A human systems biology approach to discover new drug targets in epilepsy

Epilepsia

Volumn 51, Issue SUPPL. 3, 2010, Pages 171-177

  Loeb, Jeffery A ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Computational biology; Epileptogenesis; Genomics; Systems biology; Therapeutics; Tissue banking

Indexed keywords

ANTICONVULSIVE AGENT; BIOLOGICAL MARKER; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DNA; RNA;

BRAIN CORTEX; BRAIN ELECTROPHYSIOLOGY; CLINICAL FEATURE; CONFERENCE PAPER; DISEASE ACTIVITY; DNA FINGERPRINTING; DRUG TARGETING; ELECTRICAL SYNAPSE; EPILEPSY; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; IN VIVO STUDY; NEUROSURGERY; PRIORITY JOURNAL;

ANTICONVULSANTS; BIOLOGICAL MARKERS; BRAIN; ELECTROPHYSIOLOGY; EPILEPSY; HUMANS; SYSTEMS BIOLOGY;

EID: 77954488198     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2010.02635.x     Document Type: Conference Paper

References (42)

1. Annegers JF. (1993) The Epidemiology of epilepsy. In Wyllie E (Ed.) The treatment of epilepsy: principles and practices. Lea & Febiger, Philadelphia, pp. 157-164.
2. Arion D, Sabatini M, Unger T, Pastor J, Alonso-Nanclares L, Ballesteros-Yanez I, Garcia Sola R, Munoz A, Mirnics K, DeFelipe J. (2006) Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy. Neurobiol Dis 22:374-387.
3. Asano E, Chugani DC, Muzik O, Shen C, Juhasz C, Janisse J, Ager J, Canady A, Shah JR, Shah AK, Watson C, Chugani HT. (2000) Multimodality imaging for improved detection of epileptogenic foci in tuberous sclerosis complex. Neurology 54:1976-1984.
4. Asano E, Muzik O, Shah A, Juhasz C, Chugani DC, Sood S, Janisse J, Ergun EL, Ahn-Ewing J, Shen C, Gotman J, Chugani HT. (2003) Quantitative interictal subdural EEG analyses in children with neocortical epilepsy. Epilepsia 44:425-434.
5. Asano E, Juhasz C, Shah A, Sood S, Chugani HT. (2009) Role of subdural electrocorticography in prediction of long-term seizure outcome in epilepsy surgery. Brain 132:1038-1047.
6. Babb TL, Pretorius JK. (1993) Pathologic substrates of epilepsy. In Wyllie E (Ed.) The treatment of epilepsy: principles and practices. Lea &Febiger, Philadelphia, pp. 55-70.
7. Barkmeier DT, Loeb JA. (2009) An animal model to study the clinical significance of interictal spiking. Clin EEG Neurosci 40:234-238.
8. Bautista RE, Cobbs MA, Spencer DD, Spencer SS. (1999) Prediction of surgical outcome by interictal epileptiform abnormalities during intracranial EEG monitoring in patients with extrahippocampal seizures. Epilepsia 40:880-890.
9. Baybis M, Lynch D, Lee A, Patel A, McKhann G 2nd, Chugani D,WJK, Aronica E, Crino PB. (2004) Altered expression of neurotransmitter-receptor subunit and uptake site mRNAs in hemimegalencephaly. Epilepsia 45:1517-1524.
10. Becker AJ, Chen J, Zien A, Sochivko D, Normann S, Schramm J, Elger CE, Wiestler OD, Blumcke I. (2003) Correlated stage- and subfield-associated hippocampal gene expression patterns in experimental and human temporal lobe epilepsy. Eur J Neurosci 18:2792-2802.
11. Berkovic SF, Steinlein OK. (1999) Genetics of partial epilepsies. Adv Neurol 79:375-381.
12. Chen J, Sochivko D, Beck H, Marechal D, Wiestler OD, Becker AJ. (2001) Activity-induced expression of common reference genes in individual CNS neurons. Lab Invest 81:913-916. (Pubitemid 32553412)
13. Chugani DC, Chugani HT, Muzik O, Shah JR, Shah AK, Canady A, Mangner TJ, Chakraborty PK. (1998) Imaging epileptogenic tubers in children with tuberous sclerosis complex using alpha-[11C] methyl-L-tryptophan positron emission tomography. Ann Neurol 44:858-866. (Pubitemid 28558246)
14. Colantuoni C, Jeon OH, Hyder K, Chenchik A, Khimani AH, Narayanan V, Hoffman EP, Kaufmann WE, Naidu S, Pevsner J. (2001) Gene expression profiling in postmortem Rett Syndrome brain: differential gene expression and patient classification. Neurobiol Dis 8:847-865.
15. Coulter DA. (2001) Epilepsy-associated plasticity in gamma-aminobutyric acid receptor expression, function, and inhibitory synaptic properties. Int Rev Neurobiol 45:237-252.
16. Crino PB. (2007) Gene expression, genetics, and genomics in epilepsy: some answers, more questions. Epilepsia 48(Suppl 2):42-50.
17. Doherty J, Dingledine R. (2002) The roles of metabotropic glutamate receptors in seizures and epilepsy. Curr Drug Targets CNS Neurol Disord 1:251-260.
18. Dzhala VI, Staley KJ. (2003) Transition from interictal to ictal activity in limbic networks in vitro. J Neurosci 23:7873-7880.
19. French PJ, O'Connor V, Voss K, Stean T, Hunt SP, Bliss TV. (2001) Seizure-induced gene expression in area CA1 of the mouse hippocampus. Eur J Neurosci 14:2037-2041.
20. Gotman J. (1991) Relationships between interictal spiking and seizures: human and experimental evidence. Can J Neurol Sci 18:573-576.
21. Hua J, He Y, Qin H. (2004) Multiresolution Heterogeneous Solid Modeling and Visualization Using Trivariate Simplex Splines, 9th ACM Symposium on Solid Modeling and Applications.
22. Kanazawa O, Blume WT, Girvin JP. (1996) Significance of spikes at temporal lobe electrocorticography. Epilepsia 37:50-55.
23. Katz LC, Shatz CJ. (1996) Synaptic activity and the construction of cortical circuits. Science 274:1133-1138.
24. Khatri P, Voichita C, Kattan K, Ansari N, Khatri A, Georgescu C, Tarca AL, Draghici S. (2007) Onto-Tools: new additions and improvements in 2006. Nucleic Acids Res 35:W206-W211.
25. Loeb JA, Beaumont TL. (2009) What goes in is what comes out: how to design and implement a successful microarray experiment. In Krawetz S (Ed.) Bioinformatics for systems biology. Springer, New York, pp. 209-226.
26. McAllister AK, Katz LC, Lo DC. (1999) Neurotrophins and synaptic plasticity. Annu Rev Neurosci 22:295-318.
27. McBride MC, Binnie CD, Janota I, Polkey CE. (1991) Predictive value of intraoperative electrocorticograms in resective epilepsy surgery. Ann Neurol 30:526-532.
28. Mody I. (1998) Ion channels in epilepsy. Int Rev Neurobiol 42:199-226.
29. Najm I, Ying Z, Babb T, Crino PB, Macdonald R, Mathern GW, Spreafico R. (2004) Mechanisms of epileptogenicity in cortical dysplasias. Neurology 62:S9-S13.
30. Noebels JL. (2003) The biology of epilepsy genes. Annu Rev Neurosci 26:599-625.
31. Overweg J, Binnie CD, Oosting J, Rowan AJ. (1987) Clinical and EEG prediction of seizure recurrence following antiepileptic drug withdrawal. Epilepsy Res 1:272-283.
32. Parker A, McCaffery I, Patterson S. (2009) Examining molecular biology in humans. BioTechniques 46:358-360.
33. Rakhade SN, Yao B, Ahmed S, Asano E, Beaumont TL, Shah AK, Draghici S, Krauss R, Chugani HT, Sood S, Loeb JA. (2005) A common pattern of persistent gene activation in human neocortical epileptic foci. Ann Neurol 58:736-747.
34. Rakhade SN, Shah AK, Agarwal R, Yao B, Asano E, Loeb JA. (2007) Activity-dependent gene expression correlates with interictal spiking in human neocortical epilepsy. Epilepsia 48(Suppl 5):86-95.
35. Rakhade SN, Loeb JA. (2008) Focal reduction of neuronal glutamate transporters in human neocortical epilepsy. Epilepsia 49:226-236.
36. Reid CA, Berkovic SF, Petrou S. (2009) Mechanisms of human inherited epilepsies. Prog Neurobiol 87:41-57.
37. Schwartzkroin PA. (1993) Epilepsy: models, mechanisms, and concepts. Cambridge University Press, Cambridge, New York.
38. Staley K, Hellier JL, Dudek FE. (2005) Do interictal spikes drive epileptogenesis? Neuroscientist 11:272-276.
39. Steinlein OK. (2004) Genetic mechanisms that underlie epilepsy. Nat Rev Neurosci 5:400-408. (Pubitemid 38568500)
40. Tao JX, Ray A, Hawes-Ebersole S, Ebersole JS. (2005) Intracranial EEG substrates of scalp EEG interictal spikes. Epilepsia 46:669-676.
41. Wolfinger RD, Gibson G, Wolfinger ED, Bennett L, Hamadeh H, Bushel P, Afshari C, Paules RS. (2001) Assessing gene significance from cDNA microarray expression data via mixed models. J Comput Biol 8:625-637.
42. Yao B, Rakhade SN, Li Q, Ahmed S, Krauss R, Draghici S, Loeb JA. (2004) Accuracy of cDNA microarray methods to detect small gene expression changes induced by neuregulin on breast epithelial cells. BMC Bioinformatics 5:99.