The first decade of continuous progress in retinal transplantation

Microscopy Research and Technique

Volumn 36, Issue 2, 1997, Pages 130-141

  Del Cerro, Manuel ^a   Lazar, Eliot S ^a   DiLoreto, David ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

epithelium; grafts; neural retina; retina; retinal pigment; retinal transplants; transplantation

Indexed keywords

ALDEHYDES; CLINICAL RESEARCH; LABORATORIES;

CLINICAL DISEASE; EPITHELIUM; HUMAN PATIENTS; NEURAL RETINA; RETINA; RETINAL PIGMENT; RETINAL TRANSPLANT; RETINITIS PIGMENTOSA; TRANSPLANTATION; VISUAL ACTIVITY;

OPHTHALMOLOGY;

ARTICLE; DONOR; FETAL TISSUE TRANSPLANTATION; HUMAN; NERVE TRANSPLANTATION; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PUPIL REFLEX; RETINA DISEASE; RETINA NEUROEPITHELIAL LAYER; TISSUE PRESERVATION;

ANIMALIA;

EID: 0030966395     PISSN: 1059910X     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0029(19970115)36:2<130::AID-JEMT6>3.0.CO;2-T     Document Type: Article

References (131)

1. Adolph, A.R., Zucker, C.L., Ehinger, B., and Bergström, A. (1996) Function and structure in retinal transplants. J. Neural Transpl. (in press).
2. Aguayo, A.J., Bray, G.M., Rasminsky, M., Zwimper, T., Carter, D., and Vidal-Sanz, M. (1990) Synaptic connections made by axons regenerating in the central nervous system of adult mammals. J. Exp. Biol., 153:199-224.
3. Amman, F., Klein, D., and Franceschetti, A. (1965) Genetic and epidemiological investigation of pigmentary degeneration of the retina and allied disorders in Switzerland. J. Neurol. Sci., 2:183-196.
4. Aramant, R., and Seiler, M. (1991a) The fate of retinal ganglion cells, retrogradely labeled with Fluorogold and transplanted to rat retina. Invest. Ophthalmol. Vis. Sci., 32(Suppl.):1545.
5. Aramant, R., and Seiler, M. (1991b) Cryopreservation and transplant of immature rat retina into adult rat retina. Dev. Brain Res., 61:151-159.
6. Aramant, R., and Turner, J.E. (1988) Cross-species grafting of embryonic mouse and grafting of older postnatal rat retinas into the lesioned adult rat eye: The importance of cyclosporin A for survival. Brain Res., 469:303-307.
7. Aramant, R., Seiler, M., and Turner, J.E. (1988) Donor age influences on the success of retinal grafts to adult rat retina. Invest. Ophthalmol. Vis. Sci., 29:498-503.
8. Aramant, R., Seiler, M., Ehinger, B., Bergström, A., Gustavii, B., Brundin, P., and Adolph, A.R. (1990a) Transplantation of human embryonic retina to adult rat retina. Restor. Neurol. Neurosci., 2:3-33.
9. Aramant, R., Seiler, M., Ehinger, B., Bergström, A., Gustavii, B., Brundin, P., and Adolph, A.R. (1990b). Transplantation of human embryonic retina to adult retina. Restor. Neurol. Neurosci., 2:9-22.
10. Bergström, A., Ehinger, B., Wilke, K., Zucker, C.L., Adolph, A.R., Aramant, R., and Seiler, M. (1992) Transplantation of embryonic retina to the subretinal space in rabbits. Exp. Eye Res., 55:29-37.
11. Bergström, A., Ehinger, B., Wilke, K., Zucker, C.L., Adolph, A.R., and Szel, A. (1994) Development of cell markers in subretinal rabbit retinal transplants. Exp. Eye Res., 58:301-314.
12. Berson, E.L. (1993) Retinitis pigmentosa. The Friedenwald Lecture. Invest. Ophthalmol. Vis. Sci., 34:1659-1676.
13. Berson, E.L., Rosner, B., Sandberg, M.A., Hayes, K.C., Nicholson, B.W., Weigel-Difranco, C., and Willett, W. (1993) A randomized trial of vitamin A and vitamin E supplementation for retinitis pigmentosa. Arch. Ophthalmol., 111:761-772.
14. Bickford-Wimer, P., Granholm, A.C., Bygdeman, M., Hoffer, B., Olson, L., Seiger, A., and Stromberg, I. (1987) Human fetal cerebellar and cortical tissue transplanted to the anterior chamber of athymic rats: Electrophysiological and structural studies. Proc. Natl. Acad. Sci. U.S.A. 84:5957-5961.
15. Björklund, A., and Stenevi, U. (1984) Intracerebral neural implants: Neural replacement and reconstruction of damaged circuits. Ann. Rev. Neurosci., 7:279-308.
16. Blair, J.R., and Turner, J.E. (1987) Optimum conditions for successful transplantation of immature rat retina to the lesioned adult retina. Dev. Brain Res. 36:257-270.
17. Blair, J.R., Gaur, V., Laedtke, T.W., Li, L., Liu, Y., Sheedlo, H., Yamaguchi, K., Yamaguchi, K., and Turner, J.E. (1991) In oculo transplantation studies involving the neural retina and its pigment epithelium. In: Progress in Retinal Research. Vol. 10. N. Osborne, and G. Chader, eds. Pergamon Press, Oxford, UK, pp. 69-88.
18. Bok., D., and Hall, M.O. (1971) The role of the pigment epithelium in the etiology of inherited retinal dystrophy in the rat. J. Cell. Biol., 49:664-682.
19. Boughman, J.A., Conneally, P.M., and Nance, W.E. (1980) Population genetic studies of retinitis pigmentosa. Am. J. Hum. Genet. 32:223-235.
20. Bowes, C., Li, T., Danciger, M., Baxter, L.C., Applebury, M.L., and Farber, D.B. (1990) Retinal degeneration in the rd mouse is caused by a β-subunit of rod cGMP-phosphodiesterase. Nature, 347:677-680.
21. Bunker, C.H., Berson, E.L., Bromley, W.C., Hayes, R.P., and Roderick, T.H. (1984) Prevalence of retinitis pigmentosa in Maine. Am. J. Ophthalmol., 97:357-365.
22. Carter-Dawson, L.D., LaVail, M.M., and Sidman, R.I. (1978) Differential effect of the rd mutation on rods and cones in the mouse retina. Invest. Ophthalmol. Vis. Sci., 17:489-498.
23. Collier, R., del Cerro, M., Yeh, H., del Cerro, C., Trojanczyk, L., and Westenberg, L. (1989) Electroretinographic assessment of intraocular retinal transplants. Invest. Ophthalmol. Vis. Sci., 30(Suppl.): 349.
24. Culling, C.F.A. (1963) In: Handbook of Histopathological Techniques. 2nd ed. Butterworths, London, p. 219.
25. Davenport, H.A., McArthur, J., and Bruesch, S.R. (1939) Staining parafin sections with protargol. Stain Tech., 14:21-26.
26. del Cerro, M. (1990) Intraocular retinal transplantation. In: Progress in Retinal Research. N.N. Osborne, and G.J. Chader, eds. Pergamon Press, Oxford, pp. 229-272.
27. del Cerro, M., Gash, D.M., Rao, G.N., Notter, M.F.D., Wiegand, S.J., and Ishida, N. (1984) Intraocular retinal transplants. Invest. Ophthalmol. Vis. Sci., 25(Suppl.):62.
28. del Cerro, M., Gash, D.M., Rao, G.N., Notter, M.F., Wiegand, S.J., and Gupta, M. (1985) Intraocular retinal transplants. Invest. Ophthalmol. Vis. Sci., 26:1182-1185.
29. del Cerro, M., Gash, D.M., Rao, G.N., Notter, M.F., Wiegand, S.J., Sathi, S., and del Cerro, C. (1987) Retinal transplants into the anterior chamber of the rat eye. Neuroscience, 21:707-23.
30. del Cerro, M., Notter, M.F., Grover, D.A., Gash, D.M., Jiang, L.Q., and del Cerro, C. (1988a) Retinal transplants into adult eyes affected by phototoxic retinopathy. In: Progress. Brain Res., Vol. 78, D.M. Gash and J.R. Sladek, Jr., eds. Elsevier, Amsterdam, pp. 125-130.
31. del Cerro, M., Notter, M.F.D., del Cerro, C., Wiegand, S.J., Grover, D.A., and Lazar, E. (1988b) Intraretinal transplantation for rod-cell replacement in light-damaged retinas. J. Neural Transpl., 1:1-10.
32. del Cerro, M., Notter, M.F.D., Wiegand, S.J., Jiang, L.Q., and del Cerro, C. (1988c) Intraretinal transplantation of fluorescently labeled retinal cell suspensions. Neurosci. Lett., 2:21-26.
33. del Cerro, M., Notter, M.F., Grover, D.A., Olchowka, J., Jiang, L.Q., S. Wiegand, J., Lazar, E., and del Cerro, C. (1989a) Retinal transplants for cell replacement in phototoxic retinal degeneration. In: Inherited and Environmentally Induced Retinal Degenerations. M. LaVail, ed. Alan R. Liss, New York. pp.
34. del Cerro, M., Notter, M.F.D., del Cerro, C., Wiegand, S.J., Grover, D.A., and Lazar, E. (1989b) Intraretinal transplantation for rod-cell replacement in light-damaged retina. J. Neural Transpl., 1:1-10.
35. del Cerro, M., Yeh, H.H., Marrero-Rodriguez, A., Lazar, E., and del Cerro, C. (1990) Intraocular transplantation of cell layers derived from neonatal rat retina. Brain Res., 535:25-32.
36. del Cerro, M., Kordower, J.H., Lazar, E., Grover, D.A., and del Cerro, C. (1991a) Presence of rod and cone photoreceptor cells in intraretinal grafts. In: Retinal Degenerations. R.E. Anderson, J. Hollyfield, and M. LaVail, eds. CRC Press, Boston, pp. 303-311.
37. del Cerro, M., Ison, J.R., Bowen, G.P. Lazar, E., and del Cerro, C. (1991b) Intraretinal grafting restores visual function in light-blinded rats. NeuroReports, 2:529-532.
38. del Cerro, M., Kordower, J.H., Lazar, E., Grover, D.A., and del Cerro, C. (1992a) Photoreceptor differentiation in retinal xenografts of fetal monkey retina. Brain Res., 574:1-8.
39. del Cerro, M., Notter, M.F., Seigel, G.M., Lazar, E., Chader, G., and del Cerro, C. (1992b) Intraretinal xenografts of differentiated human retinoblastoma cells integrate with the host retina. Brain Res., 583:12-22.
40. DiLoreto, Jr., D. Epstein, L.G., Lazar, E., Britt, W.J., and del Cerro, M. (1994a) Cytomegalovirus infection of the human retina: An in vivo model. Lab. Invest., 71:141-148.
41. DiLoreto, Jr., D., Cox, C., Grover, D.A., Lazar, E., del Cerro, C., and del Cerro, M. (1994b) The influences of age, retinal topography, and gender on retinal degeneration in the Fischer 344 rat. Brain Res., 687:181-191.
42. DiLoreto, Jr., D. Grover, D.A., del Cerro, C., and del Cerro, M. (1994c) A new procedure for fundus photography and fluorescein angiography in small laboratory animal eyes. Curr. Eye Res., 13:157-161.
43. Dryja, T.P., McGee, T.L., Reichel, E., Hahn, L.B., Cowley, G.S., Yandell, D.W., Sandberg, M.A., and Berson, E.L. (1990) A point mutation of the rhodopsin gene in one form of retinitis pigmentosa. Nature, 343:364-366.
44. Du, J., Gouras, P., Kjeldbye, H., Kwun, R., and Lopez, R. (1992) Monitoring photoreceptor transplants with nuclear and cytoplasmic markers. Exp. Neurol., 115:79-86.
45. Ehinger, B., Bergström, A., Seiler, M., Aramant, R., Zucker, C.L., Gustavii, B., and Adolph, A.R. (1991) Ultrastructure of human retinal cell transplants with long survival times in rats. Exp. Eye Res., 53:447-460.
46. Faktorovich, E.G., Steinberg, R.H., Yasumura, D., Matthes, M.T., and LaVail, M.M. (1990) Photoreceptor degeneration in inherited retinal dystrophy delayed by basic fibroblast growth factor. Nature, 347: 83-86.
47. Feeney-Burns, L., Hilderbrand, E.S., Eldridge, S. (1984) Aging human RPE. Morphometric analysis of macular, equatorial, and peripheral cells. Invest. Ophthalmol. Vis. Sci., 25:195-200.
48. Freed, C.R., Breeze, R.E., Rosenberg, N.L., Schneck, S.A., Wells, T.H., Barret, J.N., Grafton, S.C., Huang, D., Eilberg, and Rottenberg, D.A. (1990) Transplantation of human fetal dopamine cells for Parkinson's disease: Results at 1 year. Arch. Neurol. 47:505-512.
49. Freed, C.R., Breeze, R.E., Schneck, S.A., O'Brian, C.F., Mazziotta, J.C., Hutchinson, M., Bakay, R.A.E., and Ansari, A.A. (1994) Immunosuppressants are not needed and can interfere with transplant survival in rat, monkey, and human models of Parkinson's Disease. Am. Soc. Neural. Transpl., 1:17.
50. Gansmuller, A., Kruger, F., Gumpel, M., and Baron-Van Evercooren (1992) Photoconverted carbocyanine Dil allows direct visualization of transplanted glial cells at the ultramicroscopical level. Neurosci. Lett., 147:151-154.
51. Gash, D.M. (1984) Neural transplants in mammals: A historical overview. In: Neural Transplants. Development and Function. J.R. Sladek, and D.M. Gash, eds. Plenum Press, New York, pp. 1-12.
52. Gao, H., Rayborn, M.E., Myers, K.M., Hollyfield, J.G. (1990) Differential loss of neurons during aging of the human retina. Invest. Ophthalmol. Vis. Sci., 31(Suppl):357.
53. Gartner, S., and Henkind, P. (1982) Pathology of retinitis pigmentosa. Ophthalmology, 89:1425-1432.
54. Goldman, A.I., and O'Brien, P.J. (1978) Phagocytosis in the retinal pigment epithelium of the RCS rat. Science, 201:1023-1025.
55. Gouras, P., and Lopez, R. (1989) Transplantation of retinal epithelial cells. Invest. Ophthalmol. Vis. Sci., 30:1681-1683.
56. Gouras, P., Flood, M.T., Kjeldbye, H., and Krebs, W. (1984) Transplantation of cultured human retinal cells to monkey retina. Ann. Acad. Brasil Cienc. 56:431-443.
57. Gouras, P., Lopez, R., Kjeldbye, H., Sullivan, B., and Britis, M. (1989) Transplantation of retinal epithelium prevents photoreceptor degeneration in the RCS rat. In: Inherited and Environmentally Induced Retinal Degenerations. M.M. LaVail, R.E. Anderson, and J.G. Hollyfield, eds. Alan R. Liss, New York, pp. 659-671.
58. Gouras, P., Du, J., Gelanze, M., Lopez, R., Kwun, R., Kjeldbye, H., and Krebs, W. (1991a) Survival and synapse formation of transplanted rat rods. J. Neurotranspl. Plast., 2:91-100.
59. Gouras, P., Du, J., Gelanze, M., Lopez, R., Kwun, R., Kjeldbye, H., and Krebs, W. (1991b) Transplantation of photoreceptor labeled with tritiated thymidine into RCS rats. Invest. Ophthalmol. Vis. Sci., 32:1704-1707.
60. Gouras, P., Du, J., Kjeldbye, H., Kwun, R., Lopez, R., Lopez, R., and Zack, D.J. (1991c) Transplantated photoreceptors identified in dystrophic mouse retina by a transgenic reporter gene. Invest. Ophthalmol. Vis. Sci., 32:3167-3174.
61. Gouras, P., Du, J., Kjeldbye, H., and Zack, D.J. (1992) Reconstruction of degenerate rd mouse retina by transplantation of transgenic photoreceptors. Invest. Ophthamol. Vis. Sci., 33:2579-2586.
62. Gouras, P., Du, J., Kjeldbye, H., Yamamoto, S., and Zack, D.J. (1994) Long-term photoreceptor transplants in dystrophic and normal mouse retina. Invest. Ophthamol. Vis. Sci., 35:3145-3153.
63. Granholm, A.C., Eriksdotter-Nilsson, M., Stromberg, I., Steig, P., Seiger, A., Bygdeman, M., Geffard, M., Oertel, W., Dahl, D.. Olson, L., Hoffer, B., and Freedman, R. (1989) Morphological and electrophysiological studies of human hippocampal transplants in the anterior chamber of athymic nude rats. Exp. Neurol., 104:162-171.
64. Greene, H.S.N. (1967) The use of transplanted tissues in biology and histology. In: In Vivo Techniques in Histology. G.H. Bourne, ed. The Williams and Wilkins Co., Baltimore, pp. 80-112.
65. Haim, M., Holm, N.V., and Rosenberg, T. (1992) Prevalence of retinitis pigmentosa and allied disorders in Denmark. Acta Ophthalmol., 70:178-186.
66. Heckenlively, J.R. (1988) Retinitis Pigmentosa. J.B. Lippincott, Philadelphia.
67. Heron, W.L., Riegel, B.W. Meyers, O.E., and Rubin, M.L. (1969) Retinal dystrophy in the rat: A pigment epithelial disease. Invest. Ophthalmol. Vis. Sci., 8:595-604.
68. Hitchcock, E. (1992) Neural implants and recovery of function: human work. Adv. Exp. Med. Biol., 325:67-78.
69. Hu, D.N. (1967) Genetic aspects of retinitis pigmentosa in China. Am. J. Mod. Genet., 12:51-56.
70. Jay, M. (1991) On the heredity of retinitis pigmentosa. Br. J. Ophthalmol. 66:405-416.
71. Jiang, L.Q., and del Cerro, M. (1992) Reciprocal transplantation as a tool for the study of retinal degeneration. Brain Res., 115:325-334.
72. Jiang, L.Q., and Streilein, J.W. (1991a) Immune responses elicited by transplantation and tissue-restricted antigens expressed on retinal tissues implanted subconjunctivally. Transplantation, 52:513-519.
73. Jiang, L.Q., and Streilein, J.W. (1991b) Immunological privilege evoked by histoincompatible intracameral retinal transplants. Regional Immunol., 3:121-130.
74. Jiang, L.Q., and Streilein, J.W. (1992a) Immunity and immune privilege elicited by autoantigens expressed on syngeneic neonatal neural retina grafts. Curr. Eye Res., 11:697-709.
75. Jiang, L.Q., and Streilein, J.W. (1992b) Enhancement of survival of intraocular neural retinal grafts by prior antigen-specific immune deviation. Transpl. Proc., 24:2883-2884.
76. Kajiwara, K., Hahn, L.B., Mukai, S., Travis, G.H., Berson, E.L., and Dryja, T.P. (1991) Mutations in the human retinal degeneration slow gene in autosomal dominant retinitis pigmentosa. Nature, 354:480-483.
77. Keunen, J.E., van Norren, D., and van Meel, G.J. (1987) Density of foveal cone pigments at older age. Invest. Ophthalmol. Vis. Sci., 28:985-991.
78. Kolb, H., and Gouras, P. (1974) Electron microscopic observations of human retinitis pigmentosa dominantly inherited. Invest. Ophthalmol. Vis. Sci., 13:487-498.
79. Kovalevsky, G., Liang, F.Q., del Cerro, C., DiLoreto, D.A., Grimsrud, C. Cox, C., and del Cerro, M. (.1994) The intensity of the pupillary light reflex is not an indicator of the population of photoreceptor cells in the rat retina. Invest. Ophthalmol. Vis. Sci., 35(Suppl):1523.
80. Lai, Y.L., Jacoby, R.O., and Jonas, A.M. (1978) Age-related and light associated retinal changes in Fischer rats. Invest. Ophthalmol. Vis. Sci., 17:634-638.
81. LaVail, M.M., Gorrin, G.M., Rapaci, M.A., and Yasumura, D. (1987) Light-induced retinal degeneration in albino mice and rats: Strain and species differences. In: Degenerative Retinal Disorders. Progress in Clinical and Biological Research, Vol. 247. J.G. Hollyfield, R.E. Anderson, and M.M. LaVail, eds. Alan R. Liss, New York, pp. 439-454.
82. LaVail, M.M., Unoki, K., Yasumura, D., Matthes, M.T., Yankopoulus, G.D., and Steinberg, R.H. (1992a) Multiple growth factors, cytokines, and neurotrophins rescue photoreceptors from the damaging effects of constant light. Proc. Natl. Acad. Sci. U.S.A., 89:11249-11253.
83. LaVail, M.M., Li, L., Turner, J.E., and Yasumura, D. (1992b) Retinal pigment epithelial cell transplantation in RCS rats: Normal metabolism in rescued photoreceptors. Exp. Eye Res., 55:555-562.
84. Lazar, E.S., and del Cerro, M. (1992) A new procedure for multiple intraretinal transplantation into mammalian eyes. J. Neurosci. Methods., 42:157-169.
85. Leibowitz, H. M., Krueger, D.E., Maunder, L.R., Milton, R.C., Kini, M.M., Kahn, H.A., Nickerson, R.J., Pool, J., Colton, T.L., Ganley, J.P., Loewenstein, J.I., Dawber, T.R. (1980) The Framingham eye study monograph. Surv. Ophthalmol. 24(Suppl):335-610.
86. Li, L., and Turner, J.E. (1988a) Transplantation of retinal pigment epithelial cells to immature and adult rat hosts: Short-and long-term survival characteristics. Exp. Eye Res., 47:771-785.
87. Li, L., and Turner, J.E. (1988b) Inherited retinal dystrophy in the RCS rat Photoreceptor rescue by RPE transplantation. Exp. Eye Res., 47:911-917.
88. Li, L., and Turner, J.E. (1991) Optimal conditions for long-term photoreceptor cell rescue in RCS rats: The necessity for healthy RPE cell transplants. Exp. Eye Res., 52:669-679.
89. Li, L., Sheedlo, H.J., and Turner, J.E. (1990) Long-term rescue of photoreceptor cells in the retinas of RCS dystrophic rats by RPE transplants. In: Progress in Brain Research. Vol. 82, S.R. Dunnet, and S.J. Richards, eds. Elsevier, Amsterdam, pp. 179-185.
90. Li, L., Sheedlo, H.J., Gaur, V., and Turner, J.E. (1991) Effects of macrophages and retinal pigment epithelial cells on photoreceptor cell rescue in RCS rats: The necessity for healthy RPE cell transplants. Curr. Eye Res., 10:947-958.
91. Liang, F.Q., Bassage, S.D., del Cerro, C., DiLoreto, D., Castillo, B., Lazar, E.S., Aquavella, J.V., and del Cerro, M. (1994) A new procedure for obtaining photoreceptor cells for transplantation. Invest. Ophthalmol. Vis. Sci., 35(Suppl):1523.
92. Lindvall, O. (1991) Prospects of transplantation in human neurodegenerative diseases. Trends Neurosci., 14:376-384.
93. Lopez, R., Gouras, P., Britis, M., and Kjeldbye, H. (1987) Transplantation of cultured rabbit retinal epithelium to rabbit retina using a closed eye method. Invest. Ophthalmol. Vis. Sci., 28:1131-1137.
94. McLaughlin, Sandberg, M.A., Berson, E.L., and Dryja, T.P. (1993) Recessive mutations in the gene encoding the β-subunit of rod phosphodiesterase in patients with retinitis pigmentosa. Nature Genet., 4:130-133.
95. Mosinger Ogilvie, J., Landgraf, M., Lett, J.M., Tenkova, T., Wang, X., Wu, M., and Silverman, M.S. (1994) Synaptic connectivity of transplanted photoreceptors in rd mice expressing the transgenic marker LacZ. Invest. Ophthalmol. Vis. Sci., 35(Suppl):1523.
96. Noell, W.K., Walker, B.S., Kang, B.S., and Bergamn, S. (1966) Retinal damage by light in rats. Invest. Ophthalmol. Vis. Sci., 5:450-473.
97. Olsson, J.E., Gordon, J.W., Pawlyk, B.S., Roof, D., Hayes, A., Molday, R.S., Mukai, S., Cowley, G.S., Berson, E.L., and Dryja, T.P. (1992) Transgenic mice with a rhodopsin mutation (Pro23His): A mouse model of autosomal dominant retinitis pigmentosa. Neuron, 9:815-830.
98. Penn, J.S., and Anderson, R.E. (1987) Effect of the light history on rod outer-segment membrane composition in the rat. Exp. Eye Res., 44:767-778.
99. Pittler, S.E., and Baehr, W., (1991) Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase β-subunit gene of the rd mouse. Proc. Nat. Acad. Sci. U.S.A., 88:8322-8326.
100. Redmond, D.E., Jr., Roth, R.H., Spencer, D.D., Naftolin, F., Leranth, C., Robbins, R.J., Marek, K.L., Elsworth, J.D., Taylor, J.R., Sass, K.J., and Sladek, J.R. Jr. (1993) Neural transplantation for neurodegenerative diseases: past, present, and future. Ann. N.Y. Acad. Med., 695:258-266.
101. Rosenfeld, P.J., Cowley, G.S., McGee, T.L., Sandberg, M.A., Berson, E.L., and Dryja, T.P., (1992) A null mutation in the rhodopsin gene causes rod photoreceptor dysfunction and autosomal recessive Retinitis Pigmentosa. Nature Genet. 1:209-213.
102. Royo, P.E., and Quay, W.B. (1959) Retinal transplantation from fetal to maternal mammalian eye. Growth. 23:313-336.
103. Sandell, J.H., and Masland, R.H. (1988) Photoconversion of some fluorescent markers to a diaminobenzidine development. J. Cell Biol., 104:635-643.
104. Schmued, L.C., and Snavely, L.F. (1993) Photoconversion and electron microscopic localization of the fluorescent axon tracer Fluor-ruby (Rhodamine-dextranamine). J. Histochem. Cytochem., 41:777-782.
105. Schuschereba, S.T., and Silverman, M.S. (1992) Retinal cell and photoreceptor transplantation between adult New Zealand red rabbit retinas. Exp. Neurol., 115:95-99.
106. Seiler, M., Aramant, R. (1994a) Photoreceptor and glial markers in human embryonic retinal transplants and human embryonic retinal transplants to the rat retina. Dev. Brain Res., 80:81-95.
107. Seiler, M., and Aramant, R. (1994b) Synaptic connections between embryonic retinal transplants and host retina. Soc. Neurosci. Abstr. 20:261.
108. Seiler, M., Aramant, R., Ehinger, B., Bergström, A., and Adolph, A.R. (1991a) Characteristics of embryonic retina transplanted to rat and rabbit retina. Neuroophthalmology, 11:263-279.
109. Seiler, M., Aramant, R., Ehinger, B., and Adolph, A.R. (1991b) Transplantation of embryonic retina to adult retina in rabbits. Exp. Eye Res., 51:225-228.
110. Sheedlo, H.J., Li, L., and Turner, J.E. (1989) Functional and structural characteristics of photoreceptor cells rescued in RPE-cell grafted retinas of RCS dystrophic rats. Exp. Eye Res., 48:841-854.
111. Sheedlo, H.J., Li, L., and Turner, J.E. (1990) Photoreceptor cell rescue at early and late RPE-cell transplantation periods during retinal disease in RCS dystrophic rats. J. Neural Transpl. Plast., 2:55-63.
112. Sidman, R.I. (1961) Histogenesis of the mouse retina studied with thymidine-H3. In: The Structure of the Eye. Snelser, G.K., ed. Academic Press, New York, pp. 487-505.
113. Sidman, R.I., and Green, M.C. (1965) Retinal degeneration in the mouse. Location of the rd locus in linkage group XVII. J. Hered., 56:23-29.
114. Silverman, M.S., and Hughes, S.E. (1989a) Transplantation of photoreceptors to light damaged retina. Invest. Ophthalmol. Vis. Sci., 30:1684-1690.
115. Silverman, M.S., and Hughes, S.E. (1989b) Photoreceptor transplantation in inherited and environmentally induced retinal degeneration: Anatomy, immunohistochemistry and function. In: Inherited and Environmentally Induced Retinal Degeneration. M.M. LaVail, R.E. Anderson, and J.G. Hollyfield, eds. Alan R. Liss, New York, pp. 687-704.
116. Silverman, M.S., and Hughes, S.E. (1990) Photoreceptor rescue in the RCS rat without pigment epithelium transplantation. Curr. Eye Res., 9:183-191.
117. Silverman, M.S., Hughes, S.E., Valentino, T.S., and Liu, Y. (1991) Photoreceptor transplantation to dystrophic retina. In: Retinal Degenerations. R.E. Anderson, J.G. Hollyfield, and M.M. LaVail, eds CRC Press, Boston, pp. 321-335.
118. Silverman, M.S., Hughes, S.E., Valentino, T.S., and Liu, Y. (1992) Photoreceptor transplantation: Anatomic, electrophysiologic, and behavioral evidence for the functional reconstruction of retinas lacking photoreceptors. Exp. Neurol., 115:87-94.
119. Sinden, J.D., Marsden, K.M., and Hodges, H. (1992) Neural transplantation and recovery of function: Animal studies. Adv. Exp. Med. Biol., 325:35-65.
120. Sommer, A., Tielsch, J.M., Katz, J., Quigley, H.A., Gottsch, J.D., Javitt, J.C., Martone, J.F.. Royall, R.M., Witt, K.A., and Ezrine, S. (1991) Racial differences in the cause-specific prevalence of blindness in East Baltimore. N. Engl. J. Med., 325:1412-1417.
121. Szamier, R.B., Berson, E.L., Klein, R., and Meyers, S. (1979) Sex-linked Retinitis Pigmentosa: Ultrastructure of photoreceptors and pigment epithelium. Invest. Ophthalmol. Vis. Sci., 18:145-160.
122. Tansley, K., (1954) An inherited retinal degeneration in the mouse. J. Hered., 45:123-127.
123. Thanos, S., Richter, W., and Thiel, H.J. (1994) The protective role of microglia-inhibiting factor in the retina of the RCS-rats with hereditary photoreceptor dystrophy. Invest. Ophthalmol. Vis. Sci., 35(Suppl):1957.
124. Turner, J.E., and Blair, J.R. (1986) Newborn rat retinal cells transplanted into a retinal lesion site in adult host eyes. Dev. Brain Res., 26:91-104.
125. Van Dooremaal, J.C. (1873) De onwikkeling van levende weefsels op vreemden bodem geent. Onderz. Physiol. Lab. Rijksuniv. Utrechtsche Hoogeschool 3:277-290.
126. Villegas-Perez, M.P., Vidal-Sanz, M., Bray, G.M., and Aguayo, A.J. (1988) Influences of peripheral nerve grafts on the survival and regrowth of axotomized retinal ganglion cells in adult rats. J. Neurosci., 8:265-280.
127. Wang, X., Wu, M., Landgraf, M., Rastelli, A.L., and Silverman, M.S. (1994) A surgical procedure for transplantation of extended photoreceptor sheets to the subretinal space. Invest. Ophthalmol. Vis. Sci., 35(Suppl):1523.
128. Williams, T.P., and Howell, W.L., (1983) Action spectrum of retinal light damage in albino rats. Invest. Ophthalmol. Vis. Sci., 24:285-287.
129. Wongpichedchai, S.J., Weiter, J., Weber, P., and Dorey, C.K. (1992) Comparison of external and internal approaches for transplantation of autologous pigment epithelium. Invest. Ophthalmol. Vis. Sci. 33:3341-3352.
130. Yamamoto, S., Du, J., Gouras, P., and Kjeldbye, H. (1993) Retinal pigment transplantation and retinal function in RCS rats. Invest. Ophthalmol. Vis. Sci., 34:3068-3075.
131. Young, R.W. (1985) Cell differentiation in the retina of the mouse. Anat. Rec., 212:199-205.