Astrocytes in the hippocampus of patients with temporal lobe epilepsy display changes in potassium conductances

European Journal of Neuroscience

Volumn 12, Issue 6, 2000, Pages 2087-2096

  Hinterkeuser, Stefan ^b   Schröder, Wolfgang ^b   Hager, Gerhard ^a,b   Seifert, Gerald ^b   Blümcke, Ingmar ^b   Elger, Christian E ^b   Schramm, Johannes ^b   Steinhäuser, Christian ^b  

^a MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

Glial cells; Human; Kir channels; Patch clamp; Sclerosis

Indexed keywords

ADULT; ARTICLE; ASTROCYTE; CELL LOSS; CLINICAL ARTICLE; DEPOLARIZATION; ELECTRIC POTENTIAL; FEMALE; GLIA CELL; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; PATCH CLAMP; POTASSIUM TRANSPORT; PRIORITY JOURNAL; SCLEROSIS; SODIUM CURRENT; TEMPORAL LOBE EPILEPSY;

ADULT; ASTROCYTES; CALCIUM-BINDING PROTEINS; EPILEPSY, TEMPORAL LOBE; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HUMANS; KINETICS; MALE; MEMBRANE POTENTIALS; NERVE GROWTH FACTORS; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RNA, MESSENGER; S100 PROTEINS; SCLEROSIS; SODIUM; TETRODOTOXIN;

EID: 0013652589     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1460-9568.2000.00104.x     Document Type: Article

References (58)

1. 2+ currents. Glia, 17, 181-194.
2. Akopian, G., Kuprijanova, E., Kressin, K. & Steinhäuser, C. (1997) Analysis of ion channel expression by astrocytes in red nucleus brain stem slices of the rat. Glia, 19, 234-246.
3. Allore, R.J., Friend, W.C., O'Hanlon, D., Neilson, K.M., Baumal, R., Dunn, R.J. & Marks, A. (1990) Cloning and expression of the human S100β gene. J. Biol. Chem., 265, 15537-15543.
4. Barger, S.W., Wolchok, S.R. & van Eldik, L.J. (1992) Disulfide-linked S100β dimers and signal transduction. Biochem. Biophys. Acta, 1160, 105-112.
5. Barna, B.P., Estes, M.L., Jacobs, B.S., Hudson, S. & Ransohoff, R.M. (1990) Human astrocytes proliferate in response to tumor necrosis factor alpha. J. Neuroimmunol., 30, 239-243.
6. Behrens, E., Zentner, J., Van Roost, D., Hufnagel, A., Elger, C.E. & Schramm, J. (1994) Subdural and depth electrodes in the presurgical evaluation of epilepsy. Acta Neurochir., 128, 84-87.
7. Bordey, A. & Sontheimer, H. (1997) Postnatal development of ionic currents in rat hippocampal astrocytes in situ. J. Neurophysiol., 78, 461-477.
8. Bordey, A. & Sontheimer, H. (1998) Properties of human glial cells associated with epileptic seizure foci. Epilepsy Res., 32, 286-303.
9. Bringmann, A., Biedermann, B. & Reichenbach, A. (1999) Expression of potassium channels during postnatal differentiation of rabbit Muller glial cells. Eur. J. Neurosci., 11, 2883-2896.
10. + homeostasis and altered electrophysiological properties of post-traumatic hippocampal glia. J. Neuroscience, 19, 8152-8162.
11. De Bock, F., Dornand, J. & Rondouin, G. (1996) Release of TNFα in the rat hippocampus following epileptic seizures and excitotoxic neuronal damage. Neuroreport, 7, 1125-1129.
12. De Lanerolle, N.C., Kim, J.H. & Brines, M.L. (1994) Cellular and molecular alterations in partial epilepsy. Clin. Neurosci., 2, 64-81.
13. Dermietzel, R., Hertzberg, E.L., Kessler, J.A. & Spray, D.C. (1991) Gap junctions between cultured astrocytes: immunocytochemical, molecular, and electrophysiological analysis. J. Neuroscience, 11, 1421-1432.
14. Dietrich, D., Clusmann, H., Kral, T., Steinhäuser, C., Blümcke, I., Heinemann, U. & Schramm, J. (1999) Two electrophysiologically distinct types of granule cells in epileptic human hippocampus. Neuroscience, 90, 1195-1204.
15. Elger, C.E., Hufnagel, A. & Schramm, J. (1993) Presurgical evaluation protocol - University of Bonn. In Engel, J. Jr (ed.) Surgical Treatment of the Epilepsies. Raven Press, New York, pp. 740-742.
16. Fisher, R.S., Pedley, T.A., Moody, W.J. & Prince, D.A. (1976) The role of extracellular potassium in hippocampal epilepsy. Arch. Neurol., 33, 76-83.
17. Francke, M., Pannicke, T., Biedermann, B., Faude, F., Wiedemann, P., Reichenbach, A. & Reichelt, W. (1997) Loss of inwardly rectifying potassium currents by human retinal glial cells in diseases of the eye. Glia, 20, 210-218.
18. Gabriel, S., Eilers, A., Kivi, A., Kovacs, R., Schulze, K., Lehmann, T.N. & Heinemann, U. (1998a) Effects of barium on stimulus induced changes in extracellular potassium concentration in area CA1 of hippocampal slices from normal and pilocarpine-treated epileptic rats. Neurosci. Lett., 242, 9-12.
19. o and field potentials in dentate gyrus and area CA1 of human epileptic hippocampus. Neurosci. Lett., 249, 91-94.
20. Gardner-Medwin, A.R., Coles, J.A. & Tsacopoulos, M. (1981) Clearance of extracellular potassium: evidence for spatial buffering by glial cells in the retina of the drone. Brain Res., 209, 452-457.
21. Glass, M. & Dragunow, M. (1995) Neurochemical and morphological changes associated with human epilepsy. Brain Res. Rev., 21, 29-41.
22. Gray, W.P., Hinterkeuser, S., Hager, G., Sundstrom, L. & Steinhauser, C. (1999) Characterization of proliferating astrocytes in the rat hippocampus. Pflugers Arch., 437S, R121.
23. Griffin, W.S.T., Yeralan, O., Sheng, J.G., Boop, F.A., Mrak, R.E., Rovnaghi, C.R., Burnett, B.A., Feoktistova, A. & van Eldik, L.J. (1995) Overexpression of the neurotrophic cytokine S100β in human temporal lobe epilepsy. J. Neurochem., 65, 228-233.
24. Hablitz, J.J. & Heinemann, U. (1989) Alterations in the microenvironment during spreading depression associated with epileptiform activity in the immature neocortex. Dev. Brain Res., 46, 243-252.
25. Kettenmann, H., Sykova, E., Orkand, R.K. & Schachner, M. (1987) Glial potassium uptake following depletion by intracellular ionophoresis. Pflugers Arch., 410, 1-6.
26. + conductance. Neuroreport, 9, 1375-1378.
27. Köller, H., Siebler, M. & Hartung, H.-P. (1997) Immunologically induced electrophysiological dysfunction: implications for inflammatory diseases of the CNS and PNS. Prog. Neurobiol., 52, 1-26.
28. Konnerth, A., Heinemann, U. & Yaari, Y. (1984) Slow transmission of neural activity in hippocampal area CA1 in absence of active chemical synapses. Nature, 307, 69-71.
29. + conductances in glial cells of mouse hippocampal brain slices. Glia, 15, 173-187.
30. Kuffler, S.W., Nicholls, J.G. & Orkand, R.K. (1966) Physiological properties of glial cells in the central nervous system of amphibia. J. Neurophysiol., 29, 768-787.
31. Le Roux, P.D. & Reh, T.A. (1995) Independent regulation of primary dendritic and axonal growth by maturing astrocytes in vitro. Neurosci. Lett., 198, 5-8.
32. Lehmenkühler, A., Syková, E., Svoboda, J., Zilles, K. & Nicholson, C. (1993) Extracellular space parameters in the rat neocortex and subcontical white matter during postnatal development determined by diffusion analysis. Neuroscience, 55, 339-351.
33. + during spinal epileptiform seizures. Electroencephalogr. Clin. Neurophysiol., 41, 253-267.
34. Lux, H.-D., Heinemann, U. & Dietzel, I. (1986) Ionic changes and alterations in the size of the extracellular space during epileptic activity. Adv. Neurol., 44, 619-639.
35. MacFarlane, S.N. & Sontheimer, H. (1997) Electrophysiological changes that accompany reactive gliosis in vitro. J. Neuroscience, 17, 7316-7329.
36. McNamara, J.O. (1994) Cellular and molecular basis of epilepsy. J. Neuroscience, 14, 3413-3425.
37. Moody, W.J., Futamachi, K.J. & Prince, D.A. (1974) Extracellular potassium activity during epileptogenesis. Exp. Neurol., 42, 248-263.
38. Newman, E.A. (1986) High potassium conductance in astrocyte endfeet. Science, 233, 453-454.
39. Newman, E.A. (1993) Inward-rectifying potassium channels in retinal glial (Müller) cells. J. Neuroscience, 13, 3333-3345.
40. Niquet, J., Ben-Ari, Y. & Represa, A. (1994) Glial reaction after seizure induced hippocampal lesion: immunohistochemical characterization of proliferating glial cells. J. Neurocytol., 23, 641-656.
41. Orkand, R.K., Nicholls, J.G. & Kuffler, S.W. (1966) Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia. J. Neurophysiol., 29, 788-806.
42. Represa, A., Niquet, J., Pollard, H. & Ben-Ari, Y. (1995) Cell death, gliosis, and synaptic remodeling in the hippocampus of epileptic rats. J. Neurobiol., 26, 413-425.
43. Scheffler, B., Faissner, A., Beck, H., Behle, K., Wolf, H.K., Wiestier, O.D. & Blümcke, I. (1997) Hippocampal loss of tenascin boundaries in Ammon's horn sclerosis. Glia, 19, 35-46.
44. Schröder, W., Hager, G., Kouprijanova, E., Weber, M., Schmitt, A., Seifert, G. & Steinhäuser, C. (1999) Lesion-induced changes of electrophysiological properties in astrocytes of rat dentate gyrus. Glia, 28, 166-174.
45. Seifert, G., Rehn, L., Weber, M. & Steinhäuser, C. (1997a) AMPA receptor subunits expressed by single astrocytes in the juvenile mouse hippocampus. Mol. Brain Res., 47, 286-294.
46. Seifert, G., Zhou, M. & Steinhäuser, C. (1997b) Analysis of AMPA receptor properties during postnatal development of mouse hippocampal astrocytes. J. Neurophysiol., 78, 2916-2923.
47. Seifert, G., Schumacher, T., Schröder, W., Hinterkeuser, S., Schramm, J. & Steinhäuser, C. (1999) AMPA receptor properties of astrocytes in human epilepsy. J. Neurochem., 73S, 135.
48. Selmaj, K.W., Farooq, M., Norton, W.T., Raine, C.S. & Brosnan, C.F. (1990) Proliferation of astrocytes in vitro in response to cytokines-A primary role for tumor necrosis factor. J. Immunol., 144, 129-135.
49. Sivron, T., Eitan, S., Schreyer, D.J. & Schwartz, M. (1993) Astrocytes play a major role in the control of neuronal proliferation in vitro. Brain Res., 629, 199-208.
50. Sontheimer, H. & Waxman, S.G. (1993) Expression of voltage-activated ion channels by astrocytes and oligodendrocytes in the hippocampal slice. J. Neurophysiol., 70, 1863-1873.
51. Steinhäuser, C., Berger, T., Frotscher, M. & Kettenmann, H. (1992) Heterogeneity in the membrane current pattern of identified glial cells in the hippocampal slice. Eur. J. Neurosci., 4, 472-484.
52. Steinhäuser, C. & Gallo, V. (1996) News on glutamate receptors in glial cells. Trends Neurosci., 19, 339-345.
53. Steinhäuser, C., Kressin, K., Kuprijanova, E., Weber, M. & Seifert, G. (1994) Properties of voltage-activated sodium and potassium currents in mouse hippocampal glial cells in situ and after acute isolation from tissue slices. Pflugers Arch., 428, 610-620.
54. Steinhäuser, C., Schröder, W., Hinterkeuser, S., Seifert, G. & Schramm, J. (1998) Functional analysis of astrocytes in acute hippocampal slices derived from patients with temporal lobe epilepsies. Soc. Neurosci. Abstr., 24, 776.
55. Tchelingerian, J.-L., Vignais, L. & Jacque, C. (1994) TNF alpha gene expression is induced in neurones after a hippocampal lesion. Neuroreport, 5, 585-588.
56. Traynelis, S.T. & Dingledine, R. (1988) Potassium-induced spontaneous electrographic seizures in the rat hippocampal slice. J. Neurophysiol., 59, 259-276.
57. + currents in acutely isolated hippocampal astrocytes. J. Neuroscience, 12, 1781-1788.
58. Wolf, H.K., Campos, M.G., Zentner, J., Hufnagel, A., Schramm, J., Elger, C.E. & Wiestler, O.D. (1993) Surgical pathology of temporal lobe epilepsy. Experience with 216 cases. J. Neuropathol. Exp. Neurol., 52, 499-506.