-
1
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans
-
DOI 10.1038/35888
-
A. Fire, S. Xu, M.K. Montgomery, S.A. Kostas, S.E. Driver, and C.C. Mello Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans Nature 391 1998 806 811 (Pubitemid 28099681)
-
(1998)
Nature
, vol.391
, Issue.6669
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
Kostas, S.A.4
Driver, S.E.5
Mello, C.C.6
-
2
-
-
0036843787
-
In vivo-applied functional RNAs as tools in proteomics and genomics research
-
DOI 10.1016/S0167-7799(02)02063-2, PII S0167779902020632
-
M. Famulok, and S. Verma In vivo-applied functional RNAs as tools in proteomics and genomics research Trends Biotechnol. 20 2002 462 466 (Pubitemid 35292358)
-
(2002)
Trends in Biotechnology
, vol.20
, Issue.11
, pp. 462-466
-
-
Famulok, M.1
Verma, S.2
-
3
-
-
84870452224
-
Targeting the blind spot of polycationic nanocarrier-based siRNA delivery
-
M. Zheng, G.M. Pavan, M. Neeb, A.K. Schaper, A. Danani, G. Klebe, O.M. Merkel, and T. Kissel Targeting the blind spot of polycationic nanocarrier-based siRNA delivery ACS Nano 6 2012 9447 9454
-
(2012)
ACS Nano
, vol.6
, pp. 9447-9454
-
-
Zheng, M.1
Pavan, G.M.2
Neeb, M.3
Schaper, A.K.4
Danani, A.5
Klebe, G.6
Merkel, O.M.7
Kissel, T.8
-
4
-
-
84862659504
-
Therapeutic plasmid DNA versus siRNA delivery: Common and different tasks for synthetic carriers
-
C. Scholz, and E. Wagner Therapeutic plasmid DNA versus siRNA delivery: common and different tasks for synthetic carriers J. Control. Release 161 2012 554 565
-
(2012)
J. Control. Release
, vol.161
, pp. 554-565
-
-
Scholz, C.1
Wagner, E.2
-
5
-
-
67249128859
-
The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: From concept to clinic
-
M.E. Davis The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle: from concept to clinic Mol. Pharm. 6 2009 659 668
-
(2009)
Mol. Pharm.
, vol.6
, pp. 659-668
-
-
Davis, M.E.1
-
6
-
-
38749136602
-
Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV)
-
J. DeVincenzo, J.E. Cehelsky, R. Alvarez, S. Elbashir, J. Harborth, I. Toudjarska, L. Nechev, V. Murugaiah, A. Van Vliet, A.K. Vaishnaw, and R. Meyers Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV) Antiviral Res. 77 2008 225 231
-
(2008)
Antiviral Res.
, vol.77
, pp. 225-231
-
-
Devincenzo, J.1
Cehelsky, J.E.2
Alvarez, R.3
Elbashir, S.4
Harborth, J.5
Toudjarska, I.6
Nechev, L.7
Murugaiah, V.8
Van Vliet, A.9
Vaishnaw, A.K.10
Meyers, R.11
-
7
-
-
77952688315
-
A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus
-
J. DeVincenzo, R. Lambkin-Williams, T. Wilkinson, J. Cehelsky, S. Nochur, E. Walsh, R. Meyers, J. Gollob, and A. Vaishnaw A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus Proc. Natl. Acad. Sci. U. S. A. 107 2009 8800 8805
-
(2009)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 8800-8805
-
-
Devincenzo, J.1
Lambkin-Williams, R.2
Wilkinson, T.3
Cehelsky, J.4
Nochur, S.5
Walsh, E.6
Meyers, R.7
Gollob, J.8
Vaishnaw, A.9
-
8
-
-
33746883220
-
A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium
-
DOI 10.1038/sj.gt.3302777, PII 3302777
-
A. Santel, M. Aleku, O. Keil, J. Endruschat, V. Esche, G. Fisch, S. Dames, K. Loffler, M. Fechtner, W. Arnold, K. Giese, A. Klippel, and J. Kaufmann A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium Gene Ther. 13 2006 1222 1234 (Pubitemid 44184716)
-
(2006)
Gene Therapy
, vol.13
, Issue.16
, pp. 1222-1234
-
-
Santel, A.1
Aleku, M.2
Keil, O.3
Endruschat, J.4
Esche, V.5
Fisch, G.6
Dames, S.7
Loffler, K.8
Fechtner, M.9
Arnold, W.10
Giese, K.11
Klippel, A.12
Kaufmann, J.13
-
9
-
-
0346634895
-
In vitro cytotoxicity testing of polycations: Influence of polymer structure on cell viability and hemolysis
-
DOI 10.1016/S0142-9612(02)00445-3, PII S0142961202004453
-
D. Fischer, Y. Li, B. Ahlemeyer, J. Krieglstein, and T. Kissel In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis Biomaterials 24 2003 1121 1131 (Pubitemid 36069121)
-
(2003)
Biomaterials
, vol.24
, Issue.7
, pp. 1121-1131
-
-
Fischer, D.1
Li, Y.2
Ahlemeyer, B.3
Krieglstein, J.4
Kissel, T.5
-
10
-
-
33748994569
-
Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes
-
DOI 10.1021/bc060129j
-
S. Mao, M. Neu, O. Germershaus, O. Merkel, J. Sitterberg, U. Bakowsky, and T. Kissel Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft- poly(ethylene glycol) block copolymer/siRNA polyplexes Bioconjug. Chem. 17 2006 1209 1218 (Pubitemid 44455329)
-
(2006)
Bioconjugate Chemistry
, vol.17
, Issue.5
, pp. 1209-1218
-
-
Mao, S.1
Neu, M.2
Germershaus, O.3
Merkel, O.4
Sitterberg, J.5
Bakowsky, U.6
Kissel, T.7
-
11
-
-
79955782283
-
In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft- poly(ethylene glycol) block copolymers
-
O.M. Merkel, R. Urbanics, P. Bedocs, Z. Rozsnyay, L. Rosivall, M. Toth, T. Kissel, and J. Szebeni In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine- graft-poly(ethylene glycol) block copolymers Biomaterials 32 2011 4936 4942
-
(2011)
Biomaterials
, vol.32
, pp. 4936-4942
-
-
Merkel, O.M.1
Urbanics, R.2
Bedocs, P.3
Rozsnyay, Z.4
Rosivall, L.5
Toth, M.6
Kissel, T.7
Szebeni, J.8
-
12
-
-
84883504398
-
The accelerated blood clearance (ABC) phenomenon: Clinical challenge and approaches to manage
-
A.S. Abu Lila, H. Kiwada, and T. Ishida The accelerated blood clearance (ABC) phenomenon: clinical challenge and approaches to manage J. Control. Release 172 2013 38 47
-
(2013)
J. Control. Release
, vol.172
, pp. 38-47
-
-
Abu Lila, A.S.1
Kiwada, H.2
Ishida, T.3
-
13
-
-
4644293047
-
Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: In vitro and in vivo studies
-
DOI 10.1080/10611860400003858
-
A. Khan, M. Benboubetra, P.Z. Sayyed, K.W. Ng, S. Fox, G. Beck, I.F. Benter, and S. Akhtar Sustained polymeric delivery of gene silencing antisense ODNs, siRNA, DNAzymes and ribozymes: in vitro and in vivo studies J. Drug Target. 12 2004 393 404 (Pubitemid 39302465)
-
(2004)
Journal of Drug Targeting
, vol.12
, Issue.6
, pp. 393-404
-
-
Khan, A.1
Benboubetra, M.2
Sayyed, P.Z.3
Ng, K.W.4
Fox, S.5
Beck, G.6
Benter, I.F.7
Akhtar, S.8
-
14
-
-
56849117151
-
Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy
-
J. Nguyen, T.W. Steele, O. Merkel, R. Reul, and T. Kissel Fast degrading polyesters as siRNA nano-carriers for pulmonary gene therapy J. Control. Release 132 2008 243 251
-
(2008)
J. Control. Release
, vol.132
, pp. 243-251
-
-
Nguyen, J.1
Steele, T.W.2
Merkel, O.3
Reul, R.4
Kissel, T.5
-
15
-
-
84863928267
-
Nonviral pulmonary delivery of siRNA
-
O.M. Merkel, and T. Kissel Nonviral pulmonary delivery of siRNA Acc. Chem. Res. 45 2012 961 970
-
(2012)
Acc. Chem. Res.
, vol.45
, pp. 961-970
-
-
Merkel, O.M.1
Kissel, T.2
-
16
-
-
84865514367
-
Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymer microparticles ameliorates temporomandibular joint inflammation
-
P.M. Mountziaris, S.N. Tzouanas, D.C. Sing, P.R. Kramer, F.K. Kasper, and A.G. Mikos Intra-articular controlled release of anti-inflammatory siRNA with biodegradable polymer microparticles ameliorates temporomandibular joint inflammation Acta Biomater. 8 2012 3552 3560
-
(2012)
Acta Biomater.
, vol.8
, pp. 3552-3560
-
-
Mountziaris, P.M.1
Tzouanas, S.N.2
Sing, D.C.3
Kramer, P.R.4
Kasper, F.K.5
Mikos, A.G.6
-
17
-
-
77957334621
-
Biodegradable nanoparticles with sustained release of functional siRNA in skin
-
G.B. Jacobson, E. Gonzalez-Gonzalez, R. Spitler, R. Shinde, D. Leake, R.L. Kaspar, C.H. Contag, and R.N. Zare Biodegradable nanoparticles with sustained release of functional siRNA in skin J. Pharm. Sci. 99 2010 4261 4266
-
(2010)
J. Pharm. Sci.
, vol.99
, pp. 4261-4266
-
-
Jacobson, G.B.1
Gonzalez-Gonzalez, E.2
Spitler, R.3
Shinde, R.4
Leake, D.5
Kaspar, R.L.6
Contag, C.H.7
Zare, R.N.8
-
18
-
-
84864022954
-
Self-assembly nanomicelles based on cationic mPEG-PLA-b-Polyarginine(R15) triblock copolymer for siRNA delivery
-
Z.X. Zhao, S.Y. Gao, J.C. Wang, C.J. Chen, E.Y. Zhao, W.J. Hou, Q. Feng, L.Y. Gao, X.Y. Liu, L.R. Zhang, and Q. Zhang Self-assembly nanomicelles based on cationic mPEG-PLA-b-Polyarginine(R15) triblock copolymer for siRNA delivery Biomaterials 33 2012 6793 6807
-
(2012)
Biomaterials
, vol.33
, pp. 6793-6807
-
-
Zhao, Z.X.1
Gao, S.Y.2
Wang, J.C.3
Chen, C.J.4
Zhao, E.Y.5
Hou, W.J.6
Feng, Q.7
Gao, L.Y.8
Liu, X.Y.9
Zhang, L.R.10
Zhang, Q.11
-
19
-
-
80054083256
-
Local delivery of siRNA using a biodegradable polymer application to enhance BMP-induced bone formation
-
T. Manaka, A. Suzuki, K. Takayama, Y. Imai, H. Nakamura, and K. Takaoka Local delivery of siRNA using a biodegradable polymer application to enhance BMP-induced bone formation Biomaterials 32 2012 9642 9648
-
(2012)
Biomaterials
, vol.32
, pp. 9642-9648
-
-
Manaka, T.1
Suzuki, A.2
Takayama, K.3
Imai, Y.4
Nakamura, H.5
Takaoka, K.6
-
20
-
-
15244352484
-
Supramolecular gene delivery vectors showing enhanced transgene expression and good biocompatibility
-
DOI 10.1021/bc0498471
-
X. Shuai, T. Merdan, F. Unger, and T. Kissel Supramolecular gene delivery vectors showing enhanced transgene expression and good biocompatibility Bioconjug. Chem. 16 2005 322 329 (Pubitemid 40388207)
-
(2005)
Bioconjugate Chemistry
, vol.16
, Issue.2
, pp. 322-329
-
-
Shuai, X.1
Merdan, T.2
Unger, F.3
Kissel, T.4
-
21
-
-
84863587750
-
Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers
-
M. Zheng, D. Librizzi, A. Kilic, Y. Liu, H. Renz, O.M. Merkel, and T. Kissel Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers Biomaterials 33 2012 6551 6558
-
(2012)
Biomaterials
, vol.33
, pp. 6551-6558
-
-
Zheng, M.1
Librizzi, D.2
Kilic, A.3
Liu, Y.4
Renz, H.5
Merkel, O.M.6
Kissel, T.7
-
22
-
-
80051548932
-
Self-assembled biodegradable amphiphilic PEG-PCL-lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene delivery
-
T.K. Endres, M. Beck-Broichsitter, O. Samsonova, T. Renette, and T.H. Kissel Self-assembled biodegradable amphiphilic PEG-PCL-lPEI triblock copolymers at the borderline between micelles and nanoparticles designed for drug and gene delivery Biomaterials 32 2011 7721 7731
-
(2011)
Biomaterials
, vol.32
, pp. 7721-7731
-
-
Endres, T.K.1
Beck-Broichsitter, M.2
Samsonova, O.3
Renette, T.4
Kissel, T.H.5
-
23
-
-
54049107594
-
Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery
-
X.B. Xiong, H. Uludag, and A. Lavasanifar Biodegradable amphiphilic poly(ethylene oxide)-block-polyesters with grafted polyamines as supramolecular nanocarriers for efficient siRNA delivery Biomaterials 30 2009 242 253
-
(2009)
Biomaterials
, vol.30
, pp. 242-253
-
-
Xiong, X.B.1
Uludag, H.2
Lavasanifar, A.3
-
24
-
-
79951914745
-
Simultaneous delivery of siRNA and paclitaxel via a "two-in- one" micelleplex promotes synergistic tumor suppression
-
T.M. Sun, J.Z. Du, Y.D. Yao, C.Q. Mao, S. Dou, S.Y. Huang, P.Z. Zhang, K.W. Leong, E.W. Song, and J. Wang Simultaneous delivery of siRNA and paclitaxel via a "two-in-one" micelleplex promotes synergistic tumor suppression ACS Nano 5 2011 1483 1494
-
(2011)
ACS Nano
, vol.5
, pp. 1483-1494
-
-
Sun, T.M.1
Du, J.Z.2
Yao, Y.D.3
Mao, C.Q.4
Dou, S.5
Huang, S.Y.6
Zhang, P.Z.7
Leong, K.W.8
Song, E.W.9
Wang, J.10
-
25
-
-
79951581352
-
A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy
-
C.Q. Mao, J.Z. Du, T.M. Sun, Y.D. Yao, P.Z. Zhang, E.W. Song, and J. Wang A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy Biomaterials 32 2011 3124 3133
-
(2011)
Biomaterials
, vol.32
, pp. 3124-3133
-
-
Mao, C.Q.1
Du, J.Z.2
Sun, T.M.3
Yao, Y.D.4
Zhang, P.Z.5
Song, E.W.6
Wang, J.7
-
26
-
-
84890080343
-
Polycation-detachable nanoparticles self-assembled from mPEG-PCL-g-SS-PDMAEMA for in vitro and in vivo siRNA delivery
-
D. Lin, Q. Jiang, Q. Cheng, Y. Huang, P. Huang, S. Han, S. Guo, Z. Liang, and A. Dong Polycation-detachable nanoparticles self-assembled from mPEG-PCL-g-SS-PDMAEMA for in vitro and in vivo siRNA delivery Acta Biomater. 9 2013 7746 7757
-
(2013)
Acta Biomater.
, vol.9
, pp. 7746-7757
-
-
Lin, D.1
Jiang, Q.2
Cheng, Q.3
Huang, Y.4
Huang, P.5
Han, S.6
Guo, S.7
Liang, Z.8
Dong, A.9
-
27
-
-
84878649192
-
Effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers
-
C. Boyer, J. Teo, P. Phillips, R.B. Erlich, S. Sagnella, G. Sharbeen, T. Dwarte, H.T.T. Duong, D. Goldstein, T.P. Davis, M. Kavallaris, and J. McCarroll Effective delivery of siRNA into cancer cells and tumors using well-defined biodegradable cationic star polymers Mol. Pharm. 10 2013 2435 2444
-
(2013)
Mol. Pharm.
, vol.10
, pp. 2435-2444
-
-
Boyer, C.1
Teo, J.2
Phillips, P.3
Erlich, R.B.4
Sagnella, S.5
Sharbeen, G.6
Dwarte, T.7
Duong, H.T.T.8
Goldstein, D.9
Davis, T.P.10
Kavallaris, M.11
McCarroll, J.12
-
28
-
-
79960077495
-
Biodegradation, biocompatibility, and drug delivery in poly(omega-pentadecalactone-co-p-dioxanone) copolyesters
-
J. Liu, Z. Jiang, S. Zhang, C. Liu, R.A. Gross, T.R. Kyriakides, and W.M. Saltzman Biodegradation, biocompatibility, and drug delivery in poly(omega-pentadecalactone-co-p-dioxanone) copolyesters Biomaterials 32 2011 6646 6654
-
(2011)
Biomaterials
, vol.32
, pp. 6646-6654
-
-
Liu, J.1
Jiang, Z.2
Zhang, S.3
Liu, C.4
Gross, R.A.5
Kyriakides, T.R.6
Saltzman, W.M.7
-
29
-
-
33749983751
-
Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer
-
DOI 10.1038/nmat1737, PII NMAT1737
-
Y. Wang, S. Gao, W.H. Ye, H.S. Yoon, and Y.Y. Yang Co-delivery of drugs and DNA from cationic core-shell nanoparticles self-assembled from a biodegradable copolymer Nat. Mater. 5 2006 791 796 (Pubitemid 44570860)
-
(2006)
Nature Materials
, vol.5
, Issue.10
, pp. 791-796
-
-
Wang, Y.1
Gao, S.2
Ye, W.-H.3
Yoon, H.S.4
Yang, Y.-Y.5
-
30
-
-
75149133614
-
Chitosan-based formulations for delivery of DNA and siRNA
-
S. Mao, W. Sun, and T. Kissel Chitosan-based formulations for delivery of DNA and siRNA Adv. Drug Deliv. Rev. 62 1 2010 12 27
-
(2010)
Adv. Drug Deliv. Rev.
, vol.62
, Issue.1
, pp. 12-27
-
-
Mao, S.1
Sun, W.2
Kissel, T.3
-
31
-
-
77956871233
-
Chitosan as a carrier for targeted delivery of small interfering RNA
-
W.E. Rudzinski, and T.M. Aminabhavi Chitosan as a carrier for targeted delivery of small interfering RNA Int. J. Pharm. 399 2010 1 11
-
(2010)
Int. J. Pharm.
, vol.399
, pp. 1-11
-
-
Rudzinski, W.E.1
Aminabhavi, T.M.2
-
32
-
-
84880446740
-
Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique
-
T. Okuda, D. Kito, A. Oiwa, M. Fukushima, D. Hira, and H. Okamoto Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique Biol. Pharm. Bull. 36 2013 1183 1191
-
(2013)
Biol. Pharm. Bull.
, vol.36
, pp. 1183-1191
-
-
Okuda, T.1
Kito, D.2
Oiwa, A.3
Fukushima, M.4
Hira, D.5
Okamoto, H.6
-
33
-
-
84864711649
-
An inhalable beta(2)-adrenoceptor ligand-directed guanidinylated chitosan carrier for targeted delivery of siRNA to lung
-
Y. Luo, X. Zhai, C. Ma, P. Sun, Z. Fu, W. Liu, and J. Xu An inhalable beta(2)-adrenoceptor ligand-directed guanidinylated chitosan carrier for targeted delivery of siRNA to lung J. Control. Release 162 2012 28 36
-
(2012)
J. Control. Release
, vol.162
, pp. 28-36
-
-
Luo, Y.1
Zhai, X.2
Ma, C.3
Sun, P.4
Fu, Z.5
Liu, W.6
Xu, J.7
-
34
-
-
84861582256
-
HSP47 siRNA conjugated with cationized gelatin microspheres suppresses peritoneal fibrosis in mice
-
Y. Obata, T. Nishino, T. Kushibiki, R. Tomoshige, Z. Xia, M. Miyazaki, K. Abe, T. Koji, Y. Tabata, and S. Kohno HSP47 siRNA conjugated with cationized gelatin microspheres suppresses peritoneal fibrosis in mice Acta Biomater. 8 2012 2688 2696
-
(2012)
Acta Biomater.
, vol.8
, pp. 2688-2696
-
-
Obata, Y.1
Nishino, T.2
Kushibiki, T.3
Tomoshige, R.4
Xia, Z.5
Miyazaki, M.6
Abe, K.7
Koji, T.8
Tabata, Y.9
Kohno, S.10
-
35
-
-
84887162804
-
Bioreducible hyaluronic acid conjugates as siRNA carrier for tumor targeting
-
H.Y. Yoon, H.R. Kim, G. Saravanakumar, R. Heo, S.Y. Chae, W. Um, K. Kim, I.C. Kwon, J.Y. Lee, D.S. Lee, J.C. Park, and J.H. Park Bioreducible hyaluronic acid conjugates as siRNA carrier for tumor targeting J. Control. Release 172 2013 653 661
-
(2013)
J. Control. Release
, vol.172
, pp. 653-661
-
-
Yoon, H.Y.1
Kim, H.R.2
Saravanakumar, G.3
Heo, R.4
Chae, S.Y.5
Um, W.6
Kim, K.7
Kwon, I.C.8
Lee, J.Y.9
Lee, D.S.10
Park, J.C.11
Park, J.H.12
-
36
-
-
70449472493
-
Development of a functionalized polymer for stent coating in the arterial delivery of small interfering RNA
-
A. San Juan, M. Bala, H. Hlawaty, P. Portes, R. Vranckx, L.J. Feldman, and D. Letourneur Development of a functionalized polymer for stent coating in the arterial delivery of small interfering RNA Biomacromolecules 10 2009 3074 3080
-
(2009)
Biomacromolecules
, vol.10
, pp. 3074-3080
-
-
San Juan, A.1
Bala, M.2
Hlawaty, H.3
Portes, P.4
Vranckx, R.5
Feldman, L.J.6
Letourneur, D.7
-
37
-
-
84873334873
-
Endosomolytic anionic polymer for the cytoplasmic delivery of siRNAs in localized applications
-
S. Khormaee, Y. Choi, M.J. Shen, B. Xu, H. Wu, G.L. Griffiths, R. Chen, N.K. Slater, and J.K. Park Endosomolytic anionic polymer for the cytoplasmic delivery of siRNAs in localized applications Adv. Funct. Mater. 23 2006
-
(2006)
Adv. Funct. Mater.
, vol.23
-
-
Khormaee, S.1
Choi, Y.2
Shen, M.J.3
Xu, B.4
Wu, H.5
Griffiths, G.L.6
Chen, R.7
Slater, N.K.8
Park, J.K.9
-
38
-
-
84857370161
-
Bioreducible polyethylenimine-delivered siRNA targeting human telomerase reverse transcriptase inhibits HepG2 cell growth in vitro and in vivo
-
W. Xia, P. Wang, C. Lin, Z. Li, X. Gao, G. Wang, and X. Zhao Bioreducible polyethylenimine-delivered siRNA targeting human telomerase reverse transcriptase inhibits HepG2 cell growth in vitro and in vivo J. Control. Release 157 2012 427 436
-
(2012)
J. Control. Release
, vol.157
, pp. 427-436
-
-
Xia, W.1
Wang, P.2
Lin, C.3
Li, Z.4
Gao, X.5
Wang, G.6
Zhao, X.7
-
39
-
-
84872538450
-
Acid-degradable cationic poly(ketal amidoamine) for enhanced RNA interference in vitro and in vivo
-
H. Lim, J. Noh, Y. Kim, H. Kim, J. Kim, G. Khang, and D. Lee Acid-degradable cationic poly(ketal amidoamine) for enhanced RNA interference in vitro and in vivo Biomacromolecules 14 2013 240 247
-
(2013)
Biomacromolecules
, vol.14
, pp. 240-247
-
-
Lim, H.1
Noh, J.2
Kim, Y.3
Kim, H.4
Kim, J.5
Khang, G.6
Lee, D.7
-
40
-
-
1242316928
-
Biodistribution of phosphodiester and phosphorothioate siRNA
-
DOI 10.1016/j.bmcl.2003.12.074
-
D.A. Braasch, Z. Paroo, A. Constantinescu, G. Ren, O.K. Oz, R.P. Mason, and D.R. Corey Biodistribution of phosphodiester and phosphorothioate siRNA Bioorg. Med. Chem. Lett. 14 2004 1139 1143 (Pubitemid 38229843)
-
(2004)
Bioorganic and Medicinal Chemistry Letters
, vol.14
, Issue.5
, pp. 1139-1143
-
-
Braasch, D.A.1
Paroo, Z.2
Constantinescu, A.3
Ren, G.4
Oz, O.K.5
Mason, R.P.6
Corey, D.R.7
-
41
-
-
34848918210
-
Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging
-
DOI 10.1073/pnas.0707461104
-
D.W. Bartlett, H. Su, I.J. Hildebrandt, W.A. Weber, and M.E. Davis Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging Proc. Natl. Acad. Sci. U. S. A. 104 2007 15549 15554 (Pubitemid 47502954)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.39
, pp. 15549-15554
-
-
Bartlett, D.W.1
Su, H.2
Hildebrandt, I.J.3
Weber, W.A.4
Davis, M.E.5
-
42
-
-
61849179561
-
In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure
-
O.M. Merkel, D. Librizzi, A. Pfestroff, T. Schurrat, M. Behe, and T. Kissel In vivo SPECT and real-time gamma camera imaging of biodistribution and pharmacokinetics of siRNA delivery using an optimized radiolabeling and purification procedure Bioconjug. Chem. 20 2009 174 182
-
(2009)
Bioconjug. Chem.
, vol.20
, pp. 174-182
-
-
Merkel, O.M.1
Librizzi, D.2
Pfestroff, A.3
Schurrat, T.4
Behe, M.5
Kissel, T.6
-
43
-
-
68249122805
-
Nonviral siRNA delivery to the lung: Investigation of PEG-PEI polyplexes and their in vivo performance
-
O.M. Merkel, A. Beyerle, D. Librizzi, A. Pfestroff, T.M. Behr, B. Sproat, P.J. Barth, and T. Kissel Nonviral siRNA delivery to the lung: investigation of PEG-PEI polyplexes and their in vivo performance Mol. Pharm. 6 2009 1246 1260
-
(2009)
Mol. Pharm.
, vol.6
, pp. 1246-1260
-
-
Merkel, O.M.1
Beyerle, A.2
Librizzi, D.3
Pfestroff, A.4
Behr, T.M.5
Sproat, B.6
Barth, P.J.7
Kissel, T.8
-
44
-
-
67651202350
-
Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: Effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging
-
O.M. Merkel, D. Librizzi, A. Pfestroff, T. Schurrat, K. Buyens, N.N. Sanders, S.C. De Smedt, M. Behe, and T. Kissel Stability of siRNA polyplexes from poly(ethylenimine) and poly(ethylenimine)-g-poly(ethylene glycol) under in vivo conditions: effects on pharmacokinetics and biodistribution measured by Fluorescence Fluctuation Spectroscopy and Single Photon Emission Computed Tomography (SPECT) imaging J. Control. Release 138 2009 148 159
-
(2009)
J. Control. Release
, vol.138
, pp. 148-159
-
-
Merkel, O.M.1
Librizzi, D.2
Pfestroff, A.3
Schurrat, T.4
Buyens, K.5
Sanders, N.N.6
De Smedt, S.C.7
Behe, M.8
Kissel, T.9
-
45
-
-
77955240438
-
Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: The effects of peripheral groups and core structure on biological activity
-
O.M. Merkel, M.A. Mintzer, D. Librizzi, O. Samsonova, T. Dicke, B. Sproat, H. Garn, P.J. Barth, E.E. Simanek, and T. Kissel Triazine dendrimers as nonviral vectors for in vitro and in vivo RNAi: the effects of peripheral groups and core structure on biological activity Mol. Pharm. 7 2010 969 983
-
(2010)
Mol. Pharm.
, vol.7
, pp. 969-983
-
-
Merkel, O.M.1
Mintzer, M.A.2
Librizzi, D.3
Samsonova, O.4
Dicke, T.5
Sproat, B.6
Garn, H.7
Barth, P.J.8
Simanek, E.E.9
Kissel, T.10
-
46
-
-
79960091210
-
Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems
-
O.M. Merkel, M. Zheng, M.A. Mintzer, G.M. Pavan, D. Librizzi, M. Maly, H. Hoffken, A. Danani, E.E. Simanek, and T. Kissel Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems J. Control. Release 153 2011 23 33
-
(2011)
J. Control. Release
, vol.153
, pp. 23-33
-
-
Merkel, O.M.1
Zheng, M.2
Mintzer, M.A.3
Pavan, G.M.4
Librizzi, D.5
Maly, M.6
Hoffken, H.7
Danani, A.8
Simanek, E.E.9
Kissel, T.10
-
47
-
-
84872405597
-
In vivo disassembly of IV administered siRNA matrix nanoparticles at the renal filtration barrier
-
B. Naeye, H. Deschout, V. Caveliers, B. Descamps, K. Braeckmans, C. Vanhove, J. Demeester, T. Lahoutte, S.C. De Smedt, and K. Raemdonck In vivo disassembly of IV administered siRNA matrix nanoparticles at the renal filtration barrier Biomaterials 34 2012 2350 2358
-
(2012)
Biomaterials
, vol.34
, pp. 2350-2358
-
-
Naeye, B.1
Deschout, H.2
Caveliers, V.3
Descamps, B.4
Braeckmans, K.5
Vanhove, C.6
Demeester, J.7
Lahoutte, T.8
De Smedt, S.C.9
Raemdonck, K.10
-
48
-
-
22644444670
-
PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice
-
DOI 10.1021/bc049743q
-
T. Merdan, K. Kunath, H. Petersen, U. Bakowsky, K.H. Voigt, J. Kopecek, and T. Kissel PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice Bioconjug. Chem. 16 2005 785 792 (Pubitemid 41026164)
-
(2005)
Bioconjugate Chemistry
, vol.16
, Issue.4
, pp. 785-792
-
-
Merdan, T.1
Kunath, K.2
Petersen, H.3
Bakowsky, U.4
Voigt, K.H.5
Kopecek, J.6
Kissel, T.7
-
49
-
-
61849103493
-
In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes
-
A. Malek, O. Merkel, L. Fink, F. Czubayko, T. Kissel, and A. Aigner In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes Toxicol. Appl. Pharmacol. 236 2009 97 108
-
(2009)
Toxicol. Appl. Pharmacol.
, vol.236
, pp. 97-108
-
-
Malek, A.1
Merkel, O.2
Fink, L.3
Czubayko, F.4
Kissel, T.5
Aigner, A.6
-
50
-
-
67249100358
-
Target specific intracellular delivery of siRNA/PEI-HA complex by receptor mediated endocytosis
-
G. Jiang, K. Park, J. Kim, K.S. Kim, and S.K. Hahn Target specific intracellular delivery of siRNA/PEI-HA complex by receptor mediated endocytosis Mol. Pharm. 6 2009 727 737
-
(2009)
Mol. Pharm.
, vol.6
, pp. 727-737
-
-
Jiang, G.1
Park, K.2
Kim, J.3
Kim, K.S.4
Hahn, S.K.5
-
51
-
-
78651376884
-
Maltose- and maltotriose-modified, hyperbranched poly(ethylene imine)s (OM-PEIs): Physicochemical and biological properties of DNA and siRNA complexes
-
S. Hobel, A. Loos, D. Appelhans, S. Schwarz, J. Seidel, B. Voit, and A. Aigner Maltose- and maltotriose-modified, hyperbranched poly(ethylene imine)s (OM-PEIs): physicochemical and biological properties of DNA and siRNA complexes J. Control. Release 149 2011 146 158
-
(2011)
J. Control. Release
, vol.149
, pp. 146-158
-
-
Hobel, S.1
Loos, A.2
Appelhans, D.3
Schwarz, S.4
Seidel, J.5
Voit, B.6
Aigner, A.7
-
52
-
-
77349095284
-
Polyethylenimine/small interfering RNA-mediated knockdown of vascular endothelial growth factor in vivo exerts anti-tumor effects synergistically with Bevacizumab
-
S. Hobel, I. Koburger, M. John, F. Czubayko, P. Hadwiger, H.P. Vornlocher, and A. Aigner Polyethylenimine/small interfering RNA-mediated knockdown of vascular endothelial growth factor in vivo exerts anti-tumor effects synergistically with Bevacizumab J. Gene Med. 12 2010 287 300
-
(2010)
J. Gene Med.
, vol.12
, pp. 287-300
-
-
Hobel, S.1
Koburger, I.2
John, M.3
Czubayko, F.4
Hadwiger, P.5
Vornlocher, H.P.6
Aigner, A.7
-
53
-
-
78651246499
-
Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA
-
A. Kano, K. Moriyama, T. Yamano, I. Nakamura, N. Shimada, and A. Maruyama Grafting of poly(ethylene glycol) to poly-lysine augments its lifetime in blood circulation and accumulation in tumors without loss of the ability to associate with siRNA J. Control. Release 149 2011 2 7
-
(2011)
J. Control. Release
, vol.149
, pp. 2-7
-
-
Kano, A.1
Moriyama, K.2
Yamano, T.3
Nakamura, I.4
Shimada, N.5
Maruyama, A.6
-
54
-
-
84870328406
-
Synthetic polyspermine imidazole-4, 5-amide as an efficient and cytotoxicity-free gene delivery system
-
S.Y. Duan, X.M. Ge, N. Lu, F. Wu, W. Yuan, and T. Jin Synthetic polyspermine imidazole-4, 5-amide as an efficient and cytotoxicity-free gene delivery system Int. J. Nanomedicine 7 2012 3813 3822
-
(2012)
Int. J. Nanomedicine
, vol.7
, pp. 3813-3822
-
-
Duan, S.Y.1
Ge, X.M.2
Lu, N.3
Wu, F.4
Yuan, W.5
Jin, T.6
-
55
-
-
79952803061
-
Dicetyl phosphate-tetraethylenepentamine-based liposomes for systemic siRNA delivery
-
T. Asai, S. Matsushita, E. Kenjo, T. Tsuzuku, N. Yonenaga, H. Koide, K. Hatanaka, T. Dewa, M. Nango, N. Maeda, H. Kikuchi, and N. Oku Dicetyl phosphate-tetraethylenepentamine-based liposomes for systemic siRNA delivery Bioconjug. Chem. 22 2011 429 435
-
(2011)
Bioconjug. Chem.
, vol.22
, pp. 429-435
-
-
Asai, T.1
Matsushita, S.2
Kenjo, E.3
Tsuzuku, T.4
Yonenaga, N.5
Koide, H.6
Hatanaka, K.7
Dewa, T.8
Nango, M.9
Maeda, N.10
Kikuchi, H.11
Oku, N.12
-
56
-
-
74349088676
-
Polymer vesicles with a red cell-like surface charge: Microvascular imaging and in vivo tracking with near-infrared fluorescence
-
D.A. Christian, O.B. Garbuzenko, T. Minko, and D.E. Discher Polymer vesicles with a red cell-like surface charge: microvascular imaging and in vivo tracking with near-infrared fluorescence Macromol. Rapid Commun. 31 2010 135 141
-
(2010)
Macromol. Rapid Commun.
, vol.31
, pp. 135-141
-
-
Christian, D.A.1
Garbuzenko, O.B.2
Minko, T.3
Discher, D.E.4
-
57
-
-
84887003262
-
Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivo
-
C.E. Nelson, J.R. Kintzing, A. Hanna, J.M. Shannon, M.K. Gupta, and C.L. Duvall Balancing cationic and hydrophobic content of PEGylated siRNA polyplexes enhances endosome escape, stability, blood circulation time, and bioactivity in vivo ACS Nano 7 2013 8870 8880
-
(2013)
ACS Nano
, vol.7
, pp. 8870-8880
-
-
Nelson, C.E.1
Kintzing, J.R.2
Hanna, A.3
Shannon, J.M.4
Gupta, M.K.5
Duvall, C.L.6
-
58
-
-
84882691457
-
The effect of N/P ratio on the in vitro and in vivo interaction properties of PEGylated poly[2-(dimethylamino)ethyl methacrylate]-based siRNA complexes
-
D.J. Gary, J. Min, Y. Kim, K. Park, and Y.Y. Won The effect of N/P ratio on the in vitro and in vivo interaction properties of PEGylated poly[2-(dimethylamino)ethyl methacrylate]-based siRNA complexes Macromol. Biosci. 13 2013 1059 1071
-
(2013)
Macromol. Biosci.
, vol.13
, pp. 1059-1071
-
-
Gary, D.J.1
Min, J.2
Kim, Y.3
Park, K.4
Won, Y.Y.5
-
59
-
-
84876464768
-
Ternary polymeric nanoparticles for oral siRNA delivery
-
J. Zhang, C. He, C. Tang, and C. Yin Ternary polymeric nanoparticles for oral siRNA delivery Pharm. Res. 30 2013 1228 1239
-
(2013)
Pharm. Res.
, vol.30
, pp. 1228-1239
-
-
Zhang, J.1
He, C.2
Tang, C.3
Yin, C.4
-
60
-
-
82955237641
-
Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice
-
J. Zhou, C.P. Neff, X. Liu, J. Zhang, H. Li, D.D. Smith, P. Swiderski, T. Aboellail, Y. Huang, Q. Du, Z. Liang, L. Peng, R. Akkina, and J.J. Rossi Systemic administration of combinatorial dsiRNAs via nanoparticles efficiently suppresses HIV-1 infection in humanized mice Mol. Ther. 19 2011 2228 2238
-
(2011)
Mol. Ther.
, vol.19
, pp. 2228-2238
-
-
Zhou, J.1
Neff, C.P.2
Liu, X.3
Zhang, J.4
Li, H.5
Smith, D.D.6
Swiderski, P.7
Aboellail, T.8
Huang, Y.9
Du, Q.10
Liang, Z.11
Peng, L.12
Akkina, R.13
Rossi, J.J.14
-
61
-
-
14544298301
-
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
-
R.M. Schiffelers, A. Ansari, J. Xu, Q. Zhou, Q. Tang, G. Storm, G. Molema, P.Y. Lu, P.V. Scaria, and M.C. Woodle Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle Nucleic Acids Res. 32 2004 e149
-
(2004)
Nucleic Acids Res.
, vol.32
, pp. 149
-
-
Schiffelers, R.M.1
Ansari, A.2
Xu, J.3
Zhou, Q.4
Tang, Q.5
Storm, G.6
Molema, G.7
Lu, P.Y.8
Scaria, P.V.9
Woodle, M.C.10
-
62
-
-
38549175181
-
A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum
-
K. Buyens, B. Lucas, K. Raemdonck, K. Braeckmans, J. Vercammen, J. Hendrix, Y. Engelborghs, S.C. De Smedt, and N.N. Sanders A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum J. Control. Release 126 2008 67 76
-
(2008)
J. Control. Release
, vol.126
, pp. 67-76
-
-
Buyens, K.1
Lucas, B.2
Raemdonck, K.3
Braeckmans, K.4
Vercammen, J.5
Hendrix, J.6
Engelborghs, Y.7
De Smedt, S.C.8
Sanders, N.N.9
-
63
-
-
78650476432
-
The Proton Sponge: A Trick to Enter Cells the Viruses Did Not Exploit
-
J.-P. Behr The proton sponge: a trick to enter cells the viruses did not exploit CHIMIA Int. J. Chem. 51 1997 34 36 (Pubitemid 127033737)
-
(1997)
Chimia
, vol.51
, Issue.1-2
, pp. 34-36
-
-
Behr, J.-P.1
-
64
-
-
0036179935
-
Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments
-
DOI 10.1023/A:1014212630566
-
T. Merdan, K. Kunath, D. Fischer, J. Kopecek, and T. Kissel Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments Pharm. Res. 19 2002 140 146 (Pubitemid 34165398)
-
(2002)
Pharmaceutical Research
, vol.19
, Issue.2
, pp. 140-146
-
-
Merdan, T.1
Kunath, K.2
Fischer, D.3
Kopecek, J.4
Kissel, T.5
-
65
-
-
65549133368
-
Delivery of macromolecules using arginine-rich cell-penetrating peptides: Ways to overcome endosomal entrapment
-
A. El-Sayed, S. Futaki, and H. Harashima Delivery of macromolecules using arginine-rich cell-penetrating peptides: ways to overcome endosomal entrapment AAPS J. 11 2009 13 22
-
(2009)
AAPS J.
, vol.11
, pp. 13-22
-
-
El-Sayed, A.1
Futaki, S.2
Harashima, H.3
-
66
-
-
33846813849
-
Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes
-
DOI 10.1016/j.ijpharm.2006.11.050, PII S037851730601009X
-
S. Oliveira, I. van Rooy, O. Kranenburg, G. Storm, and R.M. Schiffelers Fusogenic peptides enhance endosomal escape improving siRNA-induced silencing of oncogenes Int. J. Pharm. 331 2007 211 214 (Pubitemid 46216677)
-
(2007)
International Journal of Pharmaceutics
, vol.331
, Issue.2
, pp. 211-214
-
-
Oliveira, S.1
Van Rooy, I.2
Kranenburg, O.3
Storm, G.4
Schiffelers, R.M.5
|