Perfusion of 3D encapsulated hepatocytes-A synergistic effect enhancing long-term functionality in bioreactors

Biotechnology and Bioengineering

Volumn 108, Issue 1, 2011, Pages 41-49

  Tostões, Rui M ^a   Leite, Sofia B ^a   Miranda, Joana P ^a,d   Sousa, Marcos ^a   Wang, Daniel I C ^b   Carrondo, Manuel J T ^a,c   Alves, Paula M ^a  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^d UNIVERSITY OF LISBON   (Portugal)

Author keywords

3D; Bioreactor; Hepatocytes; Liver specific functions; Long term functionality; Perfusion

Indexed keywords

3D; HEPATOCYTES; LIVER-SPECIFIC FUNCTIONS; LONG-TERM FUNCTIONALITY; PERFUSION;

ALGINATE; BIOCONVERSION; ENCAPSULATION; FEEDING; LIVER; OXYGEN; THREE DIMENSIONAL; UREA;

BIOREACTORS;

ALBUMIN; ALGINIC ACID; DRUG METABOLIZING ENZYME; UREA;

ANIMAL CELL; ARTICLE; BIOREACTOR; CELL ENCAPSULATION; CONTROLLED STUDY; CULTURE MEDIUM; DIFFUSION; DILUTION; ENZYME ACTIVITY; LIVER CELL; MALE; NONHUMAN; OXYGEN CONSUMPTION; PERFUSION; RAT; SPHEROID CELL; SYNTHESIS;

ALBUMINS; ALGINATES; ANIMALS; BIOREACTORS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CULTURE MEDIA; DIFFUSION; GLUCURONIC ACID; HEPATOCYTES; HEXURONIC ACIDS; LIVER, ARTIFICIAL; MICROSPHERES; ORGAN CULTURE TECHNIQUES; OXYGEN CONSUMPTION; RATS; RATS, WISTAR;

ANIMALIA;

EID: 78649424262     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.22920     Document Type: Article

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