PKA RIα homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and carney complex disease

Structure

Volumn 22, Issue 1, 2014, Pages 59-69

  Bruystens, Jessica G H ^a   Wu, Jian ^a   Fortezzo, Audrey ^a   Kornev, Alexandr P ^a   Blumenthal, Donald K ^b   Taylor, Susan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE REGULATORY SUBUNIT IALPHA; HETERODIMER; HOMODIMER; ISOENZYME; MONOMER;

ARTICLE; CARNEY COMPLEX; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME STRUCTURE; GENE MUTATION; MOLECULAR SENSOR; MUTAGENESIS; PRIORITY JOURNAL; RADIATION SCATTERING;

AMINO ACID SEQUENCE; ANIMALS; CARNEY COMPLEX; CATALYTIC DOMAIN; CATTLE; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASE RIALPHA SUBUNIT; ESCHERICHIA COLI; GENE EXPRESSION REGULATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN MULTIMERIZATION; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 84891847967     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2013.10.012     Document Type: Article

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