Understanding cAMP-dependent allostery by NMR spectroscopy: Comparative analysis of the EPAC1 cAMP-binding domain in its apo and cAMP-bound states

Journal of the American Chemical Society

Volumn 129, Issue 46, 2007, Pages 14482-14492

  Mazhab Jafari, Mohammad T ^a   Das, Rahul ^a   Fotheringham, Steven A ^a   SilDas, Soumita ^a   Chowdhury, Somenath ^a   Melacini, Giuseppe ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CAMP-BINDING DOMAINS (CBDS); GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF); PHOSPHATE BINDING CASSETTE (PBC);

CHEMICAL BONDS; LIGANDS; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEINS;

NUCLEOTIDES;

ANTIPORTER; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RECEPTOR; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATASE; PHOSPHATE BINDING AGENT; RAP PROTEIN; RAP1 PROTEIN; RAP2 PROTEIN; UNCLASSIFIED DRUG;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; CATALYSIS; DEUTERIUM HYDROGEN EXCHANGE; EUKARYOTE; HYPOTHESIS; MOLECULAR DOCKING; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS;

ALLOSTERIC REGULATION; APOPROTEINS; ATP-BINDING CASSETTE TRANSPORTERS; CATALYTIC DOMAIN; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DEUTERIUM; EUKARYOTIC CELLS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HYDROGEN; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PHOSPHATES; RAP GTP-BINDING PROTEINS; RAP1 GTP-BINDING PROTEINS; RECEPTORS, CYCLIC AMP;

EID: 36448948004     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0753703     Document Type: Article

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