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Strategies in antiepileptic drug development: is rational drug design superior to random screening and structural variation?
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Löscher, W.1
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The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits
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Rundfeldt C., Netzer R. The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits. Neurosci Lett 2000, 282:73-76.
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The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate
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Wuttke T.V., Seebohm G., Bail S., Maljevic S., Lerche H. The new anticonvulsant retigabine favors voltage-dependent opening of the Kv7.2 (KCNQ2) channel by binding to its activation gate. Mol Pharmacol 2005, 67:1009-1017.
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The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels
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Errington A.C., Stöhr T., Heers C., Lees G. The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels. Mol Pharmacol 2008, 73:157-169.
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Pharmacotherapy of epilepsy: newly approved and developmental agents
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Stephen L.J., Brodie M.J. Pharmacotherapy of epilepsy: newly approved and developmental agents. CNS Drugs 2011, 25:89-107.
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Antiepileptic drug therapy: does mechanism of action matter?
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Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: systematic review and meta-analysis
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Beyenburg S., Stavem K., Schmidt D. Placebo-corrected efficacy of modern antiepileptic drugs for refractory epilepsy: systematic review and meta-analysis. Epilepsia 2010, 51:7-26.
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Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma
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Löscher W., Schmidt D. Modern antiepileptic drug development has failed to deliver: ways out of the current dilemma. Epilepsia 2011, 52:657-678.
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Modern management of epilepsy: a practical approach
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Elger C.E., Schmidt D. Modern management of epilepsy: a practical approach. Epilepsy Behav 2008, 12:501-539.
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Elger, C.E.1
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The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions
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Rogawski M.A., Löscher W. The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. Nat Med 2004, 10:685-692.
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Rogawski, M.A.1
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New developments in antiepileptic drug resistance: an integrative view
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Schmidt D., Löscher W. New developments in antiepileptic drug resistance: an integrative view. Epilepsy Curr 2009, 9:47-52.
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Preventing and treating posttraumatic seizures: the human experience
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Temkin N.R. Preventing and treating posttraumatic seizures: the human experience. Epilepsia 2009, 50(Suppl. 2):10-13.
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