Emergent properties of CNS neuronal networks as targets for pharmacology: Application to anticonvulsant drug action

Progress in Neurobiology

Volumn 72, Issue 1, 2004, Pages 55-85

  Faingold, Carl L ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

AGS; Alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid; AMG; AMPA; Amygdala; Audiogenic seizures; BDNF; Blood oxygenation level dependent; BOLD; Brain derived neurotrophic factor; Central pattern generators; CN; Cochlear nucleus; CPGs; CPP

Indexed keywords

2 AMINO 7 PHOSPHONOHEPTANOIC ACID; 4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; ALCOHOL; ANESTHETIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ATYPICAL ANTIPSYCHOTIC AGENT; BARBITURIC ACID DERIVATIVE; BENZODIAZEPINE DERIVATIVE; DIZOCILPINE; FLUOXETINE; GABAPENTIN; LAMOTRIGINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; PHENOBARBITAL; PHENYTOIN; PHOSPHODIESTERASE INHIBITOR; RILUZOLE; SILDENAFIL; TIAGABINE; VALPROIC ACID;

ANESTHESIA; AUDIOGENIC SEIZURE; AUDITORY STIMULATION; CONSCIOUSNESS; DRUG EFFECT; DRUG TARGETING; EPILEPSY; EPILEPTOGENESIS; HABITUATION; HUMAN; INFERIOR COLLICULUS; NERVE CELL NETWORK; NEUROANATOMY; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PONS RETICULAR FORMATION; PRIORITY JOURNAL; RETICULAR FORMATION; REVIEW; SEIZURE SUSCEPTIBILITY; STARTLE REFLEX; SUBSTANTIA NIGRA;

ACOUSTIC STIMULATION; ANIMALS; ANTICONVULSANTS; CENTRAL NERVOUS SYSTEM; EPILEPSY; EXCITATORY AMINO ACID ANTAGONISTS; HUMANS; NERVE NET; NEURONS;

EID: 1242313225     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pneurobio.2003.11.003     Document Type: Review

References (320)

1. Agnati L.F., Fuxe K. Volume transmission as a key feature of information handling in the central nervous system possible new interpretative value of the Turing's B-type machine. Prog. Brain Res. 125:2000;3-19.
2. Agnati L.F., Zoli M., Stromberg I., Fuxe K. Intercellular communication in the brain: wiring versus volume transmission. Neuroscience. 69(3):1995;711-726.
3. Aguado F., Espinosa-Parrilla J.F., Carmona M.A., Soriano E. Neuronal activity regulates correlated network properties of spontaneous calcium transients in astrocytes in situ. J. Neurosci. 22(21):2002;9430-9444.
4. Aguayo L.G., Peoples R.W., Yeh H.H., Yevenes G.E. GABA(A) receptors as molecular sites of ethanol action. Direct or indirect actions? Curr. Top. Med. Chem. 2(8):2002;869-885.
5. Akk G., Steinbach J.H. Low doses of ethanol and a neuroactive steroid positively interact to modulate rat GABA(A) receptor function. J. Physiol. 546(Pt. 3):2003;641-646.
6. Applegate C.D., Tecott L.H. Global increases in seizure susceptibility in mice lacking 5-HT2C receptors: a behavioral analysis. Exp. Neurol. 154(2):1998;522-530.
7. Applegate C.D., Pretel S., Piekut D.T. The substantia nigra pars reticulata, seizures and Fos expression. Epilepsy Res. 20:1995;31-39.
8. Avoli M., D'Antuono M., Louvel J., Kohling R., Biagini G., Pumain R., D'Arcangelo G., Tancredi V. Network and pharmacological mechanisms leading to epileptiform synchronization in the limbic system in vitro. Prog. Neurobiol. 68(3):2002;167-207.
9. Bac P., Maurois P., Dupont C., Pages N., Stables J.P., Gressens P., Evrard P., Vamecq J. Magnesium deficiency-dependent audiogenic seizures (MDDASs) in adult mice: a nutritional model for discriminatory screening of anticonvulsant drugs and original assessment of neuroprotection properties. J. Neurosci. 18:1998;4363-4373.
10. Bach-y-Rita P., Aiello G.L. Nerve length and volume in synaptic vs. diffusion neurotransmission: a model. Neuroreport. 7(9):1996;1502-1504.
11. Bagri A., Di Scala G., Sandner G. Myoclonic and tonic seizures elicited by microinjection of cholinergic drugs into the inferior colliculus. Therapie. 54(5):1999;589-594.
12. Bajic D., Proudfit H.K. Projections of neurons in the periaqueductal gray to pontine and medullary catecholamine cell groups involved in the modulation of nociception. J. Comp. Neurol. 405(3):1999;359-379.
13. Baker P.M., Pennefather P.S., Orser B.A., Skinner F.K. Disruption of coherent oscillations in inhibitory networks with anesthetics: role of GABA(A) receptor desensitization. J. Neurophysiol. 88(5):2002;2821-2833.
14. Beck M.M., Brown-Borg H.M., Jones T.A. Peripheral and brainstem auditory function in paroxysmal (px) White Leghorn chicks. Brain Res. 406(1-2):1987;93-98.
15. Ben Ari Y., Represa A. Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampus. Trends Neurosci. 13(8):1990;312-318.
16. Ben Menachem E. International experience with tiagabine add-on therapy. Epilepsia. 36(Suppl. 6):1995;S14-S21.
17. Bertram E.H., Mangan P.S., Zhang D., Scott C.A., Williamson J.M. The midline thalamus: alterations and a potential role in limbic epilepsy. Epilepsia. 42(8):2001;967-978.
18. Bianchi M.T., Macdonald R.L. Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function. J. Physiol. 544(Pt. 1):2002;3-18.
19. Binder D.K., Croll S.D., Gall C.M., Scharfman H.E. BDNF and epilepsy: too much of a good thing? Trends Neurosci. 24(1):2001;47-53.
20. Bloms-Funke P., Loscher W. The anticonvulsant gabapentin decreases firing rates of substantia nigra pars reitulata neurons. Eur. J. Pharmacol. 316(2-3):1996;211-218.
21. Blumcke I., Schewe J.C., Normann S., Brustle O., Schramm J., Elger C.E., Wiestler O.D. Increase of nestin-immunoreactive neural precursor cells in the dentate gyrus of pediatric patients with early-onset temporal lobe epilepsy. Hippocampus. 11(3):2001;311-321.
22. Blumenfeld H., McCormick D.A. Corticothalamic inputs control the pattern of activity generated in thalamocortical networks. J. Neurosci. 20(13):2000;5153-5162.
23. Bonhaus D.W., Russell R.D., McNamara J.O. Activation of substantia nigra ars reticulata neurons: role in the initiation and behavioral expression of kindled seizures. Brain Res. 545:1991;41-48.
24. Bowery N.G., Wong E.H., Hudson A.L. Quantitative autoradiography of [3H]-MK-801 binding sites in mammalian brain. Br. J. Pharmacol. 93(4):1988;944-954.
25. Bragin A., Engel J. Jr., Wilson C.L., Fried I., Buzsaki G. High-frequency oscillations in human brain. Hippocampus. 9(2):1999;137-142.
26. Bragin A., Wilson C.L., Engel J. Jr. Chronic epileptogenesis requires development of a network of pathologically interconnected neuron clusters: a hypothesis. Epilepsia. 41(Suppl. 6):2000;S144-S152.
27. Bragin A., Wilson C.L., Staba R.J., Reddick M., Fried I., Engel J. Jr. Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortex. Ann. Neurol. 52(4):2002a;407-415.
28. Bragin A., Mody I., Wilson C.L., Englel J. Jr. Local generation of fast ripples in epileptic brain. J. Neurosci. 22(5):2002b;2012-2021.
29. Brezina V., Weiss K.R. Analyzing the functional consequences of transmitter complexity. Trends Neurosci. 20:1997;538-543.
30. Browning, R.A., 1994. Anatomy of generalized convulsive seizures. In: Malafosse, A., Genten, P., Hirsch, E., Marescaux, C., Broglin, D., Bernasconi, R. (Eds.), Idiopathic Generalized Epilepsies: Clinical, Experimental and Genetic Aspects. Libbey, London, pp. 399-413.
31. Browning R.A., Wang C., Lanker M.L., Jobe P.C. Electroshock and pentylenetetrazol-induced seizures in genetically epilepsy-prone rats: differences in threshold and pattern. Epilepsy Res. 6:1990;1-11.
32. Burger R.M., Pollak G.D. Reversible inactivation of the dorsal nucleus of the lateral lemniscus reveals its role in the processing of multiple sound sources in the inferior colliculus of bats. J. Neurosci. 21(13):2001;4830-4843.
33. Buzsaki G. The thalamic clock: emergent network properties. Neuroscience. 41:1991;351-364.
34. Buzsaki G., Smith A., Berger S., Fisher L.J., Gage F.H. Petit mal epilepsy and parkinsonian tremor: hypothesis of a common pacemaker. Neuroscience. 36(1):1990;1-14.
35. Buzsaki G., Csicsvari J., Dragoi G., Harris K., Henze D., Hirase H. Homeostatic maintenance of neuronal excitability by burst discharges in vivo. Cereb. Cortex. 12(9):2002;893-899.
36. Cangiano L., Wallen P., Grillner S. Role of apamin-sensitive k(ca) channels fo rreticulospinal synaptic transmission to motoneuron and for the afterhyperpolarization. J. Neurophyisol. 88:2002;289-299.
37. Carlen P.L., Skinner F., Zhang L., Naus C., Kushnir M., Perez Velazquez J.L. The role of gap junctions in seizures. Brain Res. Brain Res. Rev. 32(1):2000;235-241.
38. Chakravarty D.N., Faingold C.L. Aberrant neuronal responsiveness in the genetically epilepsy-prone rat: acoustic responses and influences of the central nucleus upon the external nucleus of inferior colliculus. Brain Res. 761(2):1997;263-270.
39. Chakravarty D.N., Faingold C.L. Differential roles in the neuronal network for audiogenic seizures are observed among the inferior colliculus subnuclei and the amygdala. Exp. Neurol. 157(1):1999;135-141.
40. Chang Y., Ghansah E., Chen Y., Ye J., Weiss D.S., Chang Y. Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function. J. Neurosci. 22(18):2002;7982-7990.
41. Chapman A.G., Faingold C.L., Hart G.P., Bowker H.M., Meldrum B.S. Brain regional amino acid levels in seizure susceptible rats: changes related to sound-induced seizures. Neurochem. Int. 8:1986;273-279.
42. Chen L.S., Millington D.S., Maltby D.A., McNamara J.O. Effects of intranigral application of clinically-effective anticonvulsants on electroshock-induced seizures. Neuropharmacology. 28(8):1989;781-786.
43. Chen S., Huang X., Zeng X.J., Sieghart W., Tietz E.I. Benzodiazepine-mediated regulation of alpha1, alpha2, beta1-3 and gamma2 GABA(A) receptor subunit proteins in the rat brain hippocampus and cortex. Neuroscience. 93(1):1999;33-44.
44. Chung S.H., Johnson M.S. Studies on sound-induced epilepsy in mice. Proc. R. Soc., Lond. B. Biol. Sci. 221:1984;145-168.
45. Cooper E.C., Harrington E., Jan Y.N., Jan L.Y. M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J. Neurosci. 21(24):2001;9529-9540.
46. Criswell H.E., Ming Z., Griffith B.L., Breese G.R. Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanol. J. Pharmacol. Exp. Ther. 304(1):2003;192-199.
47. Csicsvari J., Hirase H., Czurko A., Buzsaki G. Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat. Neuron. 21(1):1998;179-189.
48. D'Sa C., Duman R.S. Antidepressants and neuroplasticity. Bipolar Disord. 4(3):2002;183-194.
49. Dailey J.W., Jobe P.C. Anticonvulsant drugs and the genetically epilepsy-prone rat. Fed. Proc. 44(10):1985;2640-2644.
50. Dalby N.O. GABA-level increasing and anticonvulsant effects of three different GABA uptake inhibitors. Neuropharmacology. 39:2000;2399-2407.
51. de Vries G. Bursting as an emergent phenomenon in coupled chaotic maps. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 64(5 Pt. 1):2001;051914.
52. Del Negro C.A., Morgado-Valle C., Feldman J.L. Respiratory rhythm: an emergent network property? Neuron. 34:2002;821-830.
53. Depaulis A., Vergnes M., Liu Z., Kempf E., Marescaux C. Involvement of the nigral output pathways in the inhibitory control of the substantia nigra over generalized non-convulsive seizures in the rat. Neuroscience. 39:1990;339-349.
54. Depaulis A., Deransart C., Vergnes M., Marescaux C. GABAergic mechanisms in generalized epilepsies: the neuroanatomical dimension. Rev. Neurol. (Paris). 153(Suppl. 1):1997;S8-S13.
55. Deransart C., Marescaux C., Depaulis A. Involvement of nigral glutamatergic inputs in the control of seizures in a genetic model of absence epilepsy in the rat. Neuroscience. 71(3):1996;721-728.
56. Deransart C., Le-Pham B.T., Hirsch E., Marescaux C., Depaulis A. Inhibition of the substantia nigra suppresses absences and clonic seizures in audiogenic rats, but not tonic seizures: evidence for seizure specificity of the nigral control. Neuroscience. 105(1):2001;203-211.
57. Devor M., Zalkind V. Reversible analgesia, atonia, and loss of consciousness on bilateral intracerebral microinjection of pentobarbital. Pain. 94(1):2001;101-112.
58. DiGregorio D.A., Nusser Z., Silver R.A. Spillover of glutamate onto synaptic AMPA enhances fast transmission at a cerebellar synapse. Neuron. 35(3):2002;521-533.
59. Dudek F.E., Yasumura T., Rash J.E. 'NON-SYNAPTIC' mechanisms in seizures and epileptogenesis. Cell Biol. Int. 22(11-12):1998;793-805.
60. Dudek F.E., Patrylo P.R., Wuarin J.P. Mechanisms of neuronal synchronization during epileptiform activity. Adv. Neurol. 79:1999;699-708.
61. Duell, C.H., 1899. In: Frank, L.R. (Ed.), Quoted in Random House Webster's Quotationary. New York, 1999, p. 514.
62. Dutra Moraes M.F., Galvis-Alonso O.Y., Garcia-Cairasco N. Audiogenic kindling in the Wistar rat: a potential model for recruitment of limbic structures. Epilepsy Res. 39(3):2000;251-259.
63. Eidelberg D., Moeller J.R., Kazumata K., Antonini A., Sterio D., Dhawan V., Spetsieris P., Alterman R., Kelly P.J., Dogali M., Fazzini E., Beric A. Metabolic correlates of pallidal neuronal activity in Parkinson's disease. Brain. 120(Pt. 8):1997;1315-1324.
64. Evans M.S., Li Y., Faingold C. Inferior colliculus intracellular response abnormalities in vitro associated with susceptibility to ethanol withdrawal seizures. Alcohol. Clin. Exp. Res. 24(8):2000;1180-1186.
65. Faingold C.L. Pentylenetetrazol-induced enhancement of responses of mesencephalic reticular neurons to visual stimuli. Brain Res. 150:1978;418-423.
66. Faingold, C.L., 1992. Neuronal networks, epilepsy and the action of antiepileptic drugs. In: Faingold, C.L., Fromm, G.H. (Eds.), Drugs for Control of Epilepsy: Actions on Neuronal Networks Involved in Seizure Disorders. CRC Press, Boca Raton, pp. 1-21.
67. Faingold C.L. Locomotor behaviors in generalized convulsions are hierarchically driven from specific brain-stem nuclei in the network subserving audiogenic seizure. Ann. N. Y. Acad. Sci. 860:1998;566-569.
68. Faingold C.L. Neuronal networks in the genetically epilepsy-prone rat. Adv. Neurol. 79:1999;311-321.
69. Faingold C.L. Role of GABA abnormalities in the inferior colliculus pathophysiology - audiogenic seizures. Hear. Res. 168(1-2):2002;223-237.
70. Faingold C.L., Boersma Anderson C.A. Loss of intensity-induced inhibition in inferior colliculus neurons leads to audiogenic seizure susceptibility in behaving genetically epilepsy-prone rats. Exp. Neurol. 113:1991;354-363.
71. Faingold, C.L., Caspary, D.M., 1987. Effect of convulsant drugs on the brain-stem. In: Fromm, G.H., Faingold, C.L., Browning, R.A., Burnham, W.M. (Eds.), Epilepsy and the Reticular Formation: The Role of the Reticular Core in Convulsive Seizures. Alan R. Liss, New York, pp. 39-80.
72. Faingold, C.L., Fromm, G.H., 1992. Drugs for Control of Epilepsy: Actions on Neuronal Networks Involved in Seizure Disorders. CRC Press, Boca Raton.
73. Faingold C.L., Randall M.E. Pontine reticular formation neurons exhibit a premature and precipitous increase in acoustic responses prior to audiogenic seizures in genetically epilepsy-prone rats. Brain Res. 704:1995;218-226.
74. Faingold C.L., Randall M.E. Neurons in the deep layers of superior colliculus play a critical role in the neuronal network for audiogenic seizures: mechanisms for production of wild running behavior. Brain Res. 815:1999;250-258.
75. Faingold, C.L., Riaz, A., 1992. Neuronal networks in convulsant drug-induced seizures. In: Faingold, C.L., Fromm, G.H. (Eds.), Drugs for Control of Epilepsy: Actions on Neuronal Networks Involved in Seizure Disorders. CRC Press, Boca Raton, pp. 213-251.
76. Faingold C.L., Riaz A. Increased responsiveness of pontine reticular formation neurons associated with audiogenic seizure susceptibility during ethanol withdrawal. Brain Res. 663:1994;69-76.
77. Faingold C.L., Riaz A. Ethanol withdrawal induces increased firing in inferior colliculus neurons associated with audiogenic seizure susceptibility. Exp. Neurol. 132:1995;91-98.
78. Faingold C.L., Gehlbach G., Caspary D.M. Decreased effectiveness of GABA-mediated inhibition in the inferior colliculus of the genetically epilepsy-prone rat. Exp. Neurol. 93:1986;145-159.
79. Faingold C.L., Gehlbach G., Caspary D.M. On the role of GABA as an inhibitory neurotransmitter in inferior colliculus neurons: Iontophoretic studies. Brain Res. 500:1989a;302-312.
80. Faingold C.L., Hoffmann W.E., Caspary D.M. Effects of excitant amino acids on acoustic responses of inferior colliculus neurons. Hearing Res. 40:1989b;127-136.
81. Faingold C.L., Millan M.H., Boersma Anderson C.A., Meldrum B.S. Induction of audiogenic seizures in normal and genetically epilepsy-prone rats following focal microinjection of an excitant amino acid into reticular formation and auditory nuclei. Epilepsy Res. 3:1989c;199-205.
82. Faingold C.L., Boersma Anderson C.A., Caspary D.M. Involvement of GABA in acoustically-evoked inhibition in inferior colliculus neurons. Hearing Res. 52:1991;201-216.
83. Faingold C.L., Naritoku D.K., Copley C.A., Randall M.E., Riaz A., Boersma Anderson C.A., Arneric S.P. Glutamate in the inferior colliculus plays a critical role in audiogenic seizure initiation. Epilepsy Res. 13:1992;95-105.
84. Faingold C.L., Boersma Anderson C.A., Randall M.E. Stimulation or blockade of the dorsal nucleus of the lateral lemniscus alters binaural and tonic inhibition in contralateral inferior colliculus neurons. Hearing Res. 69:1993a;98-106.
85. Faingold C.L., Randall M.E., Naritoku D.N., Boersma Anderson C.A. Non-competitive and competitive NMDA antagonists exert anticonvulsant effects by actions on different sites within the neuronal network for audiogenic seizures. Exp. Neurol. 119:1993b;198-204.
86. Faingold C.L., Randall M.E., Anderson C.A. Blockade of GABA uptake with tiagabine inhibits audiogenic seizures and reduces neuronal firing in the inferior colliculus of the genetically epilepsy-prone rat. Exp. Neurol. 126(2):1994;225-232.
87. Faingold C.L., N'Gouemo P., Riaz A. Ethanol and neurotransmitter interactions - from molecular to integrative effects. Prog. Neurobiol. 55:1998;509-535.
88. Faingold C., Li Y., Evans M.S. Decreased GABA and increased glutamate receptor-mediated activity on inferior colliculus neurons in vitro are associated with susceptibility to ethanol withdrawal seizures. Brain Res. 868(2):2000;287-295.
89. Faingold C.L., Feng H.-J., Yang L. Focal blockade and neuronal recordings indicate that the amygdala is critical in the neuronal network for ethanol withdrawal seizures. Alcohol. Clin. Exp. Res. 27:2003;99A.
90. Faingold, C.L., Knapp, D.J., Chester, J.A., Gonzalez, L.P., 2004. Integrative neurobiology of the alcohol withdrawal syndrome - from anxiety to seizures, Alcohol. Clin. Exp. Res., in press.
91. Farrant M., Webster R.A. Neuronal activity, amino acid concentration and amino acid release in the substantia nigra of the rat after sodium valproate. Brain Res. 504:1989;49-56.
92. Faught E. Lamotrigine for startle-induced seizures. Seizure. 8(6):1999;361-363.
93. Faulkner H.J., Traub R.D., Whittington M.A. Disruption of synchronous gamma oscillations in the rat hippocampal slice: a common mechanism of anaesthetic drug action. Br. J. Pharmacol. 125(3):1998;483-492.
94. Fellous J.-M., Linster C. Computational models of neuromodulation. Neural Comput. 10:1998;771-805.
95. Fendt M., Li L., Yeomans J.S. Brain stem circuits mediating prepulse inhibition of the startle reflex. Psychopharmacology (Berl.). 156(2-3):2001;216-224.
96. Feng H.-J., Faingold C.L. Repeated generalized audiogenic seizures induce plastic changes on acoustically evoked neuronal firing in the amygdala. Brain Res. 932(1-2):2002a;61-69.
97. Feng H.-J., Faingold C.L. Synaptic plasticity in the pathway from the medial geniculate body to the lateral amygdala is induced by seizure repetition. Brain Res. 946(2):2002b;198-205.
98. Feng H.-J., Naritoku D.K., Randall M.E., Faingold C.L. Modulation of audiogenically kindled seizures by gamma-aminobutyric acid-related mechanisms in the amygdala. Exp. Neurol. 172(2):2001;477-481.
99. Fink-Jensen A., Suzdak P.D., Swedberg M.D., Judge M.E., Hansen L., Nielsen P.G. The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats. Eur. J. Pharmacol. 220(2-3):1992;197-201.
100. Fontana W., Ballati S. Complexity - why the sudden fuss? Complexity. 4:1999;14-16.
101. Frankle W.G., Laruelle M. Neuroreceptor imaging in psychiatric disorders. Ann. Nucl. Med. 16(7):2002;437-446.
102. Freeman, W.J., 1975. Mass Action in the Nervous System. Academic Press, New York.
103. Freeman W.J. Petit mal seizure spikes in olfactory bulb and cortex caused by runaway inhibition after exhaustion of excitation. Brain Res. 396:1986;259-284.
104. Freeman W.J., Kozma R., Werbos P.J. Biocomplexity: adaptive behavior in complex stochastic dynamical systems. Biosystems. 59:2001;109-123.
105. Fromm G.H. Effects of different classes of antiepileptic drugs on brain-stem pathways. Fed. Proc. 44(8):1985;2432-2435.
106. Frye G.D., McCown T.J., Breese G.R., Peterson S.L. GABAergic modulation of inferior colliculus excitability: role in ethanol withdrawal audiogenic seizures. J. Pharmacol. Exp. Therapeut. 237:1986;478-482.
107. Fuhrmann G., Markram H., Tsodyks M. Spike frequency adaptation and neocortical rhythms. J. Neurophysiol. 88:2002;761-770.
108. Gale K. Mechanisms of seizure control mediated by gamma-aminobutyric acid: role of the substantia nigra. Fed. Proc. 44:1985;2414-2424.
109. Garant D.S., Gale K. Substantia nigra-mediated anticonvulsant actions: role of nigral output pathways. Exp. Neurol. 97(1):1987;143-159.
110. Garant D.S., Xu S.G., Sperber E.F., Moshe S.L. Age-related differences in the effects of GABAA agonists microinjected into rat substantia nigra: pro- and anticonvulsant actions. Epilepsia. 36:1995;960-965.
111. Garcia-Cairasco N. A critical review on the participation of inferior colliculus in acoustic-motor and acoustic-limbic networks involved in the expression of acute and kindled audiogenic seizures. Hear. Res. 168(1-2):2002;208-222.
112. Garcia-Cairasco N., Wakamatsu H., Oliveira J.A., Gomes E.L., Del Bel E.A., Mello L.E. Neuroethological and morphological (Neo-Timm staining) correlates of limbic recruitment durig the development of audiogenic kindling in seizure susceptible Wistar rats. Epilepsy Res. 26(1):1996;177-192.
113. Gebber G.L. A defense-like reaction: an emergent property of a system of coupled non-linear oscillators. Clin. Exp. Pharmacol. Physiol. 28:2001;125-129.
114. George M.S., Nahas Z., Li X., Kozel F.A., Anderson B., Yamanaka K., Chae J.H., Foust M.J. Novel treatments of mood disorders based on brain circuitry (ECT, MST, TMS, VNS, DBS). Semin. Clin. Neuropsychiatry. 7(4):2002;293-304. Review.
115. Gil Verona J.A., Gomez Carretero M.E., Manso M.E., Gomez B.P., Garcia A.N. Morphology of the posterior colliculus in epileptic hamsters. Arch. Neurobiol. (Madr.). 53(3):1990;112-118.
116. Gonzalez L.P., Hettinger M.K. Intranigral muscimol suppresses ethanol withdrawal seizures. Brain Res. 298(1):1984;163-166.
117. Gonzalez L.P., Czachura J.F., Brewer K.W. Spontaneous versus elicited seizures following ethanol withdrawal: differential time course. Alcohol. 6(6):1989;481-487.
118. Gorji A. Spreading depression: a review of the clinical relevance. Brain Res. Brain Res. Rev. 38(1-2):2001;33-60.
119. Gower A.J., Noyer M., Verloes R., Gobert J., Wulfert E. ucb L059, a novel anti-convulsant drug: pharmacological profile in animals. Eur. J. Pharmacol. 222(2-3):1992;193-203.
120. Graumlich J.F., McLaughlin R.G., Birkhahn D., Shah N., Jobe P.C., Dailey J.W. Carbamazepine pharmacokinetics-pharmacodynamics in genetically epilepsy-prone rats. Eur. J. Pharmacol. 369(3):1999;305-311.
121. Gray W.P., Sundstrom L.E. Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat. Brain Res. 790(1-2):1998;52-59.
122. Greenfield L.J. Jr., Zaman S.H., Sutherland M.L., Lummis S.C., Niemeyer M.I., Barnard E.A., Macdonald R.L. Mutation of the GABAA receptor M1 transmembrane proline increases GABA affinity and reduces barbiturate enhancement. Neuropharmacology. 42(4):2002;502-521.
123. Grenier F., Timofeev I., Steriade M. Neocortical very fast oscillations (ripples, 80-200 Hz) during seizures: intracellular correlates. J. Neurophysiol. 89(2):2003;841-852.
124. Grillner S., Parker D., el Manira A. Vertebrate locomotion - a lamprey perspective. Ann. N. Y. Acad. Sci. 860:1998;1-18.
125. Gulley J.M., Kosobud A.E., Rebec G.V. Behavior-related modulation of substantia nigra pars reticulata neurons in rats performing a conditioned reinforcement task. Neuroscience. 111(2):2002;337-349.
126. Gulyas-Kovacs A., Doczi J., Tarnawa I., Detari L., Banczerowski-Pelyhe I., Vilagi I. Comparison of spontaneous and evoked epileptiform activity in three in vitro epilepsy models. Brain Res. 945(2):2002;174-180.
127. He L., Di Monte D.A., Langston J.W., Quik M. Autoradiographic analysis of N-methyl-D-aspartate receptor binding in monkey brain: effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and levodopa treatment. Neuroscience. 99(4):2000;697-704.
128. Hedberg T.G., Veliskova J., Sperber E.F., Nunes M.L., Moshe S.L. Age-related differences in NMDA/metabotropic glutamate receptor binding in rat substantia nigra. Int. J. Dev. Neurosci. 21(2):2003;95-103.
129. Helekar S.A., Noebels J.L. Synchronous hippocampal bursting reveals network excitability defects in an epilepsy gene mutation. Proc. Natl. Acad. Sci. U.S.A. 88(11):1991;4736-4740.
130. Hirai N., Uchida S., Maehara T., Okubo Y., Shimizu H. Enhanced gamma (30-150 Hz) frequency in the human medial temporal lobe. Neuroscience. 90(4):1999;1149-1155.
131. Hirsch E., Danober L., Simler S., Pereira de Vasconcelos A., Nehlig A., Marescaux C., Vergnes M. The amygdala is critical for seizure propagation from brainstem to forebrain. Neuroscience. 77(4):1997;975-984.
132. Hohenboken W.D., Nellhaus G. Inheritance of audiogenic seizures in the rabbit. J. Hered. 61(3):1970;107-112.
133. Horgan, J., 1999. The Undiscovered Mind: How the Human Brain Defies Replication, Medication, and Explanation. Free Press, New York.
134. Ishida Y., Nakahara D., Hashiguchi H., Nakamura M., Ebihara K., Takeda R., Nishimori T., Niki H. Fos expression in GABAergic cells and cells immunopositive for NMDA receptors in the inferior and superior colliculi following audiogenic seizures in rats. Synapse. 46(2):2002;100-107.
135. Izhikevich E.M., Desai N.S., Walcott E.C., Hoppensteadt F.C. Bursts as a unit of neural information: selective communication via resonance. Trends Neurosci. 26(3):2003;161-167.
136. Javedan S.P., Fisher R.S., Eder H.G., Smith K., Wu J. Cooling abolishes neuronal network synchronization in rat hippocampal slices. Epilepsia. 43(6):2002;574-580.
137. Jobe, P.C., 1981. Pharmacology of audiogenic seizures. In: Brown, R.D. (Ed.), Pharmacology of Hearing: Experimental Clinical Bases. Wiley, New York, pp. 271-304.
138. Jobe, P.C., 1987. Spinal seizures induced by electrical stimulation. In: Fromm, G.H., Faingold, C.L., Browning, R.A., Burnham, W.M. (Eds.), Epilepsy and the Reticular Formation: The Role of the Reticular Core in Convulsive Seizures. Alan R. Liss, New York, pp. 81-91.
139. Jobe P.C., Picchioni A.L., Chin L. Role of brain norepinephrine in audiogenic seizure in the rat. J. Pharmacol. Exp. Therap. 184:1973;1-10.
140. Jobe, P.C., Mishra, P.K., Dailey, J.W., 1992. Genetically epilepsy-prone rats: actions of antiepileptic drugs and monoaminergic neurotransmitters. In: Faingold, C.L., Fromm, G.H. (Eds.), Drugs for Control of Epilepsy, Actions on Neuronal Networks Involved in Seizure Disorders. CRC Press, Boca Raton, pp. 253-275.
141. Joo D.T., Xiong Z., MacDonald J.F., Jia Z., Roder J., Sonner J., Orser B.A. Blockade of glutamate receptors and barbiturate anesthesia: increased sensitivity to pentobarbital-induced anesthesia despite reduced inhibition of AMPA receptors in GluR2 null mutant mice. Anesthesiology. 91(5):1999;1329-1341.
142. Jordan L.M. Initiation of locomotion in mammals. Ann. N. Y. Acad. Sci. 860:1998;83-93.
143. Kao C.Q., Coulter D.A. Physiology and pharmacology of corticothalamic stimulation-evoked responses in rat somatosensory thalamic neurons in vitro. J. Neurophysiol. 77:1997;2661-2676.
144. Katoh-Semba R., Asano T., Ueda H., Morishita R., Takeuchi I.K., Inaguma Y., Kato K. Riluzole enhances expression of brain-derived neurotrophic factor with consequent proliferation of granule precursor cells in the rat hippocampus. FASEB J. 16(10):2002;1328-1330.
145. Kelly J.B., Li L. Two sources of inhibition affecting binaural evoked responses in the rat's inferior colliculus: the dorsal nucleus of the lateral lemniscus and the superior olivary complex. Hear. Res. 104(1-2):1997;112-126.
146. Kepecs A., Wang X.J., Lisman J. Bursting neurons signal input slope. J. Neurosci. 22(20):2002;9053-9062.
147. Kiesmann M., Marescaux C., Vergnes M., Micheletti G., Depaulis A., Warter J.M. Audiogenic seizures in Wistar rats before and after repeated auditory stimuli: clinical, pharmacological, and electroencephalographic studies. J. Neural. Transm. 72(3):1988;235-244.
148. Kim E. The use of newer anticonvulsants in neuropsychiatric disorders. Curr. Psychiatry Rep. 4(5):2002;331-337.
149. King P.H., Shin C., Mansbach H.H., Chen L.S., McNamara J.O. Microinjection of a benzodiazepine into substantia nigra elevates kindled seizure threshold. Brain Res. 423(1-2):1987;261-268.
150. Klausberger T., Magill P.J., Marton L.F., Roberts J.D., Cobden P.M., Buzsaki G., Somogyi P. Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo. Nature. 421(6925):2003;844-848.
151. Koch M. The neurobiology of startle. Prog. Neurobiol. 59(2):1999;107-128.
152. Kohling R., Vreugdenhil M., Bracci E., Jefferys J.G. Ictal epileptiform activity is facilitated by hippocampal GABAA receptor-mediated oscillations. J. Neurosci. 20(18):2000;6820-6829.
153. Kornhuber J., Mack-Burkhardt F., Riederer P. Regional distribution of [3H]MK-801 binding sites in the human brain. Brain Res. 489:1989;397-399.
154. Kulesza R.J. Jr., Berrebi A.S. Superior paraolivary nucleus of the rat is a GABAergic nucleus. J. Assoc. Res. Otolaryngol. 1(4):2000;255-269.
155. Kulesza R.J., Vinuela A., Saldana E., Berrebi A.S. Unbiased stereological estimates of neuron number in subcortical auditory nuclei of the rat. Hear. Res. 168(1-2):2002;12-24.
156. Kumar S., Sieghart W., Morrow A.L. Association of protein kinase C with GABA(A) receptors containing alpha1 and alpha4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. J. Neurochem. 82(1):2002;110-117.
157. LeBeau F.E., Towers S.K., Traub R.D., Whittington M.A., Buhl E.H. Fast network oscillations induced by potassium transients in the rat hippocampus in vitro. J. Physiol. 542(Pt. 1):2002;167-179.
158. Leonard J.L. Network architectures and circuit function: testing alternative hypotheses in mulfunctional networks. Brain Behav. E. 55:2000;248-255.
159. Leumann L., Sterchi D., Vollenweider F., Ludewig K., Fruh H. A neural network approach to the acoustic startle reflex and prepulse inhibition. Brain Res. Bull. 56(2):2001;101-110.
160. Lewis T.J., Rinzel J. Self-organized synchronous oscillations in a network of excitable cells coupled by gap junctions. Network. 11(4):2000;299-320.
161. Li, Y., 1997. In vitro electrophysiological properties of inferior colliculus cortex neurons in genetically epilepsy prone rats and rats undergoing ethanol withdrawal (seizures). Dissertation Abstracts Intl., vol. 59-02, Sect. B, p. 0548.
162. Li Y., Evans M.S., Faingold C.L. Inferior colliculus neuronal membrane and synaptic properties in genetically epilepsy-prone rats. Brain Res. 660(2):1994;232-240.
163. Li Y., Evans M.S., Faingold C.L. Synaptic response patterns of neurons in the cortex of rat inferior colliculus. Hear. Res. 137(1-2):1999;15-28.
164. Lindsey B.G., Morris K.F., Segers L.S., Shannon R. Respiratory neuronal assemblies. Respir. Physiol. 122:2000;183-196.
165. Lisman J.E. Bursts as a unit of neural information: making unreliable synapses reliable. Trends Neurosci. 20(1):1997;38-43.
166. Long, C., Yang, L., Evans, M.S., Faingold, C.L., 2002. Alteration of GABA receptor-mediated inhibition in periaqueductal gray (pag) neurons during ethanol withdrawal (ETX), Soc. Neurosci. Abs. 28, Prog. # 607.13.
167. Loscher W. Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy. Epilepsy Res. 50(1-2):2002;105-123.
168. Loscher W., Honack D., Bloms-Funke P. The novel antiepileptic drug levetiracetam (ucb L059) induces alterations in GABA metabolism and turnover in discrete areas of rat brain and reduces neuronal activity in substantia nigra pars reticulata. Brain Res. 735(2):1996;208-216.
169. Lothman E.W. Functional anatomy: a challenge for the decade of the brain. Epilepsia. 32(Suppl. 5):1991;S3-S13.
170. Lowenstein D.H. Recent advances related to basic mechanisms of epileptogenesis. Epilepsy Res. Suppl. 11:1996;45-60.
171. Lukyanetz E.A., Shkryl V.M., Kostyuk P.G. Selective blockade of N-type calcium channels by levetiracetam. Epilepsia. 43(1):2002;9-18.
172. Lynch M., Sutula T. Recurrent excitatory connectivity in the dentate gyrus of kindled and kainic acid-treated rats. J. Neurophysiol. 83(2):2000;693-704.
173. Maier N., Guldenagel M., Sohl G., Siegmund H., Willecke K., Draguhn A. Reduction of high-frequency network oscillations (ripples) and pathological network discharges in hippocampal slices from connexin 36-deficient mice. J. Physiol. 541(Pt. 2):2002;521-528.
174. Malberg J.E., Eisch A.J., Nestler E.J., Duman R.S. Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J. Neurosci. 20(24):2000;9104-9110.
175. Mameli O., Solinas A., Podda M.V., Caria M.A., Deriu F., Guiso M.L., Fortuna P., Becciu A., De Riu P.L. Antiepileptic treatment and oculomotor neurons. Boll. Soc. Ital. Biol. Sper. 71(9-10):1995;235-240.
176. Manford M.R., Fish D.R., Shorvon S.D. Startle provoked epileptic seizures: features in 19 patients. J. Neurol. Neurosurg. Psychiatry. 61(2):1996;151-156.
177. Marchand M.J., Ward R., Moreau B. Different patterns of dendritic branching of posterior collicular neurons in two mouse strains are associated with a difference in audiogenic seizure susceptibility. J. Hirnforsch. 37:1996;135-143.
178. Marescaux C., Vergnes M., Kiesmann M., Depaulis A., Micheletti G., Warter J.M. Kindling of audiogenic seizures in Wistar rats: an EEG study. Exp. Neurol. 97(1):1987;60-168.
179. McCormick D.A., Contreras C. On the cellular and network bases of epileptic seizures. Annu. Rev. Physiol. 63:2001;815-846.
180. McCown T.J., Greenwood R.S., Frye G.D., Breese G.R. Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy? Exp. Neurol. 86(3):1984;527-542.
181. McCown T.J., Duncan G.E., Johnson K.B., Breese G.R. Metabolic and functional mapping of the neural network subserving inferior collicular seizure generalization. Brain Res. 701(1-2):1995;117-128.
182. McIntyre D.C., Don J.C., Edson N. Distribution of [14C]2-deoxyglucose after various forms and durations of status epilepticus induced by stimulation of a kindled amygdala focus in rats. Epilepsy Res. 10(2-3):1991;119-133.
183. McNamara J.O. Kindling: an animal model of complex partial epilepsy. Ann. Neurol. 16(Suppl.):1984;S72-S76.
184. Meloni E.G., Davis M. GABA in the deep layers of the superior colliculus/mesencephalic reticular formation mediates the enhancement of startle by the dopamine D1 receptor agonist SKF 82958 in rats. J. Neurosci. 20(14):2000;5374-5381.
185. Menini C., Silva-Barrat C. The photosensitive epilepsy of the baboon. A model of generalized reflex epilepsy. Adv. Neurol. 75:1998;29-47.
186. Merrill M.A., Clough R.W., Jobe P.C., Browning R.A. Role of the superior colliculus and the intercollicular nucleus in the brainstem seizure circuitry of the genetically epilepsy-prone rat. Epilepsia. 44(3):2003;305-314.
187. Merritt H.H., Putnam T.J. A new series of anticonvulsant drugs tested by experiments on animals. Arch. Neurol. Psychiatry. 39:1938;1001-1015.
188. Mikulecky D.C. Complexity, communication between cells, and identifying the functional components of living systems: some observations. Acta Biotheor. 44:1996;179-208.
189. Millan M.H., Meldrum B.S., Faingold C.L. Induction of audiogenic seizure susceptibility by focal infusion of excitant amino acid or bicuculline into the inferior colliculus of normal rats. Exp. Neurol. 91(3):1986;634-639.
190. Millan M.H., Meldrum B.S., Boersma C.A., Faingold C.L. Excitant amino acids and audiogenic seizures in the genetically epilepsy-prone rat. II. Efferent seizure propagating pathway. Exp. Neurol. 99:1988;687-698.
191. Moshe S.L., Garant D.S. Substantia nigra GABA receptors can mediate anticonvulsant or proconvulsant effects. Epilepsy Res. Suppl. 12:1996;247-256.
192. Moshe S.L., Brown L.L., Kubova H., Veliskova J., Zukin R.S., Sperber E.F. Maturation and segregation of brain networks that modify seizures. Brain Res. 665(1):1994;141-146.
193. Mouton L.J., Holstege G. The periaqueductal gray in the cat projects to lamina VIII and the medial part of lamina VII throughout the length of the spinal cord. Exp. Brain Res. 101(2):1994;253-264.
194. Mozrzymas J.W., Barberis A., Mercik K., Zarnowska E.D. Binding sites, singly bound states, and conformation coupling shape gaba-evoked currents. J. Neurophysiol. 89(2):2003;871-883.
195. N'Gouemo P., Faingold C.L. Repetitive audiogenic seizures cause an increased acoustic response in inferior colliculus neurons and additional convulsive behaviors in the genetically-epilepsy prone rat. Brain Res. 710(1-2):1996;92-96.
196. N'Gouemo P., Faingold C.L. Audiogenic kindling increases neuronal responses to acoustic stimuli in neurons of the medial geniculate body of the genetically epilepsy-prone rat. Brain Res. 761(2):1997;217-224.
197. N'Gouemo P., Faingold C.L. Periaqueductal gray neurons exhibit increased responsiveness associated with audiogenic seizures in the genetically epilepsy-prone rat. Neuroscience. 84:1998;619-625.
198. N'Gouemo P., Faingold C.L. Phenytoin administration reveals a differential role of pontine reticular formation and periaqueductal gray neurons in generation of the convulsive behaviors of audiogenic seizures. Brain Res. 859(2):2000;311-317.
199. N'Gouemo P., Caspary D.M., Faingold C.L. Decreased GABA effectiveness in inferior colliculus neurons during ethanol withdrawal in rats susceptible to audiogenic seizures. Brain Res. 724:1996;200-204.
200. Narahashi T. Chemical modulation of sodium channels and GABAA receptor channel. Adv. Neurol. 79:1999;457-480.
201. Naritoku D.K., Randall M.E., Faingold C.L. Microinfusion of GABA agonists and 2-APH into the amygdala reduce seizure duration and clonus in repeated audiogenic seizures of the genetically epilepsy-prone rat. Epilepsia. 30(5):1989;698.
202. Naritoku D.K., Mecozzi L.B., Aiello M.T., Faingold C.L. Repetition of audiogenic seizures in genetically epilepsy-prone rats induces cortical epileptiform activity and additional seizure behaviors. Exp. Neurol. 115:1992;317-324.
203. Nath C., Gupta M.B. Role of central histaminergic system in lorazepam withdrawal syndrome in rats. Pharmacol. Biochem. Behav. 68:2001;777-782.
204. Ni H., Lu Z.H., Wang S.B., Tang M. A transient increase in CCK mRNA levels in hippocampus following audiogenic convulsions in audiogenic seizure-prone rats. Acta Pharmacol. Sin. 21(5):2000;425-428.
205. Niedermeyer E. Review of drugs for control of epilepsy: action on neuronal networks involved in seizure disorders. Electroenceph. Clin. Neurophysiol. 86:1993;357.
206. Nixon K., Crews F.T. Binge ethanol exposure decreases neurogenesis in adult rat hippocampus. J. Neurochem. 83(5):2002;1087-1093.
207. Noga, B.R., Kriellaars, D.J., Brownstone, R.M., Jordan, L.M., 2003. Mechanism for activation of locomotor centers in the spinal cord by stimulation of the mesencephalic locomotor region. J. Neurophysiol. 90, 1464-1478.
208. Norden A.D., Blumenfeld H. The role of subcortical structures in human epilepsy. Epilepsia Behav. 3:2002;219-231.
209. Oh S., Ho I.K. Changes of [3H]muscimol binding and GABA(A) receptor beta2-subunit mRNA level by tolerance to and withdrawal from pentobarbital in rats. Neurochem. Res. 24:1999;1603-1609.
210. Onimaru H., Homma I. A novel functional neuron group for respiratory rhythm generation in the ventral medulla. J. Neurosci. 23(4):2003;1478-1486.
211. Parent J.M. The role of seizure-induced neurogenesis in epileptogenesis and brain repair. Epilepsia Res. 50(1-2):2002;179-189.
212. Parent J.M., Lowenstein D.H. Seizure-induced neurogenesis: are more new neurons good for an adult brain? Prog. Brain Res. 135:2002;121-131.
213. Patrylo P.R., Dudek F.E. Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainate-induced epileptic rats. J. Neurophysiol. 79(1):1998;418-429.
214. Peterson S.L. The effect on maximal electroshock seizures induced by GABA agents and antiepileptic drugs microinfused into the nucleus reticularis pontis oralis. Epilepsia Res. 25(3):1996;161-167.
215. Pitkanen A. Drug-mediated neuroprotection and antiepileptogenesis: animal data. Neurology. 59(9 Suppl. 5):2002;S27-S33.
216. Quill U., Worgotter F. Investigations on emergent spatio-temporal neural response characteristics in a small network model. Biol. Cybern. 83:2000;461-470.
217. Radley J.J., Jacobs B.L. Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a 5-HT(1A) receptor-dependent mechanism. Brain Res. 966(1):2003;1-12.
218. Raggenbass M., Bertrand D. Nicotinic receptors in circuit excitability and epilepsy. J. Neurobiol. 53(4):2002;580-589.
219. Raisinghani M., Faingold C.L. Identification of the requisite brain sites in the neuronal network subserving generalized clonic audiogenic seizures. Brain Res. 967(1-2):2003;113-122.
220. Raisinghani M., Feng H.-J., Faingold C.L. Glutamatergic activation of the amygdala differentially mimics the effects of audiogenic seizure kindling in two sub-strains of genetically epilepsy-prone rats. Exp. Neurol. 183(2):2003;516-522.
221. Ramirez J.M., Zuperku E.J., Alheid G.F., Lieske S.P., Ptak K., McCrimmon D.R. Respiratory rhythm generation: converging concepts from in vitro and in vivo approaches? Respir. Physiolo. Neurobiol. 131(1-2):2002;43-56.
222. Rauch S.L., Shin L.M., Dougherty D.D., Alpert N.M., Fischman A.J., Jenike M.A. Predictors of fluvoxamine response in contamination-related obsessive compulsive disorder: a PET symptom provocation study. Neuropsychopharmacology. 27(5):2002;782-791.
223. Reibel S., Larmet Y., Le B.T., Carnahan J., Marescaux C., Depaulis C. Brain-derived neurotrophic factor delays hippocampal kindling in the rat. Neuroscience. 100:2002;777-788.
224. Reid K.H., Young C., Schurr A., Tsent M., Payne R.S., Keelen P., Miller J., Iyer V. Audiogenic seizures following global ischemia induced by chest compression in Long-Evans rats. Epilepsia Res. 23:1996;195-209.
225. Reigel C.E., Dailey J.W., Jobe P.C. The genetically epilepsy-prone rat: an overview of seizure-prone characteristics and responsiveness to anticonvulsant drugs. Life Sci. 39(9):1986;763-774.
226. Reilly, D.L., Cooper, L.N., 1990. An overview of neuronal networks: early models to real world systems. In: Zorngetzer, S.F., Davis, J.L., Lau, C. (Eds.), An Introduction to Neural and Electronic Networks. Academic Press, San Diego, pp. 227-245.
227. Rekling J.C., Feldman J.L. PreBotzinger complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation. Annu. Rev. Physiol. 60:1998;385-405.
228. Reti I.M., Reddy R., Worley P.F., Baraban J.M. Prominent Narp expression in projection pathways and terminal fields. J. Neurochem. 82(4):2002;935-944.
229. Riaz A., Faingold C.L. Seizures during ethanol withdrawal are blocked by focal microinjection of excitant amino acid antagonists into the inferior colliculus and pontine reticular formation. Alcohol. Clin. Exp. Res. 18:1994;456-1462.
230. Ribak E.E., Morin C.L. The role of the inferior colliculus in a genetic model of audiogenic seizures. Anat. Embryol. 191:1995;279-295.
231. Ribak C.E., Dashtipour K. Neuroplasticity in the damaged dentate gyrus of the epileptic brain. Prog. Brain Res. 136:2002;319-328.
232. Ribak C.E., Byun M.Y., Ruiz G.T., Reiffenstein R.J. Increased levels of amino acid neurotransmitters in the inferior colliculus of the genetically epilepsy-prone rat. Epilepsia Res. 2(1):1988;9-13.
233. Ribak C.E., Khurana V., Lien N.T. The effect of midbrain collicular knife cuts on audiogenic seizure severity in the genetically epilepsy-prone rat. J. Hirnforsch. 35(2):1994;303-311.
234. Ribak C.E., Manio A.L., Navetta M.S., Gall C.M. In situ hybridization for c-fos mRNA reveals the involvement of the superior colliculus in the propagation of seizure activity in genetically epilepsy-prone rats. Epilepsy Res. 26(3):1997;397-406.
235. Rick C.E., Lacey M.G. Rat substantia nigra pars reticulata neurones are tonically inhibited via GABAA, but not GABAB, receptors in vitro. Brain Res. 659(1-2):1994;133-137.
236. Rigo J.M., Hans G., Nguyen L., Rocher V., Belachew S., Malgrange B., Leprince P., Moonen G., Selak I., Matagne A., Klitgaard H. The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. Br. J. Pharmacol. 136(5):2002;659-672.
237. Rosenow F., Arzimanoglou A., Baulac M. Recent developments in treatment of status epilepticus: a review. Epileptic Disord. 4(Suppl. 2):2002;S41-S51.
238. Ross K.C., Coleman J.R., Jones L.S. Anti-epileptiform effects of audiogenic seizure printing on in vitro kindling in rat hippocampus. Neurosci. Lett. 299:2001;234-238.
239. Rubin J., Terman D. Geometric analysis of population rhythms in synaptically coupled neuronal networks. Neural Comput. 12:2000;597-645.
240. Ruppin E., Reggia J.A. Cortical spreading depression and the pathogenesis of brain disorders: a computational and neural network-based investigation. Neurol. Res. 23(5):2001;447-456.
241. Rutecki P.A., Sayin U., Yang Y., Hadar E. Determinants of ictal epileptiform patterns in the hippocampal slice. Epilepsia. 43(Suppl. 5):2002;179-183.
242. Sakamoto T., Niki H. Acoustic priming lowers the threshold for electrically induced seizures in mice inferior colliculus, but not in the deep layers of superior colliculus. Brain Res. 898(2):2001;358-363.
243. Sakamoto T., Mishina M., Niki H. Mutation of NMDA receptor subunit epsilon 1: effects on audiogenic-like seizures induced by electrical stimulation of the inferior colliculus in mice. Brain Res. Mol. Brain Res. 102(1-2):2002;113-117.
244. Saper C.B., Chou T.C., Scammell T.E. The sleep switch: hypothalamic control of sleep and wakefulness. Trends Neurosci. 24(12):2001;726-731.
245. Scannell J.W., Young M.P. Neuronal population activity and functional imaging. Proc. R. Soc., Lond. B. Biol. Sci. 266(1422):1999;875-881.
246. Shehab S., Simkins M., Dean P., Redgrave P. Regional distribution of the anticonvulsant and behavioural effects of muscimol injected into the substantia nigra of rats. Eur. J. Neurosci. 8(4):1996;749-757.
247. Shin C., Scialabba F.A., McNamara J.O. Stimulation of substantia nigra pars reticulata enhances dentate granule cell excitability. Brain Res. 411:1987a;21-27.
248. Shin C., Silver J.M., Bonhaus D.W., McNamara J.O. The role of substantia nigra in the development of kindling: pharmacologic and lesion studies. Brain Res. 412(2):1987b;311-317.
249. Shirakawa S., Funatsuka M., Osawa M., Fujita M., Oguni H. A study of the effect of color photostimulation from a cathode-ray tube (CRT) display on photosensitive patients: the effect of alternating red-cyan flicker stimulation. Epilepsia. 42(7):2001;922-929.
250. Sills G.J., Brodie M.J. Update on the mechanisms of action of antiepileptic drugs. Epileptic Disord. 3(4):2001;165-172.
251. Simler S., Vergnes M., Marescaux C. Spatial and temporal relationships between C-Fos expression and kindling of audiogenic seizures in Wistar rats. Exp. Neurol. 157(1):1999;106-119.
252. Simson P.E., Criswell H.E., Breese G.R. Inhibition of NMDA-evoked electrophysiological activity by ethanol in selected brain regions: evidence for ethanol-sensitive and ethanol-insensitive NMDA-evoked responses. Brain Res. 607(1-2):1993;9-16.
253. Sloviter R.S. Status epilepticus-induced neuronal injury and network reorganization. Epilepsia. 40(Suppl. 1):1999;S34-S39.
254. Smith B.N., Dudek F.E. Network interactions mediated by new excitatory connections between CA1 pyramidal cells in rats with kainate-induced epilepsy. J. Neurophysiol. 87(3):2002;1655-1658.
255. Smith J.C., Butera R.J., Koshiya N., Del Negro C., Wilson C.G., Johnson S.M. Respiratory rhythm generation in neonatal and adult mammals: the hybrid pacemaker-network model. Respir. Physiol. 122(2-3):2000;131-147.
256. Snyder-Keller A.M., Pierson M.G. Audiogenic seizures induce c-fos in a model of developmental epilepsy. Neurosci. Lett. 135(1):1992;108-112.
257. Song J.H., Narahashi T. Modulation of sodium channels of rat cerebellar Purkinje neurons by the pyrethroid tetramethrin. J. Pharmacol. Exp. Ther. 277(1):1996;445-453.
258. Spencer S.S. Neural networks in human epilepsy: evidence of and implications for treatment. Epilepsia. 43(3):2002;219-227.
259. Staba R.J., Wilson C.L., Bragin A., Fried I., Engel J. Jr. Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex. J. Neurophysiol. 88(4):2002;1743-1752.
260. Stables J.P., Bertram E.H., White H.S., Coulter D.A., Dichter M.A., Jacobs M.P., Loscher W., Lowenstein D.H., Moshe S.L., Noebels J.L., Davis M. Models for epilepsy and epileptogenesis: report from the NIH workshop, Bethesda, Maryland. Epilepsia. 43(11):2002;1410-1420.
261. Stanojlovic O., Zivanovic D., Susic V. Potentiation of metaphit-induced audiogenic epilepsy with N-methyl-D-aspartate in rats. Srp. Arh. Celok. Lek. 128:2000;316-321.
262. Stoop R., Blank D., Kern A., Vyver J.-J.V.d., Christen M., Lecchini S., Wagner C. Collective bursting in layer IV synchronization by small thalamic inputs and recurrent connections. Cog. Brain Res. 13:2002;293-304.
263. Straub V.A., Staras K., Kemenes G., Benjamin P.R. Endogenous and network properties of lymnaea feeding central pattern generator interneurons. J. Neurophysiol. 88:2002;1569-1583.
264. h in rat CA1 pyramidal cells. Epilepsia. 44(2):2003;150-156.
265. Sutula T. Antiepileptic drugs to prevent neural degeneration associated with epilepsy: assessing the prospects for neuroprotection. Epilepsy Res. 50(1-2):2002;125-129.
266. Sutula T., Harrison C., Steward O. Chronic epileptogenesis induced by kindling of the entorhinal cortex: the role of the dentate gyrus. Brain Res. 385(2):1986;291-299.
267. Tannenbaum A.S. The sense of consciousness. J. Theor. Biol. 211(4):2001;377-391.
268. Taylor C.P. Mechanisms of new antiepileptic drugs. Adv. Neurol. 79:1999;1011-1026.
269. Tecott L.H., Sun L.M., Akana S.F., Strack A.M., Lowenstein D.H., Dallman M.F., Julius D. Eating disorder and epilepsy in mice lacking 5-HT2c serotonin receptors. Nature. 374:1995;542-546.
270. Tegner J., Compte A., Wang X.J. The dynamical stability of reverberatory neural circuits. Biol. Cybern. 87(5-6):2002;471-481.
271. Teskey G.C., Monfils M.H., VandenBerg P.M., Kleim J.A. Motor map expansion following repeated cortical and limbic seizures is related to synaptic potentiation. Cereb. Cortex. 12(1):2002;98-105.
272. Thomson A.M. Facilitation, augmentation and potentiation at central synapses. Trends Neurosci. 23(7):2000;305-312.
273. Toyomitsu Y., Nishijo H., Uwano T., Kuratsu J., Ono T. Neuronal responses of the rat amygdala during extinction and reassociation learning in elementary and configural associative tasks. Eur. J. Neurosci. 15(4):2002;753-768.
274. Traub R.D., Wong R.K., Miles R., Knowles W.D. Neuronal interactions during epileptic events in vitro. Fed Proc. 44(15):1985;2953-2955.
275. Traub R.D., Jefferys J.G., Whittington M.A. Functionally relevant and functionally disruptive (epileptic) synchronized oscillations in brain slices. Adv. Neurol. 79:1999a;709-724.
276. Traub R.D., Schmitz D., Jefferys J.G., Draguhn A. High-frequency population oscillations are predicted to occur in hippocampal pyramidal neuronal networks interconnected by axoaxonal gap junctions. Neuroscience. 92:1999b;407-426.
277. Traub R.D., Kopell N., Bibbig A., Buhl E.H., LeBeau F.E.N., Whittington M.A. Gap junctions between interneuron dendrites can enhance synchrony of gamma oscillations in distributed networks. J. Neurosci. 21:2001a;9478-9486.
278. Traub R.D., Whittington M.A., Buhl E.H., LeBeau F.E., Bibbig A., Boyd S., Cross H., Baldeweg T. A possible role for gap junctions in generation of very fast EEG oscillations preceding the onset of, and perhaps initiating, seizures. Epilepsia. 42(2):2001b;153-170.
279. Traub R.D., Draguhn A., Whittington M.A., Baldeweg T., Bibbig A., Buhl E.H., Schmitz D. Axonal gap junctions between principal neurons: a novel source of network oscillations, and perhaps epileptogenesis. Rev. Neurosci. 13(1):2002;1-30.
280. Traub R.D., Pais I., Bibbig A., LeBeau F.E., Buhl E.H., Hormuzdi S.G., Monyer H., Whittington M.A. Contrasting roles of axonal (pyramidal cell) and dendritic (interneuron) electrical coupling in the generation of neuronal network oscillations. Proc. Natl. Acad. Sci. U.S.A. 100(3):2003;1370-1374.
281. Tsodyks M., Kenet T., Grinvald A., Arieli A. Linking spontaneous activity of single cortical neurons and the underlying functional architecture. Science. 286(5446):1999;1943-1946.
282. Urban B.W., Friederich P. Anesthetic mechanisms in vitro and in general anesthesia. Toxicol. Lett. 100-101:1998;9-16.
283. Valjakka A., Jaakkola M., Vartiainen J., Olkkonen H., Semiokhina A., Fedotova I., Virkkala J., Ylikoski J., Tuomisto L. The relationship between audiogenic seizure (AGS) susceptibility and forebrain tone-responsiveness in genetically AGS-prone Wistar rats. Physiol. Behav. 70(3-4):2000;297-309.
284. Vega-Hernandez A., Felix R. Down-regulation of N-type voltage-activated Ca2+ channels by gabapentin. Cell Mol. Neurobiol. 22(2):2002;185-190.
285. Velisek L., Veliskova J., Moshe S.L. Electrical stimulation of substantia nigra pars reticulata is anticonvulsant in adult and young male rats. Exp. Neurol. 173(1):2002;145-152.
286. A receptors involved in seizures. Eur. J. Pharmacol. 309:1996;167-173.
287. Veliskova J., Kubova H., Friedman L.K., Wu R., Sperber E.F., Zukin R.S., Moshe S.L. The expression of GABA(A) receptor subunits in the substantia nigra is developmentally regulated and region-specific. Ital. J. Neurol. Sci. 19:1998a;205-210.
288. Veliskova J., Loscher W., Moshe S.L. Regional and age specific effects of zolpidem microinfusions in the substantia nigra on seizures. Epilepsy Res. 30(2):1998b;107-114.
289. Veliskova O.J., Liptakova S., Hussain S. The effects of N-methyl-D-aspartate antagonist 2-amino-7-phosphonoheptanoic acid microinfusions into the adult male rat substantia nigra pars reticulata are site-specific. Neurosci. Lett. 316(2):2001;108-110.
290. Wada J.A. Susceptibility to audiogenic seizure induced by thiosemicarbazide. Electroenceph. Clin. Neurophysiol. 28:1970;100.
291. Wahnschaffe U., Loscher W. Effect of selective bilateral destruction of the substantia nigra on antiepileptic drug actions in kindled rats. Eur. J. Pharmacol. 186(2-3):1990;157-167.
292. Wakade C.G., Mahadik S.P., Waller J.L., Chiu F.C. Atypical neuroleptics stimulate neurogenesis in adult rat brain. J. Neurosci. Res. 69(1):2002;72-79.
293. Wall M. Furosemide reveals heterogeneous GABA(A) receptor expression at adult rat Golgi cell to granule cell synapses. Neuropharmacology. 43(4):2002;737-749.
294. Waltz S., Stephani U. Inheritance of photosensitivity. Neuropediatrics. 31(2):2000;82-85.
295. Wang Z.J., Snell L.D., Tabakoff B., Levinson S.R. Inhibition of neuronal Na+ channels by the novel antiepileptic compound DCUKA: identification of the diphenylureido moiety as an inactivation modifier. Exp. Neurol. 178(1):2002;129-138.
296. Waszczak B.L., Lee E.K., Walters J.R. Effects of anticonvulsant drugs on substantia nigra pars reticulata neurons. J. Pharmacol. Exp. Ther. 239(2):1986;606-611.
297. Weber M., Schnitzler H.U., Schmid S. Synaptic plasticity in the acoustic startle pathway: the neuronal basis for short-term habituation? Eur. J. Neurosci. 16(7):2002;1325-1332.
298. White H.S., Woodbury D.M., Chen C.F., Kemp J.W., Chow S.Y., Yen-Chow Y.C. Role of glial cation and anion transport mechanisms in etiology and arrest of seizures. Adv. Neurol. 44:1986;695-712.
299. Whittington M.A., Traub R.D., Kopell N., Ermentrout B., Buhl E.H. Inhibition-based rhythms: experimental and mathematical observations on network dynamics. Int. J. Psychophysiol. 38:2000;315-336.
300. Willoughby J.O. Mechanisms underlying partial (focal, or lesional) epilepsy. J. Clin. Neurosci. 7:2000;291-294.
301. Willoughby J.O., Fitzgibbon S.P., Pope K.J., Mackenzie L., Medvedev A.V., Clark C.R., Davey M.P., Wilcox R.A. Persistent abnormality detected in the non-ictal electroencephalogram in primary generalized epilepsy. J. Neurol. Neurosurg. Psychiatry. 74(1):2003;51-55.
302. Wolf R., Tscherne U. Valproate effect on gamma-aminobutyric acid release in pars reticulata of substantia nigra: combination of push-pull perfusion and fluorescence histochemistry. Epilepsia. 35(1):1994;226-233.
303. Wong R.K., Traub R.D., Miles R. Cellular basis of neuronal synchrony in epilepsy. Adv Neurol. 44:1986;583-592.
304. Woodbury D.M. Phenytoin: proposed mechanisms of anticonvulsant action. Adv. Neurol. 27:1980;447-471.
305. Woody C.D., Zotova E., Gruen E. Multiple representations of information in the primary auditory cortex of cats. I. Stability and change in slow components of unit activity after conditioning with a click conditioned stimulus. Brain Res. 868(1):2000;56-65.
306. Worrell G.A., Cranstoun S.D., Echauz J., Litt B. Evidence for self-organized criticality in human epileptic hippocampus. Neuroreport. 13(16):2002;2017-2021.
307. Wu J., Javedan S.P., Ellsworth K., Smith K., Fisher R.S. Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices. BMC. Neurosci. 2(1):2001;18.
308. Xi M.C., Morales F.R., Chase M.H. The motor inhibitory system operating during active sleep is tonically suppressed by GABAergic mechanisms during other states. J. Neurophysiol. 86(4):2001;1908-1915.
309. Yagil G. Complexity and hierarchy: a level rule. Complexity. 4:1999;22-27.
310. Yang K., Ma W.L., Feng Y.P., Dong Y.X., Li Y.Q. Origins of GABA(B) receptor-like immunoreactive terminals in the rat spinal dorsal horn. Brain Res. Bull. 58(5):2002;499-507.
311. Yang, L., Faingold, C.L., 2002a. The amygdala is a requisite nucleus in the neuronal network for ethanol withdrawal seizures. Soc. Neurosci. Abs. 28, Prog. #607.1.
312. Yang L., Faingold C.L. Modification of ethanol withdrawal (ETX)-induced firing patterns in periaqueductal gray (PAG) neurons by anticonvulsant drugs. Alcohol. Clin. Exp. Res. 26:2002b;22A.
313. Yang L., Long C., Faingold C.L. Audiogenic seizure susceptibility is induced by termination of continuous infusion of GABA or an NMDA antagonist into the inferior colliculus. Exp. Neurol. 171:2001;147-152.
314. Yang L., Long C., Evans M.S., Faingold C.L. Ethanol withdrawal results in aberrant membrane properties and synaptic responses in periaqueductal gray neurons associated with seizure susceptibility. Brain Res. 957(1):2002;99-108.
315. Yang L., Long C., Randall M.E., Faingold C.L. Neurons in the periaqueductal gray are critically involved in the neuronal network for audiogenic seizures during ethanol withdrawal. Neuropharmacology. 44(2):2003;275-281.
316. Yepes M., Sandkvist M., Coleman T.A., Moore E., Wu J.Y., Mitola D., Bugge T.H., Lawrence D.A. Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent. J. Clin. Invest. 109(12):2002;1571-1578.
317. Zhan R.Z., Fujiwara N., Yamakura T., Taga K., Fukuda S., Shimoji K. Differential inhibitory effects of thiopental, thiamylal and phenobarbital on both voltage-gated calcium channels and NMDA receptors in rat hippocampal slices. Br. J. Anaesth. 81(6):1998;932-939.
318. Zhang R., Wang Y., Zhang L., Zhang Z., Tsang W., Lu M., Zhang L., Chopp M. Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke. 33(11):2002;2675-2680.
319. Zifkin B.G., Kasteleijn-Nolst Trenite D. Reflex epilepsy and reflex seizures of the visual system: a clinical review. Epileptic Disord. 2(3):2000;129-136.
320. Zoli M., Agnati L.F. Wiring and volume transmission in the central nervous system: the concept of closed and open synapses. Prog. Neurobiol. 49(4):1996;363-380.