Cyclic AMP prevents retraction of axon terminals in photoreceptors prepared for transplantation: An in vitro study

Investigative Ophthalmology and Visual Science

Volumn 46, Issue 3, 2005, Pages 967-973

  Khodair, Mohamad A ^a,b   Zarbin, Marco A ^a   Townes Anderson, Ellen ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b INSTITUTE OF OPHTHALMOLOGY AND VISUAL SCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; ADENYLATE CYCLASE; CYCLIC AMP; CYCLIC AMP DERIVATIVE; FORSKOLIN; LACTATE DEHYDROGENASE; SYNAPTOPHYSIN; 8 ((4 CHLOROPHENYL)THIO)CYCLIC 3',5' AMP; 8-((4-CHLOROPHENYL)THIO)CYCLIC-3',5'-AMP; DRUG DERIVATIVE; ENZYME INHIBITOR; NEUROPROTECTIVE AGENT; NUCLEOTIDE; OPSIN;

ANIMAL TISSUE; ARTICLE; CELL TRANSPLANTATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; FEMALE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; NERVE CELL PLASTICITY; NERVE ENDING; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA BIPOLAR GANGLION CELL; RETINA DEGENERATION; RETINA HORIZONTAL NERVE CELL; SWINE; SYNAPSE; ANIMAL; CELL CULTURE; CELL SURVIVAL; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; PHYSIOLOGY; SYNAPSE VESICLE; SYNAPTOSOME; TRANSPLANTATION;

ADENYLATE CYCLASE; ANIMALS; CELL SURVIVAL; CELL TRANSPLANTATION; CELLS, CULTURED; CYCLIC AMP; ENZYME INHIBITORS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FORSKOLIN; MALE; NEURONAL PLASTICITY; NEUROPROTECTIVE AGENTS; OPSIN; PHOTORECEPTORS, VERTEBRATE; PRESYNAPTIC TERMINALS; SWINE; SYNAPTIC VESICLES; SYNAPTOPHYSIN; THIONUCLEOTIDES;

EID: 16244389334     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.04-0579     Document Type: Article

References (46)

1. Silverman MS, Hughes SE, Valentino TL, Liu Y. Photoreceptor transplantation: anatomic, electrophysiologic, and behavioral evidence for the functional reconstruction of retinas lacking photoreceptors. Exp Neurol. 1992;115:87-94.
2. Gouras P, Du J, Kjeldbye H, Yamamoto S, Zack DJ. Long-term photoreceptor transplants in dystrophic and normal mouse retina. Invest Ophthalmol Vis Sci. 1994;35:3145-3153.
3. Aramant RB, Seiler MJ. Fiber and synaptic connections between embryonic retinal transplants and host retina. Exp Neurol. 1995; 133:244-255.
4. Ghosh F, Bruun A, Ehinger B. Graft-host connections in long-term full-thickness embryonic rabbit retinal transplants. Invest Ophthalmol Vis Sci. 1999;40:126-132.
5. Zhang Y, Arner K, Ehinger B, Perez MT. Limitation of anatomical integration between subretinal transplants and the host retina. Invest Ophthalmol Vis Sci. 2003;44:324-331.
6. MacLeish PR, Townes-Anderson E. Growth and synapse formation among major classes of adult salamander retinal neurons in vitro. Neuron. 1988;1:751-760.
7. Mandell JW, MacLeish PR, Townes-Anderson E. Process outgrowth and synaptic varicosity formation by adult photoreceptors in vitro. J Neurosci. 1993;13:3533-3548.
8. Nachman-Clewner M, Townes-Anderson E. Injury-induced remodeling and regeneration of the ribbon presynaptic terminal in vitro. J Neurocytol. 1996;25:597-613.
9. Lewis GP, Linberg KA, Fisher SK. Neurite outgrowth from bipolar and horizontal cells after experimental retinal detachment. Invest Ophthalmol Vis Sci. 1998;39:424-434.
10. Lewis GP, Charteris DG, Sethi CS, Fisher SK. Animal models of retinal detachment and reattachment: identifying cellular events that may affect visual recovery. Eye. 2002;16:375-387.
11. Jansen HG, Sanyal S. Development and degeneration of retina in rds mutant mice: electron microscopy. J Comp Neurol. 1984;224: 71-84.
12. Jansen HG, Hawkins RK, Sanyal S. Synaptic growth in the rod terminals of mice after partial photoreceptor cell loss: a three-dimensional ultrastructural study. Microsc Res Tech. 1997;36:96-105.
13. Chong NH, Alexander RA, Barnett KC, Bird AC, Luthert PJ. An immunohistochemical study of an autosomal dominant feline rod/cone dysplasia (Rdy cats). Exp Eye Res. 1999;68:51-57.
14. Peng YW, Hao Y, Petters RM, Wong F. Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations. Nat Neurosci. 2000;3:1121-1127.
15. Fei Y. Cone neurite sprouting: an early onset abnormality of the cone photoreceptors in the retinal degeneration mouse. Mol Vis. 2002;8:306-314.
16. Li ZY, Kljavin IJ, Milam AH. Rod photoreceptor neurite sprouting in retinitis pigmentosa. J Neurosci. 1995;15:5429-5438.
17. Khodair MA, Zarbin MA, Townes-Anderson E. Synaptic plasticity in mammalian photoreceptors prepared as sheets for retinal transplantation. Invest Ophthalmol Vis Sci. 2003;44:4976-4988.
18. Zhou D, Song ZH. CB1 cannabinoid receptor-mediated neurite remodeling in mouse neuroblastoma N1E-115 cells. J Neurosci Res. 2001;65:346-353.
19. Wang Q, Zheng JQ. cAMP-mediated regulation of neurotrophin-induced collapse of nerve growth cones. J Neurosci. 1998;18: 4973-4984.
20. Cai D, Qiu J, Cao Z, McAtee M, Bregman BS, Filbin MT. Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J Neurosci. 2001;21:4731-4739.
21. Huang JC, Ishida M, Hersh P, Sugino IK, Zarbin MA. Preparation and transplantation of photoreceptor sheets. Curr Eye Res. 1998; 17:573-585.
22. Rydel RE, Greene LA. cAMP analogs promote survival and neurite outgrowth in cultures of rat sympathetic and sensory neurons independently of nerve growth factor. Proc Natl Acad Sci USA. 1988;85:1257-1261.
23. Connolly BJ, Willits PB, Warrington BH, Murray KJ. 8-(4-Chlorophenyl) thio-cyclic AMP is a potent inhibitor of the cyclic GMP-specific phosphodiesterase (PDE VA). Biochem Pharmacol. 1992; 44:2303-2306.
24. Lewis GP, Matsumoto B, Fisher SK. Changes in the organization and expression of cytoskeletal proteins during retinal degeneration induced by retinal detachment. Invest Ophthalmol Vis Sci. 1995;36:2404-2416.
25. Ofori S, Bugnon O, Schorderet M. Agonist-induced desensitization of dopamine D-1 receptors in bovine retina and rat striatum. J Pharmacol Exp Ther. 1993;266:350-357.
26. Traverso V, Bush RA, Sieving PA, Deretic D. Retinal cAMP levels during the progression of retinal degeneration in rhodopsin P23H and S334ter transgenic rats. Invest Ophthalmol Vis Sci. 2002;43: 1655-1661.
27. Fassina G, Aluigi MG, Gentleman S, et al. The cAMP analog 8-Cl-cAMP inhibits growth and induces differentiation and apoptosis in retinoblastoma cells. Int J Cancer. 1997;72:1088-1094.
28. Alfinito PD, Townes-Anderson E. Activation of mislocalized opsin kills rod cells: a novel mechanism for rod cell death in retinal disease. Proc Natl Acad Sci USA. 2002;99:5655-5660.
29. Martins-Ferreira H, Nedergaard M, Nicholson C. Perspectives on spreading depression. Brain Res Brain Res Rev. 2000;32:215-234.
30. Lewis GP, Erickson PA, Anderson DH, Fisher SK. Opsin distribution and protein incorporation in photoreceptors after experimental retinal detachment. Exp Eye Res. 1991;53:629-640.
31. Nir I, Papermaster DS. Immunocytochemical localization of opsin in the inner segment and ciliary plasma membrane of photoreceptors in retinas of rds mutant mice. Invest Ophthalmol Vis Sci. 1986;27:836-840.
32. Spencer M, Detwiler PB, Bunt-Milam AH. Distribution of membrane proteins in mechanically dissociated retinal rods. Invest Ophthalmol Vis Sci. 1988;29:1012-1020.
33. Townes-Anderson E. Intersegmental fusion in vertebrate rod photoreceptors: rod cell structure revisited. Invest Ophthalmol Vis Sci. 1995;36:1918-1933.
34. Johnson PT, Williams RR, Reese BE. Developmental patterns of protein expression in photoreceptors implicate distinct environmental versus cell-intrinsic mechanisms. Vis Neurosci. 2001;18: 157-168.
35. Nir I, Haque R, Iuvone PM. Regulation of cAMP by light and dopamine receptors is dysfunctional in photoreceptors of dystrophic retinal degeneration slow (rds) mice. Exp Eye Res. 2001;73: 265-272.
36. Ivanova TN, Iuvone PM. Circadian rhythm and photic control of cAMP level in chick retinal cell cultures: a mechanism for coupling the circadian oscillator to the melatonin-synthesizing enzyme, aryl-alkylamine N-acetyltransferase, in photoreceptor cells. Brain Res. 2003;991:96-103.
37. Rex TS, Fariss RN, Lewis GP, Linberg KA, Sokal I, Fisher SK. A survey of molecular expression by photoreceptors after experimental retinal detachment. Invest Ophthalmol Vis Sci. 2002;43: 1234-1247.
38. Jalink K, van Corven EJ, Hengeveld T, Morii N, Narumiya S, Moolenaar WH. Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho. J Cell Biol. 1994;126:801-810.
39. Kozma R, Sarner S, Ahmed S, Lim L. Rho family GTPases and neuronal growth cone remodeling: relationship between increased complexity induced by Cdc42Hs, Rac1, and acetylcholine and collapse induced by RhoA and lysophosphatidic acid. Mol Cell Biol. 1997;17:1201-1211.
40. Lehmann M, Fournier A, Selles-Navarro I, et al. Inactivation of Rho signaling pathway promotes CNS axon regeneration. J Neurosci. 1999;19:7537-7547.
41. Dergham P, Ellezam B, Essagian C, Avedissian H, Lubell WD, McKerracher L. Rho signaling pathway targeted to promote spinal cord repair. J Neurosci. 2002;22:6570-6577.
42. Schoenwaelder SM, Burridge K. Bidirectional signaling between the cytoskeleton and integrins. Curr Opin Cell Biol. 1999;11:274-286.
43. Leeuwen FN, Kain HE, Kammen RA, Michiels F, Kranenburg OW, Collard JG. The guanine nucleotide exchange factor Tiam1 affects neuronal morphology; opposing roles for the small GTPases Rac and Rho. J Cell Biol. 1997;139:797-807.
44. Tucker RP. The roles of microtubule-associated proteins in brain morphogenesis: a review. Brain Res Brain Res Rev. 1990;15:101-120.
45. Sanchez Martin C, Ledesma D, Dotti CG, Avila J. Microtubule-associated protein-2 located in growth regions of rat hippocampal neurons is highly phosphorylated at its proline-rich region. Neuroscience. 2000;101:885-893.
46. Ozer RS, Halpain S. Phosphorylation-dependent localization of microtubule-associated protein MAP2c to the actin cytoskeleton. Mol Biol Cell. 2000;11:3573-3587.