Nonviral siRNA delivery to the lung: Investigation of PEG-PEI polyplexes and their in vivo performance

Molecular Pharmaceutics

Volumn 6, Issue 4, 2009, Pages 1246-1260

  Merkel, Olivia M ^a   Beyerle, Andrea ^a,b   Librizzi, Damiano ^c   Pfestroff, Andreas ^c   Behr, Thomas M ^c   Sproat, Brian ^d   Barth, Peter J ^c   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY HOSPITAL MARBURG   (Germany)

^d INTEGRATED DNA TECHNOLOGIES   (United States)

Author keywords

GFP; Intratracheal; Knockdown; Lung; Lung surfactant; Mucin; Nonviral vectors; PEI; siRNA; SPECT

Indexed keywords

MACROGOL; MACROSALB TC 99M; MUCIN; NANOCARRIER; PENTETATE INDIUM IN 111; POLYETHYLENEIMINE; SMALL INTERFERING RNA; SURFACTANT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELLULAR IMMUNITY; CIRCULAR DICHROISM; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DISTRIBUTION; GENE EXPRESSION; HUMORAL IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; LUNG; LUNG LAVAGE; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; SCINTILLATION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CIRCULAR DICHROISM; DRUG DELIVERY SYSTEMS; FLOW CYTOMETRY; GENE KNOCKDOWN TECHNIQUES; GREEN FLUORESCENT PROTEINS; LUNG; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MUCINS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 68249122805     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900107v     Document Type: Article

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