Transplantation frontiers

Retina Fifth Edition

Volumn , Issue , 2012, Pages 2058-2077

  Gullapalli, Vamsi K ^a   Khodair, Mohamad A ^b   Wang, Hao ^c   Sugino, Ilene K ^d   Madreperla, Steven ^e   Zarbin, Marco A ^d  

^a Valley Coastal Bend   (United States)

^b ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c Capital Region Retina   (United States)

^d INSTITUTE OF OPHTHALMOLOGY AND VISUAL SCIENCE   (United States)

^e UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84906801251     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-1-4557-0737-9.00125-9     Document Type: Chapter

References (385)

1. Royo PE., Quay WB Retinal transplantation from fetal to maternal mammalian eye Growth 23 1959 313-336.
2. Van Dooremaal JC De onwikkeling van levende weefsels op vreemden bodem geent Onderz Physiol Lab Rijksuniv Utrechtsche Hoogeschool 3 1873 277-290.
3. del Cerro M., Gash DM., Rao GN., et al. Intraocular retinal transplants Invest Ophthalmol Vis Sci 26 1985 1182-1185.
4. Gouras P., Flood MT., Kjedbye H., et al. Transplantation of cultured human retinal epithelium to Bruch’s membrane of the owl monkey’s eye Curr Eye Res 4 1985 253-265.
5. Li LX., Turner JE Inherited retinal dystrophy in the RCS rat: prevention of photoreceptor degeneration by pigment epithelial cell transplantation Exp Eye Res 47 1988 911-917.
6. D’Cruz PM., Yasumura D., Weir J., et al. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat Hum Mol Genet 9 2000 645-651.
7. Lund RD., Hauschka SD Transplanted neural tissue develops connections with host rat brain Science 193 1976 582-584.
8. Das GD., Hallas BH Transplantation of brain tissue in the brain of adult rats Experientia 34 1978 1304-1306.
9. Klassen H., Lund RD Retinal transplants can drive a pupillary reflex in host rat brains Proc Natl Acad Sci U S A 84 1987 6958-6960.
10. Coffey PJ., Lund RD., Rawlins JN Detecting the world through a retinal implant Progr Brain Res 82 1990 269-275.
11. Lund RD., Radel JD., Coffey PJ The impact of intracerebral retinal transplants on types of behavior exhibited by host rats Trends Neurosci 14 1991 358-362.
12. Turner JE., Blair JR Newborn rat retinal cell transplanted into a retinal lesion site in adult host eyes Dev Brain Res 26 1986 91-104.
13. Silverman MS., Hughes SE Transplantation of photoreceptors to light-damaged retina Invest Ophthalmol Vis Sci 30 1989 1684-1690.
14. Klein R., Klein BE., Linton KL Prevalence of age-related maculopathy. The Beaver Dam Eye Study Ophthalmology 99 1992 933-943.
15. Ferris FL 3rd., Fine SL., et al. Age-related macular degeneration and blindness due to neovascular maculopathy Arch Ophthalmol 102 1984 1640-1642.
16. Klein R., Klein BE., Jensen SC., et al. The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study Ophthalmology 104 1997 7-21.
17. Friedman DS., O’Colmain BJ., Munoz B., et al. Prevalence of age-related macular degeneration in the United States Arch Ophthalmol 122 2004 564-572.
18. Rosenfeld PJ., Brown DM., Heier JS., et al. Ranibizumab for neovascular age-related macular degeneration N Engl J Med 355 2006 1419-1431.
19. Brown DM., Kaiser PK., Michels M., et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration N Engl J Med 355 2006 1432-1444.
20. Hackett SF., Schoenfeld CL., Freund J., et al. Neurotrophic factors, cytokines and stress increase expression of basic fibroblast growth factor in retinal pigmented epithelial cells Exp Eye Res 64 1997 865-873.
21. Kanuga N., Winton HL., Beauchene L., et al. Characterization of genetically modified human retinal pigment epithelial cells developed for in vitro and transplantation studies Invest Ophthalmol Vis Sci 43 2002 546-555.
22. Sugino IK., Sun Q., Wang J., et al. Comparison of FRPE and human embryonic stem cell-derived rpe behavior on aged human Bruch’s membrane Invest Ophthalmol Vis Sci 52 2011 4979-4997.
23. Kolomeyer AM., Sugino IK., Zarbin MA Characterization of conditioned media collected from cultured adult versus fetal retinal pigment epithelial cells Invest Ophthalmol Vis Sci 52 2011 5973-5986.
24. Kolomeyer AM., Sugino IK., Zarbin MA Characterization of conditioned media collected from aged versus young human eye cups Invest Ophthalmol Vis Sci 52 2011 5963-5972.
25. Zarbin MA Retinal pigment epithelium-retina transplantation for retinal degenerative disease Am J Ophthalmol 146 2008 151-153.
26. Maaijwee K., Joussen AM., Kirchhof B., et al. Retinal pigment epithelium (RPE)-choroid graft translocation in the treatment of an RPE tear: preliminary results Br J Ophthalmol 92 2008 526-529.
27. Chang LK., Sarraf D Tears of the retinal pigment epithelium: an old problem in a new era Retina 27 2007 523-534.
28. Nasir MA., Sugino I., Zarbin MA Decreased choriocapillaris perfusion following surgical excision of choroidal neovascular membranes in age-related macular degeneration Br J Ophthalmol 81 1997 481-489.
29. Grossniklaus HE., Hutchinson AK., Capone A., et al. Clinicopathologic features of surgically excised choroidal neovascular membranes Ophthalmology 101 1994 1099-1111.
30. Coffey PJ., Girman S., Wang SM., et al. Long-term preservation of cortically dependent visual function in RCS rats by transplantation Nat Neurosci 5 2002 53-56.
31. Li L., Turner JE Optimal conditions for long-term photoreceptor cell rescue in RCS rats: the necessity for healthy RPE transplants Exp Eye Res 52 1991 669-679.
32. Little CW., Castillo B., DiLoreto DA., et al. Transplantation of human fetal retinal pigment epithelium rescues photoreceptor cells from degeneration in the Royal College of Surgeons rat retina Invest Ophthalmol Vis Sci 37 1996 204-211.
33. Lund RD., Adamson P., Sauve Y., et al. Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats Proc Natl Acad Sci U S A 98 2001 9942-9947.
34. Lawrence JM., Keegan DJ., Muir EM., et al. Transplantation of Schwann cell line clones secreting GDNF or BDNF into the retinas of dystrophic Royal College of Surgeons rats Invest Ophthalmol Vis Sci 45 2004 267-274.
35. Lawrence JM., Sauve Y., Keegan DJ., et al. Schwann cell grafting into the retina of the dystrophic RCS rat limits functional deterioration Invest Ophthalmol Vis Sci 41 2000 518-528.
36. Lu B., Malcuit C., Wang S., et al. Long-term safety and function of RPE from human embryonic stem cells in preclinical models of macular degeneration Stem Cells 27 2009 2126-2135.
37. Sheedlo HJ., Li L., Barnstable CJ., et al. Synaptic and photoreceptor components in retinal pigment epithelial cell transplanted retinas of Royal College of Surgeons dystrophic rats J Neurosci Res 36 1993 423-431.
38. Sauve Y., Lu B., Lund RD The relationship between full field electroretinogram and perimetry-like visual thresholds in RCS rats during photoreceptor degeneration and rescue by cell transplants Vis Res 44 2004 9-18.
39. Whiteley SJ., Litchfield TM., Coffey PJ., et al. Improvement of the pupillary light reflex of Royal College of Surgeons rats following RPE cell grafts Exp Neurol 140 1996 100-104.
40. Lund RD., Wang S., Klimanskaya I., et al. Human embryonic stem cell-derived cells rescue visual function in dystrophic RCS rats Cloning Stem Cells 8 2006 189-199.
41. McGill TJ., Lund RD., Douglas RM., et al. Preservation of vision following cell-based therapies in a model of retinal degenerative disease Vis Res 44 2004 2559-2566.
42. Mruthyunjaya P., Stinnett SS., Toth CA Change in visual function after macular translocation with 360 degrees retinectomy for neovascular age-related macular degeneration Ophthalmology 111 2004 1715-1724.
43. Pieramici DJ., De Juan E Jr., Fujii GY., et al. Limited inferior macular translocation for the treatment of subfoveal choroidal neovascularization secondary to age-related macular degeneration Am J Ophthalmol 130 2000 419-428.
44. Peyman GA., Blinder KJ., Paris CL., et al. A technique for retinal pigment epithelium transplantation for age- related macular degeneration secondary to extensive subfoveal scarring Ophthal Surg 22 1991 102-108.
45. Algvere PV., Berglin L., Gouras P., et al. Transplantation of fetal retinal pigment epithelium in age-related macular degeneration with subfoveal neovascularization Graefes Arch Clin Exp Ophthalmol 232 1994 707-716.
46. Algvere PV., Berglin L., Gouras P., et al. Transplantation of RPE in age-related macular degeneration: observations in disciform lesions and dry RPE atrophy Graefes Arch Clin Exp Ophthalmol 235 1997 149-158.
47. Stanga PE., Kychenthal A., Fitzke FW., et al. Retinal pigment epithelium translocation after choroidal neovascular membrane removal in age-related macular degeneration Ophthalmology 109 2002 1492-1498.
48. Binder S., Krebs I., Hilgers RD., et al. Outcome of transplantation of autologous retinal pigment epithelium in age-related macular degeneration: a prospective trial Invest Ophthalmol Vis Sci 45 2004 4151-4160.
49. Angunawela RI., Williamson TH., Khan MA., et al. Choroidal translocation with a pedicle following excision of a type 1 choroidal neovascular membrane Br J Ophthalmol 89 2005 386.
50. Van Meurs JC., Van Den Biesen PR Autologous retinal pigment epithelium and choroid translocation in patients with exudative age-related macular degeneration: short-term follow-up Am J Ophthalmol 136 2003 688-695.
51. MacLaren RE., Uppal GS., Balaggan KS., et al. Autologous transplantation of the retinal pigment epithelium and choroid in the treatment of neovascular age-related macular degeneration Ophthalmology 114 2007 561-570.
52. Joussen AM., Heussen FM., Joeres S., et al. Autologous translocation of the choroid and retinal pigment epithelium in age-related macular degeneration Am J Ophthalmol 142 2006 17-30.
53. Treumer F., Bunse A., Klatt C., et al. Autologous retinal pigment epithelium-choroid sheet transplantation in age related macular degeneration: morphological and functional results Br J Ophthalmol 91 2007 349-353.
54. Falkner-Radler CI., Krebs I., Glittenberg C., et al. Human retinal pigment epithelium (RPE) transplantation: outcome after autologous RPE-choroid sheet and RPE cell-suspension in a randomised clinical study Br J Ophthalmol 95 2011 370-375.
55. Del Priore LV., Kaplan HJ., Tezel TH., et al. Retinal pigment epithelial cell transplantation after subfoveal membranectomy in age-related macular degeneration: clinicopathologic correlation Am J Ophthalmol 131 2001 472-480.
56. Algvere PV., Gouras P., Dafgard Kopp E Long-term outcome of RPE allografts in non-immunosuppressed patients with AMD Eur J Ophthalmol 9 1999 217-230.
57. MacLaren RE., Bird AC., Sathia PJ., et al. Long-term results of submacular surgery combined with macular translocation of the retinal pigment epithelium in neovascular age-related macular degeneration Ophthalmology 112 2005 2081-2087.
58. Tezel TH., Del Priore LV., Kaplan HJ Reattachment of harvested retinal pigment epithelium to a substrate prevents apoptosis Graefes Arch Clin Exp Ophthalmol 235 1997 41-47.
59. Sheng Y., Gouras P., Cao H., et al. Patch transplants of human fetal retinal pigment epithelium in rabbit and monkey retina Invest Ophthalmol Vis Sci 36 1995 381-390.
60. Li LX., Turner JE Transplantation of retinal pigment epithelial cells to immature and adult rat hosts: short- and long-term survival characteristics Exp Eye Res 47 1988 771-785.
61. Lopez R., Gouras P., Kjeldbye H., et al. Transplanted retinal pigment epithelium modifies the retinal degeneration in the RCS rat Invest Ophthalmol Vis Sci 30 1989 586-588.
62. Lai CC., Gouras P., Doi K., et al. Tracking RPE transplants labeled by retroviral gene transfer with green fluorescent protein Invest Ophthalmol Vis Sci 40 1999 2141-2146.
63. Karwatowski WS., Jeffries TE., Duance VC., et al. Preparation of Bruch’s membrane and analysis of the age-related changes in the structural collagens Br J Ophthalmol 79 1995 944-952.
64. Pauleikhoff D., Harper CA., Marshall J., et al. Aging changes in Bruch’s membrane. A histochemical and morphologic study Ophthalmology 97 1990 171-178.
65. Zarbin MA Age related macular degeneration: review of pathogenesis Eur J Ophthalmol 8 1998 133-205.
66. Zarbin MA Current concepts in the pathogenesis of age-related macular degeneration Arch Ophthalmol 122 2004 598-614.
67. Tsukahara I., Ninomiya S., Castellarin A., et al. Early attachment of uncultured retinal pigment epithelium from aged donors onto Bruch’s membrane explants Exp Eye Res 74 2002 255-266.
68. Zarbin MA Analysis of retinal pigment epithelium integrin expression and adhesion to aged submacular human Bruch’s membrane Trans Am Ophthalmol Soc 101 2003 499-520.
69. Gullapalli VK., Sugino IK., Van Patten Y., et al. Impaired RPE survival on aged submacular human Bruch’s membrane Exp Eye Res 80 2005 235-248.
70. Sugino IK., Gullapalli VK., Sun Q., et al. Cell-deposited matrix improves retinal pigment epithelium survival on aged submacular human Bruch’s membrane Invest Ophthalmol Vis Sci 52 2011 1345-1358.
71. Streilein JW Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation J Leukoc Biol 74 2003 179-185.
72. Streilein JW., Ksander BR., Taylor AW Immune deviation in relation to ocular immune privilege J Immunol 158 1997 3557-3560.
73. Jiang LQ., Jorquera M., Streilein JW Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts Invest Ophthalmol Vis Sci 34 1993 3347-3354.
74. Ferguson TA The molecular basis of anterior associated immune deviation (ACAID) Ocul Immunol Inflamm 5 1997 213-215.
75. Takeuchi M., Alard P., Streilein JW TGF-beta promotes immune deviation by altering accessory signals of antigen-presenting cells J Immunol 160 1998 1589-1597.
76. Taylor AW., Streilein JW., Cousins SW Identification of alpha-melanocyte stimulating hormone as a potential immunosuppressive factor in aqueous humor Curr Eye Res 11 1992 1199-1206.
77. Taylor AW., Streilein JW., Cousins SW Immunoreactive vasoactive intestinal peptide contributes to the immunosuppressive activity of normal aqueous humor J Immunol 153 1994 1080-1086.
78. Apte RS., Sinha D., Mayhew E., et al. Cutting edge: role of macrophage migration inhibitory factor in inhibiting NK cell activity and preserving immune privilege J Immunol 160 1998 5693-5696.
79. Griffith TS., Brunner T., Fletcher SM., et al. Fas ligand-induced apoptosis as a mechanism of immune privilege Science 270 1995 1189-1192.
80. Bora NS., Gobleman CL., Atkinson JP., et al. Differential expression of the complement regulatory proteins in the human eye Invest Ophthalmol Vis Sci 34 1993 3579-3584.
81. Vega JL., Keino H., Masli S Surgical denervation of ocular sympathetic afferents decreases local transforming growth factor-beta and abolishes immune privilege Am J Pathol 175 2009 1218-1225.
82. Streilein JW Unraveling immune privilege Science 270 1995 1158-1159.
83. Wenkel H., Streilein JW Analysis of immune deviation elicited by antigens injected into the subretinal space Invest Ophthalmol Vis Sci 39 1998 1823-1834.
84. Jiang L., Streilein JW Immunologic privilege evoked by histoincompatible intracameral retinal transplants Reg Immunol 3 1991 121-130.
85. Liversidge J., Forrester JV Regulation of immune responses by the retinal pigment epithelium In: Marmor MF., Wolfensberger TJ The retinal pigment epithelium function and disease 1998 Oxford University Press New York 511-527.
86. Tanihara H., Yoshida M., Matsumoto M., et al. Identification of transforming growth factor B expressed in cultured human retinal pigment epithelial cells Invest Ophthalmol Vis Sci 34 1993 413-419.
87. Holtkamp GM., de Vos AF., Kijlstra A., et al. Expression of multiple forms of IL-1 receptor antagonist (IL-1ra) by human retinal pigment epithelial cells: identification of a new IL-1ra exon Eur J Immunol 29 1999 215-224.
88. Ishida K., Panjwani N., Cao Z., et al. Participation of pigment epithelium in ocular immune privilege. 3. Epithelia cultured from iris, ciliary body, and retina suppress T-cell activation by partially non-overlapping mechanisms Ocul Immunol Inflamm 11 2003 91-105.
89. Kaestel CG., Jorgensen A., Nielsen M., et al. Human retinal pigment epithelial cells inhibit proliferation and IL2R expression of activated T cells Exp Eye Res 74 2002 627-637.
90. Jorgensen A., Wiencke AK., la Cour M., et al. Human retinal pigment epithelial cell-induced apoptosis in activated T cells Invest Ophthalmol Vis Sci 39 1998 1590-1599.
91. Rezai KA., Semnani RT., Farrokh-Siar L., et al. Human fetal retinal pigment epithelial cells induce apoptosis in allogenic T-cells in a fas ligand and PGE2 independent pathway Curr Eye Res 18 1999 430-439.
92. Usui Y., Okunuki Y., Hattori T., et al. Functional expression of B7H1 on retinal pigment epithelial cells Exp Eye Res 86 2008 52-59.
93. Sugita S., Usui Y., Horie S., et al. T-cell suppression by programmed cell death 1 ligand 1 on retinal pigment epithelium during inflammatory conditions Invest Ophthalmol Vis Sci 50 2009 2862-2870.
94. Sugita S., Horie S., Nakamura O., et al. Retinal pigment epithelium-derived CTLA-2alpha induces TGFbeta-producing T regulatory cells J Immunol 181 2008 7525-7536.
95. Wenkel H., Streilein JW Evidence that retinal pigment epithelium functions as an immune- privileged tissue Invest Ophthalmol Vis Sci 41 2000 3467-3473.
96. Zamiri P., Zhang Q., Streilein JW Vulnerability of allogeneic retinal pigment epithelium to immune T-cell-mediated damage in vivo and in vitro Invest Ophthalmol Vis Sci 45 2004 177-184.
97. Rezai KA., Semnani RT., Patel SC., et al. The immunogenic potential of human fetal retinal pigment epithelium and its relation to transplantation Invest Ophthalmol Vis Sci 38 1997 2662-2671.
98. Liversidge JM., Sewell HF., Forrester JV Human retinal pigment epithelial cells differentially express MHC class II (HLA, DP, DR and DQ) antigens in response to in vitro stimulation with lymphokine or purified IFN-gamma Clin Exp Immunol 73 1988 489-494.
99. Liversidge J., Sewell HF., Thomson AW., et al. Lymphokine-induced MHC class II antigen expression on cultured retinal pigment epithelial cells and the influence of cyclosporin A Immunology 63 1988 313-317.
100. Percopo CM., Hooks JJ., Shinohara T., et al. Cytokine-mediated activation of a neuronal retinal resident cell provokes antigen presentation J Immunol 145 1990 4101-4107.
101. Sun D., Enzmann V., Lei S., et al. Retinal pigment epithelial cells activate uveitogenic T cells when they express high levels of MHC class II molecules, but inhibit T cell activation when they express restricted levels J Neuroimmunol 144 2003 1-8.
102. Leonard DS., Zhang XG., Panozzo G., et al. Clinicopathologic correlation of localized retinal pigment epithelium debridement Invest Ophthalmol Vis Sci 38 1997 1094-1109.
103. Del Priore LV., Kaplan HJ., Hornbeck R., et al. Retinal pigment epithelial debridement as a model for the pathogenesis and treatment of macular degeneration Am J Ophthalmol 122 1996 629-643.
104. Anderson DH., Radeke MJ., Gallo NB., et al. The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited Prog Retin Eye Res 29 2010 95-112.
105. Jiang LQ., Streilein JW Neural retina and retinal pigment epithelium allografts suffer different immunological fates in the eye Reg Immunol 6 1994 90-94.
106. Grisanti S., Ishioka M., Kosiewicz M., et al. Immunity and immune privilege elicited by cultured retinal pigment epithelial cell transplants Invest Ophthalmol Vis Sci 38 1997 1619-1626.
107. Zhang X., Bok D Transplantation of retinal pigment epithelial cells and immune response in the subretinal space Invest Ophthalmol Vis Sci 39 1998 1021-1027.
108. Weisz JM., Humayun MS., De Juan E., et al. Allogenic fetal retinal pigment epithelial cell transplant in a patient with geographic atrophy Retina 19 1999 540-545.
109. Kohen L., Enzmann V., Faude F., et al. Mechanisms of graft rejection in the transplantation of retinal pigment epithelial cells Ophthal Res 29 1997 298-304.
110. Berglin L., Gouras P., Sheng Y., et al. Tolerance of human fetal retinal pigment epithelium xenografts in monkey retina Graefes Arch Clin Exp Ophthalmol 235 1997 103-110.
111. Crafoord S., Algvere P., et al. Long-term outcome of RPE allografts to the subretinal space of rabbits Seregard S Acta Ophthalmol Scand 77 1999 247-254.
112. Lai CC., Gouras P., Doi K., et al. Local immunosuppression prolongs survival of RPE xenografts labeled by retroviral gene transfer Invest Ophthalmol Vis Sci 41 2000 3134-3141.
113. Ishida M., Lui GM., Yamani A., et al. Culture of human retinal pigment epithelial cells from peripheral scleral flap biopsies Curr Eye Res 17 1998 392-402.
114. Boulton M., Roanowska M., Wess T Ageing of the retinal pigment epithelium: implications for transplantation Graefes Arch Clin Exp Ophthalmol 242 2003 76-84.
115. Cahill MT., Mruthyunjaya P., Bowes Rickman C., et al. Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy Arch Ophthalmol 123 2005 935-938.
116. Ogata N., Nishizawa M., Ando A., et al. Transfection.of basic fibroblast growth factor (bFGF) gene or bFGF antisense gene into human retinal pigment epithelial cells Graefes Arch Clin Exp Ophthalmol 237 1999 678-684.
117. Lund RD., Kwan AS., Keegan DJ., et al. Cell transplantation as a treatment for retinal disease Prog Retin Eye Res 20 2001 415-449.
118. Kaplan HJ., Tezel TH., Berger AS., et al. Human photoreceptor transplantation in retinitis pigmentosa Arch Ophthalmol 115 1997 1168-1172.
119. Del Priore LV., Ishida O., Johnson EW., et al. Triple immune suppression increases short-term survival of porcine fetal retinal pigment epithelium xenografts Invest Ophthalmol Vis Sci 44 2003 4044-4053.
120. Tezel TH., Del Priore LV Reattachment to a substrate prevents apoptosis of human retinal pigment epithelium Graefes Arch Clin Exp Ophthalmol 235 1997 41-47.
121. Castellarin AA., Sugino IK., Vargas JA., et al. In vitro transplantation of fetal human retinal pigment epithelial cells onto human cadaver Bruch’s membrane Exp Eye Res 66 1998 49-67.
122. Ho TC., Del Priore LV Reattachment of cultured human retinal pigment epithelium to extracellular matrix and human Bruch’s membrane Invest Ophthalmol Vis Sci 38 1997 1110-1118.
123. Tezel TH., Kaplan HJ., Del Priore LV Fate of human retinal pigment epithelial cells seeded onto layers of human Bruch’s membrane Invest Ophthalmol Vis Sci 40 1999 467-476.
124. Tezel TH., Del Priore LV Repopulation of different layers of host human Bruch’s membrane by retinal pigment epithelial cell grafts Invest Ophthalmol Vis Sci 40 1999 767-774.
125. Del Priore LV., Tezel TH Reattachment rate of human retinal pigment epithelium to layers of human Bruch’s membrane Arch Ophthalmol 116 1998 335-341.
126. Gullapalli VK., Sugino IK., Zarbin MA Culture-induced increase in alpha integrin subunit expression in retinal pigment epithelium is important for improved resurfacing of aged human Bruch’s membrane Exp Eye Res 86 2008 189-200.
127. Starita C., Hussain AA., Pagliarini S., et al. Hydrodynamics of ageing Bruch’s membrane: implications for macular disease Exp Eye Res 62 1996 565-572.
128. Lopez PF., Grossniklaus HE., Lambert HM., et al. Pathologic features of surgically excised subretinal neovascular membranes in age-related macular degeneration Am J Ophthalmol 112 1991 647-656.
129. Hsu JK., Thomas MA., Ibanez H., et al. Clinicopathologic studies of an eye after submacular membranectomy for choroidal neovascularization Retina 15 1995 43-52.
130. Castellarin AA., Nasir MA., Sugino IK., et al. Clinicopathological correlation of primary and recurrent choroidal neovascularisation following surgical excision in age related macular degeneration Br J Ophthalmol 82 1998 480-487.
131. Ormerod LD., Puklin JE., Frank RN Long-term outcomes after the surgical removal of advanced subfoveal neovascular membranes in age-related macular degeneration Ophthalmology 101 1994 1201-1210.
132. Rudolf M., Curcio CA Esterified cholesterol is highly localized to Bruch’s membrane, as revealed by lipid histochemistry in wholemounts of human choroid J Histochem Cytochem 57 2009 731-739.
133. Thumann G., Bartz-Schmidt KU., El Bakri H., et al. Transplantation of autologous iris pigment epithelium to the subretinal space in rabbits Transplantation 68 1999 195-201.
134. Thumann G., Kociok N., Bartz-Schmidt KU., et al. Detection of mRNA for proteins involved in retinol metabolism in iris pigment epithelium Graefes Arch Clin Exp Ophthalmol 237 1999 1046-1051.
135. Sugano E., Tomita H., Abe T., et al. Comparative study of cathepsins D and S in rat IPE and RPE cells Exp Eye Res 77 2003 203-209.
136. Borlongan CV., Stahl CE., Cameron DF., et al. CNS immunological modulation of neural graft rejection and survival Neurol Res 18 1996 297-304.
137. Ishioka M., Okamoto S., Streilein JW., et al. Effect of cyclosporine on anterior chamber-associated immune deviation with retinal transplantation Invest Ophthalmol Vis Sci 38 1997 2152-2160.
138. Rao KV., Andersen RC., O’Brien TJ Successful renal transplantation in a patient with anaphylactic reaction to Solu-Medrol (methylprednisolone sodium succinate) Am J Med 72 1982 161-163.
139. Mittal R., Agarwal SK., Dash SC., et al. Treatment of acute rejection in live related renal allograft recipients: a comparison of three different protocols Nephron 77 1997 186-189.
140. Delmonico FL., Tolkoff RN Treatment of acute rejection in real transplantation In: Brenner BM., Stein JH Contemporary issues in nephrology 1989 Churchill Livingstone Edinburgh 129-146.
141. Hirano T., Oka K., Takeuchi H., et al. Clinical significance of glucocorticoid pharmacodynamics assessed by antilymphocyte action in kidney transplantation. Marked difference between prednisolone and methylprednisolone Transplantation 57 1994 1341-1348.
142. Yoshizumi MO., Bhavsar AR., Dessouki A., et al. Safety of repeated intravitreous injections of antibiotics and dexamethasone Retina 19 1999 437-441.
143. Kagaya F., Usui T., Kamiya K., et al. Intraocular dexamethasone delivery system for corneal transplantation in an animal model Cornea 21 2002 200-202.
144. Haller JA., Kuppermann BD., Blumenkranz MS., et al. Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema Arch Ophthalmol 128 2010 289-296.
145. Jaffe GJ., Martin D., Callanan D., et al. Fluocinolone acetonide implant (Retisert) for noninfectious posterior uveitis: thirty-four-week results of a multicenter randomized clinical study Ophthalmology 113 2006 1020-1027.
146. Gullapalli VG. Paucity of cellular integrin receptors and aging changes in Bruch’s membrane contribute to poor resurfacing of aged Bruch’s membrane by retinal pigment epithelium. PHD thesis, Graduate School of Biomedical Sciences, UMDNJ; 2005.
147. Gullapalli VK., Sugino IK., Van Patten Y., et al. Retinal pigment epithelium resurfacing of aged submacular human Bruch’s membrane Trans Am Ophthalmol Soc 102 2004 123-137 discussion 37-38.
148. Tezel TH., Del Priore LV., Kaplan HJ Reengineering of aged Bruch’s membrane to enhance retinal pigment epithelium repopulation Invest Ophthalmol Vis Sci 45 2004 3337-3348.
149. Tezel TH., Oda J., Hornbeck R., et al. RPE repopulation of aged inner collagenous layer (ICL) is inhibited by reversible alterations in Bruch’s membrane Invest Ophthalmol Vis Sci 42 2001 ARVO abstract 4995.
150. Fang IM., Yang CH., Yang CM., et al. Overexpression of integrin alpha6 and beta4 enhances adhesion and proliferation of human retinal pigment epithelial cells on layers of porcine Bruch’s membrane Exp Eye Res 88 2009 12-21.
151. Lu L., Garcia CA., Mikos AG Retinal pigment epithelium cell culture on thin biodegradable poly(DL-lactic-co-glycolic acid) films J Biomater Sci Polym Ed 9 1998 1187-1205.
152. Tomita M., Lavik E., Klassen H., et al. Biodegradable polymer composite grafts promote the survival and differentiation of retinal progenitor cells Stem Cells 23 2005 1579-1588.
153. Treharne AJ., Grossel MC., Lotery AJ., et al. The chemistry of retinal transplantation: the influence of polymer scaffold properties on retinal cell adhesion and control Br J Ophthalmol 95 2011 768-773.
154. Krishna Y., Sheridan CM., Kent DL., et al. Polydimethylsiloxane as a substrate for retinal pigment epithelial cell growth J Biomed Mater Res A 80 2007 669-678.
155. Thomson HA., Treharne AJ., Walker P., et al. Optimisation of polymer scaffolds for retinal pigment epithelium (RPE) cell transplantation Br J Ophthalmol 95 2011 563-568.
156. Castellarin AA., Nasir MA., Sugino IK., et al. Progressive presumed choriocapillaris atrophy after surgery for age-related macular degeneration Retina 18 1998 143-149.
157. Hergott GJ., Kalnins VI., Expression of proliferating cell nuclear antigen in migrating retinal pigment epithelial cells during wound healing in organ culture Exp Cell Res 195 1991 307-314.
158. Kamei M., Lewis JM., Hayashi A., et al. A new wound healing model of retinal pigment epithelial cells in sheet culture Curr Eye Res 15 1996 714-718.
159. MacDonald IM., Peters C., Chen MH Effect of retinoic acid on wound healing of laser burns to porcine retinal pigment epithelium Can J Ophthalmol 31 1996 175-178.
160. Del Priore LV., Hornbeck R., Kaplan HJ., et al. Débridement of the pig retinal pigment epithelium in vivo Arch Ophthalmol 113 1995 939-944.
161. Lopez PF., Yan Q., Kohen L., et al. Retinal pigment epithelial wound healing in vivo Arch Ophthalmol 113 1995 1437-1446.
162. Valentino TL., Kaplan HJ., Del Priore LV., et al. Retinal pigment epithelial repopulation in monkeys after submacular surgery Arch Ophthalmol 113 1995 932-938.
163. Ho TC., Del Priore LV., Hornbeck R Effect of mitomycin-C on human retinal pigment epithelium in culture Curr Eye Res 16 1997 572-576.
164. Wang H., Ninomiya Y., Sugino IK., et al. Retinal pigment epithelium wound healing on human Bruch’s membrane explants Invest Ophthalmol Vis Sci 44 2003 2199-2210.
165. Sugino IK., Wang H., Zarbin MA Age-related macular degeneration and retinal pigment epithelium wound healing Mol Neurobiol 28 2003 177-194.
166. Burton TC Recovery of visual acuity after retinal detachment involving the macula Trans Am Ophthalmol Soc 80 1982 475-497.
167. Machemer R Experimental retinal detachment in the owl monkey. IV. The reattached retina Am J Ophthalmol 66 1968 1075-1091.
168. Anderson DH., Guerin CJ., Erickson PA., et al. Morphological recovery in the reattached retina Invest Ophthalmol Vis Sci 27 1986 168-183.
169. Mervin K., Valter K., Maslim J., et al. Limiting photoreceptor death and deconstruction during experimental retinal detachment: the value of oxygen supplementation Am J Ophthalmol 128 1999 155-164.
170. Erickson PA., Fisher SK., Anderson DH., et al. Retinal detachment in the cat: the outer nuclear and outer plexiform layers Invest Ophthalmol Vis Sci 24 1983 927-942.
171. Fisher SK., Stone J., Rex TS., et al. Experimental retinal detachment: a paradigm for understanding the effects of induced photoreceptor degeneration Prog Brain Res 131 2001 679-698.
172. Sakai T., Calderone JB., Lewis GP., et al. Cone photoreceptor recovery after experimental detachment and reattachment: an immunocytochemical, morphological, and electrophysiological study Invest Ophthalmol Vis Sci 44 2003 416-425.
173. Sakai T., Lewis GP., Linberg KA., et al. The ability of hyperoxia to limit the effects of experimental detachment in cone-dominated retina Invest Ophthalmol Vis Sci 42 2001 3264-3273.
174. Wobus AM., Boheler KR Embryonic stem cells: prospects for developmental biology and cell therapy Physiol Rev 85 2005 635-678.
175. Bharti K., Miller SS., Arnheiter H The new paradigm: retinal pigment epithelium cells generated from embryonic or induced pluripotent stem cells Pigment Cell Melanoma Res 24 2011 21-34.
176. Jaenisch R., Young R Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming Cell 132 2008 567-582.
177. Thomson JA., Itskovitz-Eldor J., Shapiro SS., et al. Embryonic stem cell lines derived from human blastocysts Science 282 1998 1145-1147.
178. Reubinoff BE., Pera MF., Fong CY., et al. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro Nat Biotechnol 18 2000 399-404.
179. Gage FH Mammalian neural stem cells Science 287 2000 1433-1438.
180. Weissman IL Translating stem and progenitor cell biology to the clinic: barriers and opportunities Science 287 2000 1442-1446.
181. Ahmad I., Tang L., Pham H Identification of neural progenitors in the adult mammalian eye Biochem Biophys Res Commun 270 2000 517-521.
182. Tropepe V., Coles BL., Chiasson BJ., et al. Retinal stem cells in the adult mammalian eye Science 287 2000 2032-2036.
183. Ferrari G., Cusella-De Angelis G., Coletta M., et al. Muscle regeneration by bone marrow-derived myogenic progenitors Science 279 1998 1528-1530.
184. Galli R., Borello U., Gritti A., et al. Skeletal myogenic potential of human and mouse neural stem cells Nat Neurosci 3 2000 986-991.
185. Blau HM., Brazelton TR., Weimann JM The evolving concept of a stem cell: entity or function? Cell 105 2001 829-841.
186. Marquardt T Transcriptional control of neuronal diversification in the retina Prog Retin Eye Res 22 2003 567-577.
187. Fischer AJ., Reh TA Identification of a proliferating marginal zone of retinal progenitors in postnatal chickens Dev Biol 220 2000 197-210.
188. Johns PR Growth of the adult goldfish eye. III. Source of the new retinal cells J Comp Neurol 176 1977 343-357.
189. Reh TA., Nagy T Characterization of Rana germinal neuroepithelial cells in normal and regenerating retina Neurosci Res Suppl 10 1989 S151-S161.
190. Raymond PA., Hitchcock PF Retinal regeneration: common principles but a diversity of mechanisms Adv Neurol 72 1997 171-184.
191. Spence JR., Madhavan M., Ewing JD., et al. The hedgehog pathway is a modulator of retina regeneration Development 131 2004 4607-4621.
192. Coles BL., Angenieux B., Inoue T., et al. Facile isolation and the characterization of human retinal stem cells Proc Natl Acad Sci U S A 101 2004 15772-15777.
193. Mayer EJ., Carter DA., Ren Y., et al. Neural progenitor cells from postmortem adult human retina Br J Ophthalmol 89 2005 102-106.
194. Yang P., Seiler MJ., Aramant RB., et al. In vitro isolation and expansion of human retinal progenitor cells Exp Neurol 177 2002 326-331.
195. Carter DA., Mayer EJ., Dick AD The effect of postmortem time, donor age and sex on the generation of neurospheres from adult human retina Br J Ophthalmol 91 2007 1216-1218.
196. Gong J., Sagiv O., Cai H., et al. Effects of extracellular matrix and neighboring cells on induction of human embryonic stem cells into retinal or retinal pigment epithelial progenitors Exp Eye Res 86 2008 957-965.
197. Vossmerbaeumer U., Kuehl S., Kern S., et al. Induction of retinal pigment epithelium properties in ciliary margin progenitor cells Clin Exp Ophthalmol 36 2008 358-366.
198. Klimanskaya I., Chung Y., Becker S., et al. Human embryonic stem cell lines derived from single blastomeres Nature 2006.
199. Chung Y., Klimanskaya I., Becker S., et al. Human embryonic stem cell lines generated without embryo destruction Cell Stem Cell 2 2008 113-117.
200. Wilmut I., Schnieke AE., McWhir J., et al. Viable offspring derived from fetal and adult mammalian cells Nature 385 1997 810-813.
201. Byrne JA., Pedersen DA., Clepper LL., et al. Producing primate embryonic stem cells by somatic cell nuclear transfer Nature 450 2007 497-502.
202. Park IH., Zhao R., West JA., et al. Reprogramming of human somatic cells to pluripotency with defined factors Nature 451 2008 141-146.
203. Takahashi K., Tanabe K., Ohnuki M., et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors Cell 131 2007 861-872.
204. Kim K., Doi A., Wen B., et al. Epigenetic memory in induced pluripotent stem cells Nature 467 2010 285-290.
205. Zhao T., Zhang ZN., Rong Z., et al. Immunogenicity of induced pluripotent stem cells Nature 474 2011 212-215.
206. Chin MH., Mason MJ., Xie W., et al. Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures Cell Stem Cell 5 2009 111-123.
207. Doi A., Park IH., Wen B., et al. Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts Nature Gen 41 2009 1350-1353.
208. Polo JM., Liu S., Figueroa ME., et al. Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells Nat Biotechnol 28 2010 848-855.
209. Haruta M., Sasai Y., Kawasaki H., et al. In vitro and in vivo characterization of pigment epithelial cells differentiated from primate embryonic stem cells Invest Ophthalmol Vis Sci 45 2004 1020-1025.
210. Klimanskaya I., Hipp J., Rezai KA., et al. Derivation and comparative assessment of retinal pigment epithelium from human embryonic stem cells using transcriptomics Cloning Stem Cells 6 2004 217-245.
211. Idelson M., Alper R., Obolensky A., et al. Directed differentiation of human embryonic stem cells into functional retinal pigment epithelium cells Cell Stem Cell 5 2009 396-408.
212. Buchholz DE., Hikita ST., Rowland TJ., et al. Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells Stem Cells 27 2009 2427-2434.
213. Osakada F., Ikeda H., Sasai Y., et al. Stepwise differentiation of pluripotent stem cells into retinal cells Nat Protoc 4 2009 811-824.
214. Osakada F., Ikeda H., Mandai M., et al. Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells Nat Biotechnol 26 2008 215-224.
215. Arnhold S., Klein H., Semkova I., et al. Neurally selected embryonic stem cells induce tumor formation after long-term survival following engraftment into the subretinal space Invest Ophthalmol Vis Sci 45 2004 4251-4255.
216. Nakagawa M., Koyanagi M., Tanabe K., et al. Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts Nat Biotechnol 26 2008 101-106.
217. Huangfu D., Osafune K., Maehr R., et al. Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2 Nat Biotechnol 26 2008 1269-1275.
218. Shi Y., Desponts C., Do JT., et al. Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds Cell Stem Cell 3 2008 568-574.
219. Yu J., Hu K., Smuga-Otto K., et al. Human induced pluripotent stem cells free of vector and transgene sequences Science 324 2009 797-801.
220. Kaji K., Norrby K., Paca A., et al. Virus-free induction of pluripotency and subsequent excision of reprogramming factors Nature 458 2009 771-775.
221. Kokkinaki M., Sahibzada N., Golestaneh N Human induced pluripotent stem-derived retinal pigment epithelium (RPE) cells exhibit ion transport, membrane potential, polarized vascular endothelial growth factor secretion, and gene expression pattern similar to native RPE Stem Cells 29 2011 825-835.
222. Arnhold S., Heiduschka P., Klein H., et al. Adenovirally transduced bone marrow stromal cells differentiate into pigment epithelial cells and induce rescue effects in RCS rats Invest Ophthalmol Vis Sci 47 2006 4121-4129.
223. Chiou SH., Kao CL., Peng CH., et al. A novel in vitro retinal differentiation model by co-culturing adult human bone marrow stem cells with retinal pigmented epithelium cells Biochem Biophys Res Commun 326 2005 578-585.
224. Atmaca-Sonmez P., Li Y., Yamauchi Y., et al. Systemically transferred hematopoietic stem cells home to the subretinal space and express RPE-65 in a mouse model of retinal pigment epithelium damage Exp Eye Res 83 2006 1295-1302.
225. Lund RD., Wang S., Lu B., et al. Cells isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease Stem Cells 25 2007 602-611.
226. Feng Q., Lu SJ., Klimanskaya I., et al. Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence Stem Cells 28 2010 704-712.
227. Lamba DA., Reh TA Microarray characterization of human embryonic stem cell-derived retinal cultures Invest Ophthalmol Vis Sci 52 2011 4897-4906.
228. Banin E., Obolensky A., Idelson M., et al. Retinal incorporation and differentiation of neural precursors derived from human embryonic stem cells Stem Cells 24 2006 246-257.
229. Vugler A., Carr AJ., Lawrence J., et al. Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation Exp Neurol 214 2008 347-361.
230. Arnhold S., Absenger Y., Klein H., et al. Transplantation of bone marrow-derived mesenchymal stem cells rescue photoreceptor cells in the dystrophic retina of the rhodopsin knockout mouse Graefes Arch Clin Exp Ophthalmol 245 2007 414-422.
231. Inoue Y., Iriyama A., Ueno S., et al. Subretinal transplantation of bone marrow mesenchymal stem cells delays retinal degeneration in the RCS rat model of retinal degeneration Exp Eye Res 85 2007 234-241.
232. Kolomeyer A., Sugino I., Zarbin M Characterization of conditioned media collected from cultured adult versus fetal retinal pigment epithelial cells Invest Ophthalmol Vis Sci 52 2011 5973-5986.
233. Marmorstein AD., Marmorstein LY., Rayborn M., et al. Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium Proc Natl Acad Sci U S A 97 2000 12758-12763.
234. Bakall B., Radu RA., Stanton JB., et al. Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2) Exp Eye Res 85 2007 34-43.
235. Morimura H., Fishman GA., Grover SA., et al. Mutations in the RPE65 gene in patients with autosomal recessive retinitis pigmentosa or Leber congenital amaurosis Proc Natl Acad Sci U S A 95 1998 3088-3093.
236. Maw MA., Kennedy B., Knight A., et al. Mutation of the gene encoding cellular retinaldehyde-binding protein in autosomal recessive retinitis pigmentosa Nat Genet 17 1997 198-200.
237. Mata NL., Weng J., Travis GH Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration Proc Natl Acad Sci U S A 97 2000 7154-7159.
238. Allikmets R., Singh N., Sun H., et al. A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy Nat Genet 15 1997 236-246.
239. Berson EL Retinitis pigmentosa: unfolding its mystery Proc Natl Acad Sci U S A 93 1996 4526-4528.
240. Milam AH., Li ZY., Fariss RN Histopathology of the human retina in retinitis pigmentosa Prog Retin Eye Res 17 1998 175-205.
241. Santos A., Humayun MS., de Juan E., et al. Preservation of the inner retina in retinitis pigmentosa. A morphometric analysis Arch Ophthalmol 115 1997 511-515.
242. Humayun MS., Prince M., de Juan E., et al. Morphometric analysis of the extramacular retina from postmortem eyes with retinitis pigmentosa Invest Ophthalmol Vis Sci 40 1999 143-148.
243. Li ZY., Kljavin IJ., Milam AH Rod photoreceptor neurite sprouting in retinitis pigmentosa J Neurosci 15 1995 5429-5438.
244. Jones BW., Watt CB., Frederick JM., et al. Retinal remodeling triggered by photoreceptor degenerations J Comp Neurol 464 2003 1-16.
245. Ali RR., Sarra GM., Stephens C., et al. Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy Nat Genet 25 2000 306-310.
246. Bennett J., Tanabe T., Sun D., et al. Photoreceptor cell rescue in retinal degeneration (rd) mice by in vivo gene therapy Nat Med 2 1996 649-654.
247. Vollrath D., Feng W., Duncan JL., et al. Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk Proc Natl Acad Sci U S A 98 2001 12584-12589.
248. Maguire AM., Simonelli F., Pierce EA., et al. Safety and efficacy of gene transfer for Leber’s congenital amaurosis N Engl J Med 358 2008 2240-2248.
249. Bainbridge JW., Smith AJ., Barker SS., et al. Effect of gene therapy on visual function in Leber’s congenital amaurosis N Engl J Med 358 2008 2231-2239.
250. LaVail MM., Yasumura D., Matthes MT., et al. Protection of mouse photoreceptors by survival factors in retinal degenerations Invest Ophthalmol Vis Sci 39 1998 592-602.
251. Sieving PA., Caruso RC., Tao W., et al. Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants Proc Natl Acad Sci U S A 103 2006 3896-3901.
252. Lakhanpal RR., Yanai D., Weiland JD., et al. Advances in the development of visual prostheses Curr Opin Ophthalmol 14 2003 122-127.
253. Karl MO., Reh TA Regenerative medicine for retinal diseases: activating endogenous repair mechanisms Trends Mol Med 16 2010 193-202.
254. del Cerro M., Lazar ES., Diloreto D Jr., The first decade of continuous progress in retinal transplantation Microsc Res Tech 36 1997 130-141.
255. Gust J., Reh TA Adult donor rod photoreceptors integrate into the mature mouse retina Invest Ophthalmol Vis Sci 52 2011 5266-5272.
256. Meyer JS., Katz ML., Maruniak JA., et al. Neural differentiation of mouse embryonic stem cells in vitro and after transplantation into eyes of mutant mice with rapid retinal degeneration Brain Res 1014 2004 131-144.
257. Meyer JS., Katz ML., Maruniak JA., et al. Embryonic stem cell-derived neural progenitors incorporate into degenerating retina and enhance survival of host photoreceptors Stem Cells 24 2006 274-283.
258. Radtke ND., Aramant RB., Petry HM., et al. Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium Am J Ophthalmol 146 2008 172-182.
259. Seiler MJ., Aramant RB., Thomas BB., et al. Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets Eur J Neurosci 31 2010 508-520.
260. Lamba DA., Gust J., Reh TA Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice Cell Stem Cell 4 2009 73-79.
261. Mohand-Said S., Deudon-Combe A., Hicks D., et al. Normal retina releases a diffusible factor stimulating cone survival in the retinal degeneration mouse Proc Natl Acad Sci U S A 95 1998 8357-8362.
262. Mohand-Said S., Hicks D., Dreyfus H., et al. Selective transplantation of rods delays cone loss in a retinitis pigmentosa model Arch Ophthalmol 118 2000 807-811.
263. Leveillard T., Mohand-Said S., Lorentz O., et al. Identification and characterization of rod-derived cone viability factor Nat Genet 36 2004 755-759.
264. Chalmel F., Leveillard T., Jaillard C., et al. Rod-derived cone viability factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential BMC Mol Biol 8 2007 74.
265. Geller AM., Sieving PA How many cones are required to “see?": lessons from Stargardt’s macular dystrophy and from modeling with degenerate photoreceptor arrays In: Hollyfield JG., Anderson RE., La Vail MM Retinal degeneration 1993 Plenum Press New York 25-34.
266. Lavail M Analysis of neurological mutants with inherited retinal degeneration Invest Ophthalmol Vis Sci 21 1981 638-657.
267. Sanyal S., De Ruiter A., Hawkins RK Development and degeneration of retina in rds mutant mice: light microscopy J Comp Neurol 194 1980 193-207.
268. Narfstrom K., Nilsson SE Hereditary rod-cone degeneration in a strain of Abyssinian cats Prog Clin Biol Res 247 1987 349-368.
269. Noell WK., Walker VS., Kang BS., et al. Retinal damage by light in rats Invest Ophthalmol 5 1966 450-473.
270. Schuschereba ST., Silverman MS Retinal cell and photoreceptor transplantation between adult New Zealand red rabbit retinas Exp Neurol 115 1992 95-99.
271. Olsson JE., Gordon JW., Pawlyk BS., et al. Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa Neuron 9 1992 815-830.
272. Petters RM., Alexander CA., Wells KD., et al. Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa Nat Biotechnol 15 1997 965-970.
273. del Cerro M., Ison JR., Bowen GP., et al. Intraretinal grafting restores visual function in light-blinded rats Neuroreport 2 1991 529-532.
274. Seiler MJ., Aramant RB Intact sheets of fetal retina transplanted to restore damaged rat retinas Invest Ophthalmol Vis Sci 39 1998 2121-2131.
275. Gouras P., Du J., Kjeldbye H., et al. Reconstruction of degenerate rd mouse retina by transplantation of transgenic photoreceptors Invest Ophthal Vis Sci 33 1992 2579-2586.
276. Silverman MS., Hughes SE., Valentino TL., et al. Photoreceptor transplantation: Anatomic, electrophysiologic, and behavioral evidence for the functional reconstruction of retinas lacking photoreceptors Exp Neurol 115 1992 87-94.
277. Kwan AS., Wang S., Lund RD Photoreceptor layer reconstruction in a rodent model of retinal degeneration Exp Neurol 159 1999 21-33.
278. Radner W., Sadda SR., Humayun MS., et al. Light-driven retinal ganglion cell responses in blind rd mice after neural retinal transplantation Invest Ophthalmol Vis Sci 42 2001 1057-1065.
279. Otani A., Dorrell MI., Kinder K., et al. Rescue of retinal degeneration by intravitreally injected adult bone marrow-derived lineage-negative hematopoietic stem cells J Clin Invest 114 2004 765-774.
280. Yang Y., Mohand-Said S., Leveillard T., et al. Transplantation of photoreceptor and total neural retina preserves cone function in P23H rhodopsin transgenic rat PloS ONE 5 2010 e13469.
281. Aramant RB., Seiler MJ., Ball SL Successful cotransplantation of intact sheets of fetal retina with retinal pigment epithelium Invest Ophthalmol Vis Sci 40 1999 1557-1564.
282. Carter-Dawson LD., LaVail MM Rods and cones in the mouse retina: Structural analysis using light and electron microscopy J Comp Neurol 188 1979 245-262.
283. Ivert L., Gouras P., Naeser P., et al. Photoreceptor allografts in a feline model of retinal degeneration Graefes Arch Clin Exp Ophthalmol 236 1998 844-852.
284. Bragadottir R., Narfstrom K Lens sparing pars plana vitrectomy and retinal transplantation in cats Vet Ophthalmol 6 2003 135-139.
285. Bergstrom A., Ehinger B., Wilke K., et al. Transplantation of embryonic retina to the subretinal space in rabbits Exp Eye Res 55 1992 29-37.
286. Ghosh F., Bruun A., Ehinger B Immunohistochemical markers in full thickness embryonic rabbit retinal transplants Ophthalmic Res 31 1999 5-15.
287. Ghosh F., Arner K Transplantation of full-thickness retina in the normal porcine eye: surgical and morphologic aspects Retina 22 2002 478-486.
288. Prince JH Diesem CD., Eglitis I., et al. Anatomy and histology of the eye and orbit in domestic animals 1960 Charles C. Thomas Springfield IL p. 260-97.
289. Beauchemin ML The fine structure of the pig’s retina Graefes Arch Clin Exp Ophthalmol 190 1974 27-45.
290. Simoens P., De Schaepdrijver L., Lauwers H Morphologic and clinical study of the retinal circulation in the miniature pig. A: Morphology of the retinal microvasculature Exp Eye Res 54 1992 965-973.
291. Ghosh F., Engelsberg K., English RV., et al. Long-term neuroretinal full-thickness transplants in a large animal model of severe retinitis pigmentosa Graefes Arch Clin Exp Ophthalmol 245 2007 835-846.
292. Seiler M., Aramant RB., Ehinger B., et al. Transplantation of embryonic retina to adult retina in rabbits Exp Eye Res 51 1990 225-228.
293. Lazar E., del Cerro M A new procedure for multiple intraretinal transplantation into mammalian eyes J Neurosci Methods 43 1992 157-169.
294. del Cerro M., Kordower JH., Lazar E., et al. Photoreceptor differentiation in retinal xenografts of fetal monkey retina Brain Res 574 1992 1-8.
295. Rauer O., Ghosh F Survival of full-thickness retinal xenotransplants without immunosuppression Graefes Arch Clin Exp Ophthalmol 239 2001 145-151.
296. Juliusson B., Bergström A., van Veen T., et al. Cellular organization in retinal transplants using cell suspensions or fragments of embryonic retinal tissue Cell Transplant 2 1993 411-418.
297. Sharma RK Dissection and cotransplantation of large pieces of RPE and neural retina; effect of protease K on the development Acta Ophthalmol Scand 78 2000 3-8.
298. Geller AM., Sieving PA Assessment of foveal cone photoreceptors in Stargardt’s macular dystrophy using a small dot detection task Vis Res 33 1993 1509-1524.
299. Tezel TH., Kaplan HJ Harvest and storage of adult human photoreceptor cells: the vibratome compared to the excimer laser Curr Eye Res 17 1998 748-756.
300. Aramant R., Seiler M., Turner JE Donor age influences on the success of retinal grafts to adult rat retina Invest Ophthalmol Vis Sci 29 1988 498-503.
301. Salchow DJ., Trokel SL., Kjeldbye H., et al. Isolation of human fetal cones Curr Eye Res 22 2001 85-89.
302. Pinilla I., Cuenca N., Martinez-Navarrete G., et al. Intraretinal processing following photoreceptor rescue by non-retinal cells Vis Res 49 2009 2067-2077.
303. Keegan DJ., Kenna P., Humphries MM., et al. Transplantation of syngeneic Schwann cells to the retina of the rhodopsin knockout (rho(-/-)) mouse Invest Ophthalmol Vis Sci 44 2003 3526-3532.
304. Hicks D., Sahel J The implications of rod-dependent cone survival for basic and clinical research Invest Ophthalmol Vis Sci 40 1999 3071-3074.
305. LaVail MM., Unoki K., Yasumura D., et al. Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light Proc Natl Acad Sci U S A 89 1992 11249-11253.
306. Cayouette M., Gravel C Adenovirus-mediated gene transfer of ciliary neurotrophic factor can prevent photoreceptor degeneration in the retinal degeneration (rd) mouse Hum Gene Ther 8 1997 423-430.
307. Chaum E Retinal neuroprotection by growth factors: a mechanistic perspective J Cell Biochem 88 2003 57-75.
308. Wenzel A., Grimm C., Samardzija M., et al. Molecular mechanisms of light-induced photoreceptor apoptosis and neuroprotection for retinal degeneration Prog Retin Eye Res 24 2005 275-306.
309. Wen R., Song Y., Cheng T., et al. Injury-induced upregulation of bFGF and CNTF mRNAs in the rat retina J Neurosci 15 1995 7377-7385.
310. Faktorovich EG., Steinberg RH., Yasumura D., et al. Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor Nature 347 1990 83-86.
311. Cao W., Wen R., Li F., et al. Mechanical injury increases bFGF and CNTF mRNA expression in the mouse retina Exp Eye Res 65 1997 241-248.
312. Silverman MS., Hughes SE Photoreceptor rescue in the RCS rat without pigment epithelium transplantation Curr Eye Res 9 1990 183-191.
313. Sharma RK., Ehinger B Retinal cell transplants: How close to clinical application? Acta Ophthalmol Scand 75 1997 355-363.
314. Coffey PJ., Whiteley SJ., Lund RD Preservation and restoration of vision following transplantation Prog Brain Res 127 2000 489-499.
315. Das T., del Cerro M., Jalali S., et al. The transplantation of human fetal neuroretinal cells in advanced retinitis pigmentosa patients: results of a long-term safety study Exp Neurol 157 1999 58-68.
316. Humayun MS., de Juan E Jr., del Cerro M., et al. Human neural retinal transplantation Invest Ophthalmol Vis Sci 41 2000 3100-3106.
317. Radtke ND., Seiler MJ., Aramant RB., et al. Transplantation of intact sheets of fetal neural retina with its retinal pigment epithelium in retinitis pigmentosa patients Am J Ophthalmol 133 2002 544-550.
318. Berger AS., Tezel TH., Del Priore LV., et al. Photoreceptor transplantation in retinitis pigmentosa: short-term follow-up Ophthalmology 110 2003 383-391.
319. del Cerro M., Humayun MS., Sadda SR., et al. Histologic correlation of human neural retinal transplantation Invest Ophthalmol Vis Sci 41 2000 3142-3148.
320. Zhang Y., Arner K., Ehinger B., et al. Limitation of anatomical integration between subretinal transplants and the host retina Invest Ophthalmol Vis Sci 44 2003 324-331.
321. West EL., Pearson RA., Tschernutter M., et al. Pharmacological disruption of the outer limiting membrane leads to increased retinal integration of transplanted photoreceptor precursors Exp Eye Res 86 2008 601-611.
322. Pearson RA., Barber AC., West EL., et al. Targeted disruption of outer limiting membrane junctional proteins (Crb1 and ZO-1) increases integration of transplanted photoreceptor precursors into the adult wild-type and degenerating retina Cell Transplant 19 2010 487-503.
323. Zhang Y., Sharma RK., Ehinger B., et al. Nitric oxide-producing cells project from retinal grafts to the inner plexiform layer of the host retina Invest Ophthalmol Vis Sci 40 1999 3062-3066.
324. MacLaren RE., Pearson RA., MacNeil A., et al. Retinal repair by transplantation of photoreceptor precursors Nature 444 2006 203-207.
325. Bartsch U., Oriyakhel W., Kenna PF., et al. Retinal cells integrate into the outer nuclear layer and differentiate into mature photoreceptors after subretinal transplantation into adult mice Exp Eye Res 86 2008 691-700.
326. Gamm DM., Wang S., Lu B., et al. Protection of visual functions by human neural progenitors in a rat model of retinal disease PloS One 2 2007 e338.
327. Kovalevsky G., DiLoreto D Jr., Wyatt J., et al. The intensity of the pupillary light reflex does not correlate with the number of retinal photoreceptor cells Exp Neurol 133 1995 43-49.
328. Chacko DM., Rogers JA., Turner JE., et al. Survival and differentiation of cultured retinal progenitors transplanted in the subretinal space of the rat Biochem Biophys Res Commun 268 2000 842-846.
329. Sakaguchi DS., Van Hoffelen SJ., Grozdanic SD., et al. Neural progenitor cell transplants into the developing and mature central nervous system Ann N Y Acad Sci 1049 2005 118-134.
330. Klassen H., Schwartz PH., Ziaeian B., et al. Neural precursors isolated from the developing cat brain show retinal integration following transplantation to the retina of the dystrophic cat Vet Ophthal 10 2007 245-253.
331. Van Hoffelen SJ., Young MJ., Shatos MA., et al. Incorporation of murine brain progenitor cells into the developing mammalian retina Invest Ophthalmol Vis Sci 44 2003 426-434.
332. Sam TN., Xiao J., Roehrich H., et al. Engrafted neural progenitor cells express a tissue-restricted reporter gene associated with differentiated retinal photoreceptor cells Cell Transplant 15 2006 147-160.
333. Klassen H., Sakaguchi DS., Young MJ Stem cells and retinal repair Prog Retin Eye Res 23 2004 149-181.
334. Maclaren RE., Pearson RA., Macneil A., et al. Retinal repair by transplantation of photoreceptor precursors Nature 2006.
335. Gruen L., Grabel L Concise review: scientific and ethical roadblocks to human embryonic stem cell therapy Stem Cells 24 2006 2162-2169.
336. MacNeil A., Pearson RA., MacLaren RE., et al. Comparative analysis of progenitor cells isolated from the iris, pars plana, and ciliary body of the adult porcine eye Stem Cells 25 2007 2430-2438.
337. Kokkinopoulos I., Pearson RA., Macneil A., et al. Isolation and characterisation of neural progenitor cells from the adult Chx10(orJ/orJ) central neural retina Mol Cell Neurosci 38 2008 359-373.
338. Akagi T., Mandai M., Ooto S., et al. Otx2 homeobox gene induces photoreceptor-specific phenotypes in cells derived from adult iris and ciliary tissue Invest Ophthalmol Vis Sci 45 2004 4570-4575.
339. Jomary C., Jones SE Induction of functional photoreceptor phenotype by exogenous Crx expression in mouse retinal stem cells Invest Ophthalmol Vis Sci 49 2008 429-437.
340. Yang P., Seiler MJ., Aramant RB., et al. Differential lineage restriction of rat retinal progenitor cells in vitro and in vivo J Neurosci Res 69 2002 466-476.
341. Canola K., Angenieux B., Tekaya M., et al. Retinal stem cells transplanted into models of late stages of retinitis pigmentosa preferentially adopt a glial or a retinal ganglion cell fate Invest Ophthalmol Vis Sci 48 2007 446-454.
342. Klassen H., Kiilgaard JF., Zahir T., et al. Progenitor cells from the porcine neural retina express photoreceptor markers after transplantation to the subretinal space of allorecipients Stem Cells 25 2007 1222-1230.
343. Klassen HJ., Ng TF., Kurimoto Y., et al. Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior Invest Ophthalmol Vis Sci 45 2004 4167-4173.
344. Liu IH., Chen SJ., Ku HH., et al. Comparison of the proliferation and differentiation ability between adult rat retinal stem cells and cerebral cortex-derived neural stem cells Ophthalmologica 219 2005 171-176.
345. Del Debbio CB., Balasubramanian S., Parameswaran S., et al. Notch and Wnt signaling mediated rod photoreceptor regeneration by Muller cells in adult mammalian retina PloS One 5 2010 e12425.
346. Lawrence JM., Singhal S., Bhatia B., et al. MIO-M1 cells and similar Muller glial cell lines derived from adult human retina exhibit neural stem cell characteristics Stem Cells 25 2007 2033-2043.
347. Das AV., Mallya KB., Zhao X., et al. Neural stem cell properties of Muller glia in the mammalian retina: regulation by Notch and Wnt signaling Dev Biol 299 2006 283-302.
348. Limb GA., Salt TE., Munro PM., et al. In vitro characterization of a spontaneously immortalized human Muller cell line (MIO-M1) Invest Ophthalmol Vis Sci 43 2002 864-869.
349. Singhal S., Lawrence JM., Bhatia B., et al. Chondroitin sulfate proteoglycans and microglia prevent migration and integration of grafted Muller stem cells into degenerating retina Stem Cells 26 2008 1074-1082.
350. Xu C., Inokuma MS., Denham J., et al. Feeder-free growth of undifferentiated human embryonic stem cells Nat Biotechnol 19 2001 971-974.
351. Ludwig TE., Bergendahl V., Levenstein ME., et al. Feeder-independent culture of human embryonic stem cells Nat Methods 3 2006 637-646.
352. Lamba DA., Karl MO., Ware CB., et al. Efficient generation of retinal progenitor cells from human embryonic stem cells Proc Natl Acad Sci U S A 103 2006 12769-12774.
353. Schraermeyer U., Thumann G., Luther T., et al. Subretinally transplanted embryonic stem cells rescue photoreceptor cells from degeneration in the RCS rats Cell Transplant 10 2001 673-680.
354. Amirpour N., Karamali F., Rabiee F., et al. Differentiation of human embryonic stem cell-derived retinal progenitors into retinal cells by sonic hedgehog and/or retinal pigmented epithelium and transplantation into the subretinal space of sodium iodate-injected rabbits Stem Cells Dev 21 2011 42-53.
355. Lamba DA., McUsic A., Hirata RK., et al. Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells PLoS ONE 5 2010 e8763.
356. Tucker BA., Park IH., Qi SD., et al. Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice PloS One 6 2011 e18992.
357. Zhou L., Wang W., Liu Y., et al. Differentiation of induced pluripotent stem cells of swine into rod photoreceptors and their integration into the retina Stem Cells 29 2011 972-980.
358. Kicic A., Shen WY., Wilson AS., et al. Differentiation of marrow stromal cells into photoreceptors in the rat eye J Neurosci 23 2003 7742-7749.
359. Sun X., Chen M., Li J., et al. E13.5 retinal progenitors induce mouse bone marrow mesenchymal stromal cells to differentiate into retinal progenitor-like cells Cytotherapy 13 2011 294-303.
360. Tao YX., Xu HW., Zheng QY., et al. Noggin induces human bone marrow-derived mesenchymal stem cells to differentiate into neural and photoreceptor cells Indian J Exp Biol 48 2010 444-452.
361. Radtke ND., Aramant RB., Seiler M., et al. Preliminary report: indications of improved visual function after retinal sheet transplantation in retinitis pigmentosa patients Am J Ophthalmol 128 1999 384-387.
362. Siqueira RC., Messias A., Voltarelli JC., et al. Intravitreal injection of autologous bone marrow-derived mononuclear cells for hereditary retinal dystrophy: a phase I trial Retina 31 2011 1207-1214.
363. Wang HM., Kaplan HJ., Chan WC., et al. The distribution and ontogeny of MHC antigens in murine ocular tissue Invest Ophthalmol Vis Sci 28 1987 1383-1389.
364. Jiang LQ., Jorquera M., Streilein JW., et al. Unconventional rejection of neural retinal allografts implanted into the immunologically privileged site of the eye Transplantation 59 1995 1201-1207.
365. Hori J., Ng TF., Shatos M., et al. Neural progenitor cells lack immunogenicity and resist destruction as allografts Stem Cells 21 2003 405-416.
366. Yang P., Chen L., Zwart R., et al. Immune cells in the porcine retina: distribution, characterization and morphological features Invest Ophthalmol Vis Sci 43 2002 1488-1492.
367. Provis JM., Penfold PL., Edwards AJ., et al. Human retinal microglia: expression of immune markers and relationship to the glia limitans Glia 14 1995 243-256.
368. Aramant RB., Seiler MJ Human embryonic retinal cell transplants in athymic immunodeficient rat hosts Cell Transplant 3 1994 461-474.
369. Ma J., Xu L., Othersen DK., et al. Cloning and localization of RPE65 mRNA in salamander cone photoreceptor cells1 Biochim Biophys Acta 1443 1998 255-261.
370. West EL., Pearson RA., Barker SE., et al. Long-term survival of photoreceptors transplanted into the adult murine neural retina requires immune modulation Stem Cells 28 2010 1997-2007.
371. Fawcett JW., Asher RA The glial scar and central nervous system repair Brain Res Bull 49 1999 377-391.
372. Kinouchi R., Takeda M., Yang L., et al. Robust neural integration from retinal transplants in mice deficient in GFAP and vimentin Nat Neurosci 6 2003 863-868.
373. Tucker BA., Redenti SM., Jiang C., et al. The use of progenitor cell/biodegradable MMP2-PLGA polymer constructs to enhance cellular integration and retinal repopulation Biomaterials 31 2010 9-19.
374. Lewis GP., Linberg KA., Fisher SK Neurite outgrowth from bipolar and horizontal cells after experimental retinal detachment Invest Ophthalmol Vis Sci 39 1998 424-434.
375. Jansen HG., Hawkins RK., Sanyal S Synaptic growth in the rod terminals of mice after partial photoreceptor cell loss: a three-dimensional ultrastructural study Microsc Res Tech 36 1997 96-105.
376. Fei Y Cone neurite sprouting: an early onset abnormality of the cone photoreceptors in the retinal degeneration mouse Mol Vis 8 2002 306-314.
377. Fariss RN., Li ZY., Milam AH Abnormalities in rod photoreceptors, amacrine cells, and horizontal cells in human retinas with retinitis pigmentosa Am J Ophthalmol 129 2000 215-223.
378. Fisher SK., Lewis GP Muller cell and neuronal remodeling in retinal detachment and reattachment and their potential consequences for visual recovery: a review and reconsideration of recent data Vis Res 43 2003 887-897.
379. Nachman-Clewner M., Townes-Anderson E Injury-induced remodelling and regeneration of the ribbon presynaptic terminal in vitro J Neurocytol 25 1996 597-613.
380. Mandell JW., MacLeish PR., Townes-Anderson E Process outgrowth and synaptic varicosity formation by adult photoreceptors in vitro J Neurosci 13 1993 3533-3548.
381. Khodair MA., Zarbin MA., Townes-Anderson E Synaptic plasticity in mammalian photoreceptors prepared as sheets for retinal transplantation Invest Ophthalmol Vis Sci 44 2003 4976-4988.
382. Khodair MA., Zarbin MA., Townes-Anderson E Cyclic AMP prevents retraction of axon terminals in photoreceptors prepared for transplantation: an in vitro study Invest Ophthalmol Vis Sci 46 2005 967-973.
383. Fontainhas AM., Townes-Anderson E RhoA inactivation prevents photoreceptor axon retraction in an in vitro model of acute retinal detachment Invest Ophthalmol Vis Sci 52 2011 579-587.
384. Fontainhas AM., Townes-Anderson E RhoA and its role in synaptic structural plasticity of isolated salamander photoreceptors Invest Ophthalmol Vis Sci 49 2008 4177-4187.
385. Marc RE., Jones BW., Watt CB., et al. Neural remodeling in retinal degeneration Prog Retin Eye Res 22 2003 607-655.