-
2
-
-
23844558266
-
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine
-
Wallace DC. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: A dawn for evolutionary medicine. Annu Rev Genet 2005 39 359-407
-
(2005)
Annu Rev Genet
, vol.39
, pp. 359-407
-
-
Wallace, D.C.1
-
3
-
-
84859897199
-
Mitochondrial and aging
-
Lee HC, Wei YH. Mitochondrial and aging. Adv Exp Med Biol 2012 942 311-327
-
(2012)
Adv Exp Med Biol
, vol.942
, pp. 311-327
-
-
Lee, H.C.1
Wei, Y.H.2
-
5
-
-
84863515775
-
Mitochondrial respiratory chain Dysfunction: Implications in neurodegeneration
-
Mor a n M, Moreno-Lastres D, Mar i n-Buera L, Arenas J, Martin MA, Ugalde C. Mitochondrial respiratory chain Dysfunction: Implications in neurodegeneration. Free Radic Biol Med 2012 53 595-609
-
(2012)
Free Radic Biol Med
, vol.53
, pp. 595-609
-
-
Moran, M.1
Moreno-Lastres, D.2
Marin-Buera, L.3
Arenas, J.4
Martin, M.A.5
Ugalde, C.6
-
6
-
-
84881587735
-
Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging
-
Wang CH, Wu SB, Wu YT, Wei YH. Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging. Exp Biol Med (Maywood) 2013 238 450-460
-
(2013)
Exp Biol Med (Maywood
, vol.238
, pp. 450-460
-
-
Wang, C.H.1
Wu, S.B.2
Wu, Y.T.3
Wei, Y.H.4
-
7
-
-
77149120797
-
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic fl ux
-
Wang Q, Zhang Y, Yang C, Xiong H, Lin Y, Yao J, et al. Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic fl ux. Science 2010; 327: 1004-1007
-
(2010)
Science
, vol.327
, pp. 1004-1007
-
-
Wang, Q.1
Zhang, Y.2
Yang, C.3
Xiong, H.4
Lin, Y.5
Yao, J.6
-
8
-
-
37549002891
-
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
-
Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, et al. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol 2007 27 8807-8814
-
(2007)
Mol Cell Biol
, vol.27
, pp. 8807-8814
-
-
Lombard, D.B.1
Alt, F.W.2
Cheng, H.L.3
Bunkenborg, J.4
Streeper, R.S.5
Mostoslavsky, R.6
-
9
-
-
80054746880
-
Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation
-
Lombard DB, Tishkoff DX, Bao J. Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation . Handb Exp Pharmacol 2011 206 163-188
-
(2011)
Handb Exp Pharmacol
, vol.206
, pp. 163-188
-
-
Lombard, D.B.1
Tishkoff, D.X.2
Bao, J.3
-
10
-
-
82455212901
-
SIRT3 defi ciency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome
-
Hirschey MD, Shimazu T, Jing E, Grueter CA, Collins AM, Aouizerat B, et al. SIRT3 defi ciency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell 2011 44 177-190
-
(2011)
Mol Cell
, vol.44
, pp. 177-190
-
-
Hirschey, M.D.1
Shimazu, T.2
Jing, E.3
Grueter, C.A.4
Collins, A.M.5
Aouizerat, B.6
-
11
-
-
77953285831
-
Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia
-
Gertz M, Steegborn C. Function and regulation of the mitochondrial sirtuin isoform Sirt5 in Mammalia. Biochim Biophys Acta 2 010; 1 804: 1 658-665
-
(2010)
Biochim Biophys Acta
, vol.804
, pp. 658-665
-
-
Gertz, M.1
Steegborn, C.2
-
12
-
-
34547697009
-
Metabolism, cytoskeleton and cellular signaling in the grip of protein N- and O-Acetylation
-
Yang XY, Gr e goire S. Metabolism, cytoskeleton and cellular signaling in the grip of protein N- And O-Acetylation. EMBO Rep 2007 8 556-562
-
(2007)
EMBO Rep
, vol.8
, pp. 556-562
-
-
Yang, X.Y.1
Gregoire, S.2
-
13
-
-
84870658312
-
Dietary regulation of histone acetylases and deacetylases for the prevention of metabolic diseases
-
Pham TX, Lee J. Dietary regulation of histone acetylases and deacetylases for the prevention of metabolic diseases. Nutrients 2 012; 4 1 868-1 886
-
(2012)
Nutrients
, vol.4
, pp. 868-886
-
-
Pham, T.X.1
Lee, J.2
-
14
-
-
34547897023
-
Histone deacetylases and cancer
-
Glozak MA, Seto E. Histone deacetylases and cancer. Oncogene 2007 26 5420-5432
-
(2007)
Oncogene
, vol.26
, pp. 5420-5432
-
-
Glozak, M.A.1
Seto, E.2
-
15
-
-
33746228121
-
Sirtuins in aging and age-related disease
-
Longo VD, Kennedy BK. Sirtuins in aging and age-related disease. Cell 2006 126 257-268
-
(2006)
Cell
, vol.126
, pp. 257-268
-
-
Longo, V.D.1
Kennedy, B.K.2
-
16
-
-
33746992118
-
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey
-
Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, et al. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell 2006 23 607-618
-
(2006)
Mol Cell
, vol.23
, pp. 607-618
-
-
Kim, S.C.1
Sprung, R.2
Chen, Y.3
Xu, Y.4
Ball, H.5
Pei, J.6
-
17
-
-
34547914840
-
Sirtuins: The ' magnifi cent seven ', function, metabolism and longevity
-
Dali-Youcef N, Lagouge M, Froelich S, Koehl C, Schoonjans K, Auwerx J. Sirtuins: The ' magnifi cent seven ', function, metabolism and longevity. Ann Med 2007; 39: 335-345
-
(2007)
Ann Med
, vol.39
, pp. 335-345
-
-
Dali-Youcef, N.1
Lagouge, M.2
Froelich, S.3
Koehl, C.4
Schoonjans, K.5
Auwerx, J.6
-
18
-
-
0037130175
-
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
-
Lin SJ, Kaeberlein M, Andalis AA, Sturtz LA, Defossez PA, Culotta VC, et al. Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 2002 418 344-348
-
(2002)
Nature
, vol.418
, pp. 344-348
-
-
Lin, S.J.1
Kaeberlein, M.2
Andalis, A.A.3
Sturtz, L.A.4
Defossez, P.A.5
Culotta, V.C.6
-
19
-
-
13944253348
-
Calorie restriction-The SIR2 connection
-
Guarente L, Picard F. Calorie restriction-The SIR2 connection . Cell 2005 120 473-482
-
(2005)
Cell
, vol.120
, pp. 473-482
-
-
Guarente, L.1
Picard, F.2
-
20
-
-
77949887506
-
Mammalian sirtuins: Biological insights and disease relevance
-
Haigis MC, Sinclair DA. Mammalian sirtuins: Biological insights and disease relevance. Annu Rev Pathol 2010 5 253-295
-
(2010)
Annu Rev Pathol
, vol.5
, pp. 253-295
-
-
Haigis, M.C.1
Sinclair, D.A.2
-
21
-
-
77955452426
-
SIRT1 regulates thyroid-stimulating hormone release by enhancing PIP5Kgamma activity through deacetylation of specifi c lysine residues in mammals
-
Akieda-Asai S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, et al. SIRT1 regulates thyroid-stimulating hormone release by enhancing PIP5Kgamma activity through deacetylation of specifi c lysine residues in mammals. PLoS One 2010 5 e11755
-
(2010)
PLoS One
, vol.5
-
-
Akieda-Asai, S.1
Zaima, N.2
Ikegami, K.3
Kahyo, T.4
Yao, I.5
Hatanaka, T.6
-
22
-
-
77953257025
-
Aging and disease: Connections to sirtuins
-
Donmez G, Guarente L. Aging and disease: Connections to sirtuins. Aging Cell 2010 9 285-290
-
(2010)
Aging Cell
, vol.9
, pp. 285-290
-
-
Donmez, G.1
Guarente, L.2
-
23
-
-
33748316536
-
SIRT4 inhibits glutamate dehydrogenase and opposes the eff ects of calorie restriction in pancreatic beta cells
-
Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, et al. SIRT4 inhibits glutamate dehydrogenase and opposes the eff ects of calorie restriction in pancreatic beta cells. Cell 2006 126 941-954
-
(2006)
Cell
, vol.126
, pp. 941-954
-
-
Haigis, M.C.1
Mostoslavsky, R.2
Haigis, K.M.3
Fahie, K.4
Christodoulou, D.C.5
Murphy, A.J.6
-
24
-
-
50149103440
-
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5
-
Schlicker C, Gertz M, Papatheodorou P, Kachholz B, Becker CF, Steegborn C. Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5. J Mol Biol 2008 382 790-801
-
(2008)
J Mol Biol
, vol.382
, pp. 790-801
-
-
Schlicker, C.1
Gertz, M.2
Papatheodorou, P.3
Kachholz, B.4
Becker, C.F.5
Steegborn, C.6
-
25
-
-
55749084738
-
A role for the mitochondrial deactylase Sirt3 in regulating energy homeostasis
-
Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, et al. A role for the mitochondrial deactylase Sirt3 in regulating energy homeostasis. Proc Natl Acad Sci USA 2008 105 14447-14452
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 14447-14452
-
-
Ahn, B.H.1
Kim, H.S.2
Song, S.3
Lee, I.H.4
Liu, J.5
Vassilopoulos, A.6
-
26
-
-
84868562852
-
Regulation of mitochondrial F o F 1 ATPase activity by Sirt3-catalyzed deacetylation and its defi ciency in human cells harboring 4977 bp deletion of mitochondrial DNA
-
Wu YT, Lee HC, Liao CC, Wei YH. Regulation of mitochondrial F o F 1 ATPase activity by Sirt3-catalyzed deacetylation and its defi ciency in human cells harboring 4977 bp deletion of mitochondrial DNA. Biochim Biophys Acta 2013; 1832: 216-227
-
(2013)
Biochim Biophys Acta
, vol.1832
, pp. 216-227
-
-
Wu, Y.T.1
Lee, H.C.2
Liao, C.C.3
Wei, Y.H.4
-
27
-
-
84881538902
-
Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fi broblasts
-
Liang Q, Benavides GA, Vassilopoulos A, Gius D, Darley-Usmar V, Zhang J. Bioenergetic and autophagic control by Sirt3 in response to nutrient deprivation in mouse embryonic fi broblasts. Biochem J 2013 454 249-257
-
(2013)
Biochem J
, vol.454
, pp. 249-257
-
-
Liang, Q.1
Benavides, G.A.2
Vassilopoulos, A.3
Gius, D.4
Darley-Usmar, V.5
Zhang, J.6
-
28
-
-
80051716282
-
Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity
-
Finley LW, Haas W, Desquiret-Dumas V, Wallace DC, Procaccio V, Gygi SP, et al. Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PLoS One 2011 6 e23295
-
(2011)
PLoS One
, vol.6
-
-
Finley, L.W.1
Haas, W.2
Desquiret-Dumas, V.3
Wallace, D.C.4
Procaccio, V.5
Gygi, S.P.6
-
29
-
-
77950806433
-
SIRT3 regulates mitochondrial fatty-Acid oxidation by reversible enzyme deacetylation
-
Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, et al. SIRT3 regulates mitochondrial fatty-Acid oxidation by reversible enzyme deacetylation. Nature 2010 464 121-125
-
(2010)
Nature
, vol.464
, pp. 121-125
-
-
Hirschey, M.D.1
Shimazu, T.2
Goetzman, E.3
Jing, E.4
Schwer, B.5
Lombard, D.B.6
-
30
-
-
78751513117
-
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
-
Kendrick AA, Choudhury M, Rahman SM, McCurdy CE, Friederich M, Van Hove JL, et al. Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. Biochem J 2011 433 505-514
-
(2011)
Biochem J
, vol.433
, pp. 505-514
-
-
Kendrick, A.A.1
Choudhury, M.2
Rahman, S.M.3
McCurdy, C.E.4
Friederich, M.5
Van Hove, J.L.6
-
31
-
-
84888329025
-
Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site
-
Bharathi SS, Zhang Y, Mohsen AW, Uppala R, Balasubramani M, Schreiber E, et al. Sirtuin 3 (SIRT3) protein regulates long-chain acyl-CoA dehydrogenase by deacetylating conserved lysines near the active site. J Biol Chem 2013 288 33837-33847
-
(2013)
J Biol Chem
, vol.288
, pp. 33837-33847
-
-
Bharathi, S.S.1
Zhang, Y.2
Mohsen, A.W.3
Uppala, R.4
Balasubramani, M.5
Schreiber, E.6
-
32
-
-
17144424946
-
SIRT3 a mitochondrial sirtuin Deacetylase regulates mitochondrial function and thermogenesis in brown adipocytes
-
Shi T, Wang F, Stieren E, Tong Q. SIRT3, a mitochondrial sirtuin Deacetylase, regulates mitochondrial function and thermogenesis in brown adipocytes. J Biol Chem 2005 280 13560-13567
-
(2005)
J Biol Chem
, vol.280
, pp. 13560-13567
-
-
Shi, T.1
Wang, F.2
Stieren, E.3
Tong, Q.4
-
33
-
-
76349125988
-
SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells
-
Shi T, Fan GQ, Xiao SD. SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells. J Dig Dis 2010 11 55-62
-
(2010)
J Dig Dis
, vol.11
, pp. 55-62
-
-
Shi, T.1
Fan, G.Q.2
Xiao, S.D.3
-
34
-
-
77952940043
-
Diet and exercise signals regulate SIRT3and activate AMPK and PGC-1alpha in skeletal muscle
-
Palacios OM, Carmona JJ, Michan S, Chen KY, Manabe Y, Ward JL 3rd, et al. Diet and exercise signals regulate SIRT3and activate AMPK and PGC-1alpha in skeletal muscle . Aging (Albany NY) 2009 1 771-783
-
(2009)
Aging (Albany NY
, vol.1
, pp. 771-783
-
-
Palacios, O.M.1
Carmona, J.J.2
Michan, S.3
Chen, K.Y.4
Manabe, Y.5
Ward III, J.L.6
-
35
-
-
84859951790
-
SIRT3 protein Deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status
-
Yu W, Dittenhafer-Reed KE, Denu JM. SIRT3 protein Deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status. J Biol Chem. 2012; 287: 14078-14086
-
(2012)
J Biol Chem
, vol.287
, pp. 14078-14086
-
-
Yu, W.1
Dittenhafer-Reed, K.E.2
Denu, J.M.3
-
36
-
-
84895522697
-
Are sirtuin Deacylase enzymes important modulators of mitochondrial energy metabolism?
-
Osborne B, Cooney GJ, Turner N. Are sirtuin Deacylase enzymes important modulators of mitochondrial energy metabolism?. Biochim Biophys Acta 2014 1840 1295-1302
-
(2014)
Biochim Biophys Acta
, vol.1840
, pp. 1295-1302
-
-
Osborne, B.1
Cooney, G.J.2
Turner, N.3
-
37
-
-
78651468707
-
Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction
-
Hallows WC, Yu W, Smith BC, Devries MK, Ellinger JJ, Someya S, et al. Sirt3 promotes the urea cycle and fatty acid oxidation During dietary restriction. Mol Cell 2011 41 139-149
-
(2011)
Mol Cell
, vol.41
, pp. 139-149
-
-
Hallows, W.C.1
Yu, W.2
Smith, B.C.3
Devries, M.K.4
Ellinger, J.J.5
Someya, S.6
-
38
-
-
78649509214
-
SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production
-
Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, et al. SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab 2010; 12: 654-661
-
(2010)
Cell Metab
, vol.12
, pp. 654-661
-
-
Shimazu, T.1
Hirschey, M.D.2
Hua, L.3
Dittenhafer-Reed, K.E.4
Schwer, B.5
Lombard, D.B.6
-
39
-
-
33745889628
-
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
-
Schwer B, Bunkenborg J, Verdin RO, Andersen JS, Verdin E. Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2. Proc Natl Acad Sci U S A. 2006 103 10224-10229
-
(2006)
Proc Natl Acad Sci U S A.
, vol.103
, pp. 10224-10229
-
-
Schwer, B.1
Bunkenborg, J.2
Verdin, R.O.3
Andersen, J.S.4
Verdin, E.5
-
40
-
-
33745931074
-
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases
-
Hallows WC, Lee S, Denu JM. Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases. Proc Natl Acad Sci USA 2006 103 10230-10235
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 10230-10235
-
-
Hallows, W.C.1
Lee, S.2
Denu, J.M.3
-
41
-
-
80052291180
-
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
-
Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, et al. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci USA 2011 108 14608-14613
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 14608-14613
-
-
Jing, E.1
Emanuelli, B.2
Hirschey, M.D.3
Boucher, J.4
Lee, K.Y.5
Lombard, D.6
-
42
-
-
65249087389
-
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle
-
Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell 2009 137 560-570
-
(2009)
Cell
, vol.137
, pp. 560-570
-
-
Nakagawa, T.1
Lomb, D.J.2
Haigis, M.C.3
Guarente, L.4
-
43
-
-
25844520458
-
Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism
-
Jezek P, Hlavata L. Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism. Int J Biochem Cell Biol 2005 37 2478-2503
-
(2005)
Int J Biochem Cell Biol
, vol.37
, pp. 2478-2503
-
-
Jezek, P.1
Hlavata, L.2
-
44
-
-
33745631769
-
Cell signaling H2O2, a necessary evil for cell signaling
-
Rhee SG. Cell signaling. H2O2, a necessary evil for cell signaling. Science 2006 312 1882-1883
-
(2006)
Science
, vol.312
, pp. 1882-1883
-
-
Rhee, S.G.1
-
45
-
-
33749986298
-
Free radicals and antioxidants in normal physiological functions and human Disease
-
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human Disease. Int J Biochem Cell Biol 2007 39 44-84
-
(2007)
Int J Biochem Cell Biol
, vol.39
, pp. 44-84
-
-
Valko, M.1
Leibfritz, D.2
Moncol, J.3
Cronin, M.T.4
Mazur, M.5
Telser, J.6
-
46
-
-
0038162526
-
Mitochondrial DNA mutations and oxidative stress in mitochondrial diseases
-
Wei YH, Lee HC. Mitochondrial DNA mutations and oxidative stress in mitochondrial diseases. Adv Clin Chem 2003 37 83-128
-
(2003)
Adv Clin Chem
, vol.37
, pp. 83-128
-
-
Wei, Y.H.1
Lee, H.C.2
-
47
-
-
13944278132
-
Mitochondria, oxidants, and aging
-
Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell 2005 120 483-495
-
(2005)
Cell
, vol.120
, pp. 483-495
-
-
Balaban, R.S.1
Nemoto, S.2
Finkel, T.3
-
48
-
-
84881587735
-
Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging
-
Wang CH, Wu SB, Wu YT, Wei YH. Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging. Exp Biol Med (Maywood). 2013 238 450-460
-
(2013)
Exp Biol Med (Maywood
, vol.238
, pp. 450-460
-
-
Wang, C.H.1
Wu, S.B.2
Wu, Y.T.3
Wei, Y.H.4
-
49
-
-
78650248160
-
Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress
-
Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, et al. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Mol Cell 2010; 40: 893-904
-
(2010)
Mol Cell
, vol.40
, pp. 893-904
-
-
Tao, R.1
Coleman, M.C.2
Pennington, J.D.3
Ozden, O.4
Park, S.H.5
Jiang, H.6
-
50
-
-
78649521247
-
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
-
Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab 2010 12 662-667
-
(2010)
Cell Metab
, vol.12
, pp. 662-667
-
-
Qiu, X.1
Brown, K.2
Hirschey, M.D.3
Verdin, E.4
Chen, D.5
-
51
-
-
79959541505
-
Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress
-
Ozden O, Park SH, Kim HS, Jiang H, Coleman MC, Spitz DR, Gius D. Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress. Aging (Albany NY) 2011 3 102-107
-
(2011)
Aging (Albany NY
, vol.3
, pp. 102-107
-
-
Ozden, O.1
Park, S.H.2
Kim, H.S.3
Jiang, H.4
Coleman, M.C.5
Spitz, D.R.6
Gius, D.7
-
52
-
-
79957979314
-
Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS
-
Chen Y, Zhang J, Lin Y, Lei Q, Guan KL, Zhao S, et al. Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. EMBO Rep 2011 12 534-541
-
(2011)
EMBO Rep
, vol.12
, pp. 534-541
-
-
Chen, Y.1
Zhang, J.2
Lin, Y.3
Lei, Q.4
Guan, K.L.5
Zhao, S.6
-
53
-
-
81855213133
-
Isocitrate dehydrogenase mutations in gliomas: Mechanisms, biomarkers and therapeutic target
-
Guo C, Pirozzi CJ, Lopez GY, Yan H. Isocitrate dehydrogenase mutations in gliomas: Mechanisms, biomarkers and therapeutic target. Curr Opin Neurol 2011 24 648-652
-
(2011)
Curr Opin Neurol
, vol.24
, pp. 648-652
-
-
Guo, C.1
Pirozzi, C.J.2
Lopez, G.Y.3
Yan, H.4
-
54
-
-
78651468722
-
Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction
-
Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C et al. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell 2010 143 802-812
-
(2010)
Cell
, vol.143
, pp. 802-812
-
-
Someya, S.1
Yu, W.2
Hallows, W.C.3
Xu, J.4
Vann, J.M.5
Leeuwenburgh, C.6
-
55
-
-
84881076472
-
Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress
-
Cheng Y, Ren X, Gowda AS, Shan Y, Zhang L, Yuan YS, et al. Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress. Cell Death Dis 2013 4 e731
-
(2013)
Cell Death Dis
, vol.4
-
-
Cheng, Y.1
Ren, X.2
Gowda, A.S.3
Shan, Y.4
Zhang, L.5
Yuan, Y.S.6
-
56
-
-
33644514315
-
Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo
-
Bhakat, KK, Mokkapati SK, Boldogh I, Hazra TK, Mitra S. Acetylation of human 8-oxoguanine-DNA glycosylase by p300 and its role in 8-oxoguanine repair in vivo. Mol Cell Biol 2006 26 1654-1665
-
(2006)
Mol Cell Biol
, vol.26
, pp. 1654-1665
-
-
Bhakat, K.K.1
Mokkapati, S.K.2
Boldogh, I.3
Hazra, T.K.4
Mitra, S.5
-
58
-
-
23844495832
-
The metabolic syndrome: The crossroads of diet and genetics
-
Roche HM, Phillips C, Gibney MJ. The metabolic syndrome: The crossroads of diet and genetics. Proc Nutr Soc 2005 64 371-377
-
(2005)
Proc Nutr Soc
, vol.64
, pp. 371-377
-
-
Roche, H.M.1
Phillips, C.2
Gibney, M.J.3
-
59
-
-
84855321930
-
Metabolic syndrome: Evidences for a personalized nutrition
-
Perez-Martinez P, Garcia-Rios A, Delgado-Lista J, Perez-Jimenez F, Lopez-Miranda J. Metabolic syndrome: Evidences for a personalized nutrition. Mol Nutr Food Res 2012 56 67-76
-
(2012)
Mol Nutr Food Res
, vol.56
, pp. 67-76
-
-
Perez-Martinez, P.1
Garcia-Rios, A.2
Delgado-Lista, J.3
Perez-Jimenez, F.4
Lopez-Miranda, J.5
-
60
-
-
84891506172
-
Sirt3 regulates metabolic fl exibility of skeletal muscle through reversible enzymatic deacetylation
-
Jing E, O'Neill BT, Rardin MJ, Kleinridders A, Ilkeyeva OR, Ussar S, et al. Sirt3 regulates metabolic fl exibility of skeletal muscle through reversible enzymatic deacetylation. Diabetes 2013 62 3404-3417
-
(2013)
Diabetes
, vol.62
, pp. 3404-3417
-
-
Jing, E.1
O'neill, B.T.2
Rardin, M.J.3
Kleinridders, A.4
Ilkeyeva, O.R.5
Ussar, S.6
-
61
-
-
77956173286
-
SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity
-
Bao J, Scott I, Lu Z, Pang L, Dimond CC, Gius D, Sack MN. SIRT3 is regulated by nutrient excess and modulates hepatic susceptibility to lipotoxicity. Free Radic Biol Med 2010 49 1230-1237
-
(2010)
Free Radic Biol Med
, vol.49
, pp. 1230-1237
-
-
Bao, J.1
Scott, I.2
Lu, Z.3
Pang, L.4
Dimond, C.C.5
Gius, D.6
Sack, M.N.7
-
62
-
-
80051796665
-
SIRT3 attenuates palmitate-induced ROS production and infl ammation in proximal tubular cells
-
Koyama T, Kume S, Koya D, Araki S, Isshiki K, Chin-Kanasaki M, et al. SIRT3 attenuates palmitate-induced ROS production and infl ammation in proximal tubular cells. Free Radic Biol Med 2011; 51: 1258-1267
-
(2011)
Free Radic Biol Med
, vol.51
, pp. 1258-1267
-
-
Koyama, T.1
Kume, S.2
Koya, D.3
Araki, S.4
Isshiki, K.5
Chin-Kanasaki, M.6
-
63
-
-
9344237090
-
Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: An in vivo analysis in MIRKO mice
-
Yechoor VK, Patti ME, Ueki K, Laustsen PG, Saccone R, Rauniyar R, et al. Distinct pathways of insulin-regulated versus diabetes-regulated gene expression: An in vivo analysis in MIRKO mice. Proc Natl Acad Sci USA 2004 101 16525-16530
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 16525-16530
-
-
Yechoor, V.K.1
Patti, M.E.2
Ueki, K.3
Laustsen, P.G.4
Saccone, R.5
Rauniyar, R.6
-
64
-
-
80052050501
-
Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat off spring at weaning
-
Borengasser SJ, Lau F, Kang P, Blackburn ML, Ronis MJ, Badger TM, Shankar K. Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat off spring at weaning. PLoS One 2011 6 e24068
-
(2011)
PLoS One
, vol.6
-
-
Borengasser, S.J.1
Lau, F.2
Kang, P.3
Blackburn, M.L.4
Ronis, M.J.5
Badger, T.M.6
Shankar, K.7
-
65
-
-
84885194042
-
Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus
-
Boyle KE, Newsom SA, Janssen RC, Lappas M, Friedman JE. Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus. J Clin Endocrinol Metab 2013 98 E1601-1609
-
(2013)
J Clin Endocrinol Metab
, vol.98
-
-
Boyle, K.E.1
Newsom, S.A.2
Janssen, R.C.3
Lappas, M.4
Friedman, J.E.5
-
66
-
-
19944433088
-
A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
-
Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, De Rango F, et al. A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics 2005 85 258-263
-
(2005)
Genomics
, vol.85
, pp. 258-263
-
-
Bellizzi, D.1
Rose, G.2
Cavalcante, P.3
Covello, G.4
Dato, S.5
De Rango, F.6
-
67
-
-
69849094644
-
Identifi cation of GATA2 and AP-1 activator elements within the enhancer VNTR occurring in intron 5 of the human SIRT3 gene
-
Bellizzi D, Covello G, Di Cianni F, Tong Q, De Benedictis G. Identifi cation of GATA2 and AP-1 activator elements within the enhancer VNTR occurring in intron 5 of the human SIRT3 gene. Mol Cells 2009 28 87-92
-
(2009)
Mol Cells
, vol.28
, pp. 87-92
-
-
Bellizzi, D.1
Covello, G.2
Di Cianni, F.3
Tong, Q.4
De Benedictis, G.5
-
68
-
-
58149345928
-
Endurance exercise as a countermeasure for aging
-
Lanza IR, Short DK, Short KR, Raghavakaimal S, Basu R, Joyner MJ, et al. Endurance exercise as a countermeasure for aging. Diabetes 2008 57 2933-2942
-
(2008)
Diabetes
, vol.57
, pp. 2933-2942
-
-
Lanza, I.R.1
Short, D.K.2
Short, K.R.3
Raghavakaimal, S.4
Basu, R.5
Joyner, M.J.6
-
69
-
-
73349109524
-
Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis
-
Someya S, Xu J, Kondo K, Ding D, Salvi RJ, Yamasoba T, et al. Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis. Proc Natl Acad Sci USA 2009 106 19432-19437
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 19432-19437
-
-
Someya, S.1
Xu, J.2
Kondo, K.3
Ding, D.4
Salvi, R.J.5
Yamasoba, T.6
-
70
-
-
77449120223
-
Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LJB1-AMP-Activated kinase pathway
-
Pillai VB, Sundaresan NR, Kim G, Gupta M, Rajamohan SB, Pillai JB, et al. Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LJB1-AMP-Activated kinase pathway. J Biol Chem 2010; 285: 3133-3144
-
(2010)
J Biol Chem
, vol.285
, pp. 3133-3144
-
-
Pillai, V.B.1
Sundaresan, N.R.2
Kim, G.3
Gupta, M.4
Rajamohan, S.B.5
Pillai, J.B.6
-
72
-
-
70349208608
-
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice
-
Sundaresan NR, Gupta M, Kim G, Rajamohan SB, Isbatan A, Gupta MP. Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice. J Clin Invest 2009 119 2758-2771
-
(2009)
J Clin Invest
, vol.119
, pp. 2758-2771
-
-
Sundaresan, N.R.1
Gupta, M.2
Kim, G.3
Rajamohan, S.B.4
Isbatan, A.5
Gupta, M.P.6
-
73
-
-
79952266729
-
Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy
-
Hafner AV, Dai J, Gomes AP, Xiao CY, Palmeira CM, Rosenzweig A, Sinclair DA. Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy. Aging (Albany NY) 2010 2 914-923
-
(2010)
Aging (Albany NY
, vol.2
, pp. 914-923
-
-
Hafner, A.V.1
Dai, J.2
Gomes, A.P.3
Xiao, C.Y.4
Palmeira, C.M.5
Rosenzweig, A.6
Sinclair, D.A.7
-
74
-
-
53549105529
-
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
-
Sundaresan NR, Samant SA, Pillai VB, Rajamohan SB, Gupta MP. SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70. Mol Cell Biol 2008 28 6384-6401
-
(2008)
Mol Cell Biol
, vol.28
, pp. 6384-6401
-
-
Sundaresan, N.R.1
Samant, S.A.2
Pillai, V.B.3
Rajamohan, S.B.4
Gupta, M.P.5
-
75
-
-
84893819991
-
SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress
-
Samant SA, Zhang HJ, Hong Z, Pillai VB, Sundaresan NR, Wolfgeher D, et al. SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress. Mol Cell Biol 2014 34 807-819
-
(2014)
Mol Cell Biol
, vol.34
, pp. 807-819
-
-
Samant, S.A.1
Zhang, H.J.2
Hong, Z.3
Pillai, V.B.4
Sundaresan, N.R.5
Wolfgeher, D.6
-
76
-
-
84861385983
-
Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload
-
Piquereau J, Caffi n F, Novotova M, Prola A, Garnier A, Mateo P, et al. Down-regulation of OPA1 alters mouse mitochondrial morphology, PTP function, and cardiac adaptation to pressure overload. Cardiovasc Res 2012 94 408-417
-
(2012)
Cardiovasc Res
, vol.94
, pp. 408-417
-
-
Piquereau, J.1
Caffin, F.2
Novotova, M.3
Prola, A.4
Garnier, A.5
Mateo, P.6
-
77
-
-
22044452993
-
Upregulation of matrix metalloproteinase 1 and disruption of mitochondrial network in skin fi broblasts of patients with MERRF syndrome
-
Ma YS, Chen YC, Lu CY, Liu CY, Wei YH. Upregulation of matrix metalloproteinase 1 and disruption of mitochondrial network in skin fi broblasts of patients with MERRF syndrome. Ann N Y Acad Sci 2005 1042 55-63
-
(2005)
Ann N y Acad Sci
, vol.1042
, pp. 55-63
-
-
Ma, Y.S.1
Chen, Y.C.2
Lu, C.Y.3
Liu, C.Y.4
Wei, Y.H.5
-
78
-
-
67749146967
-
Activation of PKCdelta and ERK1/2 in the sensitivity to UV-induced apoptosis of human cells harboring 4977 bp deletion of mitochondrial DNA
-
Liu CY, Lee CF, Wei YH. Activation of PKCdelta and ERK1/2 in the sensitivity to UV-induced apoptosis of human cells harboring 4977 bp deletion of mitochondrial DNA. Biochim Biophys Acta 2009 1792 783-790
-
(2009)
Biochim Biophys Acta
, vol.1792
, pp. 783-790
-
-
Liu, C.Y.1
Lee, C.F.2
Wei, Y.H.3
-
79
-
-
84872308934
-
SIRT3 protects cardiomyocytes from oxidative stress-mediated cell death by activating NF-kB
-
Chen CJ, Fu YC, Yu W, Wang W. SIRT3 protects cardiomyocytes from oxidative stress-mediated cell death by activating NF-kB. Biochem Biophys Res Commun 2013 430 798-803
-
(2013)
Biochem Biophys Res Commun
, vol.430
, pp. 798-803
-
-
Chen, C.J.1
Fu, Y.C.2
Yu, W.3
Wang, W.4
-
80
-
-
0002026429
-
Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin
-
Lu CY, Lee HC, Fahn HJ, Wei YH. Oxidative damage elicited by imbalance of free radical scavenging enzymes is associated with large-scale mtDNA deletions in aging human skin. Mutat Res 1999 423 11-21
-
(1999)
Mutat Res
, vol.423
, pp. 11-21
-
-
Lu, C.Y.1
Lee, H.C.2
Fahn, H.J.3
Wei, Y.H.4
-
81
-
-
84858297200
-
SIRT3 gene expression: A link between inherited mitochondrial DNA variants and oxidative stress
-
D'Aquila P, Rose G, Panno ML, Passarino G, Bellizzi D. SIRT3 gene expression: A link between inherited mitochondrial DNA variants and oxidative stress. Gene 2012 497 323-329
-
(2012)
Gene
, vol.497
, pp. 323-329
-
-
D'aquila, P.1
Rose, G.2
Panno, M.L.3
Passarino, G.4
Bellizzi, D.5
-
82
-
-
79955703875
-
Biochemical diagnosis of mitochondrial disorders
-
Rodenburg RJ. Biochemical diagnosis of mitochondrial disorders . J Inherit Metab Dis 2011 34 283-292
-
(2011)
J Inherit Metab Dis
, vol.34
, pp. 283-292
-
-
Rodenburg, R.J.1
-
83
-
-
0030936708
-
Maternally inherited diabetes and deafness:A diabetic subtype associated with a mutation in mitochondrial DNA
-
Maassen JA, van Den Ouweland JM, t Hart LM, Lemkes HH. Maternally inherited diabetes and deafness:a diabetic subtype associated with a mutation in mitochondrial DNA. Horm Metab Res 1997 29 50-55
-
(1997)
Horm Metab Res
, vol.29
, pp. 50-55
-
-
Maassen, J.A.1
Van Den Ouweland, J.M.T.2
Hart, L.M.3
Lemkes, H.H.4
-
84
-
-
0029135075
-
CPEO and carnitine defi ciency overlapping in MELAS syndrome
-
Hsu CC, Chuang YH, Tsai JL, Jong HJ, Shen YY, Huang HL, et al. CPEO and carnitine defi ciency overlapping in MELAS syndrome. Acta Neurol Scand 1995 92 252-255
-
(1995)
Acta Neurol Scand
, vol.92
, pp. 252-255
-
-
Hsu, C.C.1
Chuang, Y.H.2
Tsai, J.L.3
Jong, H.J.4
Shen, Y.Y.5
Huang, H.L.6
-
85
-
-
82455175476
-
Mitochondrial SIRT3 a new potential therapeutic target for metabolic syndrome
-
Yoshino J, Imai S. Mitochondrial SIRT3: A new potential therapeutic target for metabolic syndrome. Mol Cell 2011 44 170-171
-
(2011)
Mol Cell
, vol.44
, pp. 170-171
-
-
Yoshino, J.1
Imai, S.2
-
86
-
-
84855757015
-
Acetylationdependent regulation of mitochondrial ALDH2 activation by SIRT3 mediates acute ethanol-induced eNOS activation
-
Xue L, Xu F, Meng L, Wei S, Wang J, Hao P, et al. Acetylationdependent regulation of mitochondrial ALDH2 activation by SIRT3 mediates acute ethanol-induced eNOS activation. FEBS Lett 2012 586 137-142
-
(2012)
FEBS Lett
, vol.586
, pp. 137-142
-
-
Xue, L.1
Xu, F.2
Meng, L.3
Wei, S.4
Wang, J.5
Hao, P.6
-
87
-
-
84857861919
-
Mechanisms for insulin resistance: Common threads and missing links
-
Samuel VT, Shulman GI. Mechanisms for insulin resistance: Common threads and missing links. Cell 2012; 148: 852-871
-
(2012)
Cell
, vol.148
, pp. 852-871
-
-
Samuel, V.T.1
Shulman, G.I.2
-
88
-
-
84872450820
-
Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein Degradation and apoptosis in high fat diet-induced insulin resistance mice
-
Yuzefovych LV, Musiyenko SI, Wilson GL, Rachek LI. Mitochondrial DNA damage and dysfunction, and oxidative stress are associated with endoplasmic reticulum stress, protein Degradation and apoptosis in high fat diet-induced insulin resistance mice. PLoS One 2013 8 e54059
-
(2013)
PLoS One
, vol.8
-
-
Yuzefovych, L.V.1
Musiyenko, S.I.2
Wilson, G.L.3
Rachek, L.I.4
-
89
-
-
78649986930
-
Long-Term high-fat-diet feeding impairs mitochondrial biogenesis in liver of male and female rats
-
Nadal-Casellas A, Amengual-Cladera E, Proenza AM, Llad o I, Gianotti M. Long-Term high-fat-diet feeding impairs mitochondrial biogenesis in liver of male and female rats. Cell Physiol Biochem 2010 26 291-302
-
(2010)
Cell Physiol Biochem
, vol.26
, pp. 291-302
-
-
Nadal-Casellas, A.1
Amengual-Cladera, E.2
Proenza, A.M.3
Llado, I.4
Gianotti, M.5
-
90
-
-
67650815430
-
Mitochondrial H 2 O 2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans
-
Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin CT, et al. Mitochondrial H 2 O 2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest 2009 119 573-581
-
(2009)
J Clin Invest
, vol.119
, pp. 573-581
-
-
Anderson, E.J.1
Lustig, M.E.2
Boyle, K.E.3
Woodlief, T.L.4
Kane, D.A.5
Lin, C.T.6
-
91
-
-
42649127400
-
IRS-independent defects defi ne major nodes of insulin resistance
-
Hoehn KL, Hohnen-Behrens C, Cederberg A, Wu LE, Turner N, Yuasa T, et al. IRS-independent defects defi ne major nodes of insulin resistance. C ell Metab 2 008; 7 4 21-4 33
-
(2008)
C Ell Metab
, vol.7
, pp. 421-433
-
-
Hoehn, K.L.1
Hohnen-Behrens, C.2
Cederberg, A.3
Wu, L.E.4
Turner, N.5
Yuasa, T.6
-
92
-
-
84891670272
-
Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice
-
Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, et al. Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med 2014; 67: 396-407
-
(2014)
Free Radic Biol Med
, vol.67
, pp. 396-407
-
-
Cao, K.1
Xu, J.2
Zou, X.3
Li, Y.4
Chen, C.5
Zheng, A.6
-
93
-
-
84861190708
-
A long-Term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of D-galactose-induced aging rats
-
Du Z, Yang Y, Hu Y, Sun Y, Zhang S, Peng W, Zhong Y, et al. A long-Term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of D-galactose-induced aging rats. Hear Res 2012; 287: 15-24
-
(2012)
Hear Res
, vol.287
, pp. 15-24
-
-
Du, Z.1
Yang, Y.2
Hu, Y.3
Sun, Y.4
Zhang, S.5
Peng, W.6
Zhong, Y.7
-
94
-
-
79961017532
-
Biochemical study of oxidative stress markers in the liver, kidney and heart of high fat diet induced obesity in rats
-
Noeman SA, Hamooda HE, Baalash AA. Biochemical study of oxidative stress markers in the liver, kidney and heart of high fat diet induced obesity in rats. Diabetol Metab Syndr 2011 3 17-24
-
(2011)
Diabetol Metab Syndr
, vol.3
, pp. 17-24
-
-
Noeman, S.A.1
Hamooda, H.E.2
Baalash, A.A.3
-
95
-
-
84863080188
-
Lipoic acid attenuates high-fat-diet-induced oxidative stress and B-cell-related immune depression
-
Cui J, Xiao Y, Shi YH, Wang B, Le GW. Lipoic acid attenuates high-fat-diet-induced oxidative stress and B-cell-related immune depression. Nutrition 2012 28 275-280
-
(2012)
Nutrition
, vol.28
, pp. 275-280
-
-
Cui, J.1
Xiao, Y.2
Shi, Y.H.3
Wang, B.4
Le, G.W.5
-
96
-
-
83055173304
-
The fi rst identifi cation of lysine malonylation substrates and its regulatory enzyme
-
Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, et al. The fi rst identifi cation of lysine malonylation substrates and its regulatory enzyme. Mol Cell Proteomics 2011; 10: 1-12
-
(2011)
Mol Cell Proteomics
, vol.10
, pp. 1-12
-
-
Peng, C.1
Lu, Z.2
Xie, Z.3
Cheng, Z.4
Chen, Y.5
Tan, M.6
-
97
-
-
81055122671
-
Sirt5 is a NAD -dependent protein lysine demalonylase and desuccinylase
-
Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, et al. Sirt5 is a NAD- -dependent protein lysine demalonylase and desuccinylase . Science 2011 334 806-809
-
(2011)
Science
, vol.334
, pp. 806-809
-
-
Du, J.1
Zhou, Y.2
Su, X.3
Yu, J.J.4
Khan, S.5
Jiang, H.6
-
98
-
-
78650516004
-
Identifi cation of lysine succinylation as a new post-Translational modifi cation
-
Zhang Z, Tan M, Xie Z, Dai L, Chen Y, Zhao Y. Identifi cation of lysine succinylation as a new post-Translational modifi cation. Nat Chem Biol 2011 7 58-63
-
(2011)
Nat Chem Biol
, vol.7
, pp. 58-63
-
-
Zhang, Z.1
Tan, M.2
Xie, Z.3
Dai, L.4
Chen, Y.5
Zhao, Y.6
-
99
-
-
84880791239
-
SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways
-
Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, et al. SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 50 919-930
-
(2013)
Mol Cell
, vol.50
, pp. 919-930
-
-
Park, J.1
Chen, Y.2
Tishkoff, D.X.3
Peng, C.4
Tan, M.5
Dai, L.6
-
100
-
-
84889636259
-
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks
-
Rardin MJ, He W, Nishida Y, Newman JC, Carrico C, Danielson SR, et al. SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab 2013 18 920-933
-
(2013)
Cell Metab
, vol.18
, pp. 920-933
-
-
Rardin, M.J.1
He, W.2
Nishida, Y.3
Newman, J.C.4
Carrico, C.5
Danielson, S.R.6
-
101
-
-
46049084164
-
Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function
-
Lieber CS, Leo MA, Wang X, Decarli LM. Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function. Biochem Biophys Res Commun. 2008 373 246-252
-
(2008)
Biochem Biophys Res Commun
, vol.373
, pp. 246-252
-
-
Lieber, C.S.1
Leo, M.A.2
Wang, X.3
Decarli, L.M.4
-
102
-
-
58149339917
-
Opposing eff ects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity
-
Pfi ster JA, Ma C, Morrison BE, D'Mello SR. Opposing eff ects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity. PLoS One 2008 3 e4090
-
(2008)
PLoS One
, vol.3
-
-
Pfister, J.A.1
Ma, C.2
Morrison, B.E.3
D'mello, S.R.4
-
103
-
-
84886731779
-
SIRT5: A safeguard against oxidative stress-induced apoptosis in cardiomyocytes
-
Liu B, Che W, Zheng C, Liu W, Wen J, Fu H, et al. SIRT5: A safeguard against oxidative stress-induced apoptosis in cardiomyocytes . Cell Physiol Biochem 2013 32 1050-1059
-
(2013)
Cell Physiol Biochem
, vol.32
, pp. 1050-1059
-
-
Liu, B.1
Che, W.2
Zheng, C.3
Liu, W.4
Wen, J.5
Fu, H.6
-
104
-
-
70350668615
-
A survey of proteins encoded by nonsynonymous single nucleotide polymorphisms reveals a signifi cant fraction with altered stability and activity
-
Allali-Hassani A, Wasney GA, Chau I, Hong BS, Senisterra G, Loppnau P, et al. A survey of proteins encoded by nonsynonymous single nucleotide polymorphisms reveals a signifi cant fraction with altered stability and activity. Biochem J 2009 424 15-26
-
(2009)
Biochem J
, vol.424
, pp. 15-26
-
-
Allali-Hassani, A.1
Wasney, G.A.2
Chau, I.3
Hong, B.S.4
Senisterra, G.5
Loppnau, P.6
-
105
-
-
78650624567
-
Brain molecular aging, promotion of neurological disease and modulation by sirtuin 5 longevity gene polymorphism
-
Glorioso C, Oh S, Douillard GG, Sibille E. Brain molecular aging, promotion of neurological disease and modulation by sirtuin 5 longevity gene polymorphism. Neurobiol Dis 2011 41 279-290
-
(2011)
Neurobiol Dis
, vol.41
, pp. 279-290
-
-
Glorioso, C.1
Oh, S.2
Douillard, G.G.3
Sibille, E.4
-
106
-
-
80455126105
-
Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque
-
Dong C, Della-Morte D, Wang L, Cabral D, Beecham A, McClendon MS, et al. Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque. PLoS One 2011 6 e27157
-
(2011)
PLoS One
, vol.6
-
-
Dong, C.1
Della-Morte, D.2
Wang, L.3
Cabral, D.4
Beecham, A.5
McClendon, M.S.6
-
107
-
-
84874633536
-
Identifi cation of microRNAs regulated by isothiocyanates and association of polymorphisms inside their target sites with risk of sporadic colorectal cancer
-
Slaby O, Sachlova M, Brezkova V, Hezova R, Kovarikova A, Bischofov a S, et al. Identifi cation of microRNAs regulated by isothiocyanates and association of polymorphisms inside their target sites with risk of sporadic colorectal cancer. Nutr Cancer 2013 65 247-254
-
(2013)
Nutr Cancer
, vol.65
, pp. 247-254
-
-
Slaby, O.1
Sachlova, M.2
Brezkova, V.3
Hezova, R.4
Kovarikova, A.5
Bischofova, S.6
-
108
-
-
79751487260
-
Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity
-
Wolfgang MJ, Lane MD. Hypothalamic malonyl-CoA and CPT1c in the treatment of obesity. FEBS J. 2011 278 552-558
-
(2011)
FEBS J
, vol.278
, pp. 552-558
-
-
Wolfgang, M.J.1
Lane, M.D.2
-
109
-
-
68049136011
-
Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase
-
Ussher JR, Koves TR, Jaswal JS, Zhang L, Ilkayeva O, Dyck JR, et al. Insulin-stimulated cardiac glucose oxidation is increased in high-fat diet-induced obese mice lacking malonyl CoA decarboxylase. Diabetes 2009 58 1766-1775
-
(2009)
Diabetes
, vol.58
, pp. 1766-1775
-
-
Ussher, J.R.1
Koves, T.R.2
Jaswal, J.S.3
Zhang, L.4
Ilkayeva, O.5
Dyck, J.R.6
-
110
-
-
33750211736
-
Absence of malonyl coenzyme a decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury
-
Dyck JR, Hopkins TA, Bonnet S, Michelakis ED, Young ME, Watanabe M, et al. Absence of malonyl coenzyme a decarboxylase in mice increases cardiac glucose oxidation and protects the heart from ischemic injury. Circulation 2006 114 1721-1728
-
(2006)
Circulation
, vol.114
, pp. 1721-1728
-
-
Dyck, J.R.1
Hopkins, T.A.2
Bonnet, S.3
Michelakis, E.D.4
Young, M.E.5
Watanabe, M.6
-
111
-
-
4444226906
-
Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation
-
Dyck JR, Cheng JF, Stanley WC, Barr R, Chandler MP, Brown S, et al. Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation. Circ Res 2004; 94: 78-84
-
(2004)
Circ Res
, vol.94
, pp. 78-84
-
-
Dyck, J.R.1
Cheng, J.F.2
Stanley, W.C.3
Barr, R.4
Chandler, M.P.5
Brown, S.6
-
112
-
-
33749370466
-
Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; Thiazolidinedione treatment reverses these defects
-
Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM. Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes 2006 55 2277-2285
-
(2006)
Diabetes
, vol.55
, pp. 2277-2285
-
-
Bandyopadhyay, G.K.1
Yu, J.G.2
Ofrecio, J.3
Olefsky, J.M.4
-
113
-
-
84885124677
-
Metabolic characterization of a Sirt5 defi cient mouse model
-
Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, et al. Metabolic characterization of a Sirt5 defi cient mouse model. Sci Rep 2013 3 1-7
-
(2013)
Sci Rep
, vol.3
, pp. 1-7
-
-
Yu, J.1
Sadhukhan, S.2
Noriega, L.G.3
Moullan, N.4
He, B.5
Weiss, R.S.6
-
114
-
-
84894498103
-
The pivotal role of pyruvate dehydrogenase kinases in metabolic fl exibility
-
Zhang S, Hulver MW, McMillan RP, Cline MA, Gilbert ER. The pivotal role of pyruvate dehydrogenase kinases in metabolic fl exibility. Nutr Metab (Lond) 2014 11 1-9
-
(2014)
Nutr Metab (Lond
, vol.11
, pp. 1-9
-
-
Zhang, S.1
Hulver, M.W.2
McMillan, R.P.3
Cline, M.A.4
Gilbert, E.R.5
-
115
-
-
69249118245
-
Carbohydrate refeeding after a high-fat diet rapidly reverses the adaptive increase in human skeletal muscle PDH kinase activity
-
Bigrigg JK, Heigenhauser GJ, Inglis JG, LeBlanc PJ, Peters SJ. Carbohydrate refeeding after a high-fat diet rapidly reverses the adaptive increase in human skeletal muscle PDH kinase activity. Am J Physiol Regul Integr Comp Physiol 2009 297 885-891
-
(2009)
Am J Physiol Regul Integr Comp Physiol
, vol.297
, pp. 885-891
-
-
Bigrigg, J.K.1
Heigenhauser, G.J.2
Inglis, J.G.3
Leblanc, P.J.4
Peters, S.J.5
-
116
-
-
84860889760
-
The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases
-
Stacpoole PW. The pyruvate dehydrogenase complex as a therapeutic target for age-related diseases. Aging Cell 2012 11 371-377
-
(2012)
Aging Cell
, vol.11
, pp. 371-377
-
-
Stacpoole, P.W.1
-
117
-
-
77954354634
-
Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons
-
Halim ND, Mcfate T, Mohyeldin A, Okagaki P, Korotchkina LG, Patel MS, et al. Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons. Glia 2010 58 1168-1176
-
(2010)
Glia
, vol.58
, pp. 1168-1176
-
-
Halim, N.D.1
McFate, T.2
Mohyeldin, A.3
Okagaki, P.4
Korotchkina, L.G.5
Patel, M.S.6
-
118
-
-
18044384124
-
PDH kinase inhibitors: A novel therapy for type II diabetes?
-
Mayers RM, Leighton B, Kilgour E. PDH kinase inhibitors: A novel therapy for type II diabetes?. Biochem Soc Trans 2005 33 367-370
-
(2005)
Biochem Soc Trans
, vol.33
, pp. 367-370
-
-
Mayers, R.M.1
Leighton, B.2
Kilgour, E.3
-
119
-
-
0031973056
-
Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart
-
Wu P, Sato J, Zhao Y, Jaskiewicz J, Popov KM, Harris RA. Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart. Biochem J 1998 329 197-201
-
(1998)
Biochem J
, vol.329
, pp. 197-201
-
-
Wu, P.1
Sato, J.2
Zhao, Y.3
Jaskiewicz, J.4
Popov, K.M.5
Harris, R.A.6
-
120
-
-
11144305969
-
Enzymatic regulation of glucose disposal in human skeletal muscle after a high-fat, low-carbohydrate diet
-
Pehleman TL, Peters SJ, Heigenhauser GJ, Spriet LL. Enzymatic regulation of glucose disposal in human skeletal muscle after a high-fat, low-carbohydrate diet. J Appl Physiol 2005 98 100-107
-
(2005)
J Appl Physiol
, vol.98
, pp. 100-107
-
-
Pehleman, T.L.1
Peters, S.J.2
Heigenhauser, G.J.3
Spriet, L.L.4
-
121
-
-
84904263106
-
Eff ects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle
-
Biens o RS, Knudsen JG, Brandt N, Pedersen PA, Pilegaard H. Eff ects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle. Pfl ugers Arch 2014 466 1647-1657
-
(2014)
Pfl Ugers Arch
, vol.466
, pp. 1647-1657
-
-
Bienso, R.S.1
Knudsen, J.G.2
Brandt, N.3
Pedersen, P.A.4
Pilegaard, H.5
-
122
-
-
36148946735
-
Lack of AMPK-Alpha 2 enhances pyruvate dehydrogenase activity during exercise
-
Klein DK, Pilegaard H, Treebak JT, Jensen TE, Viollet B, Schjerling P, et al. Lack of AMPK-Alpha 2 enhances pyruvate dehydrogenase activity during exercise. Am J Physiol Endocrinol Metab 2007 293 1242-1249
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
, pp. 1242-1249
-
-
Klein, D.K.1
Pilegaard, H.2
Treebak, J.T.3
Jensen, T.E.4
Viollet, B.5
Schjerling, P.6
-
123
-
-
84895555985
-
Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress
-
Wu SB, Wu YT, Wu TP, Wei YH. Role of AMPK-mediated adaptive responses in human cells with mitochondrial dysfunction to oxidative stress. Biochim Biophys Acta 2014 1840 1331-1344
-
(2014)
Biochim Biophys Acta
, vol.1840
, pp. 1331-1344
-
-
Wu, S.B.1
Wu, Y.T.2
Wu, T.P.3
Wei, Y.H.4
-
124
-
-
83255189409
-
AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: Implication of the cell survival in mitochondrial diseases
-
Wu SB, Wei YH. AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: Implication of the cell survival in mitochondrial diseases. Biochim Biophys Acta 2012 1822 233-247
-
(2012)
Biochim Biophys Acta
, vol.1822
, pp. 233-247
-
-
Wu, S.B.1
Wei, Y.H.2
-
125
-
-
84887466140
-
AMPK dysregulation promotes diabetesrelated reduction of superoxide and mitochondrial function
-
Dugan LL, You YH, Ali SS, Diamond-Stanic M, Miyamoto S, DeCleves AE, et al. AMPK dysregulation promotes diabetesrelated reduction of superoxide and mitochondrial function. J Clin Invest. 2013 123 4888-4899
-
(2013)
J Clin Invest
, vol.123
, pp. 4888-4899
-
-
Dugan, L.L.1
You, Y.H.2
Ali, S.S.3
Diamond-Stanic, M.4
Miyamoto, S.5
Decleves, A.E.6
-
126
-
-
84902670910
-
SIRT3 deacetylates ATP synthase F 1 complex proteins in response to nutrient- and exerciseinduced stress
-
Vassilopoulos A, Pennington DJ, Andresson T, Rees D, Fearnley I, Ham A. SIRT3 deacetylates ATP synthase F 1 complex proteins in response to nutrient- And exerciseinduced stress. Antioxid Redox Signal. 2014 21 551-564
-
(2014)
Antioxid Redox Signal
, vol.21
, pp. 551-564
-
-
Vassilopoulos, A.1
Pennington, D.J.2
Andresson, T.3
Rees, D.4
Fearnley, I.5
Ham, A.6
-
127
-
-
77951235122
-
NAD -dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10
-
Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, et al. NAD- -dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. J Biol Chem 2010 285 7417-7429
-
(2010)
J Biol Chem
, vol.285
, pp. 7417-7429
-
-
Yang, Y.1
Cimen, H.2
Han, M.J.3
Shi, T.4
Deng, J.H.5
Koc, H.6
-
128
-
-
77951176793
-
Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria
-
Shulga N, W ilson-Smith R, P astorino J G. S irtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria. J Cell Sci 2009 123 894-902.
-
(2009)
J Cell Sci
, vol.123
, pp. 894-902
-
-
Shulga, N.1
Wilson-Smith, R.2
Pastorino, J.G.3
|