CNS immunological modulation of neural graft rejection and survival

Neurological Research

Volumn 18, Issue 4, 1996, Pages 297-304

  Borlongan, Cesario V ^a   Stahl, Christine E ^a   Cameron, Don F ^a   Saporta, Samuel ^a   Freeman, Thomas B ^a   Cahill, David W ^a   Sanberg, Paul R ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

blood brain barrier; Cyclosporine A; dopamine secreting cells; gene therapy; immunosuppression; major histocompatibility complex; Neural transplantation; neurodegeneration; Parkinson's disease; sertoli cells; xenograft

Indexed keywords

AZATHIOPRINE; BREQUINAR; CYCLOSPORIN A; IMMUNOPHILIN; IMMUNOSUPPRESSIVE AGENT; MYCOPHENOLIC ACID; POLYMER; RAPAMYCIN; STEROID; TACROLIMUS;

ADRENAL MEDULLA; BLOOD BRAIN BARRIER; DOPAMINERGIC NERVE CELL; DRUG EFFECT; GENE THERAPY; GRAFT SURVIVAL; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROENCAPSULATION; NEPHROTOXICITY; NERVOUS TISSUE; NEUROTOXICITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PARKINSON DISEASE; REVIEW; SERTOLI CELL; TISSUE TRANSPLANTATION; XENOGRAFT;

EID: 0029748617     PISSN: 01616412     EISSN: None     Source Type: Journal    
DOI: 10.1080/01616412.1996.11740425     Document Type: Review

References (70)

1. Medawar PB. Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol 1948; 29: 58-69
2. Scheinberg LC, Edelman FL, Levy AW. Is the brain an immunologically privileged site? Arch Neurol 1964; 11: 248-264
3. Barker CF, Billingham RE. Immunologically privileged sites. Adv Immunol 1985; 25: 1-54
4. Finsen BR, Sorensen T, Gonzalez B, Castellano B, Zimmer J. Immunological reactions to neural grafts in the central nervous system. Restor Neurol Neursci 1991; 2: 271-282
5. Widner H, Brundin P. Immunological aspects of grafting in the mammalian central nervous system. A review and speculative synthesis. Brain Res Rev 1988; 13: 287-324
6. Poltorak M, Freed WJ. BN rats do not reject F344 brain allografts even after systemic sensitization. Ann Neurol 1991; 29: 377-388
7. Wekerle H, Linington C, Lassmann H, Meyermann R. Cellular immune reactivity within the CNS. Trend Biochem Sci 1986; 6: 271-277
8. Sloan DJ, Wood MJ, Charlton HM. The immune response to intracerebral neural grafts. Trends Neurosci 1991; 14: 341-346
9. Freed WJ, Dymecki J, Poltorak M, Rodgers CR. Intraventricular brain allografts and xenografts: Studies of survival and rejection with and without systemic sensitization. Prog Brain Res 1988; 78: 233-241
10. Finsen BR, Pedersen EB, Sorensen T, Hokland M, Zimmer J. Immune reactions against intracerebral murine xenografts of fetal hippocampal tissue and cultured cortical astrocytes in the adult rat. Prog Brain Res 1990; 82: 111-127
11. Hudson JL, Hoffman A, Stromberg I, Hoffer BJ, Moorhead JW. Allogeneic grafts of fetal dopamine neurons: behavioral indices of immunological interactions. Neurosci Lett 1994; 171: 32-36
12. Widner H, Moller G, Johansson BB. Immune response in deep cervical lymph nodes and spleen in the mouse after antigen deposition m different cerebral sites. Scand J Immunol 1988; 28: 563-571
13. Bakay RA, Fiandaca MS, Barrow DL, Schiff A, Collins DO. Preliminary report on the use of adrenal medullary tissue to striatum in parkinsonism. First clinical trials. J Neurosurg 1985; 62: 169-173
14. Sladek JR Jr, Collier TJ, Haber SN, Roth RH, Redmond DE Jr. Survival and growth of fetal catecholamine neurons grafted into primate brain. Brain Res Bull 1986; 1: 809-818
15. Widner H, Brundin P, Bjorklund A, Moller E. Survival and immunogenicity of dissociated allogeneic fetal neural dopamine-rich grafts when implanted into the brains of adult mice. Exp Brain Res 1989; 76: 187-197
16. Freed CR, Breeze RE, Rosenberg NL, Schneck SA, Kriek E, Qi J-X, Lone T, Zhang Y-B, Snyder JA, Wells TH, Ramig LO, Thompson L, Mazziotta JC, Huang SC, Grafton ST, Brooks D, Sawle G, Schroter G, Ansari AA. Survival of implanted dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. New Eng J Med 1992; 327: 1549-1555
17. Kordower JH, Freeman TB, Snow B, Vingerhoets FJG, Muffson EJ, Sanberg PR, Hauser R, Perl DP, Olanow CW. Neuropathological evidence of graft survival and striatal reinnervation after transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. New Eng J Med 1995; 332: 1118-1124
18. Freeman TB, Olanow CW, Hauser RA, Nauert GM, Smith DA, Borlongan CV, Sanberg PR, Snow B, Vingerhoets FJG, Calne D, Gauger LL. Bilateral fetal nigral transplantation into the postcommisural putamen as a treatment for Parkinson's disease: Six month follow-up. Ann Neurol 1995; 38:379-388
19. Broadwell RD, Charlton HM, Ebert P, Hickey WF, Villegas J, Wolf AL. Angiogenesis and the blood-brain barrier in solid and dissociated cell grafts within the CNS. Prog Brain Res 1990; 82: 95-101
20. Brundin P, Widner H, Nilsson OG, Strecker RE, Björklund A. Intracerebral xenografts of dopamine neurons: The role of immunosuppression and the blood-brain barrier. Exp Brain Res 1989; 75: 195-207
21. Lampson LA. Molecular bases of the immune response to neural antigens. Trends Neurol Sci 1987; 10: 211-216
22. Nieto-Sampedro M, Berman MA. Interleukin-1-like activity in the rat brain: sources, targets, and effect of injury. J Neurosci Res 1987; 17: 214-219
23. Fontanta A, Fierz W, Wekerle H. Astrocytes present myelin basic protein to encephalitogenic T-cell lines. Nature 1984; 307: 273-276
24. Mason DW, Charlton HM, Jones AJ, Lavy CBD, Puclavec M, Simmonds SJ. The fate of allogeneic and xenogeneic neuronal tissue transplanted into the third ventricle of rodents. Neuroscience 1986; 19: 685-694
25. Freeman TB, Brandies L, Pearson J, Flamm ES. Cross-species grafts of embryonic rabbit mesencephalic tissue survive and cause behavioral recovery in the presence of chronic immunosuppression. Ann NY Acad Sci 1987, 495: 699-702
26. Brundin P, Strecker RE, Widner H, Clarke DJ, Nilsson OG, Åstedt B, Lindvall O, Björklund A. Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: Immunological aspects, spontaneous and drug-induced behaviour, and dopamine release. Exp Brain Res 1988; 70: 192-208
27. Freed CR, Richards JB, Sabol KE, Reite M. Fetal substantia nigra transplants lead to dopamine cell replacement and behavioral improvement in Bonnet monkeys with MPTP induced parkinsonism. In: Beart PM, Woodruff G, Jackson DM, eds. Pharmacology and Functional Regulation of Dopaminergic Neurons, London: Macmillan Press, 1988: pp 353-363
28. Famiglio L, Racusen L, Fivush B, Solez K, Fisher R. Central nervous system toxicity of cyclosporine in a rat model. Transplantation 1989; 48: 316-321
29. Borlongan CV, Freeman TB, Scorcia T, Sherman K, Cahill DW, Sanberg PR. Cyclosporine-A increases spontaneous and dopamine agonist locomotor activity. Cell Transplant 1995; 1: 65-73
30. Brundin P, Nilsson OG, Gage FH, Björklund A. Cyclosporin A increases survival of cross-species intrastriatal grafts of embryonic dopamine-containing neurons. Exp Brain Res 1985; 60: 204-208
31. Brundin P, Nilsson OG, Strecker RE, Lindvall O, Åstedt B, Björklund A. Behavioral effects of human fetal dopamine neurons grafted in a rat model of Parkinson's disease. Exp Brain Res 1986; 65: 235-240
32. Björklund A, Stenevi U, Dunnett SB, Gage FH. Cross-species grafting in a rat model of Parkinson's disease. Nature 1982; 298: 652-654
33. Brundin P, Björklund A. Survival, growth and function of dopaminergic neurons grafted to the brain. Prog Brain Res 1987; 71: 293-308
34. Berden JHM, Hoitsma AJ, Merx JL, Keyser A. Severe central nervous system toxicity associated with cyclosporine. Lancet 1985; 26: 219-220
35. Cilio MR, Danhaive O, Gadisseux JF, Otte JB, Sokal EM. Unusual cyclosporin related neurological complications in recipients of liver transplants. Arch Dis Child 1993; 68: 405-107
36. de Groen C, Aksamit AJ, Rakela J, Forbes GS, Krom RAF. Central nervous system toxicity after liver transplantation. New Eng J Med 1984; 317: 861-866
37. Taesch S, Niese D, Mueller EA. Sandimmun Neoral, a new oral formulation of cyclosporin A with improved pharmacokinetic characteristics: safely and tolerability in renal transplant patients. Transplant Proc 1994; 26: 3147-3149
38. Gold BG, Storm-Dikerson T, Austin DR, The immunosuppressant FK506 increases functional recovery and nerve regeneration following peripheral nerve injury. Restor Neurol Neurosci 1994; 6: 287-296
39. Dawson TM, Steiner JP, Dawson VL, Dinerman JL, Uhl GR, Snyder SH. Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity. Proc Natl Acad Sci 1993; 90: 9808-9812
40. Bach JB. Editorial. Transplant Proc 1994; 26: 3093
41. Snyder SH, Sabatini DM. Immunophilins and the nervous system. Nature Med 1995; 1: 32-37
42. Lindvall O, Backlund EO, Farde L, Sedvall G, Freedman R, Hoffer B, Nobin A, Seiger A, Olson L. Transplantation in Parkinson's disease: two cases of adrenal medullary grafts to the putamen. Ann Neurol 1987; 22: 457-468
43. Madrazo I, Ducker-Colin R, Diaz V, Martinez-Marta J, Torres C, Becceril J. Open microsurgical autograft of adrenal medulla to the right caudate nucleus in two patients with intractable Parkinson's disease. N Engl J Med 1987; 316: 831-834
44. Chen LS, Ray J, Fisher LJ, Kawaja MD, Schinstine M, Kang UJ, Gage FH. Cellular replacement therapy for neurologic disorders: potential of genetically engineered cells. J Cell Biochem 1991; 45: 252-257
45. Sagen J, Wang H, Tresco PA, Aebischer P. Transplants of immunologically isolated xenogeneic chromaffin cells provide a long-term source of pain-reducing neuroactive substances. J Neurosci 1993; 13: 2415-2423
46. Goetz C, Olanow CW, Koller WC, Penn RD, Cahill DW, Morantz R, Stebbins G, Tanner CM, Klawans HL, Shannon KM, Comelia CL, Witt T, Cox C, Waxman M, Gauger L. Multicenter study of autologous adrenal medullary transplantation to the corpus striatum in patients with advanced Parkinson's disease. N Eng J Med 1989; 320: 337-341
47. Aebischer P, Winn SR, Galletti PM. Transplantation of neural tissue in polymer capsules. Brain Res 1988; 448: 364-368
48. Emerich DF, Winn SR, Christenson L, Palmatier MA, Gentile FT, Sanberg PR. A novel approach to neural transplantation in Parkinson's disease: Use of polymer-encapsulated cell therapy. Neurosci Biobehav Rev 1992; 16: 437-447
49. Christenson L, Aebischer P, McMillan P, Galletti PM. Tissue reaction to intraperitoneal polymer implants: Species differences and effects of corticoid and doxorubicin. J Biomed Mater Res 1989; 23: 705-715
50. Lim F, Sun AM. Microencapsulated islets as a bioartificial endocrine pancreas. Science 1980; 210: 908-910
51. Cherksey BD. Microcarrier pre-adhesion enhances long term survival of adult cells implanted into the mammalian brain. Exp Neurol 1994; 129: 20
52. Borlongan CV, Sanberg PR. Rat adrenal chromaffin cells seeded with microcarrier beads produce an enhanced behavioral recovery in hemiparkinsonian rats. Soc Neurosci Abstr 1995; 21: 317
53. Sanberg PR, Borlongan CV, Saporta S, Cameron DF. Transplantation of testis-derived Sertoli cells in the rat brain alleviates 6-hydroxydopamine hemiparkinsonism. submitted 1995.
54. Clermont Y. In: Russell LD, Criswold MD, eds. The Sertoli Cell. Clearwater, FL: Cache River Press: 1993
55. Hedger MP. The testis: An 'immunologically suppressed' tissue? Reprod Fertil Dev 1989; 1: 75-81
56. Selawry HP, Cameron DF. Sertoli cell-enriched fractions in a successful islet cell transplantation. Cell Transplant 1993; 2: 123
57. Pakzaban P, Deacon TW, Burns LH, Dinsmore J, Isacson O. Enhanced survival of neural xenografts after masking of donor major histocompatibility complex class I. Soc Neurosci Abtr 1994; 20: 1708
58. Isacson O, Schumacher JM, Dinsmore J, Deacon T, Galpern W, Pakzaban P, Burns L, Tatter S, Kott S, Plamer P, Penney D, Fischman A, Dempsey P. Transplantation of porcine neural cells to restore connections and function in Parkinson's and Huntington's diseases. Cellular and Molecular Treatments of Neurological Diseases Conference Abstr 1995; 5
59. Milton AD, Fabre JW. Massive induction of donor-type class I and class II major histocompatibility complex antigens in rejecting cardiac allografts in the rat. J Exp Med 1985; 161: 98-112
60. Bartlett PF, Bailey KA, Cheesman H, Harvey AR, Kerr RSC. Prog Brain Res 1990; 82: 153-160
61. Nicholas MK, Antel JP, Stefansson K, Arnason BGW. Rejection of fetal neocortical neural transplants b H-2 incompatible mice. J Immunol 1987; 139: 2275-2283
62. Oldstone MBA, Blount P, Southern PJ, Lampert PW. Cytoimmunotherapy for persistent virus infection reveals a unique clearance pattern from the central nervous system. Nature 1986; 321: 239-243
63. Horellou P, Vigne E, Castel MN, Barneoud P, Colin P, Perricaudet M, Delaere P, Mallet J. Direct intracerebral gene transfer of an adenoviral vector expressing tyrosine hydroxylase in a rat model of Parkinson's disease. Neuroreport 1994; 6: 49-53
64. Alki S, Caillaud C, Vigne E, Statford-Perricaudet LD, Poenaru L, Perricauet M, Kahn A, Peschanski MR. Transfer of a foreign gene into the brain using adenovirus vectors. Nat Gen 1993; 3: 224-228
65. Kaplitt MG, Leone P, Samulski RJ, Xiao X, Pfaff DW, O'Malley KL, During MJ. Long-term expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nat Gene 1994; 8: 148-154
66. During MJ, Naegele JR, O'Malley KL, Geller AI. Long-term behavioral recovery in Parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 1994; 266: 1399-1403
67. Sabate O, Horellou P, Vigne E, Colin P, Perricaudet M, Buc-Caron MH, Mallet J. Transplantation to the rat brain of human neural progenitors that were genetically modified using adenoviruses. Naf Gene 1995; 9: 256-260
68. Johnson PA, Miyanohara A, Levine F, Cahill T, Friedmann T. Cytotoxicity of a replication-defective mutant of Herpes Simplex Virus Type 1. J Vir 1992; 66: 2952-2965
69. Takayama H, Ray J, Raymon H, Baird A, Hogg J, Fisher L, Gage F. Basic fibroblast growth factor increases dopaminergic graft survival and function in a rat model of Parkinson's disease. Nat Med 1995; 1: 53-58
70. Jiao S, William P, Safda N, Schultz E, Wolff J. Co-transplantation of plasmid-transfected myoblasts and myotubes into rat brains enables high levels of gene expression long-term. Cell Transplant 1993; 2: 185-192