Molecular modeling and in vivo imaging can identify successful flexible triazine dendrimer-based siRNA delivery systems

Journal of Controlled Release

Volumn 153, Issue 1, 2011, Pages 23-33

  Merkel, Olivia M ^a   Zheng, Mengyao ^a   Mintzer, Meredith A ^b   Pavan, Giovanni M ^c   Librizzi, Damiano ^d   Maly, Marek ^c,e   Höffken, Helmut ^d   Danani, Andrea ^c   Simanek, Eric E ^f   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b BOSTON UNIVERSITY   (United States)

^c UNIVERSITY OF APPLIED SCIENCES AND ARTS OF SOUTHERN SWITZERLAND   (Switzerland)

^d UNIVERSITY HOSPITAL MARBURG   (Germany)

^e J E PURKINJE UNIVERSITY   (Czech Republic)

^f TEXAS CHRISTIAN UNIVERSITY   (United States)

Author keywords

Biodistribution; Molecular modeling; Pharmacokinetics; RNA interference; SPECT imaging; Triazine dendrimers

Indexed keywords

BINDING PROPERTIES; BIODISTRIBUTIONS; CELLULAR UPTAKE; CIRCULATION TIME; DENDRIPLEXES; EXPERIMENTAL PARAMETERS; HYDRODYNAMIC DIAMETER; IN-VITRO; IN-VIVO; IN-VIVO IMAGING; MOLECULAR IMAGING; NON-INVASIVE; PHARMACOKINETIC PROFILES; PHYSICO-CHEMICALS; POLYPLEXES; RAPID DEVELOPMENT; RNA INTERFERENCE; SCINTILLATION COUNTING; SIRNA DELIVERY; SPECT IMAGING; STABLE COMPLEXES; THERMODYNAMIC PARAMETER; TRIAZINE DENDRIMERS;

AGGLOMERATION; BINDING ENERGY; HYDRODYNAMICS; MOLECULAR MODELING; PHARMACOKINETICS; RNA; ZETA POTENTIAL; MOLECULAR IMAGING;

DENDRIMERS;

DENDRIMER; SMALL INTERFERING RNA; TRIAZINE;

ANIMAL EXPERIMENT; CELL TRANSPORT; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG SYNTHESIS; HELA CELL; HUMAN; HUMAN CELL; HYDRODYNAMICS; IN VIVO STUDY; MOLECULAR DYNAMICS; MOLECULAR IMAGING; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; ZETA POTENTIAL; COMPLEX FORMATION; ENDOCYTOSIS; IN VITRO STUDY; THERMODYNAMICS;

ANIMALS; DENDRIMERS; HUMANS; MICE; MICE, INBRED BALB C; MOLECULAR DYNAMICS SIMULATION; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSFECTION; TRIAZINES;

EID: 79960091210     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.02.016     Document Type: Conference Paper

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