Precursor-directed biosynthesis of epothilone in Escherichia coil

Journal of the American Chemical Society

Volumn 126, Issue 24, 2004, Pages 7436-7437

  Boddy, Christopher N ^a   Hotta, Kinya ^a   Tse, Martha Lovato ^a   Watts, R Edward ^a   Khosla, Chaitan ^a  

^a Stanford University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPOTHILONE A;

ARTICLE; BIOENGINEERING; BIOSYNTHESIS; COMBINATORIAL CHEMISTRY; COMPLEX FORMATION; ESCHERICHIA COLI; MITOSIS; MOLECULAR BIOLOGY; NONHUMAN; PRECURSOR;

ANTIBIOTICS, ANTINEOPLASTIC; EPOTHILONES; ESCHERICHIA COLI; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; PROTEIN PRECURSORS;

EID: 2942635105     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja048108s     Document Type: Article

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27. The non-native 15R configured acyl chain is likely hydrolyzed by the thioesterase domain.4d This step is anticipated to be faster than the initial acylation of KS domain of epoD-M6.