Synthetic polyspermine imidazole-4, 5-amide as an efficient and cytotoxicity-free gene delivery system

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 3813-3822

  Duan, Shi Yue ^a   Ge, Xue Mei ^a   Lu, Nan ^a   Wu, Fei ^a   Yuan, Weien ^a   Jin, Tuo ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Biodistribution; Cytotoxicity; Gene delivery; Polyspermine; Transfection efficiency

Indexed keywords

DICARBOXYLIC ACID DERIVATIVE; IMIDAZOLE 4,5 DICARBOXYLIC ACID; LUCIFERASE; PHOSPHATE BUFFERED SALINE; PLASMID DNA; POLYSPERMINE IMIDAZOLE 4,5 AMIDE; RHODAMINE B; SMALL INTERFERING RNA; SPERMINE; SPERMINE DERIVATIVE; UNCLASSIFIED DRUG;

ADSORPTION KINETICS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MEDIATED CYTOTOXICITY; CELL VIABILITY; CHEMICAL BOND; CONTROLLED STUDY; CYTOTOXICITY TEST; DEGRADATION KINETICS; DNA TRANSFECTION; DRUG CONJUGATION; DRUG RELEASE; DRUG STABILITY; GENE DELIVERY SYSTEM; GENE SILENCING; GENETIC LINKAGE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LINKAGE ANALYSIS; LYSOSOME; MOUSE; NONHUMAN; PH MEASUREMENT; PHYSICAL CHEMISTRY; PROCESS OPTIMIZATION; STRUCTURE ANALYSIS; SURFACE PROPERTY; TRANSMISSION ELECTRON MICROSCOPY; ZETA POTENTIAL;

AMIDES; ANIMALS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COS CELLS; DNA; DRUG CARRIERS; GENE TRANSFER TECHNIQUES; HEP G2 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; MICE; MICE, INBRED BALB C; MICE, NUDE; PARTICLE SIZE; PLASMIDS; POLYETHYLENEIMINE; POLYMERS; RHODAMINES; RNA, SMALL INTERFERING; SPERMINE; TISSUE DISTRIBUTION; TRANSFECTION;

MUS MUSCULUS;

EID: 84870328406     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S33101     Document Type: Article

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