In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI(-PEG)/siRNA complexes

Toxicology and Applied Pharmacology

Volumn 236, Issue 1, 2009, Pages 97-108

  Malek, Anastasia ^a   Merkel, Olivia ^a   Fink, Ludger ^b   Czubayko, Frank ^a   Kissel, Thomas ^a   Aigner, Achim ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Biodistribution; In vivo pharmacokinetics; PEI PEG; Polyethylenimine; RNAi; siRNAs

Indexed keywords

COPOLYMER; MACROGOL; POLYETHYLENEIMINE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLEEDING; CHEMICAL REACTION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG STABILITY; DRUG UPTAKE; ERYTHROCYTE AGGREGATION; GENE TARGETING; IN VIVO STUDY; ISOTOPE LABELING; KIDNEY; LIVER; LUNG; MACROPHAGE FUNCTION; MALE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PROTECTION; RNA DEGRADATION; RNA INTERFERENCE; RNA TRANSPORT; SPLEEN; TISSUE DISTRIBUTION;

ANIMALS; BIOTRANSFORMATION; ERYTHROCYTE AGGREGATION; GENE TRANSFER TECHNIQUES; HEMORRHAGE; INJECTIONS, INTRAVENOUS; KIDNEY; LIVER; LUNG; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RNA INTERFERENCE; RNA, SMALL INTERFERING; SPLEEN; TISSUE DISTRIBUTION;

MUS;

EID: 61849103493     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.01.014     Document Type: Article

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