Bioprocessing of Human Glioblastoma Brain Cancer Tissue

Tissue Engineering - Part A

Volumn 16, Issue 4, 2010, Pages 1169-1177

  Panchalingam, Krishna M ^a   Paramchuk, Wendy J ^a   Chiang, Chun Yi Katherine ^a   Shah, Nameeta ^b   Madan, Anup ^b   Hood, Leroy ^c   Foltz, Greg ^b   Behie, Leo A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b SWEDISH MEDICAL CENTER   (United States)

^c INSTITUTE FOR SYSTEMS BIOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BATCH CELL CULTURE; BIOCONVERSION; BIOREACTORS; CELL PROLIFERATION; CRYOGENIC LIQUIDS; FLOW CYTOMETRY; GENES; PLANTS (BOTANY); STEM CELLS;

BATCH CULTURE; BIOPROCESSING; BRAIN CANCER; CANCER THERAPY; CELL DENSITY; CELL EXPANSION; CELL POPULATIONS; CONTROLLED ENVIRONMENT; FED-BATCH CULTURES; GENETIC ANALYSIS; GENOMIC CHARACTERIZATION; GLIOBLASTOMA MULTIFORME; GLIOBLASTOMAS; HIGH SHEAR; IN-VITRO; IN-VIVO; SOLID CANCER; STEM CELL; SUSPENSION CULTURES;

CELL CULTURE;

BACTERIA (MICROORGANISMS);

CD133 ANTIGEN; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; PEPTIDE;

ARTICLE; BIOREACTOR; BRAIN TUMOR; CANCER STEM CELL; CELL AGGREGATION; CELL COUNT; CELL DIFFERENTIATION; COMPARATIVE STUDY; CULTURE MEDIUM; DNA MICROARRAY; EVALUATION; GENE EXPRESSION; GENETICS; GLIOBLASTOMA; HUMAN; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; METHODOLOGY; PATHOLOGY; TISSUE CULTURE TECHNIQUE; TISSUE ENGINEERING; TUMOR CELL LINE;

ANTIGENS, CD; BIOREACTORS; BRAIN NEOPLASMS; CELL AGGREGATION; CELL COUNT; CELL DIFFERENTIATION; CELL LINE, TUMOR; CULTURE MEDIA; GENE EXPRESSION; GLIOBLASTOMA; GLYCOPROTEINS; HUMANS; NEOPLASTIC STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PEPTIDES; TISSUE CULTURE TECHNIQUES; TISSUE ENGINEERING;

EID: 77950851106     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2009.0490     Document Type: Article

References (37)

1. Jemal, A., Siegel, R., Ward, E., Murray, T., Xu, J., and Thun, M.J. Cancer statistics, 2007. CA Cancer J Clin 57, 43, 2007.
2. Dirks, P.B. Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells. Philos Trans R Soc Lond B Biol Sci 363, 139, 2008.
3. Stupp, R., Dietrich, P.Y., Ostermann Kraljevic, S., Pica, A., Maillard, I., Maeder, P., Meuli, R., Janzer, R., Pizzolato, G., Miralbell, R., Porchet, F., Regli, L., de Tribolet, N.,Mirimanoff, R.O., and Leyvraz, S. Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J Clin Oncol 20, 1375, 2002.
4. Shai, R., Shi, T., Kremen, T.J., Horvath, S., Liau, L.M., Cloughesy, T.F., Mischel, P.S., and Nelson, S.F. Gene expression profiling identifies molecular subtypes of gliomas. Oncogene 22, 4918, 2003.
5. Mischel, P.S., Shai, R., Shi, T., Horvath, S., Lu, K.V., Choe, G., Seligson, D., Kremen, T.J., Palotie, A., Liau, L.M., Cloughesy, T.F., and Nelson, S.F. Identification of molecular subtypes of glioblastoma by gene expression profiling. Oncogene 22, 2361, 2003.
6. Faury, D., Nantel, A., Dunn, S.E., Guiot, M.C., Haque, T., Hauser, P., Garami, M., Bognar, L., Hanzely, Z., Liberski, P.P., Lopez-Aguilar, E., Valera, E.T., Tone, L.G., Carret, A.S., Del Maestro, R.F., Gleave, M., Montes, J.L., Pietsch, T., Albrecht, S., and Jabado, N. Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors. J Clin Oncol 25, 1196, 2007.
7. Singh, S.K., Clarke, I.D., Hide, T., and Dirks, P.B. Cancer stem cells in nervous system tumors. Oncogene 23, 7267, 2004.
8. Reya, T., Morrison, S.J., Clarke, M.F., and Weissman, I.L. Stem cells, cancer, and cancer stem cells. Nature 414, 105, 2001.
9. Singh, S.K., Clarke, I.D., Terasaki, M., Bonn, V.E., Hawkins, C., Squire, J., and Dirks, P.B. Identification of a cancer stem cell in human brain tumors. Cancer Res 63, 5821, 2003.
10. Hemmati, H.D., Nakano, I., Lazareff, J.A., Masterman-Smith, M., Geschwind, D.H., Bronner-Fraser, M., and Kornblum, H.I. Cancerous stem cells can arise from pediatric brain tumors. Proc Natl Acad Sci USA 100, 15178, 2003.
11. Stingl, J., and Caldas, C. Molecular heterogeneity of breast carcinomas and the cancer stem cell hypothesis. Nat Rev Cancer 7, 791, 2007.
12. Ricci-Vitiani, L., Lombardi, D.G., Pilozzi, E., Biffoni, M., Todaro, M., Peschle, C., and De Maria, R. Identification and expansion of human colon-cancer-initiating cells. Nature 445, 111, 2007.
13. Li, C., Heidt, D.G., Dalerba, P., Burant, C.F., Zhang, L., Adsay, V., Wicha, M., Clarke, M.F., and Simeone, D.M. Identification of pancreatic cancer stem cells. Cancer Res 67, 1030, 2007.
14. Hope, K.J., Jin, L., and Dick, J.E. Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat Immunol 5, 738, 2004.
15. Dean, M., Fojo, T., and Bates, S. Tumour stem cells and drug resistance. Nat Rev Cancer 5, 275, 2005.
16. Joo, K.M., Kim, S.Y., Jin, X., Song, S.Y., Kong, D.S., Lee, J.I., Jeon, J.W., Kim, M.H., Kang, B.G., Jung, Y., Jin, J., Hong, S.C., Park, W.Y., Lee, D.S., Kim, H., and Nam, D.H. Clinical and biological implications of CD133-positive and CD133-negative cells in glioblastomas. Lab Invest 88, 808, 2008.
17. Ward, R.J., and Dirks, P.B. Cancer stem cells: at the headwaters of tumor development. Annu Rev Pathol 2, 175, 2007.
18. Yuan, X., Curtin, J., Xiong, Y., Liu, G., Waschsmann-Hogiu, S., Farkas, D.L., Black, K.L., and Yu, J.S. Isolation of cancer stem cells from adult glioblastoma multiforme. Oncogene 23, 9392, 2004.
19. Galli, R., Binda, E., Orfanelli, U., Cipelletti, B., Gritti, A., De Vitis, S., Fiocco, R., Foroni, C., Dimeco, F., and Vescovi, A. Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma. Cancer Res 64, 7011, 2004.
20. Beier, D., Hau, P., Proescholdt, M., Lohmeier, A., Wischhusen, J., Oefner, P.J., Aigner, L., Brawanski, A., Bogdahn, U., and Beier, C.P. CD133(+) and CD133(-) glioblastomaderived cancer stem cells show differential growth characteristics and molecular profiles. Cancer Res 67, 4010, 2007.
21. Pollard, S.M., Yoshikawa, K., Clarke, I.D., Danovi, D., Stricker, S., Russell, R., Bayani, J., Head, R., Lee, M., Bernstein, M., Squire, J.A., Smith, A., and Dirks, P. Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell 4, 568, 2009.
22. Mukhida, K., Mendez, I., McLeod, M., Kobayashi, N., Haughn, C., Milne, B., Baghbaderani, B., Sen, A., Behie, L.A., and Hong, M. Spinal GABAergic transplants attenuate mechanical allodynia in a rat model of neuropathic pain. Stem Cells 25, 2874, 2007.
23. Mukhida, K., Baghbaderani, B.A., Hong, M., Lewington, M., Phillips, T., McLeod, M., Sen, A., Behie, L.A., and Mendez, I. Survival, differentiation, and migration of bioreactorexpanded human neural precursor cells in a model of Parkinson disease in rats. Neurosurg Focus 24, E8, 2008.
24. Baghbaderani, B.A., Behie, L.A., Sen, A., Mukhida, K., Hong, M., and Mendez, I. Expansion of human neural precursor cells in large-scale bioreactors for the treatment of neurodegenerative disorders. Biotechnol Prog 24, 859, 2008.
25. Sen, A., Kallos, M.S., and Behie, L.A. Effects of hydrodynamics on cultures of mammlian neural stem cell aggregates in suspension bioreactors. Ind Eng Chem Res 40, 5350, 2001.
26. Gilbertson, J.A., Sen, A., Behie, L.A., and Kallos, M.S. Scaledup production of mammalian neural precursor cell aggregates in computer-controlled suspension bioreactors. Biotechnol Bioeng 94, 783, 2006.
27. Foltz, G., Ryu, G.Y., Yoon, J.G., Nelson, T., Fahey, J., Frakes, A., Lee, H., Field, L., Zander, K., Sibenaller, Z., Ryken, T.C., Vibhakar, R., Hood, L., and Madan, A. Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. Cancer Res 66, 6665, 2006.
28. Shamir, R., Maron-Katz, A., Tanay, A., Linhart, C., Steinfeld, I., Sharan, R., Shiloh, Y., and Elkon, R. EXPANDER-an integrative program suite for microarray data analysis. BMC Bioinformatics 6, 232, 2005.
29. Butler, M. Animal Cell Culture and Technology, 2nd edition. New York: BIOS Scientific Publishers, 2004.
30. Lyon, R.C., Cohen, J.S., Faustino, P.J., Megnin, F., and Myers, C.E. Glucose metabolism in drug-sensitive and drugresistant human breast cancer cells monitored by magnetic resonance spectroscopy. Cancer Res 48, 870, 1988.
31. Ljunggren, J., and Haggstrom, L. Glutamine limited fedbatch culture reduces the overflow metabolism of amino acids in myeloma cells. Cytotechnology 8, 45, 1992.
32. Krebs, H.A., Hems, R., Lund, P., Halliday, D., and Read, W.W. Sources of ammonia for mammalian urea synthesis. Biochem J 176, 733, 1978.
33. Griguer, C.E., Oliva, C.R., Gobin, E., Marcorelles, P., Benos, D.J., Lancaster, J.R., Jr., and Gillespie, G.Y. CD133 is a marker of bioenergetic stress in human glioma. PLoS ONE 3, e3655, 2008.
34. De Witt Hamer, P.C., Van Tilborg, A.A., Eijk, P.P., Sminia, P., Troost, D., Van Noorden, C.J., Ylstra, B., and Leenstra, S. The genomic profile of human malignant glioma is altered early in primary cell culture and preserved in spheroids. Oncogene 27, 2091, 2008.
35. Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061, 2008.
36. Miyaguchi, K. Ultrastructure of intermediate filaments of nestin-and vimentin-immunoreactive astrocytes in organotypic slice cultures of hippocampus. J Struct Biol 120, 61, 1997.
37. Brannen, C.L., and Sugaya, K. In vitro differentiation of multipotent human neural progenitors in serum-free medium. Neuroreport 11, 1123, 2000