Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin

Journal of Biological Chemistry

Volumn 277, Issue 50, 2002, Pages 48028-48034

  Kim, Beom Seok ^a   Cropp, T Ashton ^a   Beck, Brian J ^b   Sherman, David H ^b   Reynolds, Kevin A ^a,c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c Inst Struct Biol/Drug Discovery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASSAYS; BIOSYNTHESIS; CATALYSIS; CONDENSATION; ENZYMES; GENES; HYDROLYSIS;

GENE ENCODING;

BIOCHEMISTRY;

6 DEOXYERYTHRONOLIDE B SYNTHASE; ACYL CARRIER PROTEIN; METHYLMALONIC ACID; PIKROMYCIN; POLYKETIDE; POLYKETIDE SYNTHASE; RECOMBINANT ENZYME; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; DISSOCIATION; DRUG SYNTHESIS; ENZYME SPECIFICITY; GENE; GENE CLUSTER; GENETIC CODE; HYDROLYSIS; IN VITRO STUDY; NONHUMAN; PIKAV GENE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; STREPTOMYCES VENEZUELAE;

ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CATALYSIS; DNA PRIMERS; FATTY ACID SYNTHETASE COMPLEX; MACROLIDES; MUTAGENESIS, SITE-DIRECTED; RECOMBINANT PROTEINS; STREPTOMYCES; THIOLESTER HYDROLASES;

ACTINOBACTERIA (CLASS); STREPTOMYCES; STREPTOMYCES VENEZUELAE; UNCULTURED ACTINOMYCETE;

EID: 0037073685     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207770200     Document Type: Article

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