Bioreducible polyethylenimine-delivered siRNA targeting human telomerase reverse transcriptase inhibits HepG2 cell growth in vitro and in vivo

Journal of Controlled Release

Volumn 157, Issue 3, 2012, Pages 427-436

  Xia, Wei ^a,b   Wang, Peijun ^a   Lin, Chao ^a,c   Li, Zhuoquan ^a   Gao, Xiaolong ^a   Wang, Guoliang ^a   Zhao, Xiaohu ^a  

^a TONGJI UNIVERSITY   (China)

^b Putuo District People Hospital ^*  (China)

^c FUDAN UNIVERSITY   (China)

Author keywords

Disulfide; Human telomerase reverse transcriptase; Liver kidney function test; Polyethylenimine; RNA interference; SS PEI

Indexed keywords

DISULFIDE; HUMAN TELOMERASE; POLYETHYLENIMINES; RNA INTERFERENCE; SS-PEI;

CELL DEATH; CELL GROWTH; COVALENT BONDS; GENETIC ENGINEERING; GROWTH KINETICS; RNA;

MOLECULAR BIOLOGY;

DISULFIDE; POLYETHYLENEIMINE; SMALL INTERFERING RNA; TELOMERASE REVERSE TRANSCRIPTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL STRAIN HEPG2; CYTOTOXICITY; DISULFIDE BOND; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; CELL LINE, TUMOR; DRUG CARRIERS; GENE SILENCING; GENE THERAPY; HUMANS; KIDNEY; LIVER; MALE; MICE; MICE, NUDE; NEOPLASMS; POLYETHYLENEIMINE; RATS; RNA, SMALL INTERFERING; TELOMERASE; TISSUE DISTRIBUTION; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84857370161     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.10.011     Document Type: Article

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