Upregulation of a T-Type Ca2+ Channel Causes a Long-Lasting Modification of Neuronal Firing Mode after Status Epilepticus

Journal of Neuroscience

Volumn 22, Issue 9, 2002, Pages 3645-3655

  Su, Hailing ^a   Sochivko, Dmitry ^b   Becker, Albert ^b   Chen, Jian ^b   Jiang, Yanwen ^a   Yaari, Yoel ^a   Beck, Heinz ^b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

CA1; Hippocampus; Intrinsic burst discharge; Plasticity; Status epilepticus; T type Ca2+ channel

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL T TYPE; CALCIUM ION; NICKEL; PILOCARPINE; CALCIUM CHANNEL BLOCKING AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DEPOLARIZATION; EPILEPTIC STATE; IC 50; MALE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; UPREGULATION; ACTION POTENTIAL; ANIMAL; CELL MEMBRANE POTENTIAL; CELL SEPARATION; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECT; ELECTROSTIMULATION; HIPPOCAMPUS; IN VITRO STUDY; METABOLISM; NERVE CELL; NERVE CELL PLASTICITY; PATCH CLAMP; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT STRAIN; SYNAPTIC TRANSMISSION; WISTAR RAT;

ACTION POTENTIALS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CELL SEPARATION; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; HIPPOCAMPUS; MALE; MEMBRANE POTENTIALS; NEURONAL PLASTICITY; NEURONS; NICKEL; PATCH-CLAMP TECHNIQUES; PILOCARPINE; RATS; RATS, INBRED STRAINS; RATS, WISTAR; STATUS EPILEPTICUS; SYNAPTIC TRANSMISSION; UP-REGULATION;

EID: 0036583181     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-09-03645.2002     Document Type: Article

References (51)

1. Avery RB, Johnston D (1996) Multiple channel types contribute to the low-voltage-activated calcium current in hippocampal CA3 pyramidal neurons. J Neurosci 16:5567-5582.
2. Azouz R, Jensen MS, Yaari Y (1996) Ionic basis of spike after-depolarization and burst generation in adult rat hippocampal CA1 pyramidal cells. J Physiol (Lond) 492:211-223.
3. Azouz R, Alroy G, Yaari Y (1997) Modulation of endogenous firing patterns by osmolarity in rat hippocampal neurones. J Physiol (Lond) 502:175-187.
4. 2+ currents in hippocampal granule cells of patients with chronic temporal lobe epilepsy. J Neurophysiol 82:946-954.
5. Ben Ari Y (2001) Cell death and synaptic reorganizations produced by seizures. Epilepsia 42[Suppl 3]:5-7.
6. Brooks-Kayal AR, Shumate MD, Jin H, Rikhter TY, Coulter DA (1998) Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat Med 4:1166-1172.
7. Chagnac-Amitai Y, Connors BW (1989) Synchronized excitation and inhibition driven by intrinsically bursting neurons in neocortex. J Neurophysiol 62:1149-1162.
8. 2+ blockade of synaptically activated N-methyl-Daspartate receptor-channels in CA1 pyramidal neurons in kainic acid-lesioned rat hippocampus. Neuroscience 88:727-739.
9. 2+ influx. J Neurophysiol 73:2553-2557.
10. Cossart R, Dinocourt C, Hirsch JC, Merchan-Perez A, De Felipe J, Ben Ari Y, Esclapez M, Bernard C (2001) Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy. Nat Neurosci 4:52-62.
11. Coulter DA, DeLorenzo RJ (1999) Basic mechanisms of status epilepticus. Adv Neurol 79:725-733.
12. 2+ channel gene family. Circ Res 83:103-109.
13. Desai NS, Rutherford LC, Turrigiano GG (1999) Plasticity in the intrinsic excitability of cortical pyramidal neurons. Nat Neurosci 2:515-520.
14. Fisher RE, Gray R, Johnston D (1990) Properties and distribution of single voltage-gated calcium channels in adult hippocampal neurons. J Neurophysiol 64:91-104.
15. A receptor function in dentate granule and CA1 neurons. J Neurophysiol 77:1924-1938.
16. Huguenard JR (1996) Low-threshold calcium currents in central nervous system neurons. Annu Rev Physiol 58:329-348.
17. Jensen MS, Yaari Y (1997) Role of intrinsic burst firing, potassium accumulation, and electrical coupling in the elevated potassium model of hippocampal epilepsy. J Neurophysiol 77:1224-1233.
18. Jensen MS, Azouz R, Yaari Y (1994) Variant firing patterns in rat hippocampal pyramidal cells modulated by extracellular potassium. J Neurophysiol 71:831-839.
19. Jensen MS, Azouz R, Yaari Y (1996) Spike after-depolarization and burst generation in adult rat hippocampal CA1 pyramidal cells. J Physiol (Lond) 492:199-210.
20. 2+ channels. Neuron 31:35-45.
21. 2+ entry and frequency-dependence during mock action potentials. Eur J Neurosci 11:4149-4158.
22. Lee JH, Daud AN, Cribbs LL, Lacerda AE, Pereverzev A, Klockner U, Schneider T, Perez-Reyes E (1999a) Cloning and expression of a novel member of the low voltage-activated T-type calcium channel family. J Neurosci 19:1912-1921.
23. 1H. Biophys J 77:3034-3042.
24. Lothman EW, Rempe DA, Mangan PS (1995) Changes in excitatory neurotransmission in the CA1 region and dentate gyrus in a chronic model of temporal lobe epilepsy. J Neurophysiol 74:841-848.
25. Magee JC, Carruth M (1999) Dendritic voltage-gated ion channels regulate the action potential firing mode of hippocampal CA1 pyramidal neurons. J Neurophysiol 82:1895-1901.
26. Mangan PS, Rempe DA, Lothman EW (1995) Changes in inhibitory neurotransmission in the CA1 region and dentate gyrus in a chronic model of temporal lobe epilepsy. J Neurophysiol 74:829-840.
27. McNamara JO (1999) Emerging insights into the genesis of epilepsy. Nature 399:A15-A22.
28. Miles R, Wong RK (1983) Single neurones can initiate synchronized population discharge in the hippocampus. Nature 306:371-373.
29. 2+ currents. Neuropharmacology 37:957-972.
30. Perez-Reyes E, Cribbs LL, Daud A, Lacerda AE, Barclay J, Williamson MP, Fox M, Rees M, Lee JH (1998) Molecular characterization of a neuronal low-voltage-activated T-type calcium channel. Nature 391:896-900.
31. 2+ channels and neurotransmitter release at the terminal of a mouse cortical neuron. J Neurosci 21:3721-3728.
32. Randall AD, Tsien RW (1997) Contrasting biophysical and pharmacological properties of T-type and R- type calcium channels. Neuropharmacology 36:879-893.
33. 2+-dependent intrinsic bursting in the rat pilocarpine model of temporal lobe epilepsy. J Physiol (Lond) 205-216.
34. 2+ channel alpha 1 subunit. Receptors Channels 2:255-270.
35. Sloviter RS (1999) Status epilepticus-induced neuronal injury and network reorganization. Epilepsia 40[Suppl 1]:S34-S39.
36. Soong TW, Stea A, Hodson CD, Dubel SJ, Vincent SR, Snutch TP (1993) Structure and functional expression of a member of the low voltage-activated calcium channel family. Science 260:1133-1136.
37. Stemmler M, Koch C (1999) How voltage-dependent conductances can adapt to maximize the information encoded by neuronal firing rate. Nat Neurosci 2:521-527.
38. Su H, Alroy G, Kirson ED, Yaari Y (2001) Extracellular calcium modulates persistent sodium current-dependent intrinsic bursting in rat hippocampal neurons. J Neurosci 21:4173-4182.
39. Sutula T, Cascino G, Cavazos J, Parada I, Ramirez L (1989) Mossy fiber synaptic reorganization in the epileptic human temporal lobe. Ann Neurol 26:321-330.
40. Takahashi K, Wakamori M, Akaike N (1989) Hippocampal CA1 pyramidal cells of rats have four voltage-dependent calcium conductances. Neurosci Lett 104:229-234.
41. Talley EM, Cribbs LL, Lee JH, Daud A, Perez-Reyes E, Bayliss DA (1999) Differential distribution of three members of a gene family encoding low voltage-activated (T-type) calcium channels. J Neurosci 19:1895-1911.
42. Thompson SM, Schwindt W (1991) Development of calcium current subtypes in isolated rat hippocampal pyramidal cells. J Physiol (Lond) 439:671-689.
43. Traub RD, Wong RK (1982) Cellular mechanism of neuronal synchronization in epilepsy. Science 216:745-747.
44. Turner DA, Wheal HV (1991) Excitatory synaptic potentials in kainic acid-denervated rat CA1 pyramidal neurons. J Neurosci 11:2786-2794.
45. Turrigiano G, Abbott LF, Marder E (1994) Activity-dependent changes in the intrinsic properties of cultured neurons. Science 264:974-977.
46. Turrigiano GG (1999) Homeostatic plasticity in neuronal networks: the more things change, the more they stay the same. Trends Neurosci 22:221-227.
47. Turski WA, Cavalheiro EA, Schwarz M, Czuczwar SJ, Kleinrok Z, Turski L (1983) Limbic seizures produced by pilocarpine in rats: behavioural, electroencephalographic and neuropathological study. Behav Brain Res 9:315-335.
48. Williams ME, Marubio LM, Deal CR, Hans M, Brust PF, Philipson LH, Miller RJ, Johnson EC, Harpold MM, Ellis SB (1994) Structure and functional characterization of neuronal alpha 1E calcium channel sub-types. J Biol Chem 269:22347-22357.
49. Wong RK, Prince DA (1981) Afterpotential generation in hippocampal pyramidal cells. J Neurophysiol 45:86-97.
50. Wu G-L, Saggau P (1994) Pharmacological identification of two types of presynaptic voltage-dependent calcium channels at CA3-CA1 synapses of the hippocampus. J Neurosci 14:5613-5622.
51. Yaari Y, Hamon B, Lux HD (1987) Development of two types of calcium channels in cultured mammalian hippocampal neurons. Science 235:680-682.