG, Klitgaard H. Differential effects of cation-chloride cotransport-blocking diuretics in a rat hippocampal slice model of epilepsy. Epilepsy Res 2006;69:93-99.
15. Avoli M, D'Antuono M, Louvel J, Köhling R, Biagini G, Pumain R, et al. Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. Progr Neurobiol 2002;68:167-207.
16. Volterra A, Meldolesi J. Astrocytes, from brain glue to communication elements: the revolution continues. Nature Rev Neurosci 2005;6:626-640.
17. Fellin T, Pascual O, Gobbo S, Pozzan T, Haydon PG, Carmignoto G. Neuronal synchrony mediated by astrocytic glutamate through activation of extrasynaptic NMDA receptors. Neuron 2004;43:729-743.
18. Bennett MVL, Zukin RS. Electrical coupling and neuronal synchronization in the mammalian brain. Neuron 2004;41:495-511.
19. Gigout S, Louvel J, Kawasaki H, D'Antuono M, Armand V, Kurcewicz I, et al. Effects of gap junction blockers on human neocortical synchronization. Neurobiol Dis 2006;22:496-508.
20. Margineanu DG, Klitgaard H. Can gap-junction blockade preferentially inhibit neuronal hypersynchrony vs. excitability? Neuropharmacol 2001;41:377-383.
21. Hochman DW, Baraban SC, Owens JWM, Schwartzkroin PA. Dissociation of synchronization and excitability in furosemide blockade of epileptiform activity. Science 1995;270:99-102.
22. Jefferys JGR. Nonsynaptic modulation of neuronal activity in the brain: electric currents and extracellular ions. Physiol Rev 1995;75:689-723.
23. Dudek FE, Patrylo PR, Wuarin J-P. Mechanisms of neuronal synchronization during epileptiform activity. Adv Neurol 1999;79:699-708.
24. Avoli M, Louvel J, Pumain R, Köhling R. Cellular and molecular mechanisms of epilepsy in the human brain. Prog Neurobiol 2005;77:166-200.
25. Niespodziany I, Klitgaard H, Margineanu DG. Desynchronizing effect of levetiracetam on epileptiform responses in rat hippocampal slices. NeuroReport 2003;14:1273-1276.
26. Gao W-J, Goldman-Rakic PS. NMDA receptor-mediated epileptiform persistent activity requires calcium release from intracellular stores in prefrontal neurons. Exp Neurol 2006;197:495-504.
27. Margineanu DG, Klitgaard H. Caffeine-induced epileptiform field potentials in rat hippocampal slices: a pharmacological characterization. Neuropharmacol 2004;47:926-934.
28. 2+ transients and epileptiform potentials in hippocampal neurons. NeuroReport 2003;14:471-475.
29. Nagarkatti N, Deshpande LS, DeLorenzo RJ. Levetiracetam inhibits both ryanodine and IP3 receptor activated calcium induced calcium release in hippocampal neurons in culture. Neurosci Lett 2008;436:289-293.
30. Payne JA, Rivera C, Voipio J, Kaila K. Cation-chloride co-transporters in neuronal communication, development and trauma. Trends Neurosci 2003;26:199-206.
31. Stacey WC, Litt B. Technology insight: neuroengineering and epilepsy - designing devices for seizure control. Nature Clin Pract Neurol 2008;4:190-201.