메뉴 건너뛰기




Volumn 31, Issue 6, 2014, Pages 579-585

Escherichia coli as a cell factory for heterologous production of nonribosomal peptides and polyketides

Author keywords

[No Author keywords available]

Indexed keywords

METABOLIC ENGINEERING; MICROORGANISMS; PEPTIDES; PRODUCTIVITY;

EID: 84910053480     PISSN: 18716784     EISSN: 18764347     Source Type: Journal    
DOI: 10.1016/j.nbt.2014.03.006     Document Type: Article
Times cited : (45)

References (57)
  • 1
    • 84878280763 scopus 로고    scopus 로고
    • A historical overview of natural products in drug discovery
    • Dias D.A., Urban S., Roessner U. A historical overview of natural products in drug discovery. Metabolites 2012, 2:303-336.
    • (2012) Metabolites , vol.2 , pp. 303-336
    • Dias, D.A.1    Urban, S.2    Roessner, U.3
  • 2
    • 84858308226 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the 30 years from 1981 to 2010
    • Newman D.J., Cragg G.M. Natural products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod 2012, 75:311-335.
    • (2012) J Nat Prod , vol.75 , pp. 311-335
    • Newman, D.J.1    Cragg, G.M.2
  • 3
    • 0034082239 scopus 로고    scopus 로고
    • The influence of natural products upon drug discovery
    • Newman D.J., Cragg G.M., Snader K.M. The influence of natural products upon drug discovery. Nat Prod Rep 2000, 17:215-234.
    • (2000) Nat Prod Rep , vol.17 , pp. 215-234
    • Newman, D.J.1    Cragg, G.M.2    Snader, K.M.3
  • 4
    • 0033485280 scopus 로고    scopus 로고
    • The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases
    • Cane D.E., Walsh C.T. The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases. Chem Biol 1999, 6:R319-R325.
    • (1999) Chem Biol , vol.6 , pp. R319-R325
    • Cane, D.E.1    Walsh, C.T.2
  • 5
    • 0032475992 scopus 로고    scopus 로고
    • Harnessing the biosynthetic code: combinations, permutations, and mutations
    • Cane D.E., Walsh C.T., Khosla C. Harnessing the biosynthetic code: combinations, permutations, and mutations. Science 1998, 282:63-68.
    • (1998) Science , vol.282 , pp. 63-68
    • Cane, D.E.1    Walsh, C.T.2    Khosla, C.3
  • 6
    • 33748631825 scopus 로고    scopus 로고
    • Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms
    • Fischbach M.A., Walsh C.T. Assembly-line enzymology for polyketide and nonribosomal peptide antibiotics: logic, machinery, and mechanisms. Chem Rev 2006, 106:3468-3496.
    • (2006) Chem Rev , vol.106 , pp. 3468-3496
    • Fischbach, M.A.1    Walsh, C.T.2
  • 7
    • 1642304143 scopus 로고    scopus 로고
    • Polyketide and nonribosomal peptide antibiotics: modularity and versatility
    • Walsh C.T. Polyketide and nonribosomal peptide antibiotics: modularity and versatility. Science 2004, 303:1805-1810.
    • (2004) Science , vol.303 , pp. 1805-1810
    • Walsh, C.T.1
  • 8
    • 34447524208 scopus 로고    scopus 로고
    • Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis
    • Galm U., Shen B. Expression of biosynthetic gene clusters in heterologous hosts for natural product production and combinatorial biosynthesis. Expert Opin Drug Discov 2006, 1:409-437.
    • (2006) Expert Opin Drug Discov , vol.1 , pp. 409-437
    • Galm, U.1    Shen, B.2
  • 9
    • 84893170608 scopus 로고    scopus 로고
    • Recent advances in the heterologous expression of microbial natural product biosynthetic pathways
    • Ongley S.E., Bian X., Neilan B.A., Müller R. Recent advances in the heterologous expression of microbial natural product biosynthetic pathways. Nat Prod Rep 2013, 30:1121-1138.
    • (2013) Nat Prod Rep , vol.30 , pp. 1121-1138
    • Ongley, S.E.1    Bian, X.2    Neilan, B.A.3    Müller, R.4
  • 10
    • 78649391538 scopus 로고    scopus 로고
    • Methods and options for the heterologous production of complex natural products
    • Zhang H., Boghigian B.A., Armando J., Pfeifer B.A. Methods and options for the heterologous production of complex natural products. Nat Prod Rep 2011, 28:125-151.
    • (2011) Nat Prod Rep , vol.28 , pp. 125-151
    • Zhang, H.1    Boghigian, B.A.2    Armando, J.3    Pfeifer, B.A.4
  • 11
    • 42549165756 scopus 로고    scopus 로고
    • Bacterial hosts for natural product production
    • Zhang H., Wang Y., Pfeifer B.A. Bacterial hosts for natural product production. Mol Pharmaceut 2008, 5:212-225.
    • (2008) Mol Pharmaceut , vol.5 , pp. 212-225
    • Zhang, H.1    Wang, Y.2    Pfeifer, B.A.3
  • 12
    • 84863303532 scopus 로고    scopus 로고
    • Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements
    • Huang C.J., Lin H., Yang X. Industrial production of recombinant therapeutics in Escherichia coli and its recent advancements. J Ind Microbiol Biotechnol 2012, 39:383-399.
    • (2012) J Ind Microbiol Biotechnol , vol.39 , pp. 383-399
    • Huang, C.J.1    Lin, H.2    Yang, X.3
  • 13
    • 79952481797 scopus 로고    scopus 로고
    • Recent developments in difficult protein expression: a guide to E. coli strains, promoters, and relevant host mutations
    • Samuelson J.C. Recent developments in difficult protein expression: a guide to E. coli strains, promoters, and relevant host mutations. Methods Mol Biol 2011, 705:195-209.
    • (2011) Methods Mol Biol , vol.705 , pp. 195-209
    • Samuelson, J.C.1
  • 14
    • 84879147807 scopus 로고    scopus 로고
    • Expression in Escherichia coli: becoming faster and more complex
    • Vincentelli R., Romier C. Expression in Escherichia coli: becoming faster and more complex. Curr Opin Struct Biol 2013, 23:326-334.
    • (2013) Curr Opin Struct Biol , vol.23 , pp. 326-334
    • Vincentelli, R.1    Romier, C.2
  • 15
    • 77957329119 scopus 로고    scopus 로고
    • Isoprenoid pathway optimization for taxol precursor overproduction in Escherichia coli
    • Ajikumar P.K., Xiao W-H., Tyo K.E.J., Wang Y., Simeon F., Leonard E., et al. Isoprenoid pathway optimization for taxol precursor overproduction in Escherichia coli. Science 2010, 330:70-74.
    • (2010) Science , vol.330 , pp. 70-74
    • Ajikumar, P.K.1    Xiao, W.-H.2    Tyo, K.E.J.3    Wang, Y.4    Simeon, F.5    Leonard, E.6
  • 16
    • 78649323531 scopus 로고    scopus 로고
    • Engineered polyketide biosynthesis and biocatalysis in Escherichia coli
    • Gao X., Wang P., Tang Y. Engineered polyketide biosynthesis and biocatalysis in Escherichia coli. Appl Microbiol Biotechnol 2010, 88:1233-1242.
    • (2010) Appl Microbiol Biotechnol , vol.88 , pp. 1233-1242
    • Gao, X.1    Wang, P.2    Tang, Y.3
  • 18
    • 80054062747 scopus 로고    scopus 로고
    • Recombinant production of antimicrobial peptides in Escherichia coli: a review
    • Li Y. Recombinant production of antimicrobial peptides in Escherichia coli: a review. Protein Expr Purif 2011, 80:260-267.
    • (2011) Protein Expr Purif , vol.80 , pp. 260-267
    • Li, Y.1
  • 20
    • 0032501971 scopus 로고    scopus 로고
    • Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases
    • Quadri L.E.N., Weinreb P.H., Lei M., Nakano M.M., Zuber P., Walsh C.T. Characterization of Sfp, a Bacillus subtilis phosphopantetheinyl transferase for peptidyl carrier protein domains in peptide synthetases. Biochemistry 1998, 37:1585-1595.
    • (1998) Biochemistry , vol.37 , pp. 1585-1595
    • Quadri, L.E.N.1    Weinreb, P.H.2    Lei, M.3    Nakano, M.M.4    Zuber, P.5    Walsh, C.T.6
  • 21
    • 0035793858 scopus 로고    scopus 로고
    • Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli
    • Pfeifer B.A., Admiraal S.J., Gramajo H., Cane D.E., Khosla C. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science 2001, 291:1790-1792.
    • (2001) Science , vol.291 , pp. 1790-1792
    • Pfeifer, B.A.1    Admiraal, S.J.2    Gramajo, H.3    Cane, D.E.4    Khosla, C.5
  • 23
    • 2942560272 scopus 로고    scopus 로고
    • In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coli
    • Gruenewald S., Mootz H.D., Stehmeier P., Stachelhaus T. In vivo production of artificial nonribosomal peptide products in the heterologous host Escherichia coli. Appl Environ Microbiol 2004, 70:3282-3291.
    • (2004) Appl Environ Microbiol , vol.70 , pp. 3282-3291
    • Gruenewald, S.1    Mootz, H.D.2    Stehmeier, P.3    Stachelhaus, T.4
  • 24
    • 38949101150 scopus 로고    scopus 로고
    • Improved production of triostin A in engineered Escherichia coli with furnished quinoxaline chromophore by design of experiments in small-scale culture
    • Praseuth A.P., Praseuth M.B., Oguri H., Oikawa H., Watanabe K., Wang C.C.C. Improved production of triostin A in engineered Escherichia coli with furnished quinoxaline chromophore by design of experiments in small-scale culture. Biotechnol Prog 2008, 24:134-139.
    • (2008) Biotechnol Prog , vol.24 , pp. 134-139
    • Praseuth, A.P.1    Praseuth, M.B.2    Oguri, H.3    Oikawa, H.4    Watanabe, K.5    Wang, C.C.C.6
  • 25
    • 67649961441 scopus 로고    scopus 로고
    • Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product
    • Watanabe K., Hotta K., Nakaya M., Praseuth A.P., Wang C.C.C., Inada D., et al. Escherichia coli allows efficient modular incorporation of newly isolated quinomycin biosynthetic enzyme into echinomycin biosynthetic pathway for rational design and synthesis of potent antibiotic unnatural natural product. J Am Chem Soc 2009, 131:9347-9353.
    • (2009) J Am Chem Soc , vol.131 , pp. 9347-9353
    • Watanabe, K.1    Hotta, K.2    Nakaya, M.3    Praseuth, A.P.4    Wang, C.C.C.5    Inada, D.6
  • 26
    • 70349554130 scopus 로고    scopus 로고
    • Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli
    • Watanabe K., Hotta K., Praseuth A.P., Searcey M., Wang C.C.C., Oguri H., et al. Rationally engineered total biosynthesis of a synthetic analogue of a natural quinomycin depsipeptide in Escherichia coli. ChemBioChem 2009, 10:1965-1968.
    • (2009) ChemBioChem , vol.10 , pp. 1965-1968
    • Watanabe, K.1    Hotta, K.2    Praseuth, A.P.3    Searcey, M.4    Wang, C.C.C.5    Oguri, H.6
  • 27
    • 84880681824 scopus 로고    scopus 로고
    • Optimizing dimodular nonribosomal peptide synthetases and natural dipeptides in an Escherichia coli heterologous host
    • Wyatt M.A., Magarvey N.A. Optimizing dimodular nonribosomal peptide synthetases and natural dipeptides in an Escherichia coli heterologous host. Biochem Cell Biol 2013, 91:203-208.
    • (2013) Biochem Cell Biol , vol.91 , pp. 203-208
    • Wyatt, M.A.1    Magarvey, N.A.2
  • 28
    • 84884615399 scopus 로고    scopus 로고
    • High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium
    • Ongley S.E., Bian X., Zhang Y., Chau R., Gerwick W.H., Müller R., et al. High-titer heterologous production in E. coli of lyngbyatoxin, a protein kinase C activator from an uncultured marine cyanobacterium. ACS Chem Biol 2013, 8:1888-1893.
    • (2013) ACS Chem Biol , vol.8 , pp. 1888-1893
    • Ongley, S.E.1    Bian, X.2    Zhang, Y.3    Chau, R.4    Gerwick, W.H.5    Müller, R.6
  • 29
    • 84895071143 scopus 로고    scopus 로고
    • Enhanced production of the nonribosomal peptide antibiotic valinomycin in Escherichia coli through small-scale high cell density fed-batch cultivation
    • Li J., Jaitzig J., Hillig F., Süssmuth R., Neubauer P. Enhanced production of the nonribosomal peptide antibiotic valinomycin in Escherichia coli through small-scale high cell density fed-batch cultivation. Appl Microbiol Biotechnol 2014, 98:591-601.
    • (2014) Appl Microbiol Biotechnol , vol.98 , pp. 591-601
    • Li, J.1    Jaitzig, J.2    Hillig, F.3    Süssmuth, R.4    Neubauer, P.5
  • 30
    • 1942455740 scopus 로고    scopus 로고
    • Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli
    • Lau J., Tran C., Licari P., Galazzo J. Development of a high cell-density fed-batch bioprocess for the heterologous production of 6-deoxyerythronolide B in Escherichia coli. J Biotechnol 2004, 110:95-103.
    • (2004) J Biotechnol , vol.110 , pp. 95-103
    • Lau, J.1    Tran, C.2    Licari, P.3    Galazzo, J.4
  • 31
    • 18444395871 scopus 로고    scopus 로고
    • Production of the potent antibacterial polyketide erythromycin C in Escherichia coli
    • Peirú S., Menzella H.G., Rodríguez E., Carney J., Gramajo H. Production of the potent antibacterial polyketide erythromycin C in Escherichia coli. Appl Environ Microbiol 2005, 71:2539-2547.
    • (2005) Appl Environ Microbiol , vol.71 , pp. 2539-2547
    • Peirú, S.1    Menzella, H.G.2    Rodríguez, E.3    Carney, J.4    Gramajo, H.5
  • 32
    • 84856576230 scopus 로고    scopus 로고
    • Improved E. coli erythromycin A production through the application of metabolic and bioprocess engineering
    • Zhang H., Skalina K., Jiang M., Pfeifer B.A. Improved E. coli erythromycin A production through the application of metabolic and bioprocess engineering. Biotechnol Prog 2012, 28:292-296.
    • (2012) Biotechnol Prog , vol.28 , pp. 292-296
    • Zhang, H.1    Skalina, K.2    Jiang, M.3    Pfeifer, B.A.4
  • 33
    • 0031905709 scopus 로고    scopus 로고
    • Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts
    • Kealey J.T., Liu L., Santi D.V., Betlach M.C., Barr P.J. Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts. Proc Natl Acad Sci U S A 1998, 95:505-509.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 505-509
    • Kealey, J.T.1    Liu, L.2    Santi, D.V.3    Betlach, M.C.4    Barr, P.J.5
  • 34
    • 58549085193 scopus 로고    scopus 로고
    • Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli
    • Zhang W., Li Y., Tang Y. Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli. Proc Natl Acad Sci U S A 2008, 105:20683-20688.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 20683-20688
    • Zhang, W.1    Li, Y.2    Tang, Y.3
  • 35
    • 31544449418 scopus 로고    scopus 로고
    • Heterologous production of epothilone C and D in Escherichia coli
    • Mutka S.C., Carney J.R., Liu Y., Kennedy J. Heterologous production of epothilone C and D in Escherichia coli. Biochemistry 2006, 45:1321-1330.
    • (2006) Biochemistry , vol.45 , pp. 1321-1330
    • Mutka, S.C.1    Carney, J.R.2    Liu, Y.3    Kennedy, J.4
  • 36
    • 0242405686 scopus 로고    scopus 로고
    • Biosynthesis of yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host
    • Pfeifer B.A., Wang C.C.C., Walsh C.T., Khosla C. Biosynthesis of yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Appl Environ Microbiol 2003, 69:6698-6702.
    • (2003) Appl Environ Microbiol , vol.69 , pp. 6698-6702
    • Pfeifer, B.A.1    Wang, C.C.C.2    Walsh, C.T.3    Khosla, C.4
  • 37
    • 84904539894 scopus 로고    scopus 로고
    • Reconstituted biosynthesis of the nonribosomal macrolactone antibiotic valinomycin in Escherichia coli
    • Jaitzig J., Li J., Süssmuth R.D., Neubauer P. Reconstituted biosynthesis of the nonribosomal macrolactone antibiotic valinomycin in Escherichia coli. ACS Synth Biol 2013, 10.1021/sb400082j.
    • (2013) ACS Synth Biol
    • Jaitzig, J.1    Li, J.2    Süssmuth, R.D.3    Neubauer, P.4
  • 38
    • 70349645395 scopus 로고    scopus 로고
    • Valinomycin biosynthetic gene cluster in Streptomyces: conservation, ecology and evolution
    • Matter A.M., Hoot S.B., Anderson P.D., Neves S.S., Cheng Y.Q. Valinomycin biosynthetic gene cluster in Streptomyces: conservation, ecology and evolution. PLoS ONE 2009, 4:e7194.
    • (2009) PLoS ONE , vol.4 , pp. e7194
    • Matter, A.M.1    Hoot, S.B.2    Anderson, P.D.3    Neves, S.S.4    Cheng, Y.Q.5
  • 39
    • 0042100690 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production
    • Murli S., Kennedy J., Dayem L.C., Carney J.R., Kealey J.T. Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. J Ind Microbiol Biotechnol 2003, 30:500-509.
    • (2003) J Ind Microbiol Biotechnol , vol.30 , pp. 500-509
    • Murli, S.1    Kennedy, J.2    Dayem, L.C.3    Carney, J.R.4    Kealey, J.T.5
  • 40
    • 0036306047 scopus 로고    scopus 로고
    • Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B
    • Pfeifer B., Hu Z., Licari P., Khosla C. Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B. Appl Environ Microbiol 2002, 68:3287-3292.
    • (2002) Appl Environ Microbiol , vol.68 , pp. 3287-3292
    • Pfeifer, B.1    Hu, Z.2    Licari, P.3    Khosla, C.4
  • 41
    • 70350158311 scopus 로고    scopus 로고
    • Efficient experimental design and micro-scale medium enhancement of 6-deoxyerythronolide B production through Escherichia coli
    • Pistorino M., Pfeifer B.A. Efficient experimental design and micro-scale medium enhancement of 6-deoxyerythronolide B production through Escherichia coli. Biotechnol Prog 2009, 25:1364-1371.
    • (2009) Biotechnol Prog , vol.25 , pp. 1364-1371
    • Pistorino, M.1    Pfeifer, B.A.2
  • 42
    • 35648976621 scopus 로고    scopus 로고
    • Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene
    • Wang Y., Boghigian B., Pfeifer B. Improving heterologous polyketide production in Escherichia coli by overexpression of an S-adenosylmethionine synthetase gene. Appl Microbiol Biotechnol 2007, 77:367-373.
    • (2007) Appl Microbiol Biotechnol , vol.77 , pp. 367-373
    • Wang, Y.1    Boghigian, B.2    Pfeifer, B.3
  • 43
    • 0035068571 scopus 로고    scopus 로고
    • Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units
    • Heathcote M.L., Staunton J., Leadlay P.F. Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units. Chem Biol 2001, 8:207-220.
    • (2001) Chem Biol , vol.8 , pp. 207-220
    • Heathcote, M.L.1    Staunton, J.2    Leadlay, P.F.3
  • 44
    • 0037073685 scopus 로고    scopus 로고
    • Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin
    • Kim B.S., Cropp T.A., Beck B.J., Sherman D.H., Reynolds K.A. Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin. J Biol Chem 2002, 277:48028-48034.
    • (2002) J Biol Chem , vol.277 , pp. 48028-48034
    • Kim, B.S.1    Cropp, T.A.2    Beck, B.J.3    Sherman, D.H.4    Reynolds, K.A.5
  • 45
    • 74849084621 scopus 로고    scopus 로고
    • Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli
    • Zhang H., Boghigian B.A., Pfeifer B.A. Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli. Biotechnol Bioeng 2010, 105:567-573.
    • (2010) Biotechnol Bioeng , vol.105 , pp. 567-573
    • Zhang, H.1    Boghigian, B.A.2    Pfeifer, B.A.3
  • 46
    • 79954618309 scopus 로고    scopus 로고
    • Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions
    • Boghigian B.A., Zhang H., Pfeifer B.A. Multi-factorial engineering of heterologous polyketide production in Escherichia coli reveals complex pathway interactions. Biotechnol Bioeng 2011, 108:1360-1371.
    • (2011) Biotechnol Bioeng , vol.108 , pp. 1360-1371
    • Boghigian, B.A.1    Zhang, H.2    Pfeifer, B.A.3
  • 47
    • 37349092706 scopus 로고    scopus 로고
    • 6-Deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli
    • Wang Y., Pfeifer B.A. 6-Deoxyerythronolide B production through chromosomal localization of the deoxyerythronolide B synthase genes in E. coli. Metab Eng 2008, 10:33-38.
    • (2008) Metab Eng , vol.10 , pp. 33-38
    • Wang, Y.1    Pfeifer, B.A.2
  • 48
    • 78649386219 scopus 로고    scopus 로고
    • Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host
    • Zhang H., Wang Y., Wu J., Skalina K., Pfeifer B.A. Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host. Chem Biol 2010, 17:1232-1240.
    • (2010) Chem Biol , vol.17 , pp. 1232-1240
    • Zhang, H.1    Wang, Y.2    Wu, J.3    Skalina, K.4    Pfeifer, B.A.5
  • 49
    • 0034673927 scopus 로고    scopus 로고
    • Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum
    • Julien B., Shah S., Ziermann R., Goldman R., Katz L., Khosla C. Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum. Gene 2000, 249:153-160.
    • (2000) Gene , vol.249 , pp. 153-160
    • Julien, B.1    Shah, S.2    Ziermann, R.3    Goldman, R.4    Katz, L.5    Khosla, C.6
  • 50
    • 2942635105 scopus 로고    scopus 로고
    • Precursor-directed biosynthesis of epothilone in Escherichia coli
    • Boddy C.N., Hotta K., Tse M.L., Watts R.E., Khosla C. Precursor-directed biosynthesis of epothilone in Escherichia coli. J Am Chem Soc 2004, 126:7436-7437.
    • (2004) J Am Chem Soc , vol.126 , pp. 7436-7437
    • Boddy, C.N.1    Hotta, K.2    Tse, M.L.3    Watts, R.E.4    Khosla, C.5
  • 51
    • 45849114725 scopus 로고    scopus 로고
    • Current status, strategies, and potential for the metabolic engineering of heterologous polyketides in Escherichia coli
    • Boghigian B., Pfeifer B. Current status, strategies, and potential for the metabolic engineering of heterologous polyketides in Escherichia coli. Biotechnol Lett 2008, 30:1323-1330.
    • (2008) Biotechnol Lett , vol.30 , pp. 1323-1330
    • Boghigian, B.1    Pfeifer, B.2
  • 52
    • 77649311467 scopus 로고    scopus 로고
    • A novel fed-batch based cultivation method provides high cell-density and improves yield of soluble recombinant proteins in shaken cultures
    • Krause M., Ukkonen K., Haataja T., Ruottinen M., Glumoff T., Neubauer A., et al. A novel fed-batch based cultivation method provides high cell-density and improves yield of soluble recombinant proteins in shaken cultures. Microb Cell Fact 2010, 9:11.
    • (2010) Microb Cell Fact , vol.9 , pp. 11
    • Krause, M.1    Ukkonen, K.2    Haataja, T.3    Ruottinen, M.4    Glumoff, T.5    Neubauer, A.6
  • 53
    • 79960647620 scopus 로고    scopus 로고
    • Parallel production and verification of protein products using a novel high-throughput screening method
    • Tegel H., Yderland L., Boström T., Eriksson C., Ukkonen K., Vasala A., et al. Parallel production and verification of protein products using a novel high-throughput screening method. Biotechnol J 2011, 6:1018-1025.
    • (2011) Biotechnol J , vol.6 , pp. 1018-1025
    • Tegel, H.1    Yderland, L.2    Boström, T.3    Eriksson, C.4    Ukkonen, K.5    Vasala, A.6
  • 54
    • 83155185459 scopus 로고    scopus 로고
    • High-yield production of biologically active recombinant protein in shake flask culture by combination of enzyme-based glucose delivery and increased oxygen transfer
    • Ukkonen K., Vasala A., Ojamo H., Neubauer P. High-yield production of biologically active recombinant protein in shake flask culture by combination of enzyme-based glucose delivery and increased oxygen transfer. Microb Cell Fact 2011, 10:107.
    • (2011) Microb Cell Fact , vol.10 , pp. 107
    • Ukkonen, K.1    Vasala, A.2    Ojamo, H.3    Neubauer, P.4
  • 55
    • 84880886319 scopus 로고    scopus 로고
    • Effect of culture medium, host strain and oxygen transfer on recombinant Fab antibody fragment yield and leakage to medium in shaken E. coli cultures
    • Ukkonen K., Veijola J., Vasala A., Neubauer P. Effect of culture medium, host strain and oxygen transfer on recombinant Fab antibody fragment yield and leakage to medium in shaken E. coli cultures. Microb Cell Fact 2013, 12:73.
    • (2013) Microb Cell Fact , vol.12 , pp. 73
    • Ukkonen, K.1    Veijola, J.2    Vasala, A.3    Neubauer, P.4
  • 56
    • 46249123248 scopus 로고    scopus 로고
    • Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues
    • Amir-Heidari B., Thirlway J., Micklefield J. Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues. Org Biomol Chem 2008, 6:975-978.
    • (2008) Org Biomol Chem , vol.6 , pp. 975-978
    • Amir-Heidari, B.1    Thirlway, J.2    Micklefield, J.3
  • 57
    • 34347263411 scopus 로고    scopus 로고
    • Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues
    • Powell A., Al Nakeeb M., Wilkinson B., Micklefield J. Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues. Chem Commun 2007, 26:2683-2685.
    • (2007) Chem Commun , vol.26 , pp. 2683-2685
    • Powell, A.1    Al Nakeeb, M.2    Wilkinson, B.3    Micklefield, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.