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Volumn 65, Issue 11-12, 2013, Pages 1575-1588

Microfluidics-assisted in vitro drug screening and carrier production

Author keywords

Drug carrier; Drug screening; Gene carrier; High throughput; Microfluidics

Indexed keywords

BATCH-TO-BATCH VARIATIONS; DRUG CARRIER; DRUG SCREENING; GENE CARRIER; HIGH-THROUGHPUT; HIGH-THROUGHPUT ANALYSIS; MICROFLUIDIC PLATFORMS; PHARMACOKINETIC PARAMETERS;

EID: 84887615628     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2013.07.004     Document Type: Review
Times cited : (101)

References (101)
  • 1
    • 84869504124 scopus 로고    scopus 로고
    • Challenges in design of translational nanocarriers
    • Sun Q., Radosz M., Shen Y. Challenges in design of translational nanocarriers. J. Control Release 2012, 164:156-169.
    • (2012) J. Control Release , vol.164 , pp. 156-169
    • Sun, Q.1    Radosz, M.2    Shen, Y.3
  • 2
  • 3
    • 80755125404 scopus 로고    scopus 로고
    • Microfluidic approaches for gene delivery and gene therapy
    • Kim J., Hwang I., Britain D., Chung T.D., Sun Y., Kim D.H. Microfluidic approaches for gene delivery and gene therapy. Lab Chip. 2011, 11:3941-3948.
    • (2011) Lab Chip. , vol.11 , pp. 3941-3948
    • Kim, J.1    Hwang, I.2    Britain, D.3    Chung, T.D.4    Sun, Y.5    Kim, D.H.6
  • 4
    • 1642362625 scopus 로고    scopus 로고
    • Drug delivery systems: entering the mainstream
    • Allen T.M., Cullis P.R. Drug delivery systems: entering the mainstream. Science 2004, 303:1818-1822.
    • (2004) Science , vol.303 , pp. 1818-1822
    • Allen, T.M.1    Cullis, P.R.2
  • 5
    • 0037161782 scopus 로고    scopus 로고
    • Microfluidic routes to the controlled production of nanoparticles
    • Edel J.B., Fortt R., DeMello J.C., DeMello A.J. Microfluidic routes to the controlled production of nanoparticles. Chem. Commun. 2002, 1136-1137.
    • (2002) Chem. Commun. , pp. 1136-1137
    • Edel, J.B.1    Fortt, R.2    DeMello, J.C.3    DeMello, A.J.4
  • 6
    • 0029895325 scopus 로고    scopus 로고
    • Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution
    • Takakura Y., Hashida M. Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution. Pharm. Res. 1996, 13:820-831.
    • (1996) Pharm. Res. , vol.13 , pp. 820-831
    • Takakura, Y.1    Hashida, M.2
  • 7
    • 79955903566 scopus 로고    scopus 로고
    • Liposome technology for industrial purposes
    • Wagner A., Vorauer-Uhl K. Liposome technology for industrial purposes. J. Drug Deliv. 2011, 2011:591325.
    • (2011) J. Drug Deliv. , vol.2011 , pp. 591325
    • Wagner, A.1    Vorauer-Uhl, K.2
  • 8
    • 84863381095 scopus 로고    scopus 로고
    • Lifting gate PDMS microvalves and pumps for microfluidic control
    • Kim J., Kang M., Jensen E.C., Mathies R.A. Lifting gate PDMS microvalves and pumps for microfluidic control. Anal. Chem. 2012, 84:2067-2071.
    • (2012) Anal. Chem. , vol.84 , pp. 2067-2071
    • Kim, J.1    Kang, M.2    Jensen, E.C.3    Mathies, R.A.4
  • 9
    • 35548968849 scopus 로고    scopus 로고
    • Lipoplex morphologies and their influences on transfection efficiency in gene delivery
    • Ma B., Zhang S., Jiang H., Zhao B., Lv H. Lipoplex morphologies and their influences on transfection efficiency in gene delivery. J. Control Release 2007, 123:184-194.
    • (2007) J. Control Release , vol.123 , pp. 184-194
    • Ma, B.1    Zhang, S.2    Jiang, H.3    Zhao, B.4    Lv, H.5
  • 10
    • 0344737989 scopus 로고    scopus 로고
    • Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices
    • Lee J.N., Park C., Whitesides G.M. Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices. Anal. Chem. 2003, 75:6544-6554.
    • (2003) Anal. Chem. , vol.75 , pp. 6544-6554
    • Lee, J.N.1    Park, C.2    Whitesides, G.M.3
  • 11
    • 77955908299 scopus 로고    scopus 로고
    • Cyclic olefin polymers: emerging materials for lab-on-a-chip applications
    • Nunes P.S., Ohlsson P.D., Ordeig O., Kutter J.P. Cyclic olefin polymers: emerging materials for lab-on-a-chip applications. Microfluid. Nanofluid. 2010, 9:145-161.
    • (2010) Microfluid. Nanofluid. , vol.9 , pp. 145-161
    • Nunes, P.S.1    Ohlsson, P.D.2    Ordeig, O.3    Kutter, J.P.4
  • 13
    • 84870861454 scopus 로고    scopus 로고
    • Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility
    • Hashimoto M., Langer R., Kohane D.S. Benchtop fabrication of microfluidic systems based on curable polymers with improved solvent compatibility. Lab Chip. 2013, 13:252-259.
    • (2013) Lab Chip. , vol.13 , pp. 252-259
    • Hashimoto, M.1    Langer, R.2    Kohane, D.S.3
  • 14
    • 70350053403 scopus 로고    scopus 로고
    • Delivery of polyethylenimine/DNA complexes assembled in a microfluidics device
    • Koh C.G., Kang X., Xie Y., Fei Z., Guan J., Yu B., Zhang X., Lee L.J. Delivery of polyethylenimine/DNA complexes assembled in a microfluidics device. Mol. Pharm. 2009, 6:1333-1342.
    • (2009) Mol. Pharm. , vol.6 , pp. 1333-1342
    • Koh, C.G.1    Kang, X.2    Xie, Y.3    Fei, Z.4    Guan, J.5    Yu, B.6    Zhang, X.7    Lee, L.J.8
  • 15
    • 84862842189 scopus 로고    scopus 로고
    • Optimized preparation of pDNA/poly(ethylene imine) polyplexes using a microfluidic system
    • Debus H., Beck-Broichsitter M., Kissel T. Optimized preparation of pDNA/poly(ethylene imine) polyplexes using a microfluidic system. Lab Chip. 2012, 12:2498-2506.
    • (2012) Lab Chip. , vol.12 , pp. 2498-2506
    • Debus, H.1    Beck-Broichsitter, M.2    Kissel, T.3
  • 18
    • 84861981982 scopus 로고    scopus 로고
    • Optimising the self-assembly of siRNA loaded PEG-PCL-lPEI nano-carriers employing different preparation techniques
    • Endres T., Zheng M., Beck-Broichsitter M., Samsonova O., Debus H., Kissel T. Optimising the self-assembly of siRNA loaded PEG-PCL-lPEI nano-carriers employing different preparation techniques. J. Control Release 2012, 160:583-591.
    • (2012) J. Control Release , vol.160 , pp. 583-591
    • Endres, T.1    Zheng, M.2    Beck-Broichsitter, M.3    Samsonova, O.4    Debus, H.5    Kissel, T.6
  • 20
    • 79959900368 scopus 로고    scopus 로고
    • Fabrication of advanced particles and particle-based materials assisted by droplet-based microfluidics
    • Wang J.-T., Wang J., Han J.-J. Fabrication of advanced particles and particle-based materials assisted by droplet-based microfluidics. Small 2011, 7:1728-1754.
    • (2011) Small , vol.7 , pp. 1728-1754
    • Wang, J.-T.1    Wang, J.2    Han, J.-J.3
  • 21
    • 79955907483 scopus 로고    scopus 로고
    • Tuning Physical properties of nanocomplexes through microfluidics-assisted confinement
    • Ho Y.-P., Grigsby C.L., Zhao F., Leong K.W. Tuning Physical properties of nanocomplexes through microfluidics-assisted confinement. Nano Lett. 2011, 11:2178-2182.
    • (2011) Nano Lett. , vol.11 , pp. 2178-2182
    • Ho, Y.-P.1    Grigsby, C.L.2    Zhao, F.3    Leong, K.W.4
  • 22
    • 69549087912 scopus 로고    scopus 로고
    • Nonviral gene vector formation in monodispersed picolitre incubator for consistent gene delivery
    • Hsieh A.T., Hori N., Massoudi R., Pan P.J., Sasaki H., Lin Y.A., Lee A.P. Nonviral gene vector formation in monodispersed picolitre incubator for consistent gene delivery. Lab Chip. 2009, 9:2638-2643.
    • (2009) Lab Chip. , vol.9 , pp. 2638-2643
    • Hsieh, A.T.1    Hori, N.2    Massoudi, R.3    Pan, P.J.4    Sasaki, H.5    Lin, Y.A.6    Lee, A.P.7
  • 26
    • 84862957230 scopus 로고    scopus 로고
    • Microfluidic approach for highly efficient synthesis of heparin-based bioconjugates for drug delivery
    • Tran T.H., Nguyen C.T., Kim D.-P., Lee Y.-k., Huh K.M. Microfluidic approach for highly efficient synthesis of heparin-based bioconjugates for drug delivery. Lab Chip. 2012, 12:589-594.
    • (2012) Lab Chip. , vol.12 , pp. 589-594
    • Tran, T.H.1    Nguyen, C.T.2    Kim, D.-P.3    Lee, Y.-K.4    Huh, K.M.5
  • 27
    • 84855289517 scopus 로고    scopus 로고
    • Stable, biocompatible lipid vesicle generation by solvent extraction-based droplet microfluidics
    • Teh S.-Y., Khnouf R., Fan H., Lee A.P. Stable, biocompatible lipid vesicle generation by solvent extraction-based droplet microfluidics. Biomicrofluidics 2011, 5:044113.
    • (2011) Biomicrofluidics , vol.5 , pp. 044113
    • Teh, S.-Y.1    Khnouf, R.2    Fan, H.3    Lee, A.P.4
  • 28
    • 84887616502 scopus 로고    scopus 로고
    • Cell encapsulation on a microfluidic platform
    • Fisher J.S., Lee A.P. Cell encapsulation on a microfluidic platform. Proc. MicroTAS 2004, 296:647-649.
    • (2004) Proc. MicroTAS , vol.296 , pp. 647-649
    • Fisher, J.S.1    Lee, A.P.2
  • 29
    • 69149094743 scopus 로고    scopus 로고
    • Controllable microfluidic synthesis of multiphase drug-carrying lipospheres for site-targeted therapy
    • Hettiarachchi K., Zhang S., Feingold S., Lee A.P., Dayton P.A. Controllable microfluidic synthesis of multiphase drug-carrying lipospheres for site-targeted therapy. Biotechnol. Prog. 2009, 25:938-945.
    • (2009) Biotechnol. Prog. , vol.25 , pp. 938-945
    • Hettiarachchi, K.1    Zhang, S.2    Feingold, S.3    Lee, A.P.4    Dayton, P.A.5
  • 30
    • 47349107407 scopus 로고    scopus 로고
    • Biopolymer microparticle and nanoparticle formation within a microfluidic device
    • Rondeau E., Cooper-White J.J. Biopolymer microparticle and nanoparticle formation within a microfluidic device. Langmuir 2008, 24:6937-6945.
    • (2008) Langmuir , vol.24 , pp. 6937-6945
    • Rondeau, E.1    Cooper-White, J.J.2
  • 31
    • 84859569417 scopus 로고    scopus 로고
    • Synthesis of monodisperse, covalently cross-linked, degradable "smart" microgels using microfluidics
    • Kesselman L.R.B., Shinwary S., Selvaganapathy P.R., Hoare T. Synthesis of monodisperse, covalently cross-linked, degradable "smart" microgels using microfluidics. Small 2012, 8:1092-1098.
    • (2012) Small , vol.8 , pp. 1092-1098
    • Kesselman, L.R.B.1    Shinwary, S.2    Selvaganapathy, P.R.3    Hoare, T.4
  • 33
    • 84859796841 scopus 로고    scopus 로고
    • Bottom-up design and synthesis of limit size lipid nanoparticle systems with aqueous and triglyceride cores using millisecond microfluidic mixing
    • Zhigaltsev I.V., Belliveau N., Hafez I., Leung A.K.K., Huft J., Hansen C., Cullis P.R. Bottom-up design and synthesis of limit size lipid nanoparticle systems with aqueous and triglyceride cores using millisecond microfluidic mixing. Langmuir 2012, 28:3633-3640.
    • (2012) Langmuir , vol.28 , pp. 3633-3640
    • Zhigaltsev, I.V.1    Belliveau, N.2    Hafez, I.3    Leung, A.K.K.4    Huft, J.5    Hansen, C.6    Cullis, P.R.7
  • 35
    • 77950438544 scopus 로고    scopus 로고
    • Microfluidic cell culture systems for drug research
    • Wu M.-H., Huang S.-B., Lee G.-B. Microfluidic cell culture systems for drug research. Lab Chip. 2010, 10:939-956.
    • (2010) Lab Chip. , vol.10 , pp. 939-956
    • Wu, M.-H.1    Huang, S.-B.2    Lee, G.-B.3
  • 36
    • 84874700631 scopus 로고    scopus 로고
    • Three-dimensional cell culture: the missing link in drug discovery
    • Breslin S., O'Driscoll L. Three-dimensional cell culture: the missing link in drug discovery. Drug Discov. Today 2012, 10.1016/j.drudis.2012.10.003.
    • (2012) Drug Discov. Today
    • Breslin, S.1    O'Driscoll, L.2
  • 38
    • 77955009847 scopus 로고    scopus 로고
    • Simple haptotactic gradient generation within a triangular microfluidic channel
    • Park J., Kim D.H., Kim G., Kim Y., Choi E., Levchenko A. Simple haptotactic gradient generation within a triangular microfluidic channel. Lab Chip. 2010, 10:2130-2138.
    • (2010) Lab Chip. , vol.10 , pp. 2130-2138
    • Park, J.1    Kim, D.H.2    Kim, G.3    Kim, Y.4    Choi, E.5    Levchenko, A.6
  • 40
    • 34249775501 scopus 로고    scopus 로고
    • High-density microfluidic arrays for cell cytotoxicity analysis
    • Wang Z., Kim M.-C., Marquez M., Thorsen T. High-density microfluidic arrays for cell cytotoxicity analysis. Lab Chip. 2007, 7:740-745.
    • (2007) Lab Chip. , vol.7 , pp. 740-745
    • Wang, Z.1    Kim, M.-C.2    Marquez, M.3    Thorsen, T.4
  • 41
    • 36049003650 scopus 로고    scopus 로고
    • Microfluidic system for automated cell-based assays
    • Lee P., Ghorashian N., Gaige T., Hung P. Microfluidic system for automated cell-based assays. J. Lab. Autom. 2007, 12:363-367.
    • (2007) J. Lab. Autom. , vol.12 , pp. 363-367
    • Lee, P.1    Ghorashian, N.2    Gaige, T.3    Hung, P.4
  • 44
    • 34648834682 scopus 로고    scopus 로고
    • The third dimension bridges the gap between cell culture and live tissue
    • Pampaloni F., Reynaud E.G., Stelzer E.H.K. The third dimension bridges the gap between cell culture and live tissue. Nat. Rev. Mol. Cell Bio. 2007, 8:839-845.
    • (2007) Nat. Rev. Mol. Cell Bio. , vol.8 , pp. 839-845
    • Pampaloni, F.1    Reynaud, E.G.2    Stelzer, E.H.K.3
  • 45
    • 33644653456 scopus 로고    scopus 로고
    • Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents
    • Sun T., Jackson S., Haycock J.W., MacNeil S. Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents. J. Biotechnol. 2006, 122:372-381.
    • (2006) J. Biotechnol. , vol.122 , pp. 372-381
    • Sun, T.1    Jackson, S.2    Haycock, J.W.3    MacNeil, S.4
  • 46
    • 84867225972 scopus 로고    scopus 로고
    • Synthetic 3D multicellular systems for drug development
    • Rimann M., Graf-Hausner U. Synthetic 3D multicellular systems for drug development. Curr. Opin. Biotechnol. 2012, 23:803-809.
    • (2012) Curr. Opin. Biotechnol. , vol.23 , pp. 803-809
    • Rimann, M.1    Graf-Hausner, U.2
  • 48
    • 33846032329 scopus 로고    scopus 로고
    • A microfluidic platform for 3-dimensional cell culture and cell-based assays
    • Kim M.S., Yeon J.H., Park J.K. A microfluidic platform for 3-dimensional cell culture and cell-based assays. Biomed. Microdev. 2007, 9:25-34.
    • (2007) Biomed. Microdev. , vol.9 , pp. 25-34
    • Kim, M.S.1    Yeon, J.H.2    Park, J.K.3
  • 49
    • 77956116033 scopus 로고    scopus 로고
    • Alginate-based microfluidic system for tumor spheroid formation and anticancer agent screening
    • Chen M.C.W., Gupta M., Cheung K.C. Alginate-based microfluidic system for tumor spheroid formation and anticancer agent screening. Biomed. Microdev. 2010, 12:647-654.
    • (2010) Biomed. Microdev. , vol.12 , pp. 647-654
    • Chen, M.C.W.1    Gupta, M.2    Cheung, K.C.3
  • 50
    • 65649133932 scopus 로고    scopus 로고
    • A micro cell culture analog (μCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs
    • Sung J.H., Shuler M.L. A micro cell culture analog (μCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. Lab Chip. 2009, 9:1385-1394.
    • (2009) Lab Chip. , vol.9 , pp. 1385-1394
    • Sung, J.H.1    Shuler, M.L.2
  • 51
    • 38149024155 scopus 로고    scopus 로고
    • Development of perfusion-based micro 3-D cell culture platform and its application for high throughput drug testing
    • Wu M.-H., Huang S.-B., Cui Z., Cui Z., Lee G.-B. Development of perfusion-based micro 3-D cell culture platform and its application for high throughput drug testing. Sensor. Actuat. B-Chem. 2008, 129:231-240.
    • (2008) Sensor. Actuat. B-Chem. , vol.129 , pp. 231-240
    • Wu, M.-H.1    Huang, S.-B.2    Cui, Z.3    Cui, Z.4    Lee, G.-B.5
  • 52
    • 84875865801 scopus 로고    scopus 로고
    • An integrated microfluidic cell culture system for high-throughput perfusion three-dimensional cell culture-based assays: effect of cell culture model on the results of chemosensitivity assays
    • Huang S.B., Wang S.S., Hsieh C.H., Lin Y.C., Lai C.S., Wu M.H. An integrated microfluidic cell culture system for high-throughput perfusion three-dimensional cell culture-based assays: effect of cell culture model on the results of chemosensitivity assays. Lab Chip. 2013, 13:1133-1143.
    • (2013) Lab Chip. , vol.13 , pp. 1133-1143
    • Huang, S.B.1    Wang, S.S.2    Hsieh, C.H.3    Lin, Y.C.4    Lai, C.S.5    Wu, M.H.6
  • 54
    • 84858451188 scopus 로고    scopus 로고
    • A microfluidic system for investigation of extravascular transport and cellular uptake of drugs in tumors
    • Elliott N.T., Yuan F. A microfluidic system for investigation of extravascular transport and cellular uptake of drugs in tumors. Biotechnol. Bioeng. 2012, 109:1326-1335.
    • (2012) Biotechnol. Bioeng. , vol.109 , pp. 1326-1335
    • Elliott, N.T.1    Yuan, F.2
  • 56
    • 58749093939 scopus 로고    scopus 로고
    • Recent advances in three-dimensional multicellular spheroid culture for biomedical research
    • Lin R.Z., Chang H.Y. Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol. J. 2008, 3:1172-1184.
    • (2008) Biotechnol. J. , vol.3 , pp. 1172-1184
    • Lin, R.Z.1    Chang, H.Y.2
  • 58
    • 77952528235 scopus 로고    scopus 로고
    • Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity
    • Meng Q. Three-dimensional culture of hepatocytes for prediction of drug-induced hepatotoxicity. Expert Opin. Drug Met. 2010, 6:733-746.
    • (2010) Expert Opin. Drug Met. , vol.6 , pp. 733-746
    • Meng, Q.1
  • 60
    • 29144530591 scopus 로고    scopus 로고
    • Three-dimensional in vitro reaggregates of embryonic cardiomyocytes: a potential model system for monitoring effects of bioactive agents
    • Bartholoma P., Gorjup E., Monz D., Reininger-Mack A., Thielecke H., Robitzki A. Three-dimensional in vitro reaggregates of embryonic cardiomyocytes: a potential model system for monitoring effects of bioactive agents. J. Biomol. Screen. 2005, 10:814-822.
    • (2005) J. Biomol. Screen. , vol.10 , pp. 814-822
    • Bartholoma, P.1    Gorjup, E.2    Monz, D.3    Reininger-Mack, A.4    Thielecke, H.5    Robitzki, A.6
  • 62
    • 79953233128 scopus 로고    scopus 로고
    • Tissue models: a living system on a chip
    • Baker M. Tissue models: a living system on a chip. Nature 2011, 471:661-665.
    • (2011) Nature , vol.471 , pp. 661-665
    • Baker, M.1
  • 64
    • 78650062139 scopus 로고    scopus 로고
    • A review of three-dimensional in vitro tissue models for drug discovery and transport studies
    • Elliott N.T., Yuan F. A review of three-dimensional in vitro tissue models for drug discovery and transport studies. J. Pharm. Sci. 2011, 100:59-74.
    • (2011) J. Pharm. Sci. , vol.100 , pp. 59-74
    • Elliott, N.T.1    Yuan, F.2
  • 66
    • 79960527448 scopus 로고    scopus 로고
    • The role of body-on-a-chip devices in drug and toxicity studies
    • Esch M.B., King T.L., Shuler M.L. The role of body-on-a-chip devices in drug and toxicity studies. Annu. Rev. Biomed. Eng. 2011, 13:55-72.
    • (2011) Annu. Rev. Biomed. Eng. , vol.13 , pp. 55-72
    • Esch, M.B.1    King, T.L.2    Shuler, M.L.3
  • 67
    • 72049119863 scopus 로고    scopus 로고
    • Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments
    • Zhang C., Zhao Z., Rahim N.A.A., Noort D.v., Yu H. Towards a human-on-chip: culturing multiple cell types on a chip with compartmentalized microenvironments. Lab Chip. 2009, 9:3185-3192.
    • (2009) Lab Chip. , vol.9 , pp. 3185-3192
    • Zhang, C.1    Zhao, Z.2    Rahim, N.A.A.3    Noort, D.4    Yu, H.5
  • 70
    • 84865261166 scopus 로고    scopus 로고
    • Cytotoxicity of quantum dots assay on a microfluidic 3D-culture device based on modeling diffusion process between blood vessels and tissues
    • Wu J., Chen Q., Liu W., Zhang Y., Lin J.M. Cytotoxicity of quantum dots assay on a microfluidic 3D-culture device based on modeling diffusion process between blood vessels and tissues. Lab Chip. 2012, 12:3474-3480.
    • (2012) Lab Chip. , vol.12 , pp. 3474-3480
    • Wu, J.1    Chen, Q.2    Liu, W.3    Zhang, Y.4    Lin, J.M.5
  • 71
    • 75749153235 scopus 로고    scopus 로고
    • A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip
    • Sung J.H., Kam C., Shuler M.L. A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip. Lab Chip. 2010, 10:446-455.
    • (2010) Lab Chip. , vol.10 , pp. 446-455
    • Sung, J.H.1    Kam, C.2    Shuler, M.L.3
  • 72
    • 38049011979 scopus 로고    scopus 로고
    • Microscale culture of human liver cells for drug development
    • Khetani S.R., Bhatia S.N. Microscale culture of human liver cells for drug development. Nat. Biotechnol. 2008, 26:120-126.
    • (2008) Nat. Biotechnol. , vol.26 , pp. 120-126
    • Khetani, S.R.1    Bhatia, S.N.2
  • 74
    • 67650481611 scopus 로고    scopus 로고
    • A microfluidic 3D hepatocyte chip for drug toxicity testing
    • Toh Y.C., Lim T.C., Tai D., Xiao G., van Noort D., Yu H. A microfluidic 3D hepatocyte chip for drug toxicity testing. Lab Chip. 2009, 9:2026-2035.
    • (2009) Lab Chip. , vol.9 , pp. 2026-2035
    • Toh, Y.C.1    Lim, T.C.2    Tai, D.3    Xiao, G.4    van Noort, D.5    Yu, H.6
  • 75
    • 77951884924 scopus 로고    scopus 로고
    • A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells
    • Jang K.J., Suh K.Y. A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. Lab Chip. 2010, 10:36-42.
    • (2010) Lab Chip. , vol.10 , pp. 36-42
    • Jang, K.J.1    Suh, K.Y.2
  • 76
    • 70549099703 scopus 로고    scopus 로고
    • An open-access microfluidic model for lung-specific functional studies at an air-liquid interface
    • Nalayanda D.D., Puleo C., Fulton W.B., Sharpe L.M., Wang T.-H., Abdullah F. An open-access microfluidic model for lung-specific functional studies at an air-liquid interface. Biomed. Microdev. 2009, 11:1081-1089.
    • (2009) Biomed. Microdev. , vol.11 , pp. 1081-1089
    • Nalayanda, D.D.1    Puleo, C.2    Fulton, W.B.3    Sharpe, L.M.4    Wang, T.-H.5    Abdullah, F.6
  • 79
    • 84862207235 scopus 로고    scopus 로고
    • Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
    • Kim H.J., Huh D., Hamilton G., Ingber D.E. Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip. 2012, 12:2165-2174.
    • (2012) Lab Chip. , vol.12 , pp. 2165-2174
    • Kim, H.J.1    Huh, D.2    Hamilton, G.3    Ingber, D.E.4
  • 80
    • 84857964726 scopus 로고    scopus 로고
    • Ensembles of engineered cardiac tissue for physiological and pharmacological study: heart on a chip
    • Grosberg A., Alford P.W., McCain M.L., Parker K.K. Ensembles of engineered cardiac tissue for physiological and pharmacological study: heart on a chip. Lab Chip. 2011, 11:4165-4173.
    • (2011) Lab Chip. , vol.11 , pp. 4165-4173
    • Grosberg, A.1    Alford, P.W.2    McCain, M.L.3    Parker, K.K.4
  • 81
    • 84862778621 scopus 로고    scopus 로고
    • Integrated microfluidics platforms for investigating injury and regeneration of CNS axons
    • Kim H.J., Park J.W., Byun J.H., Vahidi B., Rhee S.W., Jeon N.L. Integrated microfluidics platforms for investigating injury and regeneration of CNS axons. Ann. Biomed. Eng. 2012, 40:1268-1276.
    • (2012) Ann. Biomed. Eng. , vol.40 , pp. 1268-1276
    • Kim, H.J.1    Park, J.W.2    Byun, J.H.3    Vahidi, B.4    Rhee, S.W.5    Jeon, N.L.6
  • 84
    • 78650177565 scopus 로고    scopus 로고
    • Microvalve enabled digital microfluidic systems for high performance biochemical and genetic analysis
    • Jensen E.C., Zeng Y., Kim J., Mathies R.A. Microvalve enabled digital microfluidic systems for high performance biochemical and genetic analysis. J. Lab. Autom. 2010, 5:455-463.
    • (2010) J. Lab. Autom. , vol.5 , pp. 455-463
    • Jensen, E.C.1    Zeng, Y.2    Kim, J.3    Mathies, R.A.4
  • 85
    • 84882715808 scopus 로고    scopus 로고
    • Universal microfluidic automaton for autonomous sample processing: application to the Mars organic analyzer
    • Kim J., Jensen E.C., Stockton A.M., Mathies R.A. Universal microfluidic automaton for autonomous sample processing: application to the Mars organic analyzer. Anal. Chem. 2013, 10.1021/ac303767m.
    • (2013) Anal. Chem.
    • Kim, J.1    Jensen, E.C.2    Stockton, A.M.3    Mathies, R.A.4
  • 86
    • 79960998416 scopus 로고    scopus 로고
    • The Wyss Institute at Harvard University
    • Ingber D.E. The Wyss Institute at Harvard University. IEEE Pulse 2011, 2:43-46.
    • (2011) IEEE Pulse , vol.2 , pp. 43-46
    • Ingber, D.E.1
  • 87
    • 1942502193 scopus 로고    scopus 로고
    • Microfabrication and microfluidics for tissue engineering: state of the art and future opportunities
    • Andersson H., van den Berg A. Microfabrication and microfluidics for tissue engineering: state of the art and future opportunities. Lab Chip. 2004, 4:98-103.
    • (2004) Lab Chip. , vol.4 , pp. 98-103
    • Andersson, H.1    Van Den Berg, A.2
  • 92
    • 12144263348 scopus 로고    scopus 로고
    • Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays
    • Hung P.J., Lee P.J., Sabounchi P., Lin R., Lee L.P. Continuous perfusion microfluidic cell culture array for high-throughput cell-based assays. Biotechnol. Bioeng. 2005, 89:1-8.
    • (2005) Biotechnol. Bioeng. , vol.89 , pp. 1-8
    • Hung, P.J.1    Lee, P.J.2    Sabounchi, P.3    Lin, R.4    Lee, L.P.5
  • 93
    • 80053914815 scopus 로고    scopus 로고
    • Microfluidic array for three-dimensional perfusion culture of human mammary epithelial cells
    • Chen S.Y.C., Hung P.J., Lee P.J. Microfluidic array for three-dimensional perfusion culture of human mammary epithelial cells. Biomed. Microdev. 2011, 13:753-758.
    • (2011) Biomed. Microdev. , vol.13 , pp. 753-758
    • Chen, S.Y.C.1    Hung, P.J.2    Lee, P.J.3
  • 95
    • 84874816346 scopus 로고    scopus 로고
    • Enabling screening in 3D microenvironments: probing matrix and stromal effects on the morphology and proliferation of T47D breast carcinoma cells
    • Montanez-Sauri S.I., Sung K.E., Berthier E., Beebe D.J. Enabling screening in 3D microenvironments: probing matrix and stromal effects on the morphology and proliferation of T47D breast carcinoma cells. Integr. Biol. 2013, 5:631-640.
    • (2013) Integr. Biol. , vol.5 , pp. 631-640
    • Montanez-Sauri, S.I.1    Sung, K.E.2    Berthier, E.3    Beebe, D.J.4
  • 96
    • 77955546121 scopus 로고    scopus 로고
    • 3D microchannel co-culture: method and biological validation
    • Bauer M., Su G., Beebe D.J., Friedl A. 3D microchannel co-culture: method and biological validation. Integr. Biol. 2010, 2:371-378.
    • (2010) Integr. Biol. , vol.2 , pp. 371-378
    • Bauer, M.1    Su, G.2    Beebe, D.J.3    Friedl, A.4
  • 97
    • 63049111520 scopus 로고    scopus 로고
    • High content cell screening in a microfluidic device
    • Cheong R., Wang C.J., Levchenko A. High content cell screening in a microfluidic device. Mol. Cell. Proteomics 2009, 8:433-442.
    • (2009) Mol. Cell. Proteomics , vol.8 , pp. 433-442
    • Cheong, R.1    Wang, C.J.2    Levchenko, A.3
  • 98
    • 68849100182 scopus 로고    scopus 로고
    • Using a microfluidic device for high-content analysis of cell signaling
    • Cheong R., Wang C.J., Levchenko A. Using a microfluidic device for high-content analysis of cell signaling. Sci. Signal. 2009, 2:pl2.
    • (2009) Sci. Signal. , vol.2
    • Cheong, R.1    Wang, C.J.2    Levchenko, A.3
  • 99
    • 33947116356 scopus 로고    scopus 로고
    • Multifunctional encoded particles for high-throughput biomolecule analysis
    • Pregibon D.C., Toner M., Doyle P.S. Multifunctional encoded particles for high-throughput biomolecule analysis. Science 2007, 315:1393-1396.
    • (2007) Science , vol.315 , pp. 1393-1396
    • Pregibon, D.C.1    Toner, M.2    Doyle, P.S.3
  • 100
    • 77956048370 scopus 로고    scopus 로고
    • Colour-barcoded magnetic microparticles for multiplexed bioassays
    • Lee H., Kim J., Kim H., Kim J., Kwon S. Colour-barcoded magnetic microparticles for multiplexed bioassays. Nat. Mater. 2010, 9:745-749.
    • (2010) Nat. Mater. , vol.9 , pp. 745-749
    • Lee, H.1    Kim, J.2    Kim, H.3    Kim, J.4    Kwon, S.5
  • 101
    • 84867231150 scopus 로고    scopus 로고
    • Free-floating amphiphilic picoliter droplet carriers for multiplexed liquid loading in a microfluidic channel
    • Park W., Han S., Lee H., Kwon S. Free-floating amphiphilic picoliter droplet carriers for multiplexed liquid loading in a microfluidic channel. Microfluid. Nanofluid. 2012, 13:511-518.
    • (2012) Microfluid. Nanofluid. , vol.13 , pp. 511-518
    • Park, W.1    Han, S.2    Lee, H.3    Kwon, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.