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Volumn 21, Issue 4, 2011, Pages 342-343

Antiepileptic drug discovery: Does mechanism of action matter?

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; PLACEBO; PROGABIDE; TIAGABINE; VIGABATRIN;

EID: 79961212342     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2011.03.037     Document Type: Note
Times cited : (16)

References (12)
  • 1
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    • Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?
    • Löscher W., Schmidt D. Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?. Epilepsy Res 1994, 17:95-134.
    • (1994) Epilepsy Res , vol.17 , pp. 95-134
    • Löscher, W.1    Schmidt, D.2
  • 2
    • 0034677733 scopus 로고    scopus 로고
    • The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits
    • Rundfeldt C., Netzer R. The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits. Neurosci Lett 2000, 282:73-76.
    • (2000) Neurosci Lett , vol.282 , pp. 73-76
    • Rundfeldt, C.1    Netzer, R.2
  • 3
    • 15744400656 scopus 로고    scopus 로고
    • The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate
    • Wuttke T.V., Seebohm G., Bail S., Maljevic S., Lerche H. The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol Pharmacol 2005, 67:1009-1017.
    • (2005) Mol Pharmacol , vol.67 , pp. 1009-1017
    • Wuttke, T.V.1    Seebohm, G.2    Bail, S.3    Maljevic, S.4    Lerche, H.5
  • 4
    • 37349071555 scopus 로고    scopus 로고
    • The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels
    • Errington A.C., Stöhr T., Heers C., Lees G. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Mol Pharmacol 2008, 73:157-169.
    • (2008) Mol Pharmacol , vol.73 , pp. 157-169
    • Errington, A.C.1    Stöhr, T.2    Heers, C.3    Lees, G.4
  • 5
    • 78951483902 scopus 로고    scopus 로고
    • Pharmacotherapy of epilepsy: newly approved and developmental agents
    • Stephen L.J., Brodie M.J. Pharmacotherapy of epilepsy: newly approved and developmental agents. CNS Drugs 2011, 25:89-107.
    • (2011) CNS Drugs , vol.25 , pp. 89-107
    • Stephen, L.J.1    Brodie, M.J.2
  • 6
    • 80051470588 scopus 로고    scopus 로고
    • Antiepileptic drug therapy: does mechanism of action matter?
    • Epilepsy Behav in press.
    • Brodie MJ, Covanis A, Gil-Nagel A, et al. Antiepileptic drug therapy: does mechanism of action matter? Epilepsy Behav in press.
    • Brodie, M.J.1    Covanis, A.2    Gil-Nagel, A.3
  • 7
    • 76249085581 scopus 로고    scopus 로고
    • Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: systematic review and meta-analysis
    • Beyenburg S., Stavem K., Schmidt D. Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: systematic review and meta-analysis. Epilepsia 2010, 51:7-26.
    • (2010) Epilepsia , vol.51 , pp. 7-26
    • Beyenburg, S.1    Stavem, K.2    Schmidt, D.3
  • 8
    • 79953705357 scopus 로고    scopus 로고
    • Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma
    • Löscher W., Schmidt D. Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 2011, 52:657-678.
    • (2011) Epilepsia , vol.52 , pp. 657-678
    • Löscher, W.1    Schmidt, D.2
  • 9
    • 40849139088 scopus 로고    scopus 로고
    • Modern management of epilepsy: a practical approach
    • Elger C.E., Schmidt D. Modern management of epilepsy: a practical approach. Epilepsy Behav 2008, 12:501-539.
    • (2008) Epilepsy Behav , vol.12 , pp. 501-539
    • Elger, C.E.1    Schmidt, D.2
  • 10
    • 3142774111 scopus 로고    scopus 로고
    • The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions
    • Rogawski M.A., Löscher W. The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. Nat Med 2004, 10:685-692.
    • (2004) Nat Med , vol.10 , pp. 685-692
    • Rogawski, M.A.1    Löscher, W.2
  • 11
    • 66849131768 scopus 로고    scopus 로고
    • New developments in antiepileptic drug resistance: an integrative view
    • Schmidt D., Löscher W. New developments in antiepileptic drug resistance: an integrative view. Epilepsy Curr 2009, 9:47-52.
    • (2009) Epilepsy Curr , vol.9 , pp. 47-52
    • Schmidt, D.1    Löscher, W.2
  • 12
    • 58849130137 scopus 로고    scopus 로고
    • Preventing and treating posttraumatic seizures: the human experience
    • Temkin N.R. Preventing and treating posttraumatic seizures: the human experience. Epilepsia 2009, 50(Suppl. 2):10-13.
    • (2009) Epilepsia , vol.50 , Issue.SUPPL. 2 , pp. 10-13
    • Temkin, N.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.