Regenerative medicine for retinal diseases: activating endogenous repair mechanisms

Trends in Molecular Medicine

Volumn 16, Issue 4, 2010, Pages 193-202

  Karl, M O ^a   Reh, T A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXCITATORY AMINO ACID; GROWTH FACTOR; N METHYL DEXTRO ASPARTIC ACID; NEUROTOXIN; TRANSCRIPTION FACTOR;

CELL DEDIFFERENTIATION; CELL DIFFERENTIATION; DRUG ACTIVITY; EMBRYONIC STEM CELL; FISH; MAMMAL; MUELLER CELL; NONHUMAN; PIGMENT EPITHELIUM; REGENERATION; REGENERATIVE MEDICINE; RETINA; RETINA DEGENERATION; RETINA INJURY; REVIEW; SALAMANDER; STIMULATION;

ANIMALS; BIRDS; CELL DEDIFFERENTIATION; FISHES; HUMANS; MICE; NERVE REGENERATION; NEUROGENESIS; NEUROGLIA; NEURONS; RATS; RETINA; RETINAL DEGENERATION; STEM CELL TRANSPLANTATION;

AVES; MAMMALIA; RATTUS; VERTEBRATA;

EID: 77950486864     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2010.02.003     Document Type: Review

References (71)

1. Jones B.W., et al. Retinal remodeling triggered by photoreceptor degenerations. J. Comp. Neurol. 464 (2003) 1-16
2. Fariss R.N., et al. Abnormalities in rod photoreceptors, amacrine cells, and horizontal cells in human retinas with retinitis pigmentosa. Am. J. Ophthalmol. 129 (2000) 215-223
3. Moshiri A., et al. Retinal stem cells and regeneration. Int. J. Dev. Biol. 48 (2004) 1003-1014
4. Tropepe V., et al. Retinal stem cells in the adult mammalian eye. Science 287 (2000) 2032-2036
5. Cicero S.A., et al. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 6685-6690
6. Reh T.A., and Fischer A.J. Retinal stem cells. Methods Enzymol. 419 (2006) 52-73
7. Perron M., et al. The genetic sequence of retinal development in the ciliary margin of the Xenopus eye. Dev. Biol. 199 (1998) 185-200
8. Araki M. Regeneration of the amphibian retina: role of tissue interaction and related signaling molecules on RPE transdifferentiation. Dev. Growth Differ. 49 (2007) 109-120
9. Reh T.A., et al. Common mechanisms of retinal regeneration in the larval frog and embryonic chick. Ciba Found. Symp. 160 (1991) 192-204 discussion 204-198
10. Reh T.A., et al. Retinal pigmented epithelial cells induced to transdifferentiate to neurons by laminin. Nature 330 (1987) 68-71
11. Sakami S., et al. Activin signaling limits the competence for retinal regeneration from the pigmented epithelium. Mech. Dev. 125 (2008) 106-116
12. Raymond P.A., and Hitchcock P.F. How the neural retina regenerates. Results Probl. Cell Differ. 31 (2000) 197-218
13. Bernardos R.L., et al. Late-stage neuronal progenitors in the retina are radial Muller glia that function as retinal stem cells. J. Neurosci. 27 (2007) 7028-7040
14. Braisted J.E., et al. Selective regeneration of photoreceptors in goldfish retina. Development 120 (1994) 2409-2419
15. Fausett B.V., and Goldman D. A role for alpha1 tubulin-expressing Muller glia in regeneration of the injured zebrafish retina. J. Neurosci. 26 (2006) 6303-6313
16. Morris A.C., et al. Genetic dissection reveals two separate pathways for rod and cone regeneration in the teleost retina. Dev. Neurobiol. 68 (2008) 605-619
17. Reh T.A. Cell-specific regulation of neuronal production in the larval frog retina. J. Neurosci. 7 (1987) 3317-3324
18. Fausett B.V., et al. The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration. J. Neurosci. 28 (2008) 1109-1117
19. Thummel R., et al. Inhibition of Muller glial cell division blocks regeneration of the light-damaged zebrafish retina. Dev. Neurobiol. 68 (2008) 392-408
20. Calinescu A.A., et al. Midkine expression is regulated by the circadian clock in the retina of the zebrafish. Vis. Neurosci. (2009) 1-7
21. Kassen S.C., et al. CNTF induces photoreceptor neuroprotection and Muller glial cell proliferation through two different signaling pathways in the adult zebrafish retina. Exp. Eye Res. 88 (2009) 1051-1064
22. Kassen S.C., et al. Time course analysis of gene expression during light-induced photoreceptor cell death and regeneration in albino zebrafish. Dev. Neurobiol. 67 (2007) 1009-1031
23. Yurco P., and Cameron D.A. Cellular correlates of proneural and Notch-delta gene expression in the regenerating zebrafish retina. Vis. Neurosci. 24 (2007) 437-443
24. Qin Z., et al. Genetic evidence for shared mechanisms of epimorphic regeneration in zebrafish. Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 9310-9315
25. Fischer A.J., and Reh T.A. Muller glia are a potential source of neural regeneration in the postnatal chicken retina. Nat. Neurosci. 4 (2001) 247-252
26. Fischer A.J., and Reh T.A. Exogenous growth factors stimulate the regeneration of ganglion cells in the chicken retina. Dev. Biol. 251 (2002) 367-379
27. Hayes S., et al. Notch signaling regulates regeneration in the avian retina. Dev. Biol. 312 (2007) 300-311
28. Raymond P.A., et al. Molecular characterization of retinal stem cells and their niches in adult zebrafish. BMC Dev. Biol. 6 (2006) 36
29. Petreanu L., and Alvarez-Buylla A. Maturation and death of adult-born olfactory bulb granule neurons: role of olfaction. J. Neurosci. 22 (2002) 6106-6113
30. Cameron H.A., and McKay R.D. Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus. J. Comp. Neurol. 435 (2001) 406-417
31. Bringmann A., et al. Cellular signaling and factors involved in Muller cell gliosis: neuroprotective and detrimental effects. Prog. Retin Eye Res. 28 (2009) 423-451
32. Sahel J.A., et al. Mitogenic effects of excitatory amino acids in the adult rat retina. Exp. Eye Res. 53 (1991) 657-664
33. Ooto S., et al. Potential for neural regeneration after neurotoxic injury in the adult mammalian retina. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 13654-13659
34. Wan J., et al. Preferential regeneration of photoreceptor from Muller glia after retinal degeneration in adult rat. Vision Res. 48 (2008) 223-234
35. Wan J., et al. Sonic hedgehog promotes stem-cell potential of Muller glia in the mammalian retina. Biochem. Biophys. Res. Commun. 363 (2007) 347-354
36. Close J.L., et al. Epidermal growth factor receptor expression regulates proliferation in the postnatal rat retina. Glia 54 (2006) 94-104
37. Osakada F., et al. Wnt signaling promotes regeneration in the retina of adult mammals. J. Neurosci. 27 (2007) 4210-4219
38. Dyer M.A., and Cepko C.L. Control of Muller glial cell proliferation and activation following retinal injury. Nat. Neurosci. 3 (2000) 873-880
39. Karl M.O., et al. Stimulation of neural regeneration in the mouse retina. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 19508-19513
40. Takeda M., et al. alpha-Aminoadipate induces progenitor cell properties of Muller glia in adult mice. Invest. Ophthalmol. Vis. Sci. 49 (2008) 1142-1150
41. Das A.V., et al. Neural stem cell properties of Muller glia in the mammalian retina: regulation by Notch and Wnt signaling. Dev. Biol. 299 (2006) 283-302
42. Bhatia B., et al. Distribution of Muller stem cells within the neural retina: evidence for the existence of a ciliary margin-like zone in the adult human eye. Exp. Eye Res. 89 (2009) 373-382
43. Lewis G.P., et al. Muller cell reactivity and photoreceptor cell death are reduced after experimental retinal detachment using an inhibitor of the Akt/mTOR pathway. Invest. Ophthalmol. Vis. Sci. 50 (2009) 4429-4435
44. Ryan S.J. The pathophysiology of proliferative vitreoretinopathy in its management. Am. J. Ophthalmol. 100 (1985) 188-193
45. Dyer M.A., and Bremner R. The search for the retinoblastoma cell of origin. Nat. Rev. Cancer 5 (2005) 91-101
46. Jadhav A.P., et al. Development and neurogenic potential of Muller glial cells in the vertebrate retina. Prog. Retin Eye Res. 28 (2009) 249-262
47. Heins N., et al. Glial cells generate neurons: the role of the transcription factor Pax6. Nat. Neurosci. 5 (2002) 308-315
48. Ohori Y., et al. Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord. J. Neurosci. 26 (2006) 11948-11960
49. Lamba D.A., et al. Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice. Cell Stem. Cell. 4 (2009) 73-79
50. Ikeda H., et al. Generation of Rx+/Pax6+ neural retinal precursors from embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 11331-11336
51. Lamba D.A., et al. Efficient generation of retinal progenitor cells from human embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 12769-12774
52. Lamba D.A., et al. Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS One 5 (2010) e8763
53. Meyer J.S., et al. Embryonic stem cell-derived neural progenitors incorporate into degenerating retina and enhance survival of host photoreceptors. Stem. Cells 24 (2006) 274-283
54. Osakada F., et al. Toward the generation of rod and cone photoreceptors from mouse, monkey and human embryonic stem cells. Nat. Biotechnol. 26 (2008) 215-224
55. Osakada F., et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J. Cell Sci. 122 (2009) 3169-3179
56. Lamba D.A., et al. Strategies for retinal repair: cell replacement and regeneration. Prog. Brain Res. 175 (2009) 23-31
57. Newman E., and Reichenbach A. The Muller cell: a functional element of the retina. Trends Neurosci. 19 (1996) 307-312
58. Bringmann A., and Reichenbach A. Role of Muller cells in retinal degenerations. Front Biosci. 6 (2001) E72-92
59. Bringmann A., et al. Muller cells in the healthy and diseased retina. Prog. Retin Eye Res. 25 (2006) 397-424
60. Franze K., et al. Muller cells are living optical fibers in the vertebrate retina. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 8287-8292
61. Bringmann A., et al. Role of glial K(+) channels in ontogeny and gliosis: a hypothesis based upon studies on Muller cells. Glia 29 (2000) 35-44
62. Iandiev I., et al. Atypical gliosis in Muller cells of the slowly degenerating rds mutant mouse retina. Exp. Eye Res. 82 (2006) 449-457
63. Inman D.M., and Horner P.J. Reactive nonproliferative gliosis predominates in a chronic mouse model of glaucoma. Glia 55 (2007) 942-953
64. Peterson W.M., et al. Ciliary neurotrophic factor and stress stimuli activate the Jak-STAT pathway in retinal neurons and glia. J. Neurosci. 20 (2000) 4081-4090
65. Wen R., et al. Injury-induced upregulation of bFGF and CNTF mRNAS in the rat retina. J. Neurosci. 15 (1995) 7377-7385
66. Fisher S.K., et al. Cellular remodeling in mammalian retina: results from studies of experimental retinal detachment. Prog. Retin Eye Res. 24 (2005) 395-431
67. Kuzmanovic M., et al. GFAP promoter drives Muller cell-specific expression in transgenic mice. Invest. Ophthalmol. Vis. Sci. 44 (2003) 3606-3613
68. Winter C.G., et al. A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 5865-5869
69. Fischer A.J., et al. Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage. Mol. Vis. 10 (2004) 973-986
70. Fischer A.J., et al. BMP4 and CNTF are neuroprotective and suppress damage-induced proliferation of Muller glia in the retina. Mol. Cell Neurosci. 27 (2004) 531-542
71. Vierbuchen T., et al. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463 (2010) 1035-1041