Reconstituted biosynthesis of the nonribosomal macrolactone antibiotic valinomycin in Escherichia coli

ACS Synthetic Biology

Volumn 3, Issue 7, 2014, Pages 432-438

  Jaitzig, Jennifer ^a   Li, Jian ^a   Süssmuth, Roderich D ^a   Neubauer, Peter ^a  

^a TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

Author keywords

cyclodepsipeptide antibiotic; heterologous expression; nonribosomal peptide synthetase; secondary metabolite production; synthetic biology; valinomycin biosynthesis

Indexed keywords

NONRIBOSOMAL PEPTIDE; NONRIBOSOMAL PEPTIDE SYNTHETASE; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; VALINOMYCIN; VALINOMYCIN SYNTHETASE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; PEPTIDE SYNTHASE;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CONTROLLED STUDY; CULTURE MEDIUM; CULTURE OPTIMIZATION; ENZYME ACTIVITY; ENZYME ENGINEERING; ENZYME MECHANISM; ESCHERICHIA COLI; GENETIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN PROCESSING; REPRODUCIBILITY; STREPTOMYCES; STREPTOMYCES TSUSIMAENSIS; BIOSYNTHESIS; CHEMISTRY; ENZYMOLOGY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ESCHERICHIA COLI; MASS SPECTROMETRY; PEPTIDE SYNTHASES; STREPTOMYCES; VALINOMYCIN;

EID: 84904539894     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/sb400082j     Document Type: Article

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