Investigating the role of native propionyl-CoA and methylmalonyl-CoA metabolism on heterologous polyketide production in Escherichia coli

Biotechnology and Bioengineering

Volumn 105, Issue 3, 2010, Pages 567-573

  Zhang, Haoran ^a   Boghigian, Brett A ^a   Pfeifer, Blaine A ^a  

^a Tufts University   (United States)

Author keywords

Heterologous; Metabolic engineering; Methylmalonyl CoA; Polyketide; Propionyl CoA

Indexed keywords

AGLYCONES; BATCH BIOREACTORS; DECARBOXYLASES; E. COLI; HETEROLOGOUS PRODUCTION; MACROCYCLICS; METABOLIC ENGINEERING; METHYLMALONYL-COA MUTASE; NATURAL PRODUCTS; OVER-EXPRESSION; POLYKETIDES; PROPIONYL-COA CARBOXYLASE; SHAKE-FLASK EXPERIMENTS; SYNTHETASES;

BIOCHEMISTRY; BIOSYNTHESIS; ENCODING (SYMBOLS); ESCHERICHIA COLI; GENE ENCODING; METABOLISM;

SUBSTRATES;

6 DEOXYERYTHRONOLIDE B; ENZYME; METHYLMALONYL COENZYME A DECARBOXYLASE; METHYLMALONYL COENZYME A MUTASE; METHYMALONYL COENZYME A; POLYKETIDE; PROPIONYL COENZYME A; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL METABOLISM; ESCHERICHIA COLI; FED BATCH REACTOR; GENE; GENE DELETION; GENE OVEREXPRESSION; METABOLIC ENGINEERING; NONHUMAN; PROTEIN METABOLISM; PROTEIN SYNTHESIS; YGFH GENE;

ACYL COENZYME A; COENZYME A-TRANSFERASES; ERYTHROMYCIN; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GENE DELETION; GENE DOSAGE; GENE EXPRESSION; MACROLIDES; METHYLMALONYL-COA DECARBOXYLASE; METHYLMALONYL-COA MUTASE;

ESCHERICHIA COLI;

EID: 74849084621     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22560     Document Type: Article

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