A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP

Journal of Biological Chemistry

Volumn 289, Issue 32, 2014, Pages 22205-22220

  Akimoto, Madoka ^a   Zhang, Zaiyong ^b   Boulton, Stephen ^a   Selvaratnam, Rajeevan ^a   Van Schouwen, Bryan ^a   Gloyd, Melanie ^a   Accili, Eric A ^c   Lange, Oliver F ^b,d   Melacini, Giuseppe ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b Munich Center for Integrated Protein Science   (Germany)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOLOGY;

CHANNEL OPENING; CHANNELS CONTROL; ELECTRICAL ACTIVITIES; TETRAMERIC; TETRAMERIZATION; TETRAMERS;

NUCLEOTIDES;

CYCLIC AMP; CYCLIC CMP; HCN2 PROTEIN, HUMAN; HCN4 PROTEIN, HUMAN; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; MUSCLE PROTEIN; POTASSIUM CHANNEL; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; BINDING SITE; CHANNEL GATING; CHEMICAL STRUCTURE; CHEMISTRY; ELECTRON SPIN RESONANCE; GENETICS; HUMAN; MEMBRANE POTENTIAL; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BINDING SITES; CYCLIC AMP; CYCLIC CMP; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; ION CHANNEL GATING; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUSCLE PROTEINS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POTASSIUM CHANNELS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84905836722     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.572164     Document Type: Article

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