In vitro and in vivo complement activation and related anaphylactic effects associated with polyethylenimine and polyethylenimine-graft-poly(ethylene glycol) block copolymers

Biomaterials

Volumn 32, Issue 21, 2011, Pages 4936-4942

  Merkel, Olivia M ^a   Urbanics, Rudolf ^b   Bedocs, Peter ^b,c   Rozsnyay, Zoltán ^b   Rosivall, László ^b,c   Toth, Miklós ^d   Kissel, Thomas ^a   Szebeni, Janos ^b,e,f  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b SeroScience Ltd   (Hungary)

^c SEMMELWEIS UNIVERSITY   (Hungary)

^d UNIVERSITY OF PHYSICAL EDUCATION   (Hungary)

^e BAY ZOLTÁN NONPROFIT LTD FOR APPLIED RESEARCH   (Hungary)

^f UNIVERSITY OF MISKOLC   (Hungary)

Author keywords

Cardiopulmonary distress; CARPA; Complement activation; PEGylation; PEI; Swine model

Indexed keywords

CARDIOPULMONARY DISTRESS; CARPA; COMPLEMENT ACTIVATION; PEGYLATION; PEI; SWINE MODEL;

BLOCK COPOLYMERS; DRUG DELIVERY; DRUG INTERACTIONS; ETHYLENE; ETHYLENE GLYCOL; GENE EXPRESSION; MOLECULAR WEIGHT; NUCLEIC ACIDS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES;

POLYMERS;

ETHYLENEIMINE ETHYLENE GLYCOL COPOLYMER; MACROGOL; POLYETHYLENEIMINE; UNCLASSIFIED DRUG;

ANAPHYLAXIS; ANIMAL EXPERIMENT; ARTICLE; COMPLEMENT ACTIVATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS TOLERANCE; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG SAFETY; FEMALE; HUMAN; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE; TACHYPHYLAXIS;

ANAPHYLAXIS; ANIMALS; BIOCOMPATIBLE MATERIALS; COMPLEMENT ACTIVATION; DRUG DELIVERY SYSTEMS; GENE TRANSFER TECHNIQUES; HEMODYNAMICS; HUMANS; MATERIALS TESTING; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; SWINE;

SUIDAE;

EID: 79955782283     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.03.035     Document Type: Article

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