3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Longati, Paola ^a   Jia, Xiaohui ^a   Eimer, Johannes ^a   Wagman, Annika ^a   Witt, Michael Robin ^b   Rehnmark, Stefan ^b   Verbeke, Caroline ^a   Toftgård, Rune ^a   Löhr, Matthias ^a   Heuchel, Rainer L ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Axcentua Pharmaceuticals AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ALLICIN; AXP 107 11; CYTOTOXIC AGENT; GEMCITABINE; LACTIC ACID; LUMICAN; MATRIX PROTEIN; METHYLCELLULOSE; MICRORNA; MICRORNA 146A; MICRORNA 21; MICRORNA 335; MT 100; PHOSPHOPROTEIN DARPP 32; PROTEIN SNED1; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER MODEL; CANCER RESISTANCE; CELL ADHESION; CELL METABOLISM; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; ELECTRON MICROSCOPY; ENERGY METABOLISM; GENETIC SELECTION; GLYCOLYSIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS ADENOCARCINOMA; PHENOTYPE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPHEROID CELL; TUMOR SPHEROID;

ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, PANCREATIC DUCTAL; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; ENERGY METABOLISM; EXTRACELLULAR MATRIX PROTEINS; HUMANS; LACTIC ACID; MICE; PANCREATIC NEOPLASMS; PHENOTYPE; SPHEROIDS, CELLULAR; TUMOR CELLS, CULTURED;

EID: 84874239307     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-95     Document Type: Article

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