A heterologous 3-D coculture model of breast tumor cells and fibroblasts to study tumor-associated fibroblast differentiation

Experimental Cell Research

Volumn 266, Issue 1, 2001, Pages 74-86

  Kunz Schughart, Leoni A ^a   Heyder, Paula ^a   Schroeder, Josef ^a   Knuechel, Ruth ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Breast cancer; Extracellular matrix (ECM); Myofibroblast; Normal fibroblast; Peripheral myelin protein 22 (PMP22); Spheroid cocultures; Tumor cell invasion; Tumor derived fibroblast; smooth muscle actin ( SMA)

Indexed keywords

ALPHA ACTIN; MYELIN PROTEIN; PERIPHERAL MYELIN PROTEIN 22; UNCLASSIFIED DRUG;

ARTICLE; BREAST TUMOR; CANCER CELL CULTURE; CELL ADHESION; CELL DIFFERENTIATION; CELL GROWTH; CELL INTERACTION; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; MYOFIBROBLAST; PRIORITY JOURNAL; SKIN FIBROBLAST; SPHEROID CELL;

MINK CELL FOCUS-FORMING VIRUS;

EID: 0035872250     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5210     Document Type: Article

References (64)

1. Insulin-like growth factor mediated stromal-epithelial interactions in human breast cancer
2. Desmoplasia and its relevance to colorectal tumour invasion
3. Different mechanisms of extracellular matrix remodeling by fibroblasts in response to human mammary neoplastic cells
4. Breast cancer invasion: The key role of normal cells of host tissues
5. Proliferative breast "disease." An unresolved diagnostic dilemma
6. Epithelial-stromal interactions in colon cancer
7. Fibroblasts are critical determinants in prostatic cancer growth and dissemination
8. Reciprocal mesenchymal-epithelial interaction affecting prostate tumour growth and hormonal responsiveness
9. Regulation of differentiation and growth of normal adult and neoplastic epithelia by inductive mesenchyme
10. Prostate and bone fibroblasts induce human prostate cancer growth in vivo: Implications for bidirectional tumor-stromal cell interaction in prostate carcinoma growth and metastasis
11. Genetic predisposition and mesenchymal-epithelial interactions in ras+myc-induced carcinogenesis in reconstituted mouse prostate
12. Effect of stromal and epithelial cells derived from normal and tumorous breast tissue on the proliferation of human breast cancer cell lines in coculture
13. Role of tumor-derived fibroblasts in the growth of primary cultures of human breast-cancer cells: Effects of epidermal growth factor and the somatostatin analogue octreotide
14. Influence of tumor derived fibroblasts and 1,25-dihydroxyvitamin D3 on growth of breast cancer cell lines
15. The multiple roles of tumour stroma
16. Multicellular spheroids: A three-dimensional in vitro culture system to study tumour biology
17. Three-dimensional cell cultures: From molecular mechanisms to clinical applications
18. Fibroblast-mediated differentiation in human breast carcinoma cells (MCF-7) grown as nodules in vitro
19. A heterologous in vitro coculture system to study interaction between human bladder cancer cells and fibroblasts
20. Novel fibroblast-specific monoclonal antibodies: Properties and specificities
21. RNA fingerprinting by arbitrarily primed PCR
22. DNA fingerprinting of mammalian cell lines using nonradioactive arbitrarily primed PCR (AP-PCR)
23. Improved double-stranded DNA sequencing using the linear polymerase chain reaction
24. Basic local alignment search tool
25. Multicellular tumor spheroids: Intermediates between monolayer culture and in vivo tumor
26. Invasive and metastatic properties of MCF-7 cells rasH-transfected MCF-7 cell lines
27. Lectin histochemical HPA-binding pattern of human breast and colon cancers is associated with metastases formation in severe combined immunodeficient mice
28. Outgrowth of BT-474 human breast cancer cells in immune-deficient mice: A new in vivo model for hormone-dependent breast cancer
29. Comparison of in vitro invasiveness of human breast carcinoma in early or late stage with their malignancy in vivo
30. An in vitro model for cancer invasion. 1. Grading and quantitation of aggressiveness
31. A monoclonal antibody directed against a human cell membrane antigen prevents cell substrate adhesion and tumor invasion
32. In vitro regulation of human breast cancer cell adhesion and invasion via integrin receptors to the extracellular matrix
33. Antiproliferative and antiinvasive effects of carboxy-amido-triazole on breast cancer cell lines
34. Differential display of reticulocalbin in the highly invasive cell line, MDA-MB-435, versus the poorly invasive cell line, MCF-7
35. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines
36. Culture of normal and malignant primary human mammary epithelial cells in a physiological manner simulates in vivo growth patterns and allows discrimination of cell type
37. The development of a functionally relevant cell culture model of progressive human breast cancer
38. Multicellular spheroids as an in vitro tumor model
39. Multicellular spheroids. A review on cellular aggregates in cancer research
40. Differential expression of fibronectin splice variants, oncofetal glycosylated fibronectin and laminin isoforms in nodular palmar fibromatosis
41. The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity
42. Selection of potentially metastatic subpopulations expressing c-erbB-2 from breast cancer tissue by use of an extravasation model
43. The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and collagenase genes in response to epidermal growth factor
44. Myofibroblast and concurrent ED-B fibronectin phenotype in human stromal cells cultured from non-malignant and malignant breast tissue
45. Appearance of the myofibroblastic phenotype in Dupuytren's disease is associated with a fibronectin, laminin, collagen type IV and tenascin extracellular matrix
46. Some historical and philosophical reflections on the myofibroblast concept
47. Myofibroblasts. I. Paracrine cells important in health and disease
48. The myofibroblast in neoplasia
49. Mechanisms of myofibroblast activity and phenotypic modulation
50. The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1
51. Transforming growth factor-beta initiates wound repair in rat liver through induction of the EIIIA-fibronectin splice isoform
52. Overexpression of granulocyte-macrophage colony-stimulating factor induces pulmonary granulation tissue formation and fibrosis by induction of transforming growth factor-beta 1 and myofibroblast accumulation
53. Stromal influences on breast cancer cell growth
54. Expression of tissue factor in tumor stroma correlates with progression to invasive human breast cancer: Paracrine regulation by carcinoma cell-derived members of the transforming growth factor beta family
55. Induction of transforming growth factor beta 1 in human breast cancer in vivo following tamoxifen treatment
56. Tetraspan myelin protein PMP22 and demyelinating peripheral neuropathies: New facts and hypotheses
57. The peripheral myelin protein 22 and epithelial membrane protein family
58. The anatomy and cell biology of peripheral myelin protein-22
59. Elevated level of gas3 gene expression is correlated with G0 growth arrest in human fibroblasts
60. Retroviral-mediated gene transfer of the peripheral myelin protein PMP22 in Schwann cells: Modulation of cell growth
61. Influence of elevated expression of rat wild-type PMP22 and its mutant PMP22Trembler on cell growth of NIH3T3 fibroblasts
62. Differential expression of two mRNA species indicates a dual function of peripheral myelin protein PMP22 in cell growth and myelination
63. Regulation of tissue-specific expression of alternative peripheral myelin protein-22 (PMP22) gene transcripts by two promoters