In search of models of pharmacoresistant epilepsy

Epilepsia

Volumn 51, Issue SUPPL. 3, 2010, Pages 154-159

  Wahab, Abdul ^a   Albus, Klaus ^a   Gabriel, Siegrun ^a   Heinemann, Uwe ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Anticonvulsant drugs; Drug transporters; Hippocampus; In vitro seizure models; In vivo seizure models; Organotypic hippocampal slice cultures

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOPYRIDINE; ANTICONVULSIVE AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; BICUCULLINE; CARBAMAZEPINE; MAGNESIUM; MIDAZOLAM; PHENOBARBITAL; PHENYTOIN;

CEREBROSPINAL FLUID; CONFERENCE PAPER; ENTORHINAL CORTEX; EPILEPSY; EPILEPTIC DISCHARGE; HIPPOCAMPUS; HOMEOSTASIS; HUMAN; IN VITRO STUDY; MEDICAL RESEARCH; NONHUMAN; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; RECURRENT DISEASE; TEMPORAL LOBE EPILEPSY;

ANIMALS; ANTICONVULSANTS; DISEASE MODELS, ANIMAL; DRUG RESISTANCE; EPILEPSY; HIPPOCAMPUS; HUMANS; RECEPTORS, GABA; STATUS EPILEPTICUS;

EID: 77954476039     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2010.02632.x     Document Type: Conference Paper

References (21)

1. Albus K, Wahab A, Heinemann U. (2008) Standard antiepileptic drugs fail to block epileptiform activity in rat organotypic hippocampal slice cultures. Br J Pharmacol 154:709-724.
2. Brandt C, Volk HA, Lçscher W. (2004) Striking differences in individual anticonvulsant response to phenobarbital in rats with spontaneous seizures after status epilepticus. Epilepsia 45:1488-1497.
3. Brückner C, Heinemann U. (2000) Effects of standard anticonvulsant drugs on different patterns of epileptiform discharges induced by 4-aminopyridine in combined entorhinal cortex-hippocampal slices. Brain Res 859:15-20. (Pubitemid 30138188)
4. Dreier JP, Zhang CL, Heinemann U. (1998) Phenytoin, phenobarbital, and midazolam fail to stop status epilepticus-like activity induced by low magnesium in rat entorhinal slices, but can prevent its development. Acta Neurol Scand 98:154-160.
5. Eid T, Williamson A, Lee TS, Petroff OA, de Lanerolle NC. (2008) Glutamate and astrocytes-key players in human mesial temporal lobe epilepsy? Epilepsia 49:42-52.
6. Franck JE, Pokorny J, Kunkel DD, Schwartzkroin PA. (1995) Physiologic and morphologic characteristics of granule cell circuitry in human epileptic hippocampus. Epilepsia 36:543-558.
7. Fueta Y, Avoli M. (1992) Effects of antiepileptic drugs on 4-aminopyridine-induced epileptiform activity in young and adult rat hippocampus. Epilepsy Res 12:207-215.
8. Gabriel S, Njunting M, Pomper JK, Merschhemke M, Sanabria ER, Eilers A, Kivi A, Zeller M, Meencke HJ, Cavalheiro EA, Heinemann U, Lehmann TN. (2004) Stimulus and potassium-induced epileptiform activity in the human dentate gyrus from patients with and without hippocampal sclerosis. J Neurosci 24:10416-10430.
9. Gutierrez R, Heinemann U. (1999) Synaptic reorganization in explanted cultures of rat hippocampus. Brain Res 815:304-316. (Pubitemid 29225277)
10. 2 + in cultured rat hippocampal slices. Brain Res 815:294-303.
11. Heinemann U, Draguhn A, Ficker E, Stabel J, Zhang CL. (1994) Strategies for the development of drugs for pharmacoresistant epilepsies. Epilepsia 35:S10-S21.
12. Holtkamp M, Othman J, Buchheim K, Masuhr F, Schielke E, Meierkord H. (2005) A "malignant" variant of status epilepticus. Arch Neurol 62:1428-1431.
13. Jandová K, Päsler D, Antonio LL, Raue C, Ji S, Njunting M, Kann O, Kovács R, Meencke HJ, Cavalheiro EA, Heinemann U, Gabriel S, Lehmann TN. (2006) Carbamazepine-resistance in the epileptic dentate gyrus of human hippocampal slices. Brain 129:3290-3306.
14. Kann O, Kovács R. (2007) Mitochondria and neuronal activity. Am J Physiol Cell Physiol 292:C641-C657.
15. Löscher W, Potschka H. (2005) Drug resistance in brain diseases and the role of drug efflux transporters. Nat Rev Neurosci 6:591-602. (Pubitemid 41059334)
16. Mello LE, Cavalheiro EA, Tan AM, Kupfer WR, Pretorius JK, Babb TL, Finch DM. (1993) Circuit mechanisms of seizures in the pilocarpine model of chronic epilepsy: cell loss and mossy fiber sprouting. Epilepsia 34:985-995.
17. Quilichini PP, Diabira D, Chiron C, Milh M, Ben-Ari Y, Gozlan H. (2003) Effects of antiepileptic drugs on refractory seizures in the intact immature corticohippocampal formation in vitro. Epilepsia 44:1365-1374.
18. Schmidt D, Lçscher W. (2005) Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia 46:858-877. (Pubitemid 40847354)
19. Uva L, Avoli M, de Curtis M. (2009) Synchronous GABA-receptor-dependent potentials in limbic areas of the in-vitro isolated adult guinea pig brain. Eur J Neurosci 29:911-920.
20. Wahab A, Heinemann U, Albus K. (2009) Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Res 86:113-123.
21. Zahn RK, Tolner EA, Derst C, Gruber C, Veh RW, Heinemann U. (2008) Reduced ictogenic potential of 4-aminopyridine in the perirhinal and entorhinal cortex of kainate-treated chronic epileptic rats. Neurobiol Dis 29:186-200.