메뉴 건너뛰기




Volumn 5, Issue 7, 2006, Pages 691-695

Brave little world: Spheroids as an in vitro model to study tumor-immune-cell interactions

Author keywords

Dendritic cell; Immune escape; Lactate; Lactic acid; Monocyte; Spheroid; Tumor microenvironment

Indexed keywords

CHEMOKINE; CHEMOKINE CCL20; INTERLEUKIN 8; LACTIC ACID; UNCLASSIFIED DRUG; VASCULOTROPIN;

EID: 33645707133     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.7.2624     Document Type: Review
Times cited : (74)

References (76)
  • 1
    • 16544380146 scopus 로고    scopus 로고
    • The use of 3-D cultures for high-throughput screening: The multicellular spheroid model
    • Kunz-Schughart LA, Freyer JP, Hofstaedter F, Ebner R. The use of 3-D cultures for high-throughput screening: the multicellular spheroid model. J Biomol Screen 2004; 9:273-85.
    • (2004) J Biomol Screen , vol.9 , pp. 273-285
    • Kunz-Schughart, L.A.1    Freyer, J.P.2    Hofstaedter, F.3    Ebner, R.4
  • 2
    • 0031883574 scopus 로고    scopus 로고
    • Multicellular spheroids: A three-dimensional in vitro culture system to study tumour biology
    • Kunz-Schughart LA, Kreutz M, Knuechel R. Multicellular spheroids: a three-dimensional in vitro culture system to study tumour biology. Int J Exp Pathol 1998; 79:1-23.
    • (1998) Int J Exp Pathol , vol.79 , pp. 1-23
    • Kunz-Schughart, L.A.1    Kreutz, M.2    Knuechel, R.3
  • 3
    • 0024281372 scopus 로고
    • Cell and environment interactions in tumor microregions: The multicell spheroid model
    • Sutherland RM. Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 1988; 240:177-84.
    • (1988) Science , vol.240 , pp. 177-184
    • Sutherland, R.M.1
  • 4
    • 0030697292 scopus 로고    scopus 로고
    • Three-dimensional cell culture: From molecular mechanisms to clinical applications
    • Cell Physiol.42
    • Mueller-Klieser W. Three-dimensional cell culture: from molecular mechanisms to clinical applications. Am J Physiol 1997; 273((Cell Physiol.42)):C1109-23.
    • (1997) Am J Physiol , vol.273
    • Mueller-Klieser, W.1
  • 5
    • 0033101647 scopus 로고    scopus 로고
    • Multicellular tumor spheroids: Intermediates between monolayer culture and in vivo tumor
    • Kunz-Schughart LA. Multicellular tumor spheroids: intermediates between monolayer culture and in vivo tumor. Cell Biol Int 1999; 23:157-61.
    • (1999) Cell Biol Int , vol.23 , pp. 157-161
    • Kunz-Schughart, L.A.1
  • 6
    • 0030007663 scopus 로고    scopus 로고
    • Three-dimensional co-culture of human monocytes and macrophages with tumor cells: Analysis of macrophage differentiation and activation
    • Konur A, Kreutz M, Knuchel R, Krause SW, Andreesen R. Three-dimensional co-culture of human monocytes and macrophages with tumor cells: analysis of macrophage differentiation and activation. Int J Cancer 1996; 66:645-52.
    • (1996) Int J Cancer , vol.66 , pp. 645-652
    • Konur, A.1    Kreutz, M.2    Knuchel, R.3    Krause, S.W.4    Andreesen, R.5
  • 7
    • 0027765545 scopus 로고
    • Macrophages and multicellular tumor spheroids in co-culture: A three-dimensional model to study tumor-host interactions. Evidence for macrophage-mediated tumor cell proliferation and migration
    • Hauptmann S, Zwadlo-Klarwasser G, Jansen M, Klosterhalfen B, Kirkpatrick CJ. Macrophages and multicellular tumor spheroids in co-culture: a three-dimensional model to study tumor-host interactions. Evidence for macrophage-mediated tumor cell proliferation and migration. Am J Pathol 1993; 143:1406-15.
    • (1993) Am J Pathol , vol.143 , pp. 1406-1415
    • Hauptmann, S.1    Zwadlo-Klarwasser, G.2    Jansen, M.3    Klosterhalfen, B.4    Kirkpatrick, C.J.5
  • 8
    • 0027948505 scopus 로고
    • Interactions between human macrophages and tumor cells in three-dimensional cultures
    • Audran R, Dazord L, Toujas L. Interactions between human macrophages and tumor cells in three-dimensional cultures. Cancer Immunol Immunother 1994; 39:299-304.
    • (1994) Cancer Immunol Immunother , vol.39 , pp. 299-304
    • Audran, R.1    Dazord, L.2    Toujas, L.3
  • 9
    • 0024547860 scopus 로고
    • Effect of LAK cells against three-dimensional tumor tissue. in vitro study using multi-cellular human glioma spheroids as targets
    • Jaaskelainen J, Kalliomaki P, Paetau A, Timonen T. Effect of LAK cells against three-dimensional tumor tissue. In vitro study using multi-cellular human glioma spheroids as targets. J Immunol 1989; 142:1036-45.
    • (1989) J Immunol , vol.142 , pp. 1036-1045
    • Jaaskelainen, J.1    Kalliomaki, P.2    Paetau, A.3    Timonen, T.4
  • 10
    • 0031763138 scopus 로고    scopus 로고
    • Cytokine repertoire during maturation of monocytes to macrophages within spheroids of malignant and non-malignant urothelial cells
    • Konur A, Kreutz M, Knüchel R, Krause SW, Andreesen R. Cytokine repertoire during maturation of monocytes to macrophages within spheroids of malignant and non-malignant urothelial cells. Int J Cancer 1998; 78:648-53.
    • (1998) Int J Cancer , vol.78 , pp. 648-653
    • Konur, A.1    Kreutz, M.2    Knüchel, R.3    Krause, S.W.4    Andreesen, R.5
  • 13
    • 0030882879 scopus 로고    scopus 로고
    • Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53
    • Mathupala SP, Heese C, Pedersen PL. Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. J Biol Chem 1997; 272:22776-80.
    • (1997) J Biol Chem , vol.272 , pp. 22776-22780
    • Mathupala, S.P.1    Heese, C.2    Pedersen, P.L.3
  • 15
    • 3142644996 scopus 로고    scopus 로고
    • Tumour-associated macrophages as a prototypic type II polarised phagocyte population: Role in tumour progression
    • Mantovani A, Allavena P, Sica A. Tumour-associated macrophages as a prototypic type II polarised phagocyte population: role in tumour progression. Eur J Cancer 2004; 40:1660-7.
    • (2004) Eur J Cancer , vol.40 , pp. 1660-1667
    • Mantovani, A.1    Allavena, P.2    Sica, A.3
  • 17
    • 0029816609 scopus 로고    scopus 로고
    • Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma
    • Leek RD, Lewis CE, Whitehouse R, Greenall M, Clarke J, Harris AL. Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma. Cancer Res 1996; 56:4625-9.
    • (1996) Cancer Res , vol.56 , pp. 4625-4629
    • Leek, R.D.1    Lewis, C.E.2    Whitehouse, R.3    Greenall, M.4    Clarke, J.5    Harris, A.L.6
  • 18
    • 32644466544 scopus 로고    scopus 로고
    • Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer
    • Welsh TJ, Green RH, Richardson D, Waller DA, O'Byrne KJ, Bradding P. Macrophage and mast-cell invasion of tumor cell islets confers a marked survival advantage in non-small-cell lung cancer. J Clin Oncol 2005; 23:8959-67.
    • (2005) J Clin Oncol , vol.23 , pp. 8959-8967
    • Welsh, T.J.1    Green, R.H.2    Richardson, D.3    Waller, D.A.4    O'Byrne, K.J.5    Bradding, P.6
  • 19
    • 17044366637 scopus 로고    scopus 로고
    • STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion
    • Kusmartsev S, Gabrilovich DI. STAT1 signaling regulates tumor-associated macrophage-mediated T cell deletion. J Immunol 2005; 174:4880-91.
    • (2005) J Immunol , vol.174 , pp. 4880-4891
    • Kusmartsev, S.1    Gabrilovich, D.I.2
  • 22
    • 0024548430 scopus 로고
    • S-100 protein-positive dendritic cells in colorectal adenocarcinomas. Distribution and relation to the clinical prognosis
    • Ambe K, Mori M, Enjoji M. S-100 protein-positive dendritic cells in colorectal adenocarcinomas. Distribution and relation to the clinical prognosis. Cancer 1989; 63:496-503.
    • (1989) Cancer , vol.63 , pp. 496-503
    • Ambe, K.1    Mori, M.2    Enjoji, M.3
  • 25
    • 0027727917 scopus 로고
    • S100 positive dendritic cells in human lung tumors associated with cell differentiation and enhanced survival
    • Zeid NA, Muller HK. S100 positive dendritic cells in human lung tumors associated with cell differentiation and enhanced survival. Pathology 1993; 25:338-43.
    • (1993) Pathology , vol.25 , pp. 338-343
    • Zeid, N.A.1    Muller, H.K.2
  • 26
    • 0041976915 scopus 로고    scopus 로고
    • CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer
    • Coventry BJ, Morton J. CD1a-positive infiltrating-dendritic cell density and 5-year survival from human breast cancer. Br J Cancer 2003; 89:533-8.
    • (2003) Br J Cancer , vol.89 , pp. 533-538
    • Coventry, B.J.1    Morton, J.2
  • 27
    • 0033026753 scopus 로고    scopus 로고
    • Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumors
    • Hillenbrand EE, Neville AM, Coventry BJ. Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumors. Br J Cancer 1999; 79:940-4.
    • (1999) Br J Cancer , vol.79 , pp. 940-944
    • Hillenbrand, E.E.1    Neville, A.M.2    Coventry, B.J.3
  • 29
    • 0029937941 scopus 로고    scopus 로고
    • Inflammatory cells infiltrating human colorectal carcinomas express HLA class II but not B7-1 and B7-2 costimulatory molecules of the T-cell activation
    • Chaux P, Moutet M, Faivre J, Martin F, Martin M. Inflammatory cells infiltrating human colorectal carcinomas express HLA class II but not B7-1 and B7-2 costimulatory molecules of the T-cell activation. Lab Invest 1996; 74:975-83.
    • (1996) Lab Invest , vol.74 , pp. 975-983
    • Chaux, P.1    Moutet, M.2    Faivre, J.3    Martin, F.4    Martin, M.5
  • 30
    • 0030724702 scopus 로고    scopus 로고
    • Dendritic cells as mediators of tumor-induced tolerance in metastic melanoma
    • Enk AH, Jonuleit H, Saloga J, Knop J. Dendritic cells as mediators of tumor-induced tolerance in metastic melanoma. Int J Cancer 1997; 73:309-16.
    • (1997) Int J Cancer , vol.73 , pp. 309-316
    • Enk, A.H.1    Jonuleit, H.2    Saloga, J.3    Knop, J.4
  • 32
    • 0043092221 scopus 로고    scopus 로고
    • The circulating dendritic cell compartment in patients with chronic lymphocytic leukemia is severely defective and unable to stimulate an effective T-cell response
    • Orsini E, Guarini A, Chiaretti S, Mauro FR, Foa R. The circulating dendritic cell compartment in patients with chronic lymphocytic leukemia is severely defective and unable to stimulate an effective T-cell response. Cancer Res 2003; 63:4497-506.
    • (2003) Cancer Res , vol.63 , pp. 4497-4506
    • Orsini, E.1    Guarini, A.2    Chiaretti, S.3    Mauro, F.R.4    Foa, R.5
  • 33
    • 0028845887 scopus 로고
    • Dendritic antigen-presenting cells from the peripheral blood of renal-cell-carcinoma patients
    • Radmayr C, Bock G, Hobisch A, Klocker H, Bartsch G, Thurnher M. Dendritic antigen-presenting cells from the peripheral blood of renal-cell-carcinoma patients. Int J Cancer 1995; 63:627-32.
    • (1995) Int J Cancer , vol.63 , pp. 627-632
    • Radmayr, C.1    Bock, G.2    Hobisch, A.3    Klocker, H.4    Bartsch, G.5    Thurnher, M.6
  • 34
    • 0031415650 scopus 로고    scopus 로고
    • Dendritic cells and cancer: Progress toward a new cellular therapy
    • Troy AJ, Hart DN. Dendritic cells and cancer: progress toward a new cellular therapy. J Hematother 1997; 6:523-33.
    • (1997) J Hematother , vol.6 , pp. 523-533
    • Troy, A.J.1    Hart, D.N.2
  • 38
    • 0034141907 scopus 로고    scopus 로고
    • Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cells
    • Kiertscher SM, Luo J, Dubinett SM, Roth MD. Tumors promote altered maturation and early apoptosis of monocyte-derived dendritic cells. J Immunol 2000; 164:1269-76.
    • (2000) J Immunol , vol.164 , pp. 1269-1276
    • Kiertscher, S.M.1    Luo, J.2    Dubinett, S.M.3    Roth, M.D.4
  • 39
    • 0031892785 scopus 로고    scopus 로고
    • Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells
    • Oyama T, Ran S, Ishida T, Nadaf S, Kerr L, Carbone DP, Gabrilovich DI. Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells. J Immunol 1998; 160:1224-32.
    • (1998) J Immunol , vol.160 , pp. 1224-1232
    • Oyama, T.1    Ran, S.2    Ishida, T.3    Nadaf, S.4    Kerr, L.5    Carbone, D.P.6    Gabrilovich, D.I.7
  • 40
    • 0031738664 scopus 로고    scopus 로고
    • Relationship between the expression of vascular endothelial growth factor and the density of dendritic cells in gastric adenocarcinoma tissue
    • Saito H, Tsujitani S, Ikeguchi M, Maeta M, Kaibara N. Relationship between the expression of vascular endothelial growth factor and the density of dendritic cells in gastric adenocarcinoma tissue. Br J Cancer 1998; 78:1573-7.
    • (1998) Br J Cancer , vol.78 , pp. 1573-1577
    • Saito, H.1    Tsujitani, S.2    Ikeguchi, M.3    Maeta, M.4    Kaibara, N.5
  • 41
    • 0029086123 scopus 로고
    • Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells
    • Buelens C, Willems F, Delvaux A, Pierard G, Delville JP, Velu T, Goldman M. Interleukin-10 differentially regulates B7-1 (CD80) and B7-2 (CD86) expression on human peripheral blood dendritic cells. Eur J Immunol 1995; 25:2668-72.
    • (1995) Eur J Immunol , vol.25 , pp. 2668-2672
    • Buelens, C.1    Willems, F.2    Delvaux, A.3    Pierard, G.4    Delville, J.P.5    Velu, T.6    Goldman, M.7
  • 43
    • 0032211082 scopus 로고    scopus 로고
    • Defective function of Langerhans cells in tumor-bearing animals is the result of defective maturation from hematopoietic progenitors
    • Ishida T, Oyama T, Carbone DP, Gabrilovich DI. Defective function of Langerhans cells in tumor-bearing animals is the result of defective maturation from hematopoietic progenitors. J Immunol 1998; 161:4842-51.
    • (1998) J Immunol , vol.161 , pp. 4842-4851
    • Ishida, T.1    Oyama, T.2    Carbone, D.P.3    Gabrilovich, D.I.4
  • 45
    • 0032535002 scopus 로고    scopus 로고
    • Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: Role of interleukin-6 and macrophage colony-stimulating factor
    • Menetrier-Caux C, Montmain G, Dieu MC, Bain C, Favrot MC, Caux C, Blay JY. Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor. Blood 1998; 92:4778-91.
    • (1998) Blood , vol.92 , pp. 4778-4791
    • Menetrier-Caux, C.1    Montmain, G.2    Dieu, M.C.3    Bain, C.4    Favrot, M.C.5    Caux, C.6    Blay, J.Y.7
  • 46
    • 0035300580 scopus 로고    scopus 로고
    • IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells
    • Menetrier-Caux C, Thomachot MC, Alberti L, Montmain G, Blay JY. IL-4 prevents the blockade of dendritic cell differentiation induced by tumor cells. Cancer Res 2001; 61:3096-104.
    • (2001) Cancer Res , vol.61 , pp. 3096-3104
    • Menetrier-Caux, C.1    Thomachot, M.C.2    Alberti, L.3    Montmain, G.4    Blay, J.Y.5
  • 49
    • 0348012943 scopus 로고    scopus 로고
    • The fibroblast: Sentinel cell and local immune modulator in tumor tissue
    • Silzle T, Randolph GJ, Kreutz M, Kunz-Schughart LA. The fibroblast: sentinel cell and local immune modulator in tumor tissue. Int J Cancer 2004; 108:173-80.
    • (2004) Int J Cancer , vol.108 , pp. 173-180
    • Silzle, T.1    Randolph, G.J.2    Kreutz, M.3    Kunz-Schughart, L.A.4
  • 51
    • 0035101398 scopus 로고    scopus 로고
    • Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - A potential mechanism
    • Grimshaw MJ, Balkwill FR. Inhibition of monocyte and macrophage chemotaxis by hypoxia and inflammation - a potential mechanism. Eur J Immunol 2001; 31:480-9.
    • (2001) Eur J Immunol , vol.31 , pp. 480-489
    • Grimshaw, M.J.1    Balkwill, F.R.2
  • 52
    • 0031801052 scopus 로고    scopus 로고
    • Hypoxia down-regulates MCP-1 expression: Implications for macrophage distribution in tumors
    • Negus RP, Turner L, Burke F, Balkwill FR. Hypoxia down-regulates MCP-1 expression: implications for macrophage distribution in tumors. J Leukoc Biol 1998; 63:758-65.
    • (1998) J Leukoc Biol , vol.63 , pp. 758-765
    • Negus, R.P.1    Turner, L.2    Burke, F.3    Balkwill, F.R.4
  • 53
    • 0042852121 scopus 로고    scopus 로고
    • Hypoxia reduces CD80 expression on monocytes but enhances their LPS-stimulated TNF-alpha secretion
    • Lahat N, Rahat MA, Ballan M, Weiss-Cerem L, Engelmayer M, Bitterman H. Hypoxia reduces CD80 expression on monocytes but enhances their LPS-stimulated TNF-alpha secretion. J Leukoc Biol 2003; 74:197-205.
    • (2003) J Leukoc Biol , vol.74 , pp. 197-205
    • Lahat, N.1    Rahat, M.A.2    Ballan, M.3    Weiss-Cerem, L.4    Engelmayer, M.5    Bitterman, H.6
  • 54
    • 0141425768 scopus 로고    scopus 로고
    • Hypoxia-induced gene expression in human macrophages: Implications for ischemic tissues and hypoxia-regulated gene therapy
    • Burke B, Giannoudis A, Corke KP, Gill D, Wells M, Ziegler-Heitbrock L, Lewis CE. Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Am J Pathol 2003; 163:1233-43.
    • (2003) Am J Pathol , vol.163 , pp. 1233-1243
    • Burke, B.1    Giannoudis, A.2    Corke, K.P.3    Gill, D.4    Wells, M.5    Ziegler-Heitbrock, L.6    Lewis, C.E.7
  • 55
    • 0036772856 scopus 로고    scopus 로고
    • IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension
    • Murata Y, Ohteki T, Koyasu S, Hamuro J. IFN-gamma and pro-inflammatory cytokine production by antigen-presenting cells is dictated by intracellular thiol redox status regulated by oxygen tension. Eur J Immunol 2002; 32:2866-73.
    • (2002) Eur J Immunol , vol.32 , pp. 2866-2873
    • Murata, Y.1    Ohteki, T.2    Koyasu, S.3    Hamuro, J.4
  • 56
    • 0027960791 scopus 로고
    • Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression
    • Hlatky L, Tsionou C, Hahnfeldt P, Coleman CN. Mammary fibroblasts may influence breast tumor angiogenesis via hypoxia-induced vascular endothelial growth factor up-regulation and protein expression. Cancer Res 1994; 54:6083-6.
    • (1994) Cancer Res , vol.54 , pp. 6083-6086
    • Hlatky, L.1    Tsionou, C.2    Hahnfeldt, P.3    Coleman, C.N.4
  • 57
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL. The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2000; 157:411-21.
    • (2000) Am J Pathol , vol.157 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6    Harris, A.L.7
  • 58
    • 0030045543 scopus 로고    scopus 로고
    • Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: Similarities with the regulation of erythropoietin
    • Ebert BL, Gleadle JM, O'Rourke JF, Bartlett SM, Poulton J, Ratcliffe PJ. Isoenzyme-specific regulation of genes involved in energy metabolism by hypoxia: similarities with the regulation of erythropoietin. Biochem J 1996; 313:809-14.
    • (1996) Biochem J , vol.313 , pp. 809-814
    • Ebert, B.L.1    Gleadle, J.M.2    O'Rourke, J.F.3    Bartlett, S.M.4    Poulton, J.5    Ratcliffe, P.J.6
  • 59
    • 0034326273 scopus 로고    scopus 로고
    • Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
    • Elson DA, Ryan HE, Snow JW, Johnson R, Arbeit JM. Coordinate up-regulation of hypoxia inducible factor (HIF)-1alpha and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing. Cancer Res 2000; 60:6189-95.
    • (2000) Cancer Res , vol.60 , pp. 6189-6195
    • Elson, D.A.1    Ryan, H.E.2    Snow, J.W.3    Johnson, R.4    Arbeit, J.M.5
  • 60
    • 33645723257 scopus 로고
    • On the facultative anaerobiosis of cancer cells and its use in chemotherapy
    • WARBURG O. [On the facultative anaerobiosis of cancer cells and its use in chemotherapy]. Munch Med Wochenschr 1961; 103:2504-6.
    • (1961) Munch Med Wochenschr , vol.103 , pp. 2504-2506
    • Warburg, O.1
  • 61
    • 0033039867 scopus 로고    scopus 로고
    • Change in lactate production in Myc-transformed cells precedes apoptosis and can be inhibited by Bcl-2 overexpression
    • Papas KK, Sun L, Roos ES, Gounarides JS, Shapiro M, Nalin CM. Change in lactate production in Myc-transformed cells precedes apoptosis and can be inhibited by Bcl-2 overexpression. FEBS Lett 1999; 446:338-42.
    • (1999) FEBS Lett , vol.446 , pp. 338-342
    • Papas, K.K.1    Sun, L.2    Roos, E.S.3    Gounarides, J.S.4    Shapiro, M.5    Nalin, C.M.6
  • 64
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • Lu H, Forbes RA, Verma A. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 2002; 277(26):23111-23115.
    • (2002) J Biol Chem , vol.277 , Issue.26 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 65
    • 3242798360 scopus 로고    scopus 로고
    • Lactate in solid malignant tumors: Potential basis of a metabolic classification in clinical oncology
    • Walenta S, Schroeder T, Mueller-Klieser W. Lactate in solid malignant tumors: potential basis of a metabolic classification in clinical oncology. Curr Med Chem 2004; 11:2195-204.
    • (2004) Curr Med Chem , vol.11 , pp. 2195-2204
    • Walenta, S.1    Schroeder, T.2    Mueller-Klieser, W.3
  • 66
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfor K, Rofstad EK, Mueller-Klieser, W. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 2000; 60:916-21.
    • (2000) Cancer Res , vol.60 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfor, K.5    Rofstad, E.K.6    Mueller-Klieser, W.7
  • 68
    • 0033569442 scopus 로고    scopus 로고
    • The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
    • Halestrap AP, Price NT. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 1999; 343:281-99.
    • (1999) Biochem J , vol.343 , pp. 281-299
    • Halestrap, A.P.1    Price, N.T.2
  • 69
    • 8744249212 scopus 로고    scopus 로고
    • Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes
    • Merezhinskaya N, Ogunwuyi SA, Mullick FG, Fishbein WN. Presence and localization of three lactic acid transporters (MCT1, -2, and -4) in separated human granulocytes, lymphocytes, and monocytes. J Histochem Cytochem 2004; 52:1483-93.
    • (2004) J Histochem Cytochem , vol.52 , pp. 1483-1493
    • Merezhinskaya, N.1    Ogunwuyi, S.A.2    Mullick, F.G.3    Fishbein, W.N.4
  • 70
  • 71
    • 0035927544 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
    • Shi Q, Le X, Wang B, Abbruzzese JL, Xiong Q, He Y, Xie K. Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. Oncogene 2001; 20:3751-6.
    • (2001) Oncogene , vol.20 , pp. 3751-3756
    • Shi, Q.1    Le, X.2    Wang, B.3    Abbruzzese, J.L.4    Xiong, Q.5    He, Y.6    Xie, K.7
  • 72
    • 0035881307 scopus 로고    scopus 로고
    • Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    • Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK. Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res 2001; 61:6020-4.
    • (2001) Cancer Res , vol.61 , pp. 6020-6024
    • Fukumura, D.1    Xu, L.2    Chen, Y.3    Gohongi, T.4    Seed, B.5    Jain, R.K.6
  • 73
    • 0035071662 scopus 로고    scopus 로고
    • The effects of extracellular pH on immune function
    • Lardner A. The effects of extracellular pH on immune function. J Leukoc Biol 2001; 69:522-30.
    • (2001) J Leukoc Biol , vol.69 , pp. 522-530
    • Lardner, A.1
  • 75
    • 1842486876 scopus 로고    scopus 로고
    • Induction of potent antitumor immunity by in situ targeting of intratumoral DCs
    • Furumoto K, Soares L, Engleman EG, Merad M. Induction of potent antitumor immunity by in situ targeting of intratumoral DCs. J Clin Invest 2004; 113:774-83.
    • (2004) J Clin Invest , vol.113 , pp. 774-783
    • Furumoto, K.1    Soares, L.2    Engleman, E.G.3    Merad, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.