HSP47 siRNA conjugated with cationized gelatin microspheres suppresses peritoneal fibrosis in mice

Acta Biomaterialia

Volumn 8, Issue 7, 2012, Pages 2688-2696

  Obata, Yoko ^a,b   Nishino, Tomoya ^a   Kushibiki, Toshihiro ^c   Tomoshige, Ryuji ^c   Xia, Zhiyin ^a   Miyazaki, Masanobu ^d   Abe, Katsushige ^e   Koji, Takehiko ^f   Tabata, Yasuhiko ^c   Kohno, Shigeru ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NAGASAKI UNIVERSITY HOSPITAL   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d Miyazaki Clinic   (Japan)

^e Jinikai Hospital   (Japan)

^f NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

Cationized gelatin microspheres; HSP47; Peritoneal dialysis; Peritoneal fibrosis; siRNA

Indexed keywords

BIOCHEMISTRY; CONTROLLED DRUG DELIVERY; MAMMALS; MICROSPHERES; RNA; TARGETED DRUG DELIVERY;

CATIONIZED GELATIN MICROSPHERES; CHLORHEXIDINE; COLLAGEN EXPRESSION; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 47; MACROPHAGE INFILTRATIONS; MOLECULAR CHAPERONES; PERITONEAL DIALYSIS; PERITONEAL FIBROSE; SMALL INTERFERING RNA;

COLLAGEN;

CATIONIZED GELATIN MICROSPHERE; COLLAGEN; GELATIN; HEAT SHOCK PROTEIN 47; HSP 47 SMALL INTERFERING RNA; MICROSPHERE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; MACROPHAGE; MALE; MOUSE; NONHUMAN; PERITONEAL FIBROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; SINGLE DRUG DOSE; TREATMENT OUTCOME;

MUS;

EID: 84861582256     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2012.03.050     Document Type: Article

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