Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels

Journal of Biological Chemistry

Volumn 286, Issue 52, 2011, Pages 44811-44820

  Lolicato, Marco ^a   Nardini, Marco ^a   Gazzarrini, Sabrina ^a   Mol̈ler, Stefan ^b   Bertinetti, Daniela ^b   Herberg, Friedrich W ^b   Bolognesi, Martino ^a   Martin, Holger ^a   Fasolini, Marina ^c   Bertrand, Jay A ^c   Arrigoni, Cristina ^a   Thiel, Gerhard ^d   Moroni, Anna ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF KASSEL   (Germany)

^c NERVIANO MEDICAL SCIENCES   (Italy)

^d DARMSTADT UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL DOMAINS; CYCLIC NUCLEOTIDE BINDING DOMAIN; HYPERPOLARIZATION; IN-VITRO; ISOFORMS; TETRAMERIZATION; VOLTAGE CLAMP;

BIOCHEMISTRY; BIOLOGY;

NUCLEOTIDES;

CYCLIC AMP; CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 1; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 2; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 4; ISOPROTEIN; TETRAMER; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; BIOPHYSICS; CARBOXY TERMINAL SEQUENCE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLIC NUCLEOTIDE BINDING DOMAIN; HUMAN; HYPERPOLARIZATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; TETRAMERIZATION; VOLTAGE CLAMP;

ANIMALS; CYCLIC AMP; HUMANS; ION CHANNEL GATING; ION CHANNELS; OOCYTES; PROTEIN ISOFORMS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; XENOPUS LAEVIS;

EID: 84455192507     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.297606     Document Type: Article

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