Enhancing in vivo circulation and siRNA delivery with biodegradable polyethylenimine-graft-polycaprolactone-block-poly(ethylene glycol) copolymers

Biomaterials

Volumn 33, Issue 27, 2012, Pages 6551-6558

  Zheng, Mengyao ^a   Librizzi, Damiano ^b   Kiliç, Ayşe ^a   Liu, Yu ^a,c   Renz, Harald ^a   Merkel, Olivia M ^a,d   Kissel, Thomas ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY HOSPITAL GIESSEN   (Germany)

^c UNIVERSITY OF ELECTRONIC SCIENCE AND TECHNOLOGY OF CHINA   (China)

^d WAYNE STATE UNIVERSITY   (United States)

Author keywords

Biodegradable polycations; In vivo biodistribution and pharmacokinetics; Non viral polymeric nanocarriers; SiRNA delivery; SPECT imaging

Indexed keywords

IN-VIVO; POLYCATIONS; POLYMERIC NANOCARRIERS; SIRNA DELIVERY; SPECT IMAGING;

BIODEGRADABLE POLYMERS; CARDIOVASCULAR SYSTEM; CONFOCAL MICROSCOPY; COPOLYMERS; FLOW CYTOMETRY; GOLD COMPOUNDS; GRAFTING (CHEMICAL); POLYCAPROLACTONE; POLYETHYLENE OXIDES; RNA;

POLYETHYLENE GLYCOLS;

COPOLYMER; GAPDH PROTEIN; HEPARIN; NANOCARRIER; POLYCAPROLACTONE; POLYETHYLENE; POLYETHYLENEIMINE; POLYETHYLENIMINE GRAFT POLYCAPROLACTONE BLOCK POLYETHYLENE GLYCOL COPOLYMER; PROTEIN DERIVATIVE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BIODEGRADABILITY; BIODEGRADABLE IMPLANT; CELL NUCLEUS; CIRCULATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOSOL; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG UPTAKE; FLOW CYTOMETRY; GRAFT DYSFUNCTION; IN VIVO STUDY; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

ANIMALS; ANIONS; BIOCOMPATIBLE MATERIALS; BIODEGRADATION, ENVIRONMENTAL; CELL LINE, TUMOR; ETHYLENE GLYCOLS; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; HUMANS; HYDRODYNAMICS; MICE; MICE, INBRED BALB C; MICROSCOPY, CONFOCAL; PARTICLE SIZE; POLYESTERS; POLYETHYLENEIMINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; STATIC ELECTRICITY; TISSUE DISTRIBUTION; TRANSFECTION;

EID: 84863587750     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.05.055     Document Type: Article

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