Process engineering of human pluripotent stem cells for clinical application

Trends in Biotechnology

Volumn 30, Issue 6, 2012, Pages 350-359

  Serra, Margarida ^a,b   Brito, Catarina ^a,b   Correia, Cláudia ^a,b   Alves, Paula M ^a,b  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLÓGICA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPROCESSING; CELL THERAPY; CLINICAL APPLICATION; CONTROLLED CONDITIONS; ENVIRONMENTAL FACTORS; FLEXIBLE PLATFORMS; HIGH QUALITY; LARGE-SCALE PRODUCTION; PLURIPOTENT STEM CELLS;

CELL CULTURE; PRODUCTION PLATFORMS;

STEM CELLS;

ALLOGENEIC STEM CELL TRANSPLANTATION; AUTOLOGOUS STEM CELL TRANSPLANTATION; BIOPROCESS; BIOREACTOR; CELL CULTURE; ENVIRONMENTAL FACTOR; EXTRACELLULAR MATRIX; HUMAN; HUMAN PLURIPOTENT STEM CELL; MICROENCAPSULATION; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; QUALITY CONTROL; REVIEW; SUSPENSION CELL CULTURE;

ANIMALS; BIOENGINEERING; BIOMEDICAL RESEARCH; BIOREACTORS; HUMANS; MICE; PLURIPOTENT STEM CELLS;

EID: 84861345298     PISSN: 01677799     EISSN: 18793096     Source Type: Journal    
DOI: 10.1016/j.tibtech.2012.03.003     Document Type: Review

References (80)

1. Robinton D.A., Daley G.Q. The promise of induced pluripotent stem cells in research and therapy. Nature 2012, 481:295-305.
2. Toh W.S., et al. Potential of human embryonic stem cells in cartilage tissue engineering and regenerative medicine. Stem Cell Rev. 2011, 7:544-559.
3. Hentze H., et al. Cell therapy and the safety of embryonic stem cell-derived grafts. Trends Biotechnol. 2007, 25:24-32.
4. Lui K.O., et al. Embryonic stem cells: overcoming the immunological barriers to cell replacement therapy. Curr. Stem Cell Res. Ther. 2009, 4:70-80.
5. Brignier A.C., Gewirtz A.M. Embryonic and adult stem cell therapy. J. Allergy Clin. Immunol. 2010, 125:S336-S344.
6. Malchenko S., et al. Cancer hallmarks in induced pluripotent cells: new insights. J. Cell. Physiol. 2010, 225:390-393.
7. Collin J., Lako M. Concise review: putting a finger on stem cell biology: zinc finger nuclease-driven targeted genetic editing in human pluripotent stem cells. Stem Cells 2011, 29:1021-1033.
8. Taylor C.J., et al. Banking on human embryonic stem cells: estimating the number of donor cell lines needed for HLA matching. Lancet 2005, 366:2019-2025.
9. Jing D., et al. Stem cells for heart cell therapies. Tissue Eng. B: Rev. 2008, 14:393-406.
10. Lindvall O., et al. Stem cell therapy for human neurodegenerative disorders-how to make it work. Nat. Med. 2004, 10(Suppl.):S42-S50.
11. Lock L.T., Tzanakakis E.S. Stem/progenitor cell sources of insulin-producing cells for the treatment of diabetes. Tissue Eng. 2007, 13:1399-1412.
12. Tzanakakis E.S., et al. Extracorporeal tissue engineered liver-assist devices. Annu. Rev. Biomed. Eng. 2000, 2:607-632.
13. Lamba D.A., et al. Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS ONE 2010, 5:e8763.
14. Zhao T., et al. Immunogenicity of induced pluripotent stem cells. Nature 2011, 474:212-215.
15. Tang C., et al. An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nat. Biotechnol. 2011, 29:829-834.
16. Schriebl K., et al. Selective removal of undifferentiated human embryonic stem cells using magnetic activated cell sorting followed by a cytotoxic antibody. Tissue Eng. A 2012, 18:899-909.
17. Lim D.Y., et al. Cytotoxic antibody fragments for eliminating undifferentiated human embryonic stem cells. J. Biotechnol. 2011, 153:77-85.
18. Unger C., et al. Good manufacturing practice and clinical-grade human embryonic stem cell lines. Hum. Mol. Genet. 2008, 17:R48-R53.
19. Crook J.M., et al. The generation of six clinical-grade human embryonic stem cell lines. Cell Stem Cell 2007, 1:490-494.
20. Selvaraj V., et al. Switching cell fate: the remarkable rise of induced pluripotent stem cells and lineage reprogramming technologies. Trends Biotechnol. 2010, 28:214-223.
21. Placzek M.R., et al. Stem cell bioprocessing: fundamentals and principles. J. R. Soc. Interface 2009, 6:209-232.
22. Azarin S.M., Palecek S.P. Development of scalable culture systems for human embryonic stem cells. Biochem. Eng. J. 2010, 48:378.
23. Rodin S., et al. Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat. Biotechnol. 2010, 28:611-615.
24. Kolhar P., et al. Synthetic surfaces for human embryonic stem cell culture. J. Biotechnol. 2010, 146:143-146.
25. Melkoumian Z., et al. Synthetic peptide-acrylate surfaces for long-term self-renewal and cardiomyocyte differentiation of human embryonic stem cells. Nat. Biotechnol. 2010, 28:606-610.
26. Villa-Diaz L.G., et al. Synthetic polymer coatings for long-term growth of human embryonic stem cells. Nat. Biotechnol. 2010, 28:581-583.
27. Saha K., et al. Surface-engineered substrates for improved human pluripotent stem cell culture under fully defined conditions. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:18714-18719.
28. Serra M., et al. Improving expansion of pluripotent human embryonic stem cells in perfused bioreactors through oxygen control. J. Biotechnol. 2010, 148:208-215.
29. Ferreira L.S., et al. Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells. Biomaterials 2007, 28:2706-2717.
30. Maia J., et al. Controlling the neuronal differentiation of stem cells by the intracellular delivery of retinoic acid-loaded nanoparticles. ACS Nano 2011, 5:97-106.
31. Ao A., et al. Regenerative chemical biology: current challenges and future potential. Chem. Biol. 2011, 18:413-424.
32. Burdick J.A., Watt F.M. High-throughput stem-cell niches. Nat. Methods 2011, 8:915-916.
33. Bauwens C.L., et al. Control of human embryonic stem cell colony and aggregate size heterogeneity influences differentiation trajectories. Stem Cells 2008, 26:2300-2310.
34. Ardehali R., et al. Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:3282-3287.
35. Bai H., et al. Bcl-xL enhances single-cell survival and expansion of human embryonic stem cells without affecting self-renewal. Stem Cell Res. 2012, 8:26-37.
36. Singh H., et al. Up-scaling single cell-inoculated suspension culture of human embryonic stem cells. Stem Cell Res. 2010, 4:165-179.
37. Ramos-Mejia V., et al. Maintenance of human embryonic stem cells in mesenchymal stem cell-conditioned media augments hematopoietic specification. Stem Cells Dev. 2011, 10.1089/scd.2011.0400.
38. Lee W.Y., et al. Maintenance of human pluripotent stem cells using 4SP-hFGF2-secreting STO cells. Stem Cell Res. 2011, 7:210-218.
39. Discher D.E., et al. Growth factors, matrices, and forces combine and control stem cells. Science 2009, 324:1673-1677.
40. Veraitch F.S., et al. The impact of manual processing on the expansion and directed differentiation of embryonic stem cells. Biotechnol. Bioeng. 2008, 99:1216-1229.
41. Leung H.W., et al. Agitation can induce differentiation of human pluripotent stem cells in microcarrier cultures. Tissue Eng. C: Methods 2011, 17:165-172.
42. 2 tensions and the prevention of differentiation of hES cells. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:4783-4788.
43. Forsyth N.R., et al. Physiologic oxygen enhances human embryonic stem cell clonal recovery and reduces chromosomal abnormalities. Cloning Stem Cells 2006, 8:16-23.
44. Millman J.R., et al. The effects of low oxygen on self-renewal and differentiation of embryonic stem cells. Curr. Opin. Organ Transplant. 2009, 14:694-700.
45. Powers D.E., et al. Accurate control of oxygen level in cells during culture on silicone rubber membranes with application to stem cell differentiation. Biotechnol. Prog. 2010, 26:805-818.
46. Pampaloni F., et al. The third dimension bridges the gap between cell culture and live tissue. Nat. Rev. Mol. Cell Biol. 2007, 8:839-845.
47. Mohamet L., et al. Abrogation of E-cadherin-mediated cellular aggregation allows proliferation of pluripotent mouse embryonic stem cells in shake flask bioreactors. PLoS ONE 2010, 5:e12921.
48. Cukierman E., et al. Cell interactions with three-dimensional matrices. Curr. Opin. Cell Biol. 2002, 14:633-639.
49. Lund A.W., et al. The natural and engineered 3D microenvironment as a regulatory cue during stem cell fate determination. Tissue Eng. B: Rev. 2009, 15:371-380.
50. Jensen J., et al. Human embryonic stem cell technologies and drug discovery. J. Cell. Physiol. 2009, 219:513-519.
51. Burdick J.A., Vunjak-Novakovic G. Engineered microenvironments for controlled stem cell differentiation. Tissue Eng. 2009, 15:205-219.
52. Cameron C.M., et al. Improved development of human embryonic stem cell-derived embryoid bodies by stirred vessel cultivation. Biotechnol. Bioeng. 2006, 94:938-948.
53. Come J., et al. Improvement of culture conditions of human embryoid bodies using a controlled perfused and dialyzed bioreactor system. Tissue Eng. C: Methods 2008, 14:289-298.
54. Gerecht-Nir S., et al. Bioreactor cultivation enhances the efficiency of human embryoid body (hEB) formation and differentiation. Biotechnol. Bioeng. 2004, 86:493-502.
55. Yirme G., et al. Establishing a dynamic process for the formation, propagation, and differentiation of human embryoid bodies. Stem Cells Dev. 2008, 17:1227-1241.
56. Amit M., et al. Suspension culture of undifferentiated human embryonic and induced pluripotent stem cells. Stem Cell Rev. 2010, 6:248-259.
57. Kehoe D.E., et al. Scalable stirred-suspension bioreactor culture of human pluripotent stem cells. Tissue Eng. A 2009, 16:405-421.
58. Krawetz R., et al. Large-scale expansion of pluripotent human embryonic stem cells in stirred suspension bioreactors. Tissue Eng. C: Methods 2010, 16:573-582.
59. Niebruegge S., et al. Generation of human embryonic stem cell-derived mesoderm and cardiac cells using size-specified aggregates in an oxygen-controlled bioreactor. Biotechnol. Bioeng. 2009, 102:493-507.
60. Olmer R., et al. Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium. Stem Cell Res. 2010, 5:51-64.
61. Zweigerdt R., et al. Scalable expansion of human pluripotent stem cells in suspension culture. Nat. Protoc. 2011, 6:689-700.
62. Chen A.K., et al. Expansion of human embryonic stem cells on cellulose microcarriers. Curr. Protoc. Stem Cell Biol. 2010, 14. 1C.11.1-1C.11.14.
63. Chen A.K., et al. Critical microcarrier properties affecting the expansion of undifferentiated human embryonic stem cells. Stem Cell Res. 2011, 7:97-111.
64. Fernandes A.M., et al. Successful scale-up of human embryonic stem cell production in a stirred microcarrier culture system. Braz. J. Med. Biol. Res. 2009, 42:515-522.
65. Heng B.C., et al. Translating human embryonic stem cells from 2-dimensional to 3-dimensional cultures in a defined medium on laminin- and vitronectin-coated surfaces. Stem cells Dev. 2012, (in press).
66. Lecina M., et al. Scalable platform for human embryonic stem cell differentiation to cardiomyocytes in suspended microcarrier cultures. Tissue Eng. C: Methods 2010, 16:1609-1619.
67. Lock L.T., Tzanakakis E.S. Expansion and differentiation of human embryonic stem cells to endoderm progeny in a microcarrier stirred-suspension culture. Tissue Eng. A 2009, 15:2051-2063.
68. Nie Y., et al. Scalable culture and cryopreservation of human embryonic stem cells on microcarriers. Biotechnol. Prog. 2009, 25:20-31.
69. Oh S.K., et al. Long-term microcarrier suspension cultures of human embryonic stem cells. Stem Cell Res. 2009, 2:219-230.
70. Phillips B.W., et al. Attachment and growth of human embryonic stem cells on microcarriers. J. Biotechnol. 2008, 138:24-32.
71. Storm M.P., et al. Three-dimensional culture systems for the expansion of pluripotent embryonic stem cells. Biotechnol. Bioeng. 2010, 107:683-695.
72. Serra M., et al. Microencapsulation technology: a powerful tool for integrating expansion and cryopreservation of human embryonic stem cells. PLoS ONE 2011, 6:e23212.
73. Delcroix G.J., et al. Adult cell therapy for brain neuronal damages and the role of tissue engineering. Biomaterials 2010, 31:2105-2120.
74. Hernandez R.M., et al. Microcapsules and microcarriers for in situ cell delivery. Adv. Drug Deliv. Rev. 2010, 62:711-730.
75. Chayosumrit M., et al. Alginate microcapsule for propagation and directed differentiation of hESCs to definitive endoderm. Biomaterials 2010, 31:505-514.
76. Jing D., et al. Cardiac cell generation from encapsulated embryonic stem cells in static and scalable culture systems. Cell Transplant. 2010, 19:1397-1412.
77. Siti-Ismail N., et al. The benefit of human embryonic stem cell encapsulation for prolonged feeder-free maintenance. Biomaterials 2008, 29:3946-3952.
78. Murua A., et al. Cell microencapsulation technology: towards clinical application. J. Control Release 2008, 132:76-83.
79. Kirouac D.C., et al. Dynamic interaction networks in a hierarchically organized tissue. Mol. Syst. Biol. 2010, 6:417.
80. Serra M., et al. Bioengineering strategies for stem cell expansion and differentiation. Canal Bioquim. 2010, 7:30-38.