Neural progenitor cells lack immunogenicity and resist destruction as allografts

Stem Cells

Volumn 21, Issue 4, 2003, Pages 405-416

  Hori, Junko ^a,b   Ng, Tat Fong ^a   Shatos, Marie ^a   Klassen, Henry ^c   Streilein, J Wayne ^a   Young, Michael J ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^b NIPPON MEDICAL SCHOOL   (Japan)

^c CHILDREN S HOSPITAL OF ORANGE COUNTY   (United States)

Author keywords

Anergy; MHC; Neural; Stem cells; Suppression; Tolerance; Transplantation

Indexed keywords

ALLOANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CULTURE MEDIUM; FLOW CYTOMETRY; GRAFT SURVIVAL; IMMUNOGENICITY; KIDNEY CAPSULE; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MOUSE; MOUSE STRAIN; NERVE CELL; NERVE FIBER; NONHUMAN; SENSITIZATION; STEM CELL;

ANIMALIA; MAMMALIA;

EID: 0037820641     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.21-4-405     Document Type: Article

References (32)

1. Medawar P. Immunity to homologous grafted skin, III: the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol 1948;29:58-69.
2. Hori J, Joyce NC, Streilein JW. Immune privilege and immunogenicity reside among different layers of the mouse cornea. Invest Ophtalmol Vis Sci 2000;41:3032-3042.
3. Bellgrau D, Gold D, Selawry H et al. A role for CD95 ligand in preventing graft rejection. Nature 1995;377:630-632.
4. Wenkel H, Streilein JW, Young MJ. Systemic immune deviation in the brain that does not depend on the integrity of the blood-brain barrier. J Immunol 2000;164:5125-5131.
5. Jiang LQ, Jorquera M, Streilein JW. Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts. Invest Ophthalmol Vis Sci 1993;34:3347-3354.
6. Wenkel H, Chen PW, Ksander BR et al. Immune privilege is extended, then withdrawn, from allogeneic tumor cell grafts placed in the subretinal space. Invest Ophthalmol Vis Sci 1999;40:3202-3208.
7. Gage FH, Ray J, Fisher LJ. Isolation, characterization, and use of stem cells from the CNS. Annu Rev Neurosci 1995;18:159-192.
8. Yandava BD, Billinghurst LL, Snyder EY. "Global" cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brain. Proc Natl Acad Sci USA 1999;96:7029-7034.
9. Young MJ, Ray J, Whiteley SJ et al. Integration of transplanted neural progenitor cells into the retina of immature and mature dystrophic rats. Mol Cell Neurosci 2000;16:197-205.
10. Reece-Smith H, Du Toit DF, McShane P et al. Prolonged survival of pancreatic islet allografts transplanted beneath the renal capsule. Transplantation 1981;31:305-306.
11. Okabe M, Ikawa M, Kominami K et al. 'Green mice' as a source of ubiquitous green cells. FEBS Lett 1997;407:313-319.
12. Shatos MA, Mizumoto K, Mizumoto H et al. Multipotent stem cells from the brain and retina of green mice. e-biomed: J Regen Med 2001;2-2001:13-15.
13. Hori J, Joyce N, Streilein JW. Epithelium-deficient corneal allografts display immune privilege beneath the kidney capsule. Invest Ophthalmol Vis Sci 2000;41:443-452.
14. Wenkel H, Streilein JW. Evidence that retinal pigment epithelium functions as an immune-privileged tissue, Invest Ophthalmol Vis Sci 2000;41:3467-3473.
15. Bjornson CR, Rietze RL, Reynolds BA et al. Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 1999;283:534-537.
16. Grenier Y, Ruijs TC, Robitaille Y et al. Immunohistochemical studies of adult human glial cells. J Neuroimmunol 1989;21:103-115.
17. Skias DD, Kim DK, Reder AT et al. Susceptibility of astrocytes to class I MHC antigen-specific cytotoxicity. J Immunol 1987;138:3254-3258.
18. Panek RB, Lee YJ, Itoh-Lindstrom Y et al. Characterization of astrocyte nuclear proteins involved in IFN-gamma- and TNF-alpha-mediated class II MHC gene expression. J Immunol 1994;153:4555-4564.
19. Dong Y, Rohn WM, Benveniste EN. IFN-gamma regulation of the type IV class II transactivator promoter in astrocytes. J Immunol 1999;162:4731-4739.
20. Frank E, Pulver M, de Tribolet N. Expression of class II major histocompatibility antigens on reactive astrocytes and endothelial cells within the gliosis surrounding metastases and abscesses. J Neuroimmunol 1986;12:29-36.
21. Hailer NP, Glomsda B, Blaheta RA. Astrocytic factors downregulate the expression of major histocompatibility complex-class-II and intercellular adhesion molecule-1 on human monocytes. Neurosci Lett 2001;298:33-36.
22. Williams K Jr, Ulvestad E, Cragg L et al. Induction of primary T cell responses by human glial cells. J Neurosci Res 1993;36:382-390.
23. Horwitz MS, Evans CF, Klier FG et al. Detailed in vivo analysis of interferon-gamma induced major histocompatibility complex expression in the the central nervous system: astrocytes fail to express major histocompatibility complex class I and II molecules. Lab Invest 1999;79:235-242.
24. Huh GS, Boulanger LM, Du H et al. Functional requirement for class I MHC in CNS development and plasticity. Science 2000;290:2155-2159.
25. Ma N, Streilein JW. Contribution of nicroglia as passenger leukocytes to the fate of intraocular neuronal retinal grafts. Invest Ophthalmol Vis Sci 1998;39:2384-2393.
26. Thomson JA, Itskovitz-Eldor J, Shapiro SS et al. Embryonic stem cell lines derived from human blastocysts. Science 1998;282:1145-1147.
27. Shamblott MJ, Axelman J, Wang S et al. Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci USA 1998;95:13726-13731.
28. Clarke DL, Johansson CB, Wilbertz J et al. Generalized potential of adult neural stem cells. Science 2000;288:1660-1663.
29. Lagasse E, Connors H, Al-Dhalimy M et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000;6:1229-1234.
30. Madrazo I, Leon V, Torres C et al. Transplantation of fetal substantia nigra and adrenal medulla to the caudate nucleus in two patients with Parkinson's disease. N Engl J Med 1988;318:51.
31. Freed CR, Greene PE, Breeze RE et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 2001;344:710-719.
32. Hagell P, Schrag A, Piccini P et al. Sequential bilateral transplantation in Parkinson's disease: effects of the second graft. Brain 1999:122:1121-1132.