메뉴 건너뛰기




Volumn 190, Issue , 2014, Pages 415-423

Quo vadis polyplex?

Author keywords

Biodegradation; Biodistribution; Nanocarrier; Polymer; siRNA; Stability

Indexed keywords

BIOCOMPATIBILITY; BIODEGRADATION; CONVERGENCE OF NUMERICAL METHODS; FUNCTIONAL POLYMERS; POLYMERS;

EID: 84906784810     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.06.009     Document Type: Review
Times cited : (36)

References (66)
  • 1
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
    • DOI 10.1038/35888
    • A. Fire, S. Xu, M.K. Montgomery, S.A. Kostas, S.E. Driver, and C.C. Mello Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 1998 806 811 (Pubitemid 28099681)
    • (1998) Nature , vol.391 , Issue.6669 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 2
    • 0036843787 scopus 로고    scopus 로고
    • In vivo-applied functional RNAs as tools in proteomics and genomics research
    • DOI 10.1016/S0167-7799(02)02063-2, PII S0167779902020632
    • M. Famulok, and S. Verma In vivo-applied functional RNAs as tools in proteomics and genomics research Trends Biotechnol. 20 2002 462 466 (Pubitemid 35292358)
    • (2002) Trends in Biotechnology , vol.20 , Issue.11 , pp. 462-466
    • Famulok, M.1    Verma, S.2
  • 4
    • 84862659504 scopus 로고    scopus 로고
    • Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers
    • C. Scholz, and E. Wagner Therapeutic plasmid DNA versus siRNA delivery: common and different tasks for synthetic carriers J. Control. Release 161 2012 554 565
    • (2012) J. Control. Release , vol.161 , pp. 554-565
    • Scholz, C.1    Wagner, E.2
  • 5
    • 67249128859 scopus 로고    scopus 로고
    • The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: From concept to clinic
    • M.E. Davis The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic Mol. Pharm. 6 2009 659 668
    • (2009) Mol. Pharm. , vol.6 , pp. 659-668
    • Davis, M.E.1
  • 9
    • 0346634895 scopus 로고    scopus 로고
    • In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis
    • DOI 10.1016/S0142-9612(02)00445-3, PII S0142961202004453
    • D. Fischer, Y. Li, B. Ahlemeyer, J. Krieglstein, and T. Kissel In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis Biomaterials 24 2003 1121 1131 (Pubitemid 36069121)
    • (2003) Biomaterials , vol.24 , Issue.7 , pp. 1121-1131
    • Fischer, D.1    Li, Y.2    Ahlemeyer, B.3    Krieglstein, J.4    Kissel, T.5
  • 10
    • 33748994569 scopus 로고    scopus 로고
    • Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes
    • DOI 10.1021/bc060129j
    • S. Mao, M. Neu, O. Germershaus, O. Merkel, J. Sitterberg, U. Bakowsky, and T. Kissel Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft- poly(ethylene glycol) block copolymer/siRNA polyplexes Bioconjug. Chem. 17 2006 1209 1218 (Pubitemid 44455329)
    • (2006) Bioconjugate Chemistry , vol.17 , Issue.5 , pp. 1209-1218
    • Mao, S.1    Neu, M.2    Germershaus, O.3    Merkel, O.4    Sitterberg, J.5    Bakowsky, U.6    Kissel, T.7
  • 11
    • 79955782283 scopus 로고    scopus 로고
    • In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft- poly(ethylene glycol) block copolymers
    • O.M. Merkel, R. Urbanics, P. Bedocs, Z. Rozsnyay, L. Rosivall, M. Toth, T. Kissel, and J. Szebeni In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine- graft-poly(ethylene glycol) block copolymers Biomaterials 32 2011 4936 4942
    • (2011) Biomaterials , vol.32 , pp. 4936-4942
    • Merkel, O.M.1    Urbanics, R.2    Bedocs, P.3    Rozsnyay, Z.4    Rosivall, L.5    Toth, M.6    Kissel, T.7    Szebeni, J.8
  • 12
    • 84883504398 scopus 로고    scopus 로고
    • The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage
    • A.S. Abu Lila, H. Kiwada, and T. Ishida The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage J. Control. Release 172 2013 38 47
    • (2013) J. Control. Release , vol.172 , pp. 38-47
    • Abu Lila, A.S.1    Kiwada, H.2    Ishida, T.3
  • 13
    • 4644293047 scopus 로고    scopus 로고
    • Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: In vitro and in vivo studies
    • DOI 10.1080/10611860400003858
    • A. Khan, M. Benboubetra, P.Z. Sayyed, K.W. Ng, S. Fox, G. Beck, I.F. Benter, and S. Akhtar Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies J. Drug Target. 12 2004 393 404 (Pubitemid 39302465)
    • (2004) Journal of Drug Targeting , vol.12 , Issue.6 , pp. 393-404
    • Khan, A.1    Benboubetra, M.2    Sayyed, P.Z.3    Ng, K.W.4    Fox, S.5    Beck, G.6    Benter, I.F.7    Akhtar, S.8
  • 14
    • 56849117151 scopus 로고    scopus 로고
    • Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy
    • J. Nguyen, T.W. Steele, O. Merkel, R. Reul, and T. Kissel Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy J. Control. Release 132 2008 243 251
    • (2008) J. Control. Release , vol.132 , pp. 243-251
    • Nguyen, J.1    Steele, T.W.2    Merkel, O.3    Reul, R.4    Kissel, T.5
  • 15
    • 84863928267 scopus 로고    scopus 로고
    • Nonviral pulmonary delivery of siRNA
    • O.M. Merkel, and T. Kissel Nonviral pulmonary delivery of siRNA Acc. Chem. Res. 45 2012 961 970
    • (2012) Acc. Chem. Res. , vol.45 , pp. 961-970
    • Merkel, O.M.1    Kissel, T.2
  • 16
    • 84865514367 scopus 로고    scopus 로고
    • Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymer microparticles ameliorates temporomandibular joint inflammation
    • P.M. Mountziaris, S.N. Tzouanas, D.C. Sing, P.R. Kramer, F.K. Kasper, and A.G. Mikos Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymer microparticles ameliorates temporomandibular joint inflammation Acta Biomater. 8 2012 3552 3560
    • (2012) Acta Biomater. , vol.8 , pp. 3552-3560
    • Mountziaris, P.M.1    Tzouanas, S.N.2    Sing, D.C.3    Kramer, P.R.4    Kasper, F.K.5    Mikos, A.G.6
  • 19
    • 80054083256 scopus 로고    scopus 로고
    • Local delivery of siRNA using a biodegradable polymer application to enhance BMP-induced bone formation
    • T. Manaka, A. Suzuki, K. Takayama, Y. Imai, H. Nakamura, and K. Takaoka Local delivery of siRNA using a biodegradable polymer application to enhance BMP-induced bone formation Biomaterials 32 2012 9642 9648
    • (2012) Biomaterials , vol.32 , pp. 9642-9648
    • Manaka, T.1    Suzuki, A.2    Takayama, K.3    Imai, Y.4    Nakamura, H.5    Takaoka, K.6
  • 20
    • 15244352484 scopus 로고    scopus 로고
    • Supramolecular gene delivery vectors showing enhanced transgene expression and good biocompatibility
    • DOI 10.1021/bc0498471
    • X. Shuai, T. Merdan, F. Unger, and T. Kissel Supramolecular gene delivery vectors showing enhanced transgene expression and good biocompatibility Bioconjug. Chem. 16 2005 322 329 (Pubitemid 40388207)
    • (2005) Bioconjugate Chemistry , vol.16 , Issue.2 , pp. 322-329
    • Shuai, X.1    Merdan, T.2    Unger, F.3    Kissel, T.4
  • 21
    • 84863587750 scopus 로고    scopus 로고
    • Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers
    • M. Zheng, D. Librizzi, A. Kilic, Y. Liu, H. Renz, O.M. Merkel, and T. Kissel Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers Biomaterials 33 2012 6551 6558
    • (2012) Biomaterials , vol.33 , pp. 6551-6558
    • Zheng, M.1    Librizzi, D.2    Kilic, A.3    Liu, Y.4    Renz, H.5    Merkel, O.M.6    Kissel, T.7
  • 22
    • 80051548932 scopus 로고    scopus 로고
    • Self-assembled biodegradable amphiphilic PEG-PCL-lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene delivery
    • T.K. Endres, M. Beck-Broichsitter, O. Samsonova, T. Renette, and T.H. Kissel Self-assembled biodegradable amphiphilic PEG-PCL-lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene delivery Biomaterials 32 2011 7721 7731
    • (2011) Biomaterials , vol.32 , pp. 7721-7731
    • Endres, T.K.1    Beck-Broichsitter, M.2    Samsonova, O.3    Renette, T.4    Kissel, T.H.5
  • 23
    • 54049107594 scopus 로고    scopus 로고
    • Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery
    • X.B. Xiong, H. Uludag, and A. Lavasanifar Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery Biomaterials 30 2009 242 253
    • (2009) Biomaterials , vol.30 , pp. 242-253
    • Xiong, X.B.1    Uludag, H.2    Lavasanifar, A.3
  • 24
    • 79951914745 scopus 로고    scopus 로고
    • Simultaneous delivery of siRNA and paclitaxel via a "two-in- one" micelleplex promotes synergistic tumor suppression
    • T.M. Sun, J.Z. Du, Y.D. Yao, C.Q. Mao, S. Dou, S.Y. Huang, P.Z. Zhang, K.W. Leong, E.W. Song, and J. Wang Simultaneous delivery of siRNA and paclitaxel via a "two-in-one" micelleplex promotes synergistic tumor suppression ACS Nano 5 2011 1483 1494
    • (2011) ACS Nano , vol.5 , pp. 1483-1494
    • Sun, T.M.1    Du, J.Z.2    Yao, Y.D.3    Mao, C.Q.4    Dou, S.5    Huang, S.Y.6    Zhang, P.Z.7    Leong, K.W.8    Song, E.W.9    Wang, J.10
  • 25
    • 79951581352 scopus 로고    scopus 로고
    • A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy
    • C.Q. Mao, J.Z. Du, T.M. Sun, Y.D. Yao, P.Z. Zhang, E.W. Song, and J. Wang A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy Biomaterials 32 2011 3124 3133
    • (2011) Biomaterials , vol.32 , pp. 3124-3133
    • Mao, C.Q.1    Du, J.Z.2    Sun, T.M.3    Yao, Y.D.4    Zhang, P.Z.5    Song, E.W.6    Wang, J.7
  • 26
    • 84890080343 scopus 로고    scopus 로고
    • Polycation-detachable nanoparticles self-assembled from mPEG-PCL-g-SS-PDMAEMA for in vitro and in vivo siRNA delivery
    • D. Lin, Q. Jiang, Q. Cheng, Y. Huang, P. Huang, S. Han, S. Guo, Z. Liang, and A. Dong Polycation-detachable nanoparticles self-assembled from mPEG-PCL-g-SS-PDMAEMA for in vitro and in vivo siRNA delivery Acta Biomater. 9 2013 7746 7757
    • (2013) Acta Biomater. , vol.9 , pp. 7746-7757
    • Lin, D.1    Jiang, Q.2    Cheng, Q.3    Huang, Y.4    Huang, P.5    Han, S.6    Guo, S.7    Liang, Z.8    Dong, A.9
  • 28
    • 79960077495 scopus 로고    scopus 로고
    • Biodegradation, biocompatibility, and drug delivery in poly(omega-pentadecalactone-co-p-dioxanone) copolyesters
    • J. Liu, Z. Jiang, S. Zhang, C. Liu, R.A. Gross, T.R. Kyriakides, and W.M. Saltzman Biodegradation, biocompatibility, and drug delivery in poly(omega-pentadecalactone-co-p-dioxanone) copolyesters Biomaterials 32 2011 6646 6654
    • (2011) Biomaterials , vol.32 , pp. 6646-6654
    • Liu, J.1    Jiang, Z.2    Zhang, S.3    Liu, C.4    Gross, R.A.5    Kyriakides, T.R.6    Saltzman, W.M.7
  • 29
    • 33749983751 scopus 로고    scopus 로고
    • Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer
    • DOI 10.1038/nmat1737, PII NMAT1737
    • Y. Wang, S. Gao, W.H. Ye, H.S. Yoon, and Y.Y. Yang Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer Nat. Mater. 5 2006 791 796 (Pubitemid 44570860)
    • (2006) Nature Materials , vol.5 , Issue.10 , pp. 791-796
    • Wang, Y.1    Gao, S.2    Ye, W.-H.3    Yoon, H.S.4    Yang, Y.-Y.5
  • 30
    • 75149133614 scopus 로고    scopus 로고
    • Chitosan-based formulations for delivery of DNA and siRNA
    • S. Mao, W. Sun, and T. Kissel Chitosan-based formulations for delivery of DNA and siRNA Adv. Drug Deliv. Rev. 62 1 2010 12 27
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , Issue.1 , pp. 12-27
    • Mao, S.1    Sun, W.2    Kissel, T.3
  • 31
    • 77956871233 scopus 로고    scopus 로고
    • Chitosan as a carrier for targeted delivery of small interfering RNA
    • W.E. Rudzinski, and T.M. Aminabhavi Chitosan as a carrier for targeted delivery of small interfering RNA Int. J. Pharm. 399 2010 1 11
    • (2010) Int. J. Pharm. , vol.399 , pp. 1-11
    • Rudzinski, W.E.1    Aminabhavi, T.M.2
  • 32
    • 84880446740 scopus 로고    scopus 로고
    • Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique
    • T. Okuda, D. Kito, A. Oiwa, M. Fukushima, D. Hira, and H. Okamoto Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique Biol. Pharm. Bull. 36 2013 1183 1191
    • (2013) Biol. Pharm. Bull. , vol.36 , pp. 1183-1191
    • Okuda, T.1    Kito, D.2    Oiwa, A.3    Fukushima, M.4    Hira, D.5    Okamoto, H.6
  • 33
    • 84864711649 scopus 로고    scopus 로고
    • An inhalable beta(2)-adrenoceptor ligand-directed guanidinylated chitosan carrier for targeted delivery of siRNA to lung
    • Y. Luo, X. Zhai, C. Ma, P. Sun, Z. Fu, W. Liu, and J. Xu An inhalable beta(2)-adrenoceptor ligand-directed guanidinylated chitosan carrier for targeted delivery of siRNA to lung J. Control. Release 162 2012 28 36
    • (2012) J. Control. Release , vol.162 , pp. 28-36
    • Luo, Y.1    Zhai, X.2    Ma, C.3    Sun, P.4    Fu, Z.5    Liu, W.6    Xu, J.7
  • 36
    • 70449472493 scopus 로고    scopus 로고
    • Development of a functionalized polymer for stent coating in the arterial delivery of small interfering RNA
    • A. San Juan, M. Bala, H. Hlawaty, P. Portes, R. Vranckx, L.J. Feldman, and D. Letourneur Development of a functionalized polymer for stent coating in the arterial delivery of small interfering RNA Biomacromolecules 10 2009 3074 3080
    • (2009) Biomacromolecules , vol.10 , pp. 3074-3080
    • San Juan, A.1    Bala, M.2    Hlawaty, H.3    Portes, P.4    Vranckx, R.5    Feldman, L.J.6    Letourneur, D.7
  • 38
    • 84857370161 scopus 로고    scopus 로고
    • Bioreducible polyethylenimine-delivered siRNA targeting human telomerase reverse transcriptase inhibits HepG2 cell growth in vitro and in vivo
    • W. Xia, P. Wang, C. Lin, Z. Li, X. Gao, G. Wang, and X. Zhao Bioreducible polyethylenimine-delivered siRNA targeting human telomerase reverse transcriptase inhibits HepG2 cell growth in vitro and in vivo J. Control. Release 157 2012 427 436
    • (2012) J. Control. Release , vol.157 , pp. 427-436
    • Xia, W.1    Wang, P.2    Lin, C.3    Li, Z.4    Gao, X.5    Wang, G.6    Zhao, X.7
  • 39
    • 84872538450 scopus 로고    scopus 로고
    • Acid-degradable cationic poly(ketal amidoamine) for enhanced RNA interference in vitro and in vivo
    • H. Lim, J. Noh, Y. Kim, H. Kim, J. Kim, G. Khang, and D. Lee Acid-degradable cationic poly(ketal amidoamine) for enhanced RNA interference in vitro and in vivo Biomacromolecules 14 2013 240 247
    • (2013) Biomacromolecules , vol.14 , pp. 240-247
    • Lim, H.1    Noh, J.2    Kim, Y.3    Kim, H.4    Kim, J.5    Khang, G.6    Lee, D.7
  • 42
    • 61849179561 scopus 로고    scopus 로고
    • In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure
    • O.M. Merkel, D. Librizzi, A. Pfestroff, T. Schurrat, M. Behe, and T. Kissel In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure Bioconjug. Chem. 20 2009 174 182
    • (2009) Bioconjug. Chem. , vol.20 , pp. 174-182
    • Merkel, O.M.1    Librizzi, D.2    Pfestroff, A.3    Schurrat, T.4    Behe, M.5    Kissel, T.6
  • 44
    • 67651202350 scopus 로고    scopus 로고
    • Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging
    • O.M. Merkel, D. Librizzi, A. Pfestroff, T. Schurrat, K. Buyens, N.N. Sanders, S.C. De Smedt, M. Behe, and T. Kissel Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging J. Control. Release 138 2009 148 159
    • (2009) J. Control. Release , vol.138 , pp. 148-159
    • Merkel, O.M.1    Librizzi, D.2    Pfestroff, A.3    Schurrat, T.4    Buyens, K.5    Sanders, N.N.6    De Smedt, S.C.7    Behe, M.8    Kissel, T.9
  • 45
    • 77955240438 scopus 로고    scopus 로고
    • Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: The effects of peripheral groups and core structure on biological activity
    • O.M. Merkel, M.A. Mintzer, D. Librizzi, O. Samsonova, T. Dicke, B. Sproat, H. Garn, P.J. Barth, E.E. Simanek, and T. Kissel Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity Mol. Pharm. 7 2010 969 983
    • (2010) Mol. Pharm. , vol.7 , pp. 969-983
    • Merkel, O.M.1    Mintzer, M.A.2    Librizzi, D.3    Samsonova, O.4    Dicke, T.5    Sproat, B.6    Garn, H.7    Barth, P.J.8    Simanek, E.E.9    Kissel, T.10
  • 48
    • 22644444670 scopus 로고    scopus 로고
    • PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice
    • DOI 10.1021/bc049743q
    • T. Merdan, K. Kunath, H. Petersen, U. Bakowsky, K.H. Voigt, J. Kopecek, and T. Kissel PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice Bioconjug. Chem. 16 2005 785 792 (Pubitemid 41026164)
    • (2005) Bioconjugate Chemistry , vol.16 , Issue.4 , pp. 785-792
    • Merdan, T.1    Kunath, K.2    Petersen, H.3    Bakowsky, U.4    Voigt, K.H.5    Kopecek, J.6    Kissel, T.7
  • 49
    • 61849103493 scopus 로고    scopus 로고
    • In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes
    • A. Malek, O. Merkel, L. Fink, F. Czubayko, T. Kissel, and A. Aigner In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes Toxicol. Appl. Pharmacol. 236 2009 97 108
    • (2009) Toxicol. Appl. Pharmacol. , vol.236 , pp. 97-108
    • Malek, A.1    Merkel, O.2    Fink, L.3    Czubayko, F.4    Kissel, T.5    Aigner, A.6
  • 50
    • 67249100358 scopus 로고    scopus 로고
    • Target specific intracellular delivery of siRNA/PEI-HA complex by receptor mediated endocytosis
    • G. Jiang, K. Park, J. Kim, K.S. Kim, and S.K. Hahn Target specific intracellular delivery of siRNA/PEI-HA complex by receptor mediated endocytosis Mol. Pharm. 6 2009 727 737
    • (2009) Mol. Pharm. , vol.6 , pp. 727-737
    • Jiang, G.1    Park, K.2    Kim, J.3    Kim, K.S.4    Hahn, S.K.5
  • 51
    • 78651376884 scopus 로고    scopus 로고
    • Maltose- and maltotriose-modified, hyperbranched poly(ethylene imine)s (OM-PEIs): Physicochemical and biological properties of DNA and siRNA complexes
    • S. Hobel, A. Loos, D. Appelhans, S. Schwarz, J. Seidel, B. Voit, and A. Aigner Maltose- and maltotriose-modified, hyperbranched poly(ethylene imine)s (OM-PEIs): physicochemical and biological properties of DNA and siRNA complexes J. Control. Release 149 2011 146 158
    • (2011) J. Control. Release , vol.149 , pp. 146-158
    • Hobel, S.1    Loos, A.2    Appelhans, D.3    Schwarz, S.4    Seidel, J.5    Voit, B.6    Aigner, A.7
  • 52
    • 77349095284 scopus 로고    scopus 로고
    • Polyethylenimine/small interfering RNA-mediated knockdown of vascular endothelial growth factor in vivo exerts anti-tumor effects synergistically with Bevacizumab
    • S. Hobel, I. Koburger, M. John, F. Czubayko, P. Hadwiger, H.P. Vornlocher, and A. Aigner Polyethylenimine/small interfering RNA-mediated knockdown of vascular endothelial growth factor in vivo exerts anti-tumor effects synergistically with Bevacizumab J. Gene Med. 12 2010 287 300
    • (2010) J. Gene Med. , vol.12 , pp. 287-300
    • Hobel, S.1    Koburger, I.2    John, M.3    Czubayko, F.4    Hadwiger, P.5    Vornlocher, H.P.6    Aigner, A.7
  • 53
    • 78651246499 scopus 로고    scopus 로고
    • Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA
    • A. Kano, K. Moriyama, T. Yamano, I. Nakamura, N. Shimada, and A. Maruyama Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA J. Control. Release 149 2011 2 7
    • (2011) J. Control. Release , vol.149 , pp. 2-7
    • Kano, A.1    Moriyama, K.2    Yamano, T.3    Nakamura, I.4    Shimada, N.5    Maruyama, A.6
  • 54
    • 84870328406 scopus 로고    scopus 로고
    • Synthetic polyspermine imidazole-4, 5-amide as an efficient and cytotoxicity-free gene delivery system
    • S.Y. Duan, X.M. Ge, N. Lu, F. Wu, W. Yuan, and T. Jin Synthetic polyspermine imidazole-4, 5-amide as an efficient and cytotoxicity-free gene delivery system Int. J. Nanomedicine 7 2012 3813 3822
    • (2012) Int. J. Nanomedicine , vol.7 , pp. 3813-3822
    • Duan, S.Y.1    Ge, X.M.2    Lu, N.3    Wu, F.4    Yuan, W.5    Jin, T.6
  • 56
    • 74349088676 scopus 로고    scopus 로고
    • Polymer vesicles with a red cell-like surface charge: Microvascular imaging and in vivo tracking with near-infrared fluorescence
    • D.A. Christian, O.B. Garbuzenko, T. Minko, and D.E. Discher Polymer vesicles with a red cell-like surface charge: microvascular imaging and in vivo tracking with near-infrared fluorescence Macromol. Rapid Commun. 31 2010 135 141
    • (2010) Macromol. Rapid Commun. , vol.31 , pp. 135-141
    • Christian, D.A.1    Garbuzenko, O.B.2    Minko, T.3    Discher, D.E.4
  • 57
    • 84887003262 scopus 로고    scopus 로고
    • Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivo
    • C.E. Nelson, J.R. Kintzing, A. Hanna, J.M. Shannon, M.K. Gupta, and C.L. Duvall Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivo ACS Nano 7 2013 8870 8880
    • (2013) ACS Nano , vol.7 , pp. 8870-8880
    • Nelson, C.E.1    Kintzing, J.R.2    Hanna, A.3    Shannon, J.M.4    Gupta, M.K.5    Duvall, C.L.6
  • 58
    • 84882691457 scopus 로고    scopus 로고
    • The effect of N/P ratio on the in vitro and in vivo interaction properties of PEGylated poly[2-(dimethylamino)ethyl methacrylate]-based siRNA complexes
    • D.J. Gary, J. Min, Y. Kim, K. Park, and Y.Y. Won The effect of N/P ratio on the in vitro and in vivo interaction properties of PEGylated poly[2-(dimethylamino)ethyl methacrylate]-based siRNA complexes Macromol. Biosci. 13 2013 1059 1071
    • (2013) Macromol. Biosci. , vol.13 , pp. 1059-1071
    • Gary, D.J.1    Min, J.2    Kim, Y.3    Park, K.4    Won, Y.Y.5
  • 59
    • 84876464768 scopus 로고    scopus 로고
    • Ternary polymeric nanoparticles for oral siRNA delivery
    • J. Zhang, C. He, C. Tang, and C. Yin Ternary polymeric nanoparticles for oral siRNA delivery Pharm. Res. 30 2013 1228 1239
    • (2013) Pharm. Res. , vol.30 , pp. 1228-1239
    • Zhang, J.1    He, C.2    Tang, C.3    Yin, C.4
  • 63
    • 78650476432 scopus 로고    scopus 로고
    • The Proton Sponge: A Trick to Enter Cells the Viruses Did Not Exploit
    • J.-P. Behr The proton sponge: a trick to enter cells the viruses did not exploit CHIMIA Int. J. Chem. 51 1997 34 36 (Pubitemid 127033737)
    • (1997) Chimia , vol.51 , Issue.1-2 , pp. 34-36
    • Behr, J.-P.1
  • 64
    • 0036179935 scopus 로고    scopus 로고
    • Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments
    • DOI 10.1023/A:1014212630566
    • T. Merdan, K. Kunath, D. Fischer, J. Kopecek, and T. Kissel Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments Pharm. Res. 19 2002 140 146 (Pubitemid 34165398)
    • (2002) Pharmaceutical Research , vol.19 , Issue.2 , pp. 140-146
    • Merdan, T.1    Kunath, K.2    Fischer, D.3    Kopecek, J.4    Kissel, T.5
  • 65
    • 65549133368 scopus 로고    scopus 로고
    • Delivery of macromolecules using arginine-rich cell-penetrating peptides: Ways to overcome endosomal entrapment
    • A. El-Sayed, S. Futaki, and H. Harashima Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment AAPS J. 11 2009 13 22
    • (2009) AAPS J. , vol.11 , pp. 13-22
    • El-Sayed, A.1    Futaki, S.2    Harashima, H.3
  • 66
    • 33846813849 scopus 로고    scopus 로고
    • Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes
    • DOI 10.1016/j.ijpharm.2006.11.050, PII S037851730601009X
    • S. Oliveira, I. van Rooy, O. Kranenburg, G. Storm, and R.M. Schiffelers Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes Int. J. Pharm. 331 2007 211 214 (Pubitemid 46216677)
    • (2007) International Journal of Pharmaceutics , vol.331 , Issue.2 , pp. 211-214
    • Oliveira, S.1    Van Rooy, I.2    Kranenburg, O.3    Storm, G.4    Schiffelers, R.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.